isradipine has been researched along with Pregnancy in 34 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effects of isradipine or metoprolol on insulin sensitivity and lipid profiles as well as on blood pressure and umbilical vascular resistance in pre-eclamptic women in the third trimester of pregnancy." | 9.09 | Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia. ( Cacciatore, B; Kaaja, RJ; Laakso, M; Laivuori, HM; Tikkanen, MJ; Ylikorkala, RO, 1999) |
| "Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment." | 9.08 | Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study. ( Andersson, KE; Forman, A; Ingemarsson, I; Lindberg, B; Lindeberg, S; Lunell, NO; Marsàl, K; Skajaa, K; Wide-Swensson, DH, 1995) |
| "Fourteen women with hypertension of pregnancy and who were in their last trimester were subjected to three standardized physical stress tests before and after 1-2 weeks of treatment with 5 mg of isradipine twice daily." | 9.07 | Effect of isradipine on responses to standardized physical stress tests in hypertension of pregnancy. ( Grunewald, C; Lunell, NO; Nisell, H, 1992) |
| "9 years) who had developed hypertension (blood pressure greater than 140/90 mm Hg) took part in an open pilot study with the new calcium antagonist isradipine." | 9.07 | Influence of isradipine on the maternal and fetal cardiovascular system in hypertensive disorders in pregnancy. ( Feiks, A; Grünberger, W; Meisner, W, 1991) |
| "To determine the appropriate dosage regimen of isradipine in black patients with severe hypertension of pregnancy, 10 patients (gestational age, 30 to 38 weeks; diastolic blood pressure [DBP], 110 to 148 mm Hg; no hypertensive crises; and normal central venous pressure) were given an isradipine infusion while the fetal heart rate was continuously recorded using a cardiotocograph." | 7.69 | Intravenous isradipine in the management of severe hypertension in pregnant and nonpregnant patients. A pilot study. ( Khedun, SM; Madhanpall, N; Maharaj, B; Moodley, J; van der Byl, K, 1994) |
| "To determine the haemostatic status in preeclampsia and to investigate the effects of short-term use of anti-hypertensive drugs, methyldopa and isradipine." | 6.69 | Preeclampsia: haemostatic status and the short-term effects of methyldopa and isradipine therapy. ( Arulkumaran, S; Biswas, A; Koh, SC; Malcus, P; Ratnam, SS; SvenMontan, S; Yin, KH, 1998) |
| " This pilot study was conducted to determine the appropriate dosage regimen for isradipine in black patients with severe hypertensive disorders of pregnancy." | 5.29 | Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. ( Khedun, SM; Madhanpall, N; Maharaj, B; Moodley, J; van der Byl, K, 1994) |
| "Provided that preeclampsia comprises enhanced vascular actions of thromboxane A2, the present results support the established use of Mg++ in the treatment of this condition and suggest that calcium antagonists are of potential benefit." | 5.28 | Effects of magnesium and isradipine on contractile activation induced by the thromboxane A2 analog U46619 in human uteroplacental arteries in term pregnancy. ( Andersson, KE; Forman, A; Skajaa, K; Svane, D, 1990) |
| "To study the effects of isradipine or metoprolol on insulin sensitivity and lipid profiles as well as on blood pressure and umbilical vascular resistance in pre-eclamptic women in the third trimester of pregnancy." | 5.09 | Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia. ( Cacciatore, B; Kaaja, RJ; Laakso, M; Laivuori, HM; Tikkanen, MJ; Ylikorkala, RO, 1999) |
| "Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment." | 5.08 | Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study. ( Andersson, KE; Forman, A; Ingemarsson, I; Lindberg, B; Lindeberg, S; Lunell, NO; Marsàl, K; Skajaa, K; Wide-Swensson, DH, 1995) |
| "Fourteen women with hypertension of pregnancy and who were in their last trimester were subjected to three standardized physical stress tests before and after 1-2 weeks of treatment with 5 mg of isradipine twice daily." | 5.07 | Effect of isradipine on responses to standardized physical stress tests in hypertension of pregnancy. ( Grunewald, C; Lunell, NO; Nisell, H, 1992) |
