isradipine has been researched along with Muscle Contraction in 45 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Continuous nitroglycerin (NTG) administration causes pharmacologic tolerance in humans and animals, whereas intermittent dosing is capable of avoiding or reducing tolerance development." | 5.29 | Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels. ( Bauer, JA; Fung, HL; Gopalakrishnan, M; Kwon, YW; Triggle, DJ; Zheng, W, 1993) |
| "The possible contribution of K+ channel activation to airway smooth muscle relaxation induced by vasoactive intestinal peptide (VIP) and atrial natriuretic peptide (ANP) was investigated in isolated guinea-pig trachea." | 3.69 | Involvement of K+ channels in the relaxant effect of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig trachea. ( Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S, 1997) |
| "Isradipine appears to be an effective relaxant in rat myometrium." | 1.30 | Inhibitory effects of isradipine on spontaneous and oxytocin- and carbachol-stimulated contractions of rat myometrium. ( Cetin, A; Cetin, M; Kaya, T; Sarioglu, Y, 1998) |
| "Continuous nitroglycerin (NTG) administration causes pharmacologic tolerance in humans and animals, whereas intermittent dosing is capable of avoiding or reducing tolerance development." | 1.29 | Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels. ( Bauer, JA; Fung, HL; Gopalakrishnan, M; Kwon, YW; Triggle, DJ; Zheng, W, 1993) |
| "Amlodipine treatment (10 mg/kg/day orally) significantly reduced the increase in blood pressure (BP) in SHR, but did not change BP in WKY." | 1.29 | Selective interaction of the calcium antagonist amlodipine with calcium channels in arteries of spontaneously hypertensive rats. ( Godfraind, T; Morel, N, 1994) |
| " In anesthetized rats, isradipine inhibited the dose-response curves of norepinephrine on the blood pressure in 6- and 40-week-old animals more effectively than those in 10-week-old animals." | 1.29 | [Age-related alteration of inhibitory effects of isradipine on alpha 1-adrenoceptor mediated responses]. ( Ashikawa, N; Kanai, S; Satoh, M, 1996) |
| "The role of calcium in drug-induced contractions of rat gastric fundus strips was evaluated by determining the effect of two procedures on the dose-response curves of agonists: a) removal of calcium from the nutrient solution and b) blockade of calcium channels with the dihydropyridine isradipine." | 1.28 | Comparison of the effect of calcium withdrawal from the medium and of blockade of extracellular calcium entry by isradipine on the contractile responses of the isolated rat stomach. ( Garcia, AG; Jurkiewicz, A; Jurkiewicz, NH; Smaili, SS, 1991) |
| "HOE 166 was a 4-15 times more potent inhibitor of reversible (+)-[3H]PN200-110, (-)-[3H]desmethoxyverapamil and d-cis [3H]diltiazem binding compared to its pharmacologically less active (S)-(-)-enantiomer, with IC50 values in the low nanomolar range." | 1.27 | Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166. ( Becker, R; Glossmann, H; Grabner, M; Henning, R; Kaiser, J; Knaus, HG; Linz, W; Meusburger, E; Schölkens, B; Striessnig, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (17.78) | 18.7374 |
| 1990's | 31 (68.89) | 18.2507 |
| 2000's | 6 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frei, E | 1 |
| Hofmann, F | 2 |
