isradipine has been researched along with Nervous System Disorders in 3 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An initial dose-response study using neurological deficit scores and estimates of protection from brain infarction (by histology) showed that isradipine reduced cortical infarctions compared to vehicle-treated animals at most doses (between 1." | 1.30 | Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia. ( Barone, FC; Chandra, S; Coatney, RW; Everding, D; Feuerstein, GZ; Sarkar, SK; White, RF, 1999) |
| "The nifedipine response was reproduced by isradipine and by verapamil with IC50 values of 9 and 100 nM, respectively." | 1.28 | Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity. ( Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyashita, Y | 1 |
| Peterson, D | 1 |
| Rees, JM | 1 |
| Flynn, JT | 1 |
| Chandra, S | 1 |
| White, RF | 1 |
| Everding, D | 1 |
| Feuerstein, GZ | 1 |
| Coatney, RW | 1 |
| Sarkar, SK | 1 |
| Barone, FC | 1 |
| Pizzi, M | 1 |
| Ribola, M | 1 |
| Valerio, A | 1 |
| Memo, M | 1 |
| Spano, P | 1 |
3 other studies available for isradipine and Nervous System Disorders
| Article | Year |
|---|---|
Isradipine for treatment of acute hypertension in hospitalized children and adolescents.
Topics: Acute Disease; Adolescent; Age Factors; Blood Pressure; Calcium Channel Blockers; Child; Child, Pres | 2010 |
Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationshi | 1999 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |