isradipine has been researched along with Coronary Disease in 20 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The acute hemodynamic effects of isradipine on cardiac performance, at rest and during exercise, were examined in nine male patients aged 37 to 69 years with congestive heart failure due to ischemic heart disease." | 9.06 | Hemodynamic study of short- and long-term isradipine treatment in patients with chronic ischemic congestive heart failure. ( McGrath, BP; Newman, R; Older, P, 1989) |
| " A MEDLINE search was conducted using the following indexing terms: isradipine, calcium-channel blockers, hypertension, and angina pectoris." | 8.78 | Isradipine--another calcium-channel blocker for the treatment of hypertension and angina. ( Lopez, LM; Santiago, TM, 1992) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 6.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| " In this dosage peripheral effects--decrease of peripheral vascular resistance and mean aortic pressure--did not differ significantly between them." | 6.67 | [Myocardial effects of the calcium antagonists nifedipine, nisoldipine and isradipine in coronary heart disease]. ( Ickrath, O; Karsch, KR; Kühlkamp, V; Mauser, M; Voelker, W, 1990) |
| "A total of 203 patients with hypertension (supine diastolic blood pressure of 100-119 mm Hg) from six centers entered into a 3-week placebo baseline followed by 5 weeks of active treatment (either placebo or isradipine 2." | 5.07 | Assessment of electrocardiographic ischemia in hypertensive patients treated with isradipine or placebo. ( Carr, AA; Prisant, LM, 1991) |
| "The acute hemodynamic effects of isradipine on cardiac performance, at rest and during exercise, were examined in nine male patients aged 37 to 69 years with congestive heart failure due to ischemic heart disease." | 5.06 | Hemodynamic study of short- and long-term isradipine treatment in patients with chronic ischemic congestive heart failure. ( McGrath, BP; Newman, R; Older, P, 1989) |
| " A MEDLINE search was conducted using the following indexing terms: isradipine, calcium-channel blockers, hypertension, and angina pectoris." | 4.78 | Isradipine--another calcium-channel blocker for the treatment of hypertension and angina. ( Lopez, LM; Santiago, TM, 1992) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 2.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| "Isradipine is a more potent vasodilator than nifedipine at the same infusion rate." | 2.67 | Effect of isradipine on left ventricular relaxation and diastolic filling. ( Hess, OM; Hoppeler, H; Hug, R; Krayenbühl, HP; Turina, J, 1990) |
| " In this dosage peripheral effects--decrease of peripheral vascular resistance and mean aortic pressure--did not differ significantly between them." | 2.67 | [Myocardial effects of the calcium antagonists nifedipine, nisoldipine and isradipine in coronary heart disease]. ( Ickrath, O; Karsch, KR; Kühlkamp, V; Mauser, M; Voelker, W, 1990) |
| " Patients received 5 mg nifedipine three times a day rising to 20 mg three times a day in three dosage increments over six weeks or 2." | 2.66 | Comparison of isradipine and nifedipine in chronic stable angina. ( Handler, CE; Najm, Y; Rosenthal, E; Tsagadopoulos, D, 1988) |
| " The drugs were infused intravenously within 30 min in a dosage which led to a comparable afterload reduction (nifedipine [N] 2 mg, isradipine [I] 0." | 2.66 | [Isradipine (PN 200-110), a new dihydropyridine calcium antagonist with slight negative inotropic properties in comparison with nifedipine]. ( Karsch, KR; Mauser, M; Voelker, W, 1988) |
| "Isradipine is a new dihydropyridine calcium antagonist with myocardial effects significantly different from those of nifedipine, as shown by in vitro and animal experimental data." | 1.28 | Myocardial properties of the new dihydropyridine calcium antagonist isradipine compared to nifedipine with or without additional beta blockade in coronary artery disease. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 13 (65.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Handler, CE | 2 |
| Sowton, E | 1 |
| Mauser, M | 5 |
| Voelker, W | 4 |
| Ickrath, O | 3 |
| Karsch, KR | 4 |
| van den Toren, EW | 1 |
| van Veldhuisen, DJ | 1 |
| van Bruggen, A | 1 |
| van den Broek, SA | 1 |
| van Gilst, WH | 1 |
| Lie, KI | 1 |
| Maher, MJ | 1 |
| Dworkin, LD | 1 |
| Rodríguez Moreno, C | 1 |
| Byington, RP | 1 |
| Furberg, CD | 1 |
| Craven, TE | 1 |
| Pahor, M | 1 |
| Sowers, JR | 1 |
| Bracht, C | 1 |
| Yan, XW | 1 |
| Brunner-LaRocca, HP | 1 |
| Sütsch, G | 1 |
| Amann, FW | 1 |
| Kiowski, W | 1 |
| Lopez, LM | 1 |
| Santiago, TM | 1 |
| Hoppeler, H | 1 |
| Hess, OM | 1 |
| Hug, R | 1 |
| Turina, J | 1 |
| Krayenbühl, HP | 1 |
| Griebenow, R | 1 |
| Kaufmann, W | 1 |
| Krämer, L | 1 |
| Steffen, HM | 1 |
| Wambach, G | 1 |
| Burger, KJ | 1 |
| Welzel, D | 1 |
| Burger, W | 1 |
| Herholz, H | 1 |
| Burger, K | 1 |
| Kober, G | 1 |
| Prisant, LM | 1 |
| Carr, AA | 1 |
| Bedotto, JB | 1 |
| Eichhorn, EJ | 1 |
| Popma, JJ | 1 |
| Dehmer, GJ | 1 |
| Kühlkamp, V | 2 |
| Mayer, F | 1 |
| Haasis, R | 1 |
| Seipel, L | 1 |
| McGrath, BP | 1 |
| Newman, R | 1 |
| Older, P | 1 |
| Cook, NS | 1 |
| Hof, RP | 1 |
| Rosenthal, E | 1 |
| Tsagadopoulos, D | 1 |
| Najm, Y | 1 |
2 reviews available for isradipine and Coronary Disease
| Article | Year |
|---|---|
Calcium antagonists in the treatment of hypertension: special clinical considerations.
Topics: Angina Pectoris; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; | 1996 |
Isradipine--another calcium-channel blocker for the treatment of hypertension and angina.
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Dihydropyridi | 1992 |
14 trials available for isradipine and Coronary Disease
| Article | Year |
|---|---|
Safety, tolerability and efficacy of PN 200-110, a new calcium antagonist in patients with angina and coronary heart disease.
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Diseas | 1984 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodip | 1993 |
Acute hemodynamic and long-term clinical effects of isradipine in patients with coronary artery disease and chronic heart failure. A double-blind, placebo-controlled study.
Topics: Calcium Channel Blockers; Cardiac Output, Low; Chronic Disease; Coronary Disease; Double-Blind Metho | 1996 |
Isradipine in prediabetic hypertensive subjects.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Cardiovascular Dis | 1998 |
Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia.
Topics: Aged; Blood Pressure; Cholesterol; Coronary Disease; Double-Blind Method; Endothelium, Vascular; For | 2001 |
Effect of isradipine on left ventricular relaxation and diastolic filling.
Topics: Angiocardiography; Blood Pressure; Calcium Channel Blockers; Cardiac Catheterization; Coronary Disea | 1990 |
Antiischemic and hemodynamic effects of intravenous isradipine, a new calcium antagonist, in coronary heart disease: a comparative double-blind cross-over study with nifedipine.
Topics: Calcium Channel Blockers; Coronary Disease; Double-Blind Method; Hemodynamics; Humans; Isradipine; M | 1990 |
Assessment of electrocardiographic ischemia in hypertensive patients treated with isradipine or placebo.
Topics: Adult; Aged; Antihypertensive Agents; Coronary Disease; Electrocardiography; Female; Humans; Hyperte | 1991 |
Effects of intravenous isradipine on left ventricular performance during rapid atrial pacing in coronary artery disease.
Topics: Calcium Channel Blockers; Cardiac Pacing, Artificial; Coronary Disease; Heart; Heart Rate; Heart Ven | 1990 |
[Myocardial effects of the calcium antagonists nifedipine, nisoldipine and isradipine in coronary heart disease].
Topics: Blood Pressure; Calcium Channel Blockers; Coronary Disease; Heart; Heart Rate; Humans; Infusions, In | 1990 |
[Electrophysiologic effects of the calcium antagonist isradipine, a double-blind placebo controlled study].
Topics: Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Coronary | 1990 |
Hemodynamic study of short- and long-term isradipine treatment in patients with chronic ischemic congestive heart failure.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Chronic Di | 1989 |
Comparison of isradipine and nifedipine in chronic stable angina.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Double- | 1988 |
[Isradipine (PN 200-110), a new dihydropyridine calcium antagonist with slight negative inotropic properties in comparison with nifedipine].
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Heart Rate; Hemodynamic | 1988 |
4 other studies available for isradipine and Coronary Disease
| Article | Year |
|---|---|
[Calcium antagonists and their impact on coronary risk].
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium Channel Blockers; Clinical Trials as Topic; | 1998 |
Isradipine: a