| Wegener, JW | 2 |
| Ingalls, CP | 1 |
| Warren, GL | 1 |
| Zhang, JZ | 1 |
| Hamilton, SL | 1 |
| Armstrong, RB | 1 |
| Schulla, V | 1 |
| Lee, TS | 1 |
| Koller, A | 1 |
| Feil, S | 1 |
| Feil, R | 1 |
| Kleppisch, T | 1 |
| Klugbauer, N | 1 |
| Moosmang, S | 1 |
| Welling, A | 1 |
| El Bardai, S | 1 |
| Hamaide, MC | 1 |
| Lyoussi, B | 1 |
| Quetin-Leclercq, J | 1 |
| Morel, N | 2 |
| Wibo, M | 1 |
| Arun, KH | 1 |
| Kaul, CL | 1 |
| Ramarao, P | 1 |
| Müller-Schweinitzer, E | 1 |
| Neumann, P | 1 |
| Bauer, JA | 1 |
| Fung, HL | 1 |
| Zheng, W | 2 |
| Kwon, YW | 1 |
| Gopalakrishnan, M | 2 |
| Triggle, DJ | 4 |
| Godfraind, T | 1 |
| Sakai, Y | 1 |
| Inazu, M | 1 |
| Shamoto, A | 1 |
| Zhu, B | 1 |
| Homma, I | 1 |
| Alajarin, R | 1 |
| Vaquero, JJ | 1 |
| Alvarez-Builla, J | 1 |
| Pastor, M | 1 |
| Sunkel, C | 1 |
| Fau de Casa-Juana, M | 1 |
| Priego, J | 1 |
| Statkow, PR | 1 |
| Sanz-Aparicio, J | 1 |
| Fonseca, I | 1 |
| Trivedi, S | 1 |
| Potter-Lee, L | 1 |
| McConville, MW | 1 |
| Li, JH | 1 |
| Ohnmacht, CJ | 1 |
| Trainor, DA | 1 |
| Kau, ST | 1 |
| Sakaguchi, H | 1 |
| Ishiguro, S | 1 |
| Miyamoto, A | 1 |
| Nishio, A | 1 |
| Jurkiewicz, A | 3 |
| Lafayette, SS | 1 |
| Nunes, SH | 1 |
| Martini, LC | 1 |
| Do Carmo, LG | 1 |
| Wanderley, AG | 1 |
| Jurkiewicz, NH | 3 |
| Nakajima, M | 1 |
| Adachi, I | 1 |
| Ueda, M | 1 |
| Ma, J | 1 |
| Anderson, K | 1 |
| Shirokov, R | 1 |
| Levis, R | 1 |
| González, A | 1 |
| Karhanek, M | 1 |
| Hosey, MM | 1 |
| Meissner, G | 1 |
| Ríos, E | 1 |
| Margreth, A | 1 |
| Damiani, E | 1 |
| Tobaldin, G | 1 |
| Satoh, M | 2 |
| Matsuo, K | 1 |
| Kokubu, N | 1 |
| Takayanagi, I | 1 |
| Kanai, S | 1 |
| Ashikawa, N | 1 |
| Travo, P | 1 |
| Lees, D | 1 |
| Benel, L | 1 |
| Thirstrup, S | 1 |
| Nielsen-Kudsk, JE | 1 |
| Mellemkjaer, S | 1 |
| Singh, YN | 1 |
| Johnson, A | 1 |
| Lulf, LA | 1 |
| Singh, BN | 1 |
| Pupo, AS | 1 |
| Inami, T | 1 |
| Nakano, J | 1 |
| Kizawa, Y | 1 |
| Kotake, H | 1 |
| Nakajima, Y | 1 |
| Kusama, T | 1 |
| Murakami, H | 1 |
| Yamanaga, K | 1 |
| Shinyama, H | 1 |
| Akira, T | 1 |
| Iwamoto, M | 1 |
| Uchida, T | 1 |
| Nakamura, N | 1 |
| Kagitani, Y | 1 |
| Cetin, M | 1 |
| Kaya, T | 1 |
| Cetin, A | 1 |
| Sarioglu, Y | 1 |
| Shimuta, SI | 1 |
| Borges, AC | 1 |
| Prioste, RN | 1 |
| Paiva, TB | 1 |
| Nunes, JP | 1 |
| Guimarães, S | 1 |
| Zavecz, JH | 1 |
| Bueno, O | 1 |
| Maloney, RE | 1 |
| O'Donnell, JM | 1 |
| Roerig, SC | 1 |
| Battarbee, HD | 1 |
| Mironneau, J | 3 |
| Eltze, M | 1 |
| Boer, R | 1 |
| Stoltefuss, J | 1 |
| Goldmann, S | 1 |
| Latifpour, J | 1 |
| Yoshida, M | 1 |
| Weiss, RM | 1 |
| Hu, SL | 1 |
| Kim, HS | 1 |
| Jeng, AY | 1 |
| Mironneau, C | 2 |
| Rakotoarisoa, L | 1 |
| Sayet, I | 1 |
| Smaili, SS | 1 |
| Garcia, AG | 1 |
| Galletti, F | 1 |
| Luchowski, E | 1 |
| Rüegg, UT | 1 |
| Hof, RP | 1 |
| Cook, NS | 1 |
| Dubur, GJ | 1 |
| Veveris, MM | 1 |
| Weinheimer, G | 1 |
| Bisenieks, EA | 1 |
| Makarova, NR | 1 |
| Kimenis, AA | 1 |
| Uldrikis, JR | 1 |
| Lukevics, EJ | 1 |
| Dooley, D | 1 |
| Osswald, H | 1 |
| Eglen, RM | 1 |
| Michel, AD | 1 |
| Sharif, NA | 1 |
| Swank, SR | 1 |
| Whiting, RL | 1 |
| Keith, RA | 1 |
| Mangano, TJ | 1 |
| Pacheco, MA | 1 |
| Salama, AI | 1 |
| Striessnig, J | 1 |
| Meusburger, E | 1 |
| Grabner, M | 1 |
| Knaus, HG | 1 |
