isradipine has been researched along with Seizures in 6 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the possible anticonvulsant effect of a dihydropyridine calcium antagonist, isradipine, which easily crosses the blood-brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures in mice." | 7.70 | The effect of isradipine on maximal electroshock seizures in mice. ( Akkan, AG; Gacar, N; Ozüner, Z; Ozyazgan, S; Senses, V; Ulak, G; Utkan, T; Yildiran, G, 1998) |
| "A 21-year-old white man, with propionic acidemia and seizures treated with phenytoin and carbamazepine, was started on isradipine for essential hypertension." | 3.71 | Phenytoin/isradipine interaction causing severe neurologic toxicity. ( Cachat, F; Tufro, A, 2002) |
| " The aim of this study was to investigate the possible anticonvulsant effect of a dihydropyridine calcium antagonist, isradipine, which easily crosses the blood-brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures in mice." | 3.70 | The effect of isradipine on maximal electroshock seizures in mice. ( Akkan, AG; Gacar, N; Ozüner, Z; Ozyazgan, S; Senses, V; Ulak, G; Utkan, T; Yildiran, G, 1998) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| "Nitrendipine was effective when given for two weeks but not after only two days' treatment." | 1.28 | Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment. ( Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Siarey, RJ; Whittington, MA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Stölting, G | 1 |
| Dinh, HA | 1 |
| Volkert, M | 1 |
| Hellmig, N | 1 |
| Schewe, J | 1 |
| Hennicke, L | 1 |
| Seidel, E | 1 |
| Oberacher, H | 1 |
| Zhang, J | 1 |
| Lifton, RP | 1 |
| Urban, I | 1 |
| Long, M | 1 |
| Rivalan, M | 1 |
| Nottoli, T | 1 |
| Scholl, UI | 1 |
| Cachat, F | 1 |
| Tufro, A | 1 |
| Borowicz, KK | 1 |
| Gasior, M | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Ozyazgan, S | 1 |
| Senses, V | 1 |
| Utkan, T | 1 |
| Yildiran, G | 1 |
| Ulak, G | 1 |
| Gacar, N | 1 |
| Ozüner, Z | 1 |
| Akkan, AG | 1 |
| Whittington, MA | 2 |
| Dolin, SJ | 1 |
| Patch, TL | 1 |
| Siarey, RJ | 1 |
| Butterworth, AR | 1 |
| Little, HJ | 2 |
| Green, AR | 1 |
| Davies, EM | 1 |
| Cross, AJ | 1 |
6 other studies available for isradipine and Seizures
| Article | Year |
|---|---|
Isradipine therapy in Cacna1dIle772Met/+ mice ameliorates primary aldosteronism and neurologic abnormalities.
Topics: Adenoma; Aldosterone; Animals; Autism Spectrum Disorder; Calcium; Female; Humans; Hyperaldosteronism | 2023 |
Phenytoin/isradipine interaction causing severe neurologic toxicity.
Topics: Acidosis; Adult; Anticonvulsants; Antihypertensive Agents; Calcium Channel Blockers; Drug Interactio | 2002 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
The effect of isradipine on maximal electroshock seizures in mice.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Calcium Channel Blockers; Drug Evaluation, Preclinica | 1998 |
Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment.
Topics: Adaptation, Psychological; Administration, Inhalation; Animals; Behavior, Animal; Bicuculline; Brain | 1991 |
Action of chlormethiazole in a model of ethanol withdrawal.
Topics: Animals; Calcium Channels; Chlormethiazole; Dihydropyridines; Ethanol; Isradipine; Male; Mice; Motor | 1990 |