isradipine has been researched along with Nerve Degeneration in 5 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One dihydropyridine calcium antagonist (isradipine), given in doses which have been reported to ameliorate ischemic damage due to stroke, failed to reduce damage incurred by 30 min of hypoglycemic coma, or 15 min of transient forebrain ischemia." | 7.68 | The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis. ( Ohta, S; Siesjö, BK; Smith, ML, 1991) |
| " One dihydropyridine calcium antagonist (isradipine), given in doses which have been reported to ameliorate ischemic damage due to stroke, failed to reduce damage incurred by 30 min of hypoglycemic coma, or 15 min of transient forebrain ischemia." | 3.68 | The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis. ( Ohta, S; Siesjö, BK; Smith, ML, 1991) |
| "Parkinson's disease is a common neurodegenerative disorder of unknown cause." | 2.44 | Calcium, ageing, and neuronal vulnerability in Parkinson's disease. ( Surmeier, DJ, 2007) |
| "The nifedipine response was reproduced by isradipine and by verapamil with IC50 values of 9 and 100 nM, respectively." | 1.28 | Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity. ( Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Surmeier, DJ | 1 |
| Araki, T | 1 |
| Tanji, H | 1 |
| Kato, H | 1 |
| Imai, Y | 1 |
| Mizugaki, M | 1 |
| Itoyama, Y | 1 |
| Pizzi, M | 1 |
| Ribola, M | 1 |
| Valerio, A | 1 |
| Memo, M | 1 |
| Spano, P | 1 |
| Ohta, S | 1 |
| Smith, ML | 1 |
| Siesjö, BK | 1 |
| Watson, DL | 1 |
| Carpenter, CL | 1 |
| Marks, SS | 1 |
| Greenberg, DA | 1 |
1 review available for isradipine and Nerve Degeneration
| Article | Year |
|---|---|
Calcium, ageing, and neuronal vulnerability in Parkinson's disease.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dopamine; Humans; Isradipine; N | 2007 |
4 other studies available for isradipine and Nerve Degeneration
| Article | Year |
|---|---|
Sequential changes of [H]forskolin, [H]cyclohexyladenosine and [H]PN200-110 binding sites in the brain of 6-hydroxydopamine-lesioned rats.
Topics: Adenosine; Animals; Autoradiography; Binding Sites; Brain Chemistry; Calcium Channel Blockers; Calci | 2000 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis.
Topics: Animals; Brain Diseases; Brain Ischemia; Calcium Channel Blockers; Coma; Hypoglycemia; Isradipine; M | 1991 |
Striatal calcium channel antagonist receptors in Huntington's disease and Parkinson's disease.
Topics: Aged; Calcium Channel Blockers; Corpus Striatum; Humans; Huntington Disease; Isradipine; Middle Aged | 1988 |