| Glossmann, H | 1 |
| Kaiser, J | 1 |
| Schölkens, B | 1 |
| Becker, R | 1 |
| Linz, W | 1 |
| Henning, R | 1 |
| Romey, G | 1 |
| Garcia, L | 1 |
| Rieger, F | 1 |
| Lazdunski, M | 1 |
| Dacquet, C | 1 |
1 review available for isradipine and Muscle Contraction
| Article | Year |
|---|---|
Pharmacology of the calcium antagonist isradipine.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypertension; Isradipine; Muscle | 1990 |
44 other studies available for isradipine and Muscle Contraction
| Article | Year |
|---|---|
Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Carbachol; Cholinergic Agonists; Enzyme Inhibitors; Estr | 2009 |
Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle.
Topics: Animals; Binding Sites; Caffeine; Calcium Channels, L-Type; Female; Isometric Contraction; Isradipin | 2004 |
An essential role of Cav1.2 L-type calcium channel for urinary bladder function.
Topics: Amides; Animals; Calcium; Calcium Channels, L-Type; Carbachol; Enzyme Inhibitors; Estrenes; Intracel | 2004 |
Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Di | 2004 |
AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Channels, L-Typ | 2005 |
In vitro effects of calcium antagonists PN 200-110, nifedipine, and nimodipine on human and canine cerebral arteries.
Topics: Animals; Basilar Artery; Blood Physiological Phenomena; Calcium Channel Blockers; Cerebral Arteries; | 1983 |
Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels.
Topics: Administration, Cutaneous; Animals; Aorta, Thoracic; Binding Sites; Drug Tolerance; Glyburide; Heart | 1993 |
Selective interaction of the calcium antagonist amlodipine with calcium channels in arteries of spontaneously hypertensive rats.
Topics: Administration, Oral; Amlodipine; Animals; Aorta; Binding Sites; Blood Pressure; Calcium Channels; C | 1994 |
Contractile hyperreactivity and alteration of PKC activity in gastric fundus smooth muscle of diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5 | 1994 |
Synthesis, structure, and pharmacological evaluation of the stereoisomers of furnidipine.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Chemical Phenomena; Chemistry, Physi | 1995 |
K-channel opening activity of dihydropyridine ZM244085: effect on 86Rb efflux and 3H-P1075 binding in urinary bladder smooth muscle.
Topics: Acridines; Animals; Glyburide; Guanidines; Guinea Pigs; Humans; In Vitro Techniques; Isradipine; Mus | 1995 |
Enhanced contractile response to phenylephrine and increased density of [3H]PN200-110 binding sites in thoracic aorta isolated from dietary magnesium-deficient rats.
Topics: Animals; Aorta, Thoracic; Calcium Channels; Diet; Endothelium, Vascular; Isradipine; Magnesium Defic | 1994 |
Decreased density of binding sites for the Ca2+ channel antagonist [3H]isradipine after denervation of rat vas deferens.
Topics: Animals; Binding Sites; Calcium Channels; Denervation; Dihydropyridines; Isradipine; Male; Muscle Co | 1994 |
Pharmacological studies on a new Dihydrothienopyridine calcium antagonist. 2nd communication: effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate on the 1,4-dihydropyridine binding sites in the bra
Topics: Animals; Binding, Competitive; Brain Chemistry; Calcium; Calcium Channel Blockers; Calcium Channels; | 1993 |
Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle.