| "9 years) who had developed hypertension (blood pressure greater than 140/90 mm Hg) took part in an open pilot study with the new calcium antagonist isradipine." | 5.07 | Influence of isradipine on the maternal and fetal cardiovascular system in hypertensive disorders in pregnancy. ( Feiks, A; Grünberger, W; Meisner, W, 1991) |
| "To determine the appropriate dosage regimen of isradipine in black patients with severe hypertension of pregnancy, 10 patients (gestational age, 30 to 38 weeks; diastolic blood pressure [DBP], 110 to 148 mm Hg; no hypertensive crises; and normal central venous pressure) were given an isradipine infusion while the fetal heart rate was continuously recorded using a cardiotocograph." | 3.69 | Intravenous isradipine in the management of severe hypertension in pregnant and nonpregnant patients. A pilot study. ( Khedun, SM; Madhanpall, N; Maharaj, B; Moodley, J; van der Byl, K, 1994) |
| "To assess the effect of isradipine on blood pressure, and uteroplacental and fetal blood flows in pregnancy-induced hypertension, 41 women with a diastolic blood pressure greater than or equal to 95 mm Hg were included in our study." | 3.68 | Isradipine, a new calcium antagonist: effects on maternal and fetal hemodynamics. ( Garoff, L; Grunewald, C; Lunell, NO; Nisell, H; Nylund, L; Sarby, B; Thornström, S, 1991) |
| "To determine the haemostatic status in preeclampsia and to investigate the effects of short-term use of anti-hypertensive drugs, methyldopa and isradipine." | 2.69 | Preeclampsia: haemostatic status and the short-term effects of methyldopa and isradipine therapy. ( Arulkumaran, S; Biswas, A; Koh, SC; Malcus, P; Ratnam, SS; SvenMontan, S; Yin, KH, 1998) |
| "Pretreatment with isradipine (10(-6) M) or indomethacin (10(-7) M), concentrations that themselves had no effect on spontaneous contractility, significantly increased the inhibitor responses to sevoflurane on amplitude and frequency of myometrial contractions, beginning at 1 MAC (P<0." | 1.32 | Interactive effect of sevoflurane with isradipine or indomethacin on spontaneous contractile activity of isolated pregnant rat myometrium. ( Bagcivan, I; Gursoy, S; Kafali, H; Karadas, B; Kaya, T; Kunt, N, 2004) |
| "Fetal membranes from women in preterm labor had the least amount of measured endogenous calcium channel inhibitor activity." | 1.31 | Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor. ( Carroll, EM; Collins, PL; Gianopoulos, JG, 2001) |
| "Isradipine appears to be an effective relaxant in rat myometrium." | 1.30 | Inhibitory effects of isradipine on spontaneous and oxytocin- and carbachol-stimulated contractions of rat myometrium. ( Cetin, A; Cetin, M; Kaya, T; Sarioglu, Y, 1998) |
| " After optimal time of release of inhibitor was determined, a dose-response experiment was performed with the competitive binding assay." | 1.30 | Human fetal membranes release a Ca++ channel inhibitor. ( Collins, PL; Emery, SP; Idriss, E; Richmonds, C, 1998) |
| "Pretreatment with isradipine attenuated ET-1-induced contraction by 26% at 3 x 10(-4) mol/L and by up to 80% at 10(-3) mol/L." | 1.29 | Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women. ( Kublickas, M; Kublickiene, KR; Lindblom, B; Lunell, NO; Nisell, H; Wolff, K, 1994) |
| " This pilot study was conducted to determine the appropriate dosage regimen for isradipine in black patients with severe hypertensive disorders of pregnancy." | 1.29 | Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study. ( Khedun, SM; Madhanpall, N; Maharaj, B; Moodley, J; van der Byl, K, 1994) |
| "Provided that preeclampsia comprises enhanced vascular actions of thromboxane A2, the present results support the established use of Mg++ in the treatment of this condition and suggest that calcium antagonists are of potential benefit." | 1.28 | Effects of magnesium and isradipine on contractile activation induced by the thromboxane A2 analog U46619 in human uteroplacental arteries in term pregnancy. ( Andersson, KE; Forman, A; Skajaa, K; Svane, D, 1990) |
| "Isradipine was given as a slow injection in doses of 0." | 1.28 | Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour. ( Andersson, KE; Arulkumaran, S; Ingemarsson, I; Wide-Swensson, D, 1990) |
| "The caffeine inhibition was not enhanced when calcium channels were opened by a conditioning depolarizing pulse sequence or when the number of inactivated calcium channels was increased at depolarized holding potentials." | 1.28 | Caffeine-induced inhibition of calcium channel current in cultured smooth cells from pregnant rat myometrium. ( Dacquet, C; Martin, C; Mironneau, C; Mironneau, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.82) | 18.7374 |
| 1990's | 25 (73.53) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kantas, E | 1 |
| Cetin, A | 5 |
| Kaya, T | 6 |
| Cetin, M | 5 |
| Gursoy, S | 1 |
| Kunt, N | 1 |
| Karadas, B | 1 |
| Bagcivan, I | 1 |
| Kafali, H | 1 |
| Darcie, S | 1 |
| Leone, CR | 1 |
| Calil, VM | 1 |
| Prescinotti, EP | 1 |
| Kahhale, S | 1 |
| Zugaib, M | 1 |
| Wide-Swensson, DH | 1 |
| Ingemarsson, I | 7 |
| Lunell, NO | 5 |
| Forman, A | 3 |
| Skajaa, K | 2 |
| Lindberg, B | 1 |
| Lindeberg, S | 1 |
| Marsàl, K | 1 |
| Andersson, KE | 5 |
| Brogden, RN | 1 |
| Sorkin, EM | 1 |
| Kublickiene, KR | 1 |
| Wolff, K | 1 |
| Kublickas, M | 1 |
| Lindblom, B | 1 |
| Nisell, H | 4 |
| Maharaj, B | 2 |
| Khedun, SM | 2 |
| Moodley, J | 2 |
| Madhanpall, N | 2 |
| van der Byl, K | 2 |
| Wide-Swensson, D | 5 |
| Montan, S | 2 |
| Arulkumaran, S | 6 |
| Ratnam, SS | 3 |
| Bondesson, U | 1 |
| Grunewald, C | 3 |
| Anandakumar, C | 1 |
| Ratnam, S | 1 |
| Maher, MJ | 1 |
| Dworkin, LD | 1 |
| Browne, VA | 1 |
| Stiffel, VM | 1 |
| Pearce, WJ | 1 |
| Longo, LD | 1 |
| Gilbert, RD | 1 |
| Sarioglu, Y | 4 |
| Yin, KH | 1 |
| Koh, SC | 1 |
| Malcus, P | 1 |
| SvenMontan, S | 1 |
| Biswas, A | 1 |
| Emery, SP | 1 |
| Idriss, E | 1 |
| Richmonds, C | 1 |
| Collins, PL | 3 |
| Laivuori, HM | 1 |
| Laakso, M | 1 |
| Tikkanen, MJ | 1 |
| Cacciatore, B | 1 |
| Ylikorkala, RO | 1 |
| Kaaja, RJ | 1 |
| Moore, JJ | 1 |
| Lundgren, DW | 1 |
| Choobineh, E | 1 |
| Chang, SM | 1 |
| Chang, AS | 1 |
| Carroll, EM | 1 |
| Gianopoulos, JG | 1 |
| Skoczyński, M | 1 |
| Semczuk, M | 1 |
| Garoff, L | 1 |
| Nylund, L | 1 |
| Sarby, B | 1 |
| Thornström, S | 1 |
| Feiks, A | 2 |
| Grünberger, W | 2 |
| Meisner, W | 2 |
| Svane, D | 1 |
| Martin, C | 3 |
| Arnaudeau, S | 1 |
| Jmari, K | 1 |
| Rakotoarisoa, L | 1 |
| Sayet, I | 1 |
| Dacquet, C | 3 |
| Mironneau, C | 3 |
| Mironneau, J | 3 |
| Honoré, E | 1 |
| Amédée, T | 1 |
2 reviews available for isradipine and Pregnancy
| Article | Year |
|---|---|
Isradipine. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of mild to moderate hypertension.
Topics: Cardiac Surgical Procedures; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; | 1995 |
Calcium antagonists in the treatment of hypertension: special clinical considerations.
Topics: Angina Pectoris; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; | 1996 |
11 trials available for isradipine and Pregnancy
| Article | Year |
|---|---|
Glycemia in newborns of hypertensive mothers according to maternal treatment.
Topics: Antihypertensive Agents; Apgar Score; Atenolol; Blood Glucose; Epidemiologic Methods; Female; Fetal | 2004 |
Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Female; Hear | 1995 |
Effect of methyldopa and isradipine on fetal heart rate pattern assessed by computerized cardiotocography in human pregnancy.
Topics: Adolescent; Adult; Cardiotocography; Female; Heart Rate, Fetal; Humans; Isradipine; Methyldopa; Pre- | 1993 |
Transplacental passage of isradipine in the treatment of pregnancy-induced hypertension.
Topics: Amniotic Fluid; Delayed-Action Preparations; Female; Fetal Blood; Humans; Hypertension; Isradipine; | 1993 |
Randomised controlled trial of methyldopa and isradipine in preeclampsia--effects on uteroplacental and fetal hemodynamics.
Topics: Antihypertensive Agents; Blood Pressure; Female; Gestational Age; Heart Rate; Heart Rate, Fetal; Hum | 1996 |
Preeclampsia: haemostatic status and the short-term effects of methyldopa and isradipine therapy.
Topics: Antihypertensive Agents; Female; Hemostasis; Humans; Isradipine; Methyldopa; Pre-Eclampsia; Pregnanc | 1998 |
Short-term metabolic effects of isradipine and metoprolol in pre-eclampsia.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; F | 1999 |
Effects of endothelin-1 and calcium channel blockers on contractions in human myometrium. A study on myometrial strips from normal and diabetic pregnant women.
Topics: Calcium Channel Blockers; Diabetes, Gestational; Endothelin-1; Female; Humans; Isradipine; Myometriu | 1999 |
Effect of isradipine on responses to standardized physical stress tests in hypertension of pregnancy.
Topics: Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Exercise Test; Female; Heart Rate; Human | 1992 |
Influence of isradipine on the maternal and fetal cardiovascular system in hypertensive disorders in pregnancy.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Female; Fetus; Hea | 1991 |
Effects of isradipine, a new calcium antagonist, on postpartum uterine activity.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Female; Humans; Isradipin | 1989 |
21 other studies available for isradipine and Pregnancy
| Article | Year |
|---|---|
Effect of magnesium sulfate, isradipine, and ritodrine on contractions of myometrium: pregnant human and rat.
Topics: Adrenergic alpha-Agonists; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Fema | 2002 |
Interactive effect of sevoflurane with isradipine or indomethacin on spontaneous contractile activity of isolated pregnant rat myometrium.
Topics: Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; | 2004 |
Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.
Topics: Arteries; Dose-Response Relationship, Drug; Endothelins; Female; Humans; Isradipine; Myometrium; Osm | 1994 |
Intravenous isradipine in the management of severe hypertension in pregnant and nonpregnant patients. A pilot study.
Topics: Adolescent; Adult; Black People; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Inj | 1994 |
Intravenous isradipine in the management of severe hypertension of pregnancy in black patients: a pilot study.
Topics: Adolescent; Adult; Black People; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rat | 1994 |
Activator calcium and myocardial contractility in fetal sheep exposed to long-term high-altitude hypoxia.
Topics: Altitude; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Electric Stimulation; Female | 1997 |
Effects of nimodipine and isradipine on endothelin-1-induced contraction of pregnant rat myometrium.
Topics: Animals; Calcium Channel Blockers; Endothelin-1; Female; In Vitro Techniques; Isradipine; Nimodipine | 1998 |
Inhibitory effects of isradipine on spontaneous and oxytocin- and carbachol-stimulated contractions of rat myometrium.
Topics: Animals; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Drug Interactions; F | 1998 |
Human fetal membranes release a Ca++ channel inhibitor.
Topics: Amnion; Animals; Binding Sites; Binding, Competitive; Biological Assay; Calcium Channel Blockers; Ca | 1998 |
Effect of endothelin-1 on spontaneous contractions and effects of nimodipine and isradipine on endothelin-1-induced contractions in myometrial strips isolated from normal pregnant and preeclamptic women.
Topics: Calcium Channel Blockers; Dose-Response Relationship, Drug; Endothelin-1; Female; Humans; In Vitro T | 1998 |
Gestational changes in uterine L-type calcium channel function and expression in guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Influence of magnesium sulphate and isradipine on human placental cotyledon fetal vessels in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Female; Fetus; Humans; In Vitro | 2001 |
Isradipine, a new calcium antagonist: effects on maternal and fetal hemodynamics.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Fetus; Heart Rate; Heart | 1991 |
Effects of magnesium and isradipine on contractile activation induced by the thromboxane A2 analog U46619 in human uteroplacental arteries in term pregnancy.
Topics: Antihypertensive Agents; Arteries; Calcium Channel Blockers; Digoxin; Female; Humans; Indomethacin; | 1990 |
Effects of isradipine, a new calcium antagonist, on maternal cardiovascular system and uterine activity in labour.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Drug Administration Schedule; Female; Heart Rate; H | 1990 |
[Isradipine in therapy of hypertensive pregnancy complications].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Infant, Newborn; Israd | 1990 |
Maternal and fetal cardiovascular changes after intravenous injections of isradipine to pregnant women.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Female; Fetus; Humans; Injections, | 1990 |
Identification and properties of voltage-sensitive sodium channels in smooth muscle cells from pregnant rat myometrium.
Topics: Action Potentials; Amiloride; Animals; Binding Sites; Cell Membrane; Cell Separation; Electric Condu | 1990 |
Calcium channel current and its sensitivity to (+) isradipine in cultured pregnant rat myometrial cells. An electrophysiological and a binding study.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cells, Cultured; Cesium; Cobalt; | 1989 |
Caffeine-induced inhibition of calcium channel current in cultured smooth cells from pregnant rat myometrium.
Topics: Animals; Binding, Competitive; Caffeine; Calcium Channels; Electrophysiology; Female; In Vitro Techn | 1989 |