isradipine has been researched along with Hypertrophy, Left Ventricular in 21 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month course with one of three different antihypertensive regimens (the calcium channel blocker isradipine, the angiotensin converting enzyme inhibitor spirapril in monotherapy, or a combination of the two drugs, n = 15 per group) on blood pressure, LVH regression, and various functional correlates of LVH." | 9.08 | Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity. ( Beldekos, D; Bresnahan, M; Cokkinos, DV; Foussas, S; Gavras, H; Gavras, I; Handanis, S; Haralabidis, G; Hatzissavas, J; Manolis, AJ, 1998) |
| " Isradipine was used as first-line antihypertensive treatment in 15 patients who had mild-to-moderate hypertension and LVH, and who were studied before and after 6 months of treatment." | 9.07 | Regression of left ventricular hypertrophy with isradipine in previously untreated hypertensive patients. ( Antonopoulos, S; Athanasopoulos, G; Cokkinos, DV; Handanis, S; Kolovou, G; Manolis, AJ, 1993) |
| "The objective of this study was to analyze the long-term hemodynamic effects of the calcium antagonist isradipine in mild hypertension compared with those of the beta 1-selective adrenoceptor antagonist atenolol, focusing in particular on the development of cardiac hypertrophy." | 9.07 | Beneficial effect of isradipine on the development of left ventricular hypertrophy in mild hypertension. ( Gleerup, G; Haedersdal, C; Mehlsen, J; Winther, K, 1993) |
| "Isradipine is a dihydropyridine calcium antagonist used for the treatment of hypertension." | 8.78 | Cardiac effects of isradipine in patients with hypertension. ( Lund-Johansen, P, 1993) |
| " We attempted to verify the effectiveness of a new calcium antagonist, isradipine 5 mg SRO, on the reversal of left ventricular hypertrophy." | 7.69 | Evaluation of the effectiveness of isradipine SRO in the treatment of hypertensive patients with left ventricular hypertrophy. ( Baraldi, P; Masciocco, G; Mattioli, G; Modena, MG; Rossi, R, 1994) |
| "The purpose of this study was to ascertain if Isradipine treatment in spontaneously hypertensive rats (SHR) decreased hypertension-dependent left ventricular and coronary vascular hypertrophy." | 7.69 | Influence of isradipine treatment on left ventricular and coronary vascular hypertrophy in spontaneously hypertensive rats. ( Amenta, F; Ferrante, F, 1994) |
| "Left ventricular hypertrophy is a common clinical feature in hypertensive patients and may be associated with structural changes in vessel morphology." | 6.68 | Influence of isradipine and spirapril on left ventricular hypertrophy and resistance arteries. ( Heagerty, AM; Kenedi, P; Rietbrock, N; Stephens, N; Thürmann, PA; Weidinger, G, 1996) |
| "Patients with mild to moderate diastolic hypertension and LV mass in excess of 1 SD of normal values were randomized to isradipine (n = 89) or hydrochlorothiazide therapy (n = 45)." | 5.08 | Hydrochlorothiazide is superior to isradipine for reduction of left ventricular mass: results of a multicenter trial. The Isradipine Study Group. ( Chase, GA; Cushman, WG; Gottdiener, JS; Gottdiener, PS; Narayan, P; Papademetriou, V; Zachariah, PK, 1997) |
| "This study was designed to evaluate in 45 hypertensive patients with left ventricular hypertrophy (LVH) the effects of a 6-month course with one of three different antihypertensive regimens (the calcium channel blocker isradipine, the angiotensin converting enzyme inhibitor spirapril in monotherapy, or a combination of the two drugs, n = 15 per group) on blood pressure, LVH regression, and various functional correlates of LVH." | 5.08 | Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity. ( Beldekos, D; Bresnahan, M; Cokkinos, DV; Foussas, S; Gavras, H; Gavras, I; Handanis, S; Haralabidis, G; Hatzissavas, J; Manolis, AJ, 1998) |
| "The aim of the present study was to evaluate the effect of dihydropyridine calcium antagonist isradipine on left ventricular (LV) structure and function in patients with essential hypertension." | 5.07 | Reduction of left ventricular mass by short-term antihypertensive treatment with isradipine: a double-blind comparison with enalapril. ( Celentano, A; de Divitiis, O; Galderisi, M; Garofalo, M; Oliviero, M; Petrocelli, A; Tammaro, P, 1994) |
| " Isradipine was used as first-line antihypertensive treatment in 15 patients who had mild-to-moderate hypertension and LVH, and who were studied before and after 6 months of treatment." | 5.07 | Regression of left ventricular hypertrophy with isradipine in previously untreated hypertensive patients. ( Antonopoulos, S; Athanasopoulos, G; Cokkinos, DV; Handanis, S; Kolovou, G; Manolis, AJ, 1993) |
| "The objective of this study was to analyze the long-term hemodynamic effects of the calcium antagonist isradipine in mild hypertension compared with those of the beta 1-selective adrenoceptor antagonist atenolol, focusing in particular on the development of cardiac hypertrophy." | 5.07 | Beneficial effect of isradipine on the development of left ventricular hypertrophy in mild hypertension. ( Gleerup, G; Haedersdal, C; Mehlsen, J; Winther, K, 1993) |
| "Isradipine is a dihydropyridine calcium antagonist used for the treatment of hypertension." | 4.78 | Cardiac effects of isradipine in patients with hypertension. ( Lund-Johansen, P, 1993) |
| "The effect of regression of left ventricular hypertrophy was studied in deoxycorticosterone-acetate-salt hypertensive rats (DOCA-salt hypertensive rats) treated with tetrandrine." | 3.69 | Effects of tetrandrine on left ventricle hypertrophy in deoxycorticosterone acetate-salt hypertensive rats. ( Rao, MR; Xu, Y, 1995) |
| " We attempted to verify the effectiveness of a new calcium antagonist, isradipine 5 mg SRO, on the reversal of left ventricular hypertrophy." | 3.69 | Evaluation of the effectiveness of isradipine SRO in the treatment of hypertensive patients with left ventricular hypertrophy. ( Baraldi, P; Masciocco, G; Mattioli, G; Modena, MG; Rossi, R, 1994) |
| "The purpose of this study was to ascertain if Isradipine treatment in spontaneously hypertensive rats (SHR) decreased hypertension-dependent left ventricular and coronary vascular hypertrophy." | 3.69 | Influence of isradipine treatment on left ventricular and coronary vascular hypertrophy in spontaneously hypertensive rats. ( Amenta, F; Ferrante, F, 1994) |
| "Patients with severe left ventricular hypertrophy (left ventricular mass >360 g) had lower glomerular filtration fraction, greater renal vascular resistance, lower renal blood flow and increased microalbuminuria in comparison with patients with less pronounced cardiac changes." | 2.69 | Long-term renal and cardiovascular effects of antihypertensive treatment regimens based upon isradipine, perindopril and thiazide. ( Krusell, LR; Lederballe, O; Sihm, I; Thygesen, K, 2000) |
| "Untreated essential hypertension is associated with left ventricular hypertrophy (LVH) and structural changes in resistance vessels." | 2.68 | Normalization of structural cardiovascular changes during antihypertensive treatment with a regimen based on the ACE-inhibitor perindopril. ( Aalkjaer, C; Holm, M; Lederballe, O; Mulvany, M; Mørn, B; Schroeder, AP; Sihm, I; Thygesen, K, 1995) |
| "Left ventricular hypertrophy is a common clinical feature in hypertensive patients and may be associated with structural changes in vessel morphology." | 2.68 | Influence of isradipine and spirapril on left ventricular hypertrophy and resistance arteries. ( Heagerty, AM; Kenedi, P; Rietbrock, N; Stephens, N; Thürmann, PA; Weidinger, G, 1996) |
| "SHRs showed a significant left ventricular hypertrophy." | 1.29 | Effect of chronic dihydropyridine (isradipine) on the large arterial walls of spontaneously hypertensive rats. ( Duriez, M; Levy, BI; Michel, JB; Phillipe, M; Poitevin, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (85.71) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sihm, I | 3 |
| Schroeder, AP | 2 |
| Aalkjaer, C | 2 |
| Holm, M | 2 |
| Mørn, B | 2 |
| Mulvany, M | 2 |
| Thygesen, K | 3 |
| Lederballe, O | 2 |
| Xu, Y | 1 |
| Rao, MR | 1 |
| Galderisi, M | 1 |
| Celentano, A | 1 |
| Garofalo, M | 1 |
| Tammaro, P | 1 |
| Oliviero, M | 1 |
| Petrocelli, A | 1 |
| de Divitiis, O | 1 |
| Pedersen, OL | 1 |
| Levy, BI | 1 |
| Duriez, M | 1 |
| Phillipe, M | 1 |
| Poitevin, P | 1 |
| Michel, JB | 1 |
| Modena, MG | 1 |
| Masciocco, G | 1 |
| Rossi, R | 1 |
| Baraldi, P | 1 |
| Mattioli, G | 1 |
| Ferrante, F | 1 |
| Amenta, F | 1 |
| Lund-Johansen, P | 1 |
| Vyssoulis, GP | 1 |
| Karpanou, EA | 1 |
| Pitsavos, CE | 1 |
| Soulas, DK | 1 |
| Toutouzas, PK | 1 |
| Saragoça, MA | 1 |
| Cassiolatto, JL | 1 |
| Vanetta, AM | 1 |
| Canziani, ME | 1 |
| Abreu, P | 1 |
| Ventura, RT | 1 |
| Ramos, OL | 1 |
| Manolis, AJ | 2 |
| Kolovou, G | 1 |
| Handanis, S | 2 |
| Athanasopoulos, G | 1 |
| Antonopoulos, S | 1 |
| Cokkinos, DV | 2 |
| Mehlsen, J | 1 |
| Gleerup, G | 1 |
| Haedersdal, C | 1 |
| Winther, K | 1 |
| Grandi, AM | 1 |
| Bignotti, M | 1 |
| Gaudio, G | 1 |
| Zanzi, P | 1 |
| Guasti, L | 1 |
| Venco, A | 1 |
| Thürmann, PA | 1 |
| Stephens, N | 1 |
| Heagerty, AM | 1 |
| Kenedi, P | 1 |
| Weidinger, G | 1 |
| Rietbrock, N | 1 |
| Albrecht, T | 1 |
| Dulce, MC | 1 |
| Dulce, KK | 1 |
| Gotzen, R | 1 |
| Wolf, KJ | 1 |
| Papademetriou, V | 1 |
| Gottdiener, JS | 1 |
| Narayan, P | 1 |
| Cushman, WG | 1 |
| Zachariah, PK | 1 |
| Gottdiener, PS | 1 |
| Chase, GA | 1 |
| Beldekos, D | 1 |
| Haralabidis, G | 1 |
| Hatzissavas, J | 1 |
| Foussas, S | 1 |
| Bresnahan, M | 1 |
| Gavras, I | 1 |
| Gavras, H | 1 |
| Strauer, BE | 1 |
| Schwartzkopff, B | 1 |
| De Rosa, ML | 1 |
| Maddaluno, G | 1 |
| Lionetti, F | 1 |
| Di Palma, U | 1 |
| Albanese, L | 1 |
| Cardace, P | 1 |
| Baiano, A | 1 |
| Vigorito, C | 1 |
| Milnes, JT | 1 |
| MacLeod, KT | 1 |
| Krusell, LR | 1 |
1 review available for isradipine and Hypertrophy, Left Ventricular
| Article | Year |
|---|---|
Cardiac effects of isradipine in patients with hypertension.
Topics: Coronary Artery Bypass; Heart; Heart Failure; Hemodynamics; Humans; Hypertension; Hypertrophy, Left | 1993 |
13 trials available for isradipine and Hypertrophy, Left Ventricular
| Article | Year |
|---|---|
Normalization of structural cardiovascular changes during antihypertensive treatment with a regimen based on the ACE-inhibitor perindopril.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteries; Drug Therapy, Co | 1995 |
Reduction of left ventricular mass by short-term antihypertensive treatment with isradipine: a double-blind comparison with enalapril.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Echocardiography, Doppler; Enalapril; | 1994 |
Normalization of resistance artery structure and left ventricular morphology with a perindopril-based regimen.
Topics: Antihypertensive Agents; Arteries; Echocardiography; Female; Humans; Hypertension; Hypertrophy, Left | 1994 |
Regression of left ventricular hypertrophy with isradipine antihypertensive therapy.
Topics: Aged; Echocardiography; Female; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricula | 1993 |
Reversal of left ventricular hypertrophy with isradipine induces diminution of cardiac arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Female; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left | 1993 |
Regression of left ventricular hypertrophy with isradipine in previously untreated hypertensive patients.
Topics: Adult; Echocardiography, Doppler; Female; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left | 1993 |
Beneficial effect of isradipine on the development of left ventricular hypertrophy in mild hypertension.
Topics: Aged; Atenolol; Blood Pressure; Double-Blind Method; Exercise Tolerance; Heart Rate; Heart Ventricle | 1993 |
Ambulatory blood pressure and left ventricular changes during antihypertensive treatment: perindopril versus isradipine.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Ch | 1995 |
Influence of isradipine and spirapril on left ventricular hypertrophy and resistance arteries.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteries; Blood Pressure; Drug Co | 1996 |
Hydrochlorothiazide is superior to isradipine for reduction of left ventricular mass: results of a multicenter trial. The Isradipine Study Group.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diuretics; Double-Blind Method; E | 1997 |
Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Press | 1998 |
Effects of enalapril and isradipine alone and in combination on blood pressure, renal function and echocardiographic parameters in mild hypertension.
Topics: Analysis of Variance; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Double-Blind Meth | 2000 |
Long-term renal and cardiovascular effects of antihypertensive treatment regimens based upon isradipine, perindopril and thiazide.
Topics: Adult; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Creatine; Diuretics; Follow-Up St | 2000 |
7 other studies available for isradipine and Hypertrophy, Left Ventricular
| Article | Year |
|---|---|
Effects of tetrandrine on left ventricle hypertrophy in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Alkaloids; Animals; Antihypertensive Agents; Benzylisoquinolines; Binding, Competitive; Blood Pressu | 1995 |
Effect of chronic dihydropyridine (isradipine) on the large arterial walls of spontaneously hypertensive rats.
Topics: Animals; Aorta; Biomechanical Phenomena; Carotid Arteries; Collagen; Compliance; Elastin; Hemodynami | 1994 |
Evaluation of the effectiveness of isradipine SRO in the treatment of hypertensive patients with left ventricular hypertrophy.
Topics: Aged; Echocardiography; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Isradipine; Mal | 1994 |
Influence of isradipine treatment on left ventricular and coronary vascular hypertrophy in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Coronary Vessels; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular; | 1994 |
Hypertensive heart disease: quantitative evaluation of response to therapy with cine MR imaging.
Topics: Adult; Analysis of Variance; Antihypertensive Agents; Cardiac Volume; Evaluation Studies as Topic; F | 1997 |
Objectives of high blood pressure treatment: left ventricular hypertrophy, diastolic function, and coronary reserve.
Topics: Antihypertensive Agents; Arterioles; Bisoprolol; Blood Pressure; Coronary Circulation; Diastole; Dil | 1998 |
Reduced ryanodine receptor to dihydropyridine receptor ratio may underlie slowed contraction in a rabbit model of left ventricular cardiac hypertrophy.
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells | 2001 |