itaconic acid has been researched along with Innate Inflammatory Response in 52 studies
itaconic acid : A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a consequence of the first break, anti-microbial itaconic acid (itaconate) is produced whereas the second break activates hypoxia-inducible factor-1α (Hif-1α)." | 4.12 | Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1). ( Burczyk, G; Cichon, I; Kolaczkowska, E, 2022) |
| "Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide." | 2.72 | Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine. ( Ayaz, F; Crabtree, MJ; Diotallevi, M; Nicol, T, 2021) |
| "The incidence of colorectal cancer (CRC) among patients <50 years of age has increased dramatically over the last decades." | 2.66 | Metabolic dysfunction and early-onset colorectal cancer - how macrophages build the bridge. ( Billeter, AT; Galandiuk, S; O'Brien, SJ; Scheurlen, KM, 2020) |
| "Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss." | 1.72 | Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system. ( Chen, T; Jing, X; Song, J; Wang, D; Wang, S; Xin, L; Xu, S; Zhang, C; Zhong, W; Zhou, F, 2022) |
| "Controlling inflammation is critical for preventing many diseases including cancer, autoimmune disorders and hypersensitivity reactions." | 1.56 | Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose. ( Broz, P; Carreira, EM; Kopf, M; Muri, J; Wolleb, H, 2020) |
| "Itaconic acid is an important metabolite produced by macrophages after stimulation with LPS." | 1.46 | Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly. ( Burant, CF; ElAzzouny, M; Evans, CR; Gallagher, KA; Martin, BR; Olson, LL; Tanga, MJ; Tom, CT, 2017) |
| "Itaconic acid is an organic compound that inhibits isocitrate lyase, the key enzyme of the glyoxylate shunt, a pathway essential for bacterial growth under specific conditions." | 1.39 | Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. ( Balling, R; Binz, T; Buttini, M; Cordes, T; Ghelfi, J; Goldmann, O; Hiller, K; Linster, CL; Medina, E; Michelucci, A; Pailot, A; Rausell, A; Reiling, N; Tallam, A; Wegner, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (40.38) | 24.3611 |
| 2020's | 31 (59.62) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, X | 2 |
| Guo, Y | 1 |
| Liu, Z | 1 |
| Yang, J | 2 |
| Tang, H | 1 |
| Wang, Y | 2 |
| Diotallevi, M | 2 |
| Ayaz, F | 1 |
| Nicol, T | 2 |
| Crabtree, MJ | 2 |
| Jaiswal, AK | 1 |
| Yadav, J | 1 |
| Makhija, S | 1 |
| Mazumder, S | 1 |
| Mitra, AK | 1 |
| Suryawanshi, A | 1 |
| Sandey, M | 1 |
| Mishra, A | 1 |
| Wu, Y | 3 |
| Zheng, L | 1 |
| Yang, H | 1 |
| Lyu, X | 1 |
| Peace, CG | 1 |
| O'Neill, LA | 4 |
| Ni, L | 2 |
| Lin, Z | 1 |
| Hu, S | 1 |
| Shi, Y | 1 |
| Jiang, Z | 1 |
| Zhao, J | 1 |
| Zhou, Y | 2 |
| Tian, N | 2 |
| Sun, L | 2 |
| Wu, A | 2 |
| Pan, Z | 1 |
| Zhang, X | 2 |
| Wang, X | 2 |
| Xiao, J | 1 |
| Zhang, D | 1 |
| Shao, Z | 1 |
| Huang, C | 1 |
| Wang, S | 3 |
| Xin, L | 1 |
| Zhou, F | 1 |
| Zhang, C | 1 |
| Zhong, W | 1 |
| Xu, S | 1 |
| Jing, X | 1 |
| Wang, D | 1 |
| Chen, T | 1 |
| Song, J | 1 |
| Shi, J | 1 |
| Cai, C | 1 |
| Burczyk, G | 1 |
| Cichon, I | 1 |
| Kolaczkowska, E | 1 |
| Fedotcheva, N | 1 |
| Beloborodova, N | 1 |
| McGettrick, AF | 3 |
| Shi, X | 3 |
| Zhou, H | 3 |
| Wei, J | 3 |
| Mo, W | 3 |
| Li, Q | 3 |
| Lv, X | 3 |
| Day, EA | 1 |
| O'Neill, LAJ | 3 |
| Maassen, S | 1 |
| Coenen, B | 1 |
| Ioannidis, M | 1 |
| Harber, K | 1 |
| Grijpstra, P | 1 |
| Van den Bossche, J | 1 |
| van den Bogaart, G | 1 |
| Xiao, H | 1 |
| Dong, Y | 1 |
| Wan, D | 1 |
| Wan, J | 1 |
| Huang, J | 1 |
| Tang, L | 1 |
| Zhou, J | 1 |
| Yang, T | 1 |
| Liu, Y | 2 |
| Li, W | 2 |
| Li, Y | 4 |
| Kang, J | 2 |
| Jiang, H | 3 |
| Gong, W | 2 |
| Chen, L | 2 |
| Wu, C | 1 |
| Liu, M | 2 |
| Wu, X | 2 |
| Zhao, Y | 2 |
| Ren, J | 2 |
| Duan, X | 1 |
| Hu, M | 1 |
| Yang, L | 1 |
| Zhang, S | 1 |
| Wang, B | 1 |
| Li, T | 1 |
| Tan, Y | 1 |
| Liu, X | 1 |
| Zhan, Z | 1 |
| Yuk, JM | 1 |
| Park, EJ | 1 |
| Kim, IS | 1 |
| Jo, EK | 1 |
| Lv, L | 1 |
| Song, D | 1 |
| Zhou, X | 1 |
| Chen, F | 1 |
| Ren, L | 1 |
| Xie, Y | 1 |
| Zeng, M | 1 |
| Wu, R | 1 |
| Liu, J | 2 |
| Tang, D | 1 |
| Kang, R | 1 |
| Crossley, JL | 1 |
| Ostashevskaya-Gohstand, S | 1 |
| Comazzetto, S | 1 |
| Hook, JS | 1 |
| Guo, L | 1 |
| Vishlaghi, N | 1 |
| Juan, C | 1 |
| Xu, L | 1 |
| Horswill, AR | 1 |
| Hoxhaj, G | 1 |
| Moreland, JG | 1 |
| Tower, RJ | 1 |
| Levi, B | 1 |
| Xu, Y | 1 |
| Li, J | 1 |
| Wu, W | 1 |
| Liu, P | 1 |
| Li, X | 1 |
| Ni, C | 1 |
| Li, S | 1 |
| Liao, ST | 1 |
| Han, C | 1 |
| Xu, DQ | 1 |
| Fu, XW | 1 |
| Wang, JS | 1 |
| Kong, LY | 1 |
| Long, D | 1 |
| Zabalawi, M | 1 |
| Ingram, B | 1 |
| Yoza, BK | 1 |
| Stacpoole, PW | 1 |
| McCall, CE | 1 |
| Sun, KA | 1 |
| Meliton, AY | 1 |
| Woods, PS | 1 |
| Kimmig, LM | 1 |
| Cetin-Atalay, R | 1 |
| Hamanaka, RB | 1 |
| Mutlu, GM | 1 |
| Zasłona, Z | 1 |
| Song, H | 1 |
| Xu, T | 1 |
| Feng, X | 1 |
| Lai, Y | 1 |
| Yang, Y | 1 |
| Zheng, H | 1 |
| He, X | 1 |
| Wei, G | 1 |
| Liao, W | 1 |
| Liao, Y | 1 |
| Zhong, L | 1 |
| Bin, J | 1 |
| Li, R | 1 |
| Zhang, P | 1 |
| Tao, K | 1 |
| Muri, J | 1 |
| Wolleb, H | 1 |
| Broz, P | 1 |
| Carreira, EM | 1 |
| Kopf, M | 1 |
| Scheurlen, KM | 1 |
| Billeter, AT | 1 |
| O'Brien, SJ | 1 |
| Galandiuk, S | 1 |
| Fischer, NL | 1 |
| Shin, S | 1 |
| Brodsky, IE | 1 |
| Nonnenmacher, Y | 1 |
| Hiller, K | 4 |
| Nair, S | 2 |
| Huynh, JP | 1 |
| Lampropoulou, V | 3 |
| Loginicheva, E | 3 |
| Esaulova, E | 1 |