Topics: Animals; Calcium Channels; Calcium Radioisotopes; Cations; Electrophysiology; Guinea Pigs; Heart; In | 1993 |
Ratio of dihydropyridine to ryanodine receptors in mammalian and frog twitch muscles in relation to the mechanical hypothesis of excitation-contraction coupling.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Isradipine; Kinetics; Male; Musc | 1993 |
Inhibitory effect of phorbol 12,13-dibutyrate on norepinephrine-induced contraction in rabbit iris dilator muscle.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, D | 1996 |
[Age-related alteration of inhibitory effects of isradipine on alpha 1-adrenoceptor mediated responses].
Topics: Aging; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels | 1996 |
An hypothesis for the interpretation of the contractile response of vascular smooth muscle at the cellular level.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Biphenyl Compounds; Cells, Culture | 1996 |
Involvement of K+ channels in the relaxant effect of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig trachea.
Topics: Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Calcium Channel Blockers; C | 1997 |
Study of in vitro and in vitro effects of isradipine in skeletal muscles and interaction with some drugs.
Topics: Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Clindamycin; Diaphragm; Dose-Response Rela | 1996 |
Functional change of the balance between alpha 1A and alpha 1B adrenoceptor populations after transplantation of the vas deferens to the intestine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Clonidin | 1997 |
Synergistic actions of pentobarbital and dihydropyridine Ca2+ antagonists on guinea pig isolated thoracic aorta.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Drug Interactions; Guinea Pigs; Isradipine; Male | 1997 |
AE0047-mediated calcium channel blocking in vascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Calcium Radioisotopes; Cattle; Chemical Phenomen | 1997 |
Inhibitory effects of isradipine on spontaneous and oxytocin- and carbachol-stimulated contractions of rat myometrium.
Topics: Animals; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Drug Interactions; F | 1998 |
Different pathways for Ca2+ mobilization by angiotensin II and carbachol in the circular muscle of the guinea-pig ileum.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Calcium Channel Blockers; Carbac | 1999 |
The influence of the wall tension on the contractile responses of arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aorta, Thoracic; Arteries; E | 1999 |
Cardiac excitation-contraction coupling in the portal hypertensive rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Transduction pathways for noradrenaline-induced modulation of calcium channels in vascular smooth muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Horses; In | 1992 |
The adrenoceptor agonist, SDZ NVI 085, discriminates between alpha 1A- and alpha 1B-adrenoceptor subtypes in vas deferens, kidney and aorta of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Bridged Bicyclo C | 1992 |
Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Evidence for the presence of regional differences in the calcium antagonist receptors in lower urinary tract smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Carbachol; Dihydropyridines; Drug Interactions; Fe | 1992 |
Dual action of endothelin-1 on the Ca2(+)-activated K+ channel in smooth muscle cells of porcine coronary artery.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Coronary Vessels; Electrophysiology; Endothelin | 1991 |
Modulation of [3H]dihydropyridine binding by activation of protein kinase C in vascular smooth muscle.
Topics: Aluminum; Animals; Binding Sites; Calcium Channels; Dihydropyridines; Enzyme Activation; Fluorine; H | 1991 |
Comparison of the effect of calcium withdrawal from the medium and of blockade of extracellular calcium entry by isradipine on the contractile responses of the isolated rat stomach.
Topics: Animals; Calcium; Carbachol; Dihydropyridines; Female; Isradipine; Male; Muscle Contraction; Rats; R | 1991 |
Irreversible modification of the voltage-sensitive calcium channel by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channels; Guinea Pigs; Isradipine; Male; Mus | 1990 |
1,4-Dihydropyridine activators in the tiamdipine series.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Ileum | 1990 |
Effect of some potassium channel blockers on contractile responses of the rabbit aorta.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Aorta, Thoracic; Apamin; Calcium Channel Bl | 1989 |
Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydro-pyridine-3,5-di- carboxylic acid.
Topics: Animals; Calcium; Cats; Cerebral Cortex; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Este | 1989 |
The pharmacological properties of the peptide, endothelin.
Topics: Animals; Blood Pressure; Calcium Channels; Carbachol; Cerebral Cortex; Endothelins; Female; Guinea P | 1989 |
Characterization of the effects of omega-conotoxin GVIA on the responses of voltage-sensitive calcium channels.
Topics: Acetylcholine; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; gam | 1989 |
Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166.
Topics: Action Potentials; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Guinea | 1988 |
Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyri | 1988 |
Effects of calcium entry blockers on calcium-dependent contractions of rat portal vein.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Isradipine; Mu | 1987 |