itaconic acid has been researched along with Disease Models, Animal in 11 studies
itaconic acid : A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As these pathways are dysregulated in systemic lupus erythematosus (SLE), we investigated the role of an itaconic acid derivative in the treatment of established murine lupus." | 1.72 | Modulation of the Itaconate Pathway Attenuates Murine Lupus. ( Blanco, LP; Carmona-Rivera, C; Claybaugh, D; Desta, E; Kaplan, MJ; Nakabo, S; Patino-Martinez, E; Pedersen, HL; Wang, X; Yu, ZX; Zhang, M, 2022) |
| "However, the key mediators of reperfusion injury remain unclear, and therefore, there is considerable interest in therapeutically targeting metabolism and the cellular response to oxidative stress." | 1.56 | Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury. ( Cabrales, P; Cordes, T; Divakaruni, AS; Lucas, A; Metallo, CM; Murphy, AN, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 8 (72.73) | 2.80 |
| Authors | Studies |
|---|---|
| Ni, L | 1 |
| Lin, Z | 1 |
| Hu, S | 1 |
| Shi, Y | 1 |
| Jiang, Z | 1 |
| Zhao, J | 1 |
| Zhou, Y | 1 |
| Wu, Y | 1 |
| Tian, N | 1 |
| Sun, L | 1 |
| Wu, A | 1 |
| Pan, Z | 1 |
| Zhang, X | 1 |
| Wang, X | 3 |
| Zhang, P | 1 |
| Peng, Q | 1 |
| Jin, Y | 1 |
| Shi, G | 1 |
| Fan, Z | 1 |
| Zhou, Z | 1 |
| Blanco, LP | 1 |
| Patino-Martinez, E | 1 |
| Nakabo, S | 1 |
| Zhang, M | 1 |
| Pedersen, HL | 1 |
| Carmona-Rivera, C | 1 |
| Claybaugh, D | 1 |
| Yu, ZX | 1 |
| Desta, E | 1 |
| Kaplan, MJ | 1 |
| Cordes, T | 1 |
| Lucas, A | 1 |
| Divakaruni, AS | 1 |
| Murphy, AN | 1 |
| Cabrales, P | 1 |
| Metallo, CM | 1 |
| Beier, UH | 1 |
| Hartung, EA | 1 |
| Concors, S | 1 |
| Hernandez, PT | 1 |
| Wang, Z | 1 |
| Perry, C | 1 |
| Baur, JA | 1 |
| Denburg, MR | 1 |
| Hancock, WW | 1 |
| Gade, TP | 1 |
| Levine, MH | 1 |
| Song, H | 1 |
| Xu, T | 1 |
| Feng, X | 1 |
| Lai, Y | 1 |
| Yang, Y | 1 |
| Zheng, H | 1 |
| He, X | 1 |
| Wei, G | 1 |
| Liao, W | 1 |
| Liao, Y | 1 |
| Zhong, L | 1 |
| Bin, J | 1 |
| Ogger, PP | 1 |
| Albers, GJ | 1 |
| Hewitt, RJ | 1 |
| O'Sullivan, BJ | 1 |
| Powell, JE | 1 |
| Calamita, E | 1 |
| Ghai, P | 1 |
| Walker, SA | 1 |
| McErlean, P | 1 |
| Saunders, P | 1 |
| Kingston, S | 1 |
| Molyneaux, PL | 1 |
| Halket, JM | 1 |
| Gray, R | 1 |
| Chambers, DC | 1 |
| Maher, TM | 1 |
| Lloyd, CM | 1 |
| Byrne, AJ | 1 |
| Azzimato, V | 1 |
| Chen, P | 1 |
| Barreby, E | 1 |
| Morgantini, C | 1 |
| Levi, L | 1 |
| Vankova, A | 1 |
| Jager, J | 1 |
| Sulen, A | 1 |
| Diotallevi, M | 1 |
| Shen, JX | 1 |
| Miller, A | 1 |
| Ellis, E | 1 |
| Rydén, M | 1 |
| Näslund, E | 1 |
| Thorell, A | 1 |
| Lauschke, VM | 1 |
| Channon, KM | 1 |
| Crabtree, MJ | 1 |
| Haschemi, A | 1 |
| Craige, SM | 1 |
| Mori, M | 1 |
| Spallotta, F | 1 |
| Aouadi, M | 1 |
| Hato, T | 1 |
| Zollman, A | 1 |
| Plotkin, Z | 1 |
| El-Achkar, TM | 1 |
| Maier, BF | 1 |
| Pay, SL | 1 |
| Dube, S | 1 |
| Cabral, P | 1 |
| Yoshimoto, M | 1 |
| McClintick, J | 1 |
| Dagher, PC | 1 |
| Daniels, BP | 1 |
| Kofman, SB | 1 |
| Smith, JR | 1 |
| Norris, GT | 1 |
| Snyder, AG | 1 |
| Kolb, JP | 1 |
| Gao, X | 1 |
| Locasale, JW | 1 |
| Martinez, J | 1 |
| Gale, M | 1 |
| Loo, YM | 1 |
| Oberst, A | 1 |
| Naujoks, J | 1 |
| Tabeling, C | 1 |
| Dill, BD | 1 |
| Hoffmann, C | 1 |
| Brown, AS | 1 |
| Kunze, M | 1 |
| Kempa, S | 1 |
| Peter, A | 1 |
| Mollenkopf, HJ | 1 |
| Dorhoi, A | 1 |
| Kershaw, O | 1 |
| Gruber, AD | 1 |
| Sander, LE | 1 |
| Witzenrath, M | 1 |
| Herold, S | 1 |
| Nerlich, A | 1 |
| Hocke, AC | 1 |
| van Driel, I | 1 |
| Suttorp, N | 1 |
| Bedoui, S | 1 |
| Hilbi, H | 1 |
| Trost, M | 1 |
| Opitz, B | 1 |
11 other studies available for itaconic acid and Disease Models, Animal
| Article | Year |
|---|---|
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Topics: Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Inflammation; Interleukin-1beta | 2022 |
Four-Octyl Itaconate Protects Chondrocytes against H
Topics: Animals; Apoptosis; Cells, Cultured; Chondrocytes; Disease Models, Animal; Hydrogen Peroxide; Kelch- | 2022 |
Modulation of the Itaconate Pathway Attenuates Murine Lupus.
Topics: Animals; Antibodies, Antinuclear; Disease Models, Animal; Female; Humans; Infant, Newborn; Lupus Ery | 2022 |
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Male; Mice; | 2020 |
Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection.
Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Kidney; Kidney Transplantation; Kynurenine | 2020 |
Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Carboxy-Lyases; C | 2020 |
Itaconate controls the severity of pulmonary fibrosis.
Topics: Administration, Inhalation; Adoptive Transfer; Adult; Aged; Animals; Bleomycin; Bronchoalveolar Lava | 2020 |
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Topics: Animals; Carboxy-Lyases; Citric Acid Cycle; Disease Models, Animal; Fatty Liver; Fumarate Hydratase; | 2021 |
Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney.
Topics: Animals; Arginine; Bacterial Load; Cellular Reprogramming; Chimera; Cytokines; Disease Models, Anima | 2018 |
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Glycoproteins; Humans; Hydro-Lyases; M | 2019 |
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation; Gene Ontology; Hydro-Lyases; Im | 2016 |