isradipine has been researched along with Myocardial Ischemia in 12 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isradipine is a dihydropyridine calcium antagonist used for the treatment of hypertension." | 8.78 | Cardiac effects of isradipine in patients with hypertension. ( Lund-Johansen, P, 1993) |
| "The present results provide indirect support for other studies which showed that halothane inhibited the Ca2+ accumulation associated with myocardial ischemia in isolated guinea pig hearts (6), demonstrating a potentially beneficial effect of the anesthetic on the ischemic heart." | 7.69 | Effect of halothane on sarcolemmal calcium channels during myocardial ischemia and reperfusion. ( Drenger, B; Ginosar, Y; Gozal, Y, 1994) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 6.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| "Isradipine is a dihydropyridine calcium antagonist used for the treatment of hypertension." | 4.78 | Cardiac effects of isradipine in patients with hypertension. ( Lund-Johansen, P, 1993) |
| "The present results provide indirect support for other studies which showed that halothane inhibited the Ca2+ accumulation associated with myocardial ischemia in isolated guinea pig hearts (6), demonstrating a potentially beneficial effect of the anesthetic on the ischemic heart." | 3.69 | Effect of halothane on sarcolemmal calcium channels during myocardial ischemia and reperfusion. ( Drenger, B; Ginosar, Y; Gozal, Y, 1994) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 2.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (91.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shangina, OA | 1 |
| Kostin, VI | 1 |
| Koturga, LI | 1 |
| Wout van den Toren, E | 1 |
| de Vries, RJ | 1 |
| Portegies, MC | 1 |
| Blanksma, PK | 1 |
| van Gilst, WH | 1 |
| Hillege, HJ | 1 |
| van Veldhuisen, DJ | 1 |
| Lie, KI | 1 |
| Blanck, TJ | 2 |
| Gardner, TJ | 2 |
| Drenger, B | 2 |
| Ginosar, Y | 2 |
| Gozal, Y | 2 |
| Stokke, M | 2 |
| Aksnes, G | 1 |
| Lande, K | 1 |
| Hagelin, EM | 2 |
| Brørs, O | 2 |
| Chandra, M | 1 |
| Reches, A | 1 |
| Lund-Johansen, P | 1 |
| Mauser, M | 1 |
| Voelker, W | 1 |
| Ickrath, O | 1 |
| Karsch, KR | 1 |
| Zucchi, R | 1 |
| Ronca-Testoni, S | 1 |
| Yu, G | 1 |
| Galbani, P | 1 |
| Ronca, G | 1 |
| Mariani, M | 1 |
| Kirkebøen, KA | 1 |
| Naess, PA | 1 |
| Ilebekk, A | 1 |
| Yasukochi, S | 1 |
| Quigg, M | 1 |
| Curtis, WE | 1 |
| Burger, W | 1 |
| Fuchs, S | 1 |
| Burger, KJ | 1 |
| Kober, G | 1 |
1 review available for isradipine and Myocardial Ischemia
| Article | Year |
|---|---|
Cardiac effects of isradipine in patients with hypertension.
Topics: Coronary Artery Bypass; Heart; Heart Failure; Hemodynamics; Humans; Hypertension; Hypertrophy, Left | 1993 |
3 trials available for isradipine and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of isradipine and nifedipine on diastolic function in patients with left ventricular dysfunction due to coronary artery disease: a randomized, double-blind, nuclear, stethoscope study.
Topics: Adult; Aged; Angina Pectoris; Atrial Function, Right; Cardiac Pacing, Artificial; Diastole; Double-B | 1994 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodip | 1993 |
Comparison of negative inotropic and vasodilator effects of isradipine and nifedipine after complete autonomic blockade in ischemic heart disease.
Topics: Autonomic Nerve Block; Depression, Chemical; Double-Blind Method; Heart Rate; Hemodynamics; Humans; | 1992 |
8 other studies available for isradipine and Myocardial Ischemia
| Article | Year |
|---|---|
[Effects of therapy with various groups of antianginal agents on life quality of the elderly with coronary heart disease and comorbid depression].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Atenolol; Calcium Channel Blockers; Depression; Dise | 2005 |
Voltage-sensitive calcium channels and ischemia.
Topics: Animals; Calcium Channels; Dogs; Isradipine; Myocardial Ischemia; Swine | 1995 |
Effect of halothane on sarcolemmal calcium channels during myocardial ischemia and reperfusion.
Topics: Animals; Calcium Channels; Dogs; Halothane; Isradipine; Myocardial Ischemia; Myocardial Reperfusion; | 1994 |
Density of L-type calcium channels in ischaemically preconditioned porcine heart regions.
Topics: Animals; Calcium Channels; Female; Heart; Hemodynamics; Isradipine; Male; Myocardial Ischemia; Myoca | 1994 |
Halothane modifies ischemia-associated injury to the voltage-sensitive calcium channels in canine heart sarcolemma.
Topics: Animals; Binding Sites; Calcium Channels; Dogs; Electrophysiology; Halothane; Isradipine; Kinetics; | 1994 |
Are dihydropyridine receptors downregulated in the ischemic myocardium?
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Down-Regulation; Isradipine; Mic | 1995 |
Equal changes in L-type calcium channel density after 60 min of ischaemia in normal and ischaemically preconditioned porcine myocardium.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Female; Hemodynamics; In Vitro Techniques; Isch | 1996 |
Global ischemia increases the density of voltage-dependent calcium channels in porcine cardiac sarcolemma.
Topics: 5'-Nucleotidase; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Heart Ventri | 1997 |