| Gounder, AP | 1 |
| Boon, ACM | 1 |
| Schwarzkopf, EA | 1 |
| Bradstreet, TR | 1 |
| Edelson, BT | 1 |
| Artyomov, MN | 4 |
| Stallings, CL | 1 |
| Diamond, MS | 2 |
| Bambouskova, M | 2 |
| Gorvel, L | 1 |
| Sergushichev, A | 2 |
| Johnson, K | 1 |
| Korenfeld, D | 1 |
| Mathyer, ME | 1 |
| Kim, H | 1 |
| Huang, LH | 1 |
| Duncan, D | 1 |
| Bregman, H | 1 |
| Keskin, A | 1 |
| Santeford, A | 1 |
| Apte, RS | 1 |
| Sehgal, R | 1 |
| Johnson, B | 1 |
| Amarasinghe, GK | 1 |
| Soares, MP | 1 |
| Satoh, T | 1 |
| Akira, S | 1 |
| Hai, T | 1 |
| de Guzman Strong, C | 1 |
| Auclair, K | 1 |
| Roddy, TP | 1 |
| Biller, SA | 1 |
| Jovanovic, M | 1 |
| Klechevsky, E | 1 |
| Stewart, KM | 1 |
| Randolph, GJ | 2 |
| Bordon, Y | 1 |
| Infantino, V | 1 |
| Pierri, CL | 1 |
| Iacobazzi, V | 1 |
| Perico, L | 1 |
| Wyatt, CM | 1 |
| Benigni, A | 1 |
| Yu, XH | 1 |
| Zhang, DW | 1 |
| Zheng, XL | 1 |
| Tang, CK | 1 |
| Ferreira, AV | 1 |
| Netea, MG | 1 |
| Domínguez-Andrés, J | 1 |
| Bailey, JD | 1 |
| McNeill, E | 1 |
| Shaw, A | 1 |
| Chuaiphichai, S | 1 |
| Hale, A | 1 |
| Starr, A | 1 |
| Nandi, M | 1 |
| Stylianou, E | 1 |
| McShane, H | 1 |
| Davis, S | 1 |
| Fischer, R | 1 |
| Kessler, BM | 1 |
| McCullagh, J | 1 |
| Channon, KM | 1 |
| Qin, W | 1 |
| Qin, K | 1 |
| Zhang, Y | 1 |
| Jia, W | 1 |
| Chen, Y | 1 |
| Cheng, B | 1 |
| Peng, L | 1 |
| Chen, N | 1 |
| Zhou, W | 1 |
| Wang, YL | 1 |
| Chen, X | 1 |
| Wang, C | 1 |
| Michelucci, A | 2 |
| Cordes, T | 2 |
| Ghelfi, J | 2 |
| Pailot, A | 1 |
| Reiling, N | 1 |
| Goldmann, O | 1 |
| Binz, T | 1 |
| Wegner, A | 1 |
| Tallam, A | 1 |
| Rausell, A | 1 |
| Buttini, M | 1 |
| Linster, CL | 1 |
| Medina, E | 1 |
| Balling, R | 1 |
| Meiser, J | 1 |
| Krämer, L | 1 |
| Sapcariu, SC | 1 |
| Battello, N | 1 |
| D'Herouel, AF | 1 |
| Skupin, A | 1 |
| Calles, JA | 1 |
| López-García, A | 1 |
| Vallés, EM | 1 |
| Palma, SD | 1 |
| Diebold, Y | 1 |
| Vincent, EE | 1 |
| Cervantes-Barragan, L | 1 |
| Ma, X | 1 |
| Huang, SC | 1 |
| Griss, T | 1 |
| Weinheimer, CJ | 1 |
| Khader, S | 1 |
| Pearce, EJ | 1 |
| Jones, RG | 1 |
| Diwan, A | 1 |
| Luan, HH | 1 |
| Medzhitov, R | 1 |
| ElAzzouny, M | 1 |
| Tom, CT | 1 |
| Evans, CR | 1 |
| Olson, LL | 1 |
| Tanga, MJ | 1 |
| Gallagher, KA | 1 |
| Martin, BR | 1 |
| Burant, CF | 1 |
17 reviews available for itaconic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine.
Topics: Biomarkers; Cardiovascular Diseases; Energy Metabolism; Glycolysis; Humans; Inflammation; Inflammati | 2021 |
[Research progress of itaconate on the regulation of macrophage inflammation].
Topics: Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Macrophages; NF-E2-Related Factor 2; Succ | 2021 |
The role of itaconate in host defense and inflammation.
Topics: Animals; Citric Acid Cycle; Humans; Inflammation; Macrophage Activation; Macrophages; Succinates | 2022 |
Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism.
Topics: Humans; Inflammation; Macrophage Activation; Macrophages; Succinates | 2022 |
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; Humans; Inflammation; R | 2023 |
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; Humans; Inflammation; R | 2023 |
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; Humans; Inflammation; R | 2023 |
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antiviral Agents; COVID-19; Humans; Inflammation; R | 2023 |
The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases.
Topics: Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Macrophages; NF-E2-Related Factor 2; Oxid | 2022 |
The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases.
Topics: Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Macrophages; NF-E2-Related Factor 2; Oxid | 2022 |
The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases.
Topics: Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Macrophages; NF-E2-Related Factor 2; Oxid | 2022 |
The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases.
Topics: Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Macrophages; NF-E2-Related Factor 2; Oxid | 2022 |
Itaconate family-based host-directed therapeutics for infections.
Topics: Anti-Inflammatory Agents; Humans; Inflammation | 2023 |
The Dual Role of ACOD1 in Inflammation.
Topics: Animals; Immunity, Innate; Inflammation; Macrophages; Mice; Succinates | 2023 |
Cytokine-like Roles for Metabolites in Immunity.
Topics: Animals; Carboxylic Acids; Citric Acid Cycle; Cytokines; Energy Metabolism; Humans; Immunity; Inflam | 2020 |
Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress.
Topics: Anti-Inflammatory Agents; Humans; Inflammation; Oxidative Stress; Succinates | 2020 |
Metabolic dysfunction and early-onset colorectal cancer - how macrophages build the bridge.
Topics: Adiposity; Adolescent; Adult; Cell Polarity; Cellular Reprogramming; Child; Colonic Neoplasms; Human | 2020 |
Biochemistry of proinflammatory macrophage activation.
Topics: Animals; Communicable Diseases; Energy Metabolism; Glycolysis; Humans; Inflammation; Macrophage Acti | 2018 |
Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target.
Topics: Animals; ATP Citrate (pro-S)-Lyase; Carrier Proteins; Humans; Inflammation; Mitochondria; Oxidative | 2019 |
Itaconate: an emerging determinant of inflammation in activated macrophages.
Topics: Animals; B-Cell Lymphoma 3 Protein; Humans; Inflammation; Macrophage Activation; Macrophages; NF-E2- | 2019 |
Itaconate: the poster child of metabolic reprogramming in macrophage function.
Topics: Animals; Child; Humans; Inflammation; Interferon Type I; Macrophage Activation; Macrophages; Oxidati | 2019 |
Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite.
Topics: Animals; Anti-Infective Agents; Aspergillus; Bacteria; Carboxy-Lyases; Citric Acid Cycle; Energy Met | 2015 |
Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense.
Topics: Anti-Infective Agents; Energy Metabolism; Food; Immunity; Inflammation; Metabolome; Succinates | 2016 |
35 other studies available for itaconic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cytokines; Gene Expression Regulation; Glu | 2021 |
Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation.
Topics: Allergens; Animals; Dendritic Cells; Hydro-Lyases; Inflammation; Metabolic Networks and Pathways; Mi | 2022 |
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Topics: Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Inflammation; Interleukin-1beta | 2022 |
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Topics: Animals; Hydro-Lyases; Inflammation; Lipopolysaccharides; Mice; Microglia; NF-E2-Related Factor 2; S | 2022 |
Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system.
Topics: Alveolar Bone Loss; Animals; Antioxidants; Inflammation; Kelch-Like ECH-Associated Protein 1; Mice; | 2022 |
Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1).
Topics: Animals; Endothelial Cells; Extracellular Traps; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hyp | 2022 |
Influence of Microbial Metabolites and Itaconic Acid Involved in Bacterial Inflammation on the Activity of Mitochondrial Enzymes and the Protective Role of Alkalization.
Topics: Glutamate Dehydrogenase; Glutamic Acid; Humans; Inflammation; Mitochondria; Oxidation-Reduction; Pyr | 2022 |
Protein targeting by the itaconate family in immunity and inflammation.
Topics: Animals; Inflammation; Kelch-Like ECH-Associated Protein 1; Mice; NF-E2-Related Factor 2; Succinates | 2022 |
Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages.
Topics: Collagen; Cyclooxygenase 2; Humans; Inflammation; Lipopolysaccharides; Macrophages; Phenotype; Trans | 2023 |
Injectable hydrogel loaded with 4-octyl itaconate enhances cartilage regeneration by regulating macrophage polarization.
Topics: Animals; Cartilage; Cell Polarity; Gelatin; Hydrogels; Inflammation; Macrophages; Rats; Regeneration | 2023 |
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING.
Topics: Alkylation; Humans; Inflammation; Membrane Proteins; Proteins; Succinates | 2023 |
IRG1 prevents excessive inflammatory responses and cardiac dysfunction after myocardial injury.
Topics: Animals; Doxorubicin; Inflammation; Mice; Mice, Knockout; Myocardial Infarction; NF-E2-Related Facto | 2023 |
Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
Topics: Animals; Gout; Inflammation; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Sirtuin 3; Uric Acid | 2023 |
Itaconate-producing neutrophils regulate local and systemic inflammation following trauma.
Topics: Humans; Inflammation; Macrophages; Neutrophils; Succinates | 2023 |
Itaconate inhibits SYK through alkylation and suppresses inflammation against hvKP induced intestinal dysbiosis.
Topics: Alkylation; Dysbiosis; Humans; Inflammation; Klebsiella Infections; Klebsiella pneumoniae; Syk Kinas | 2023 |
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Topics: Alkylation; Animals; Antimetabolites; Cysteine; Deoxyglucose; Down-Regulation; Endotoxemia; Glucose; | 2019 |
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes.
Topics: Algorithms; Amino Acids; Carnitine; Citric Acid Cycle; Cytokines; Energy Metabolism; Humans; Inflamm | 2020 |
Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response.
Topics: Animals; Carboxy-Lyases; Inflammation; Macrophages, Alveolar; Mice; Mice, Knockout; NF-E2-Related Fa | 2020 |
Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Carboxy-Lyases; C | 2020 |
Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose.
Topics: Humans; Inflammation; NF-E2-Related Factor 2; Pyroptosis; Succinates | 2020 |
Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation.
Topics: Humans; Inflammasomes; Inflammation; NLR Family, Pyrin Domain-Containing 3 Protein; Succinates | 2021 |
Topics: Animals; Cytokines; Disease Progression; Female; Gene Expression; Hydro-Lyases; Inflammation; Lung D | 2018 |
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Topics: Activating Transcription Factor 3; Animals; Cells, Cultured; Cytokines; Female; Gene Expression Regu | 2018 |
Itaconate charges down inflammation.
Topics: Activating Transcription Factor 3; Humans; Inflammation; Succinates | 2018 |
A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system.
Topics: Alkylation; Anti-Inflammatory Agents; Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; NF- | 2018 |
Itaconate as an immune modulator.
Topics: Animals; Autoimmune Diseases; Inflammation; Macrophages; Mice; Succinates | 2019 |
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Topics: Animals; Biopterins; Citric Acid Cycle; Electron Transport; Endotoxemia; Glycolysis; GTP Cyclohydrol | 2019 |
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate.
Topics: Animals; Cysteine; Fructose-Bisphosphate Aldolase; Gene Expression Regulation; Glycolysis; Glycosyla | 2019 |
Sweetly profiling the cysteinome.
Topics: Carbohydrates; Cysteine; Humans; Inflammation; Macrophages; Proteins; Succinates | 2019 |
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
Topics: Animals; Carboxy-Lyases; Catalysis; Cell Line; Gene Expression Regulation; Green Fluorescent Protein | 2013 |
Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression.
Topics: Animals; Cell Line; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammat | 2016 |
Preliminary characterization of dexamethasone-loaded cross-linked hyaluronic acid films for topical ocular therapy.
Topics: Administration, Topical; Cell Line; Cell Proliferation; Cornea; Dexamethasone; Humans; Hyaluronic Ac | 2016 |
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Topics: Animals; Cell Respiration; Female; Inflammation; Lipopolysaccharides; Macrophage Activation; Macroph | 2016 |
Itaconate and Inflammation, miRs in Zebrafish Embryos, and SHP2 Inhibitor.
Topics: Animals; Embryo, Nonmammalian; Enzyme Inhibitors; Humans; Inflammation; MicroRNAs; Protein Tyrosine | 2016 |
Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly.
Topics: Animals; Cells, Cultured; Inflammation; Lipopolysaccharides; Macrophages; Metabolome; Metabolomics; | 2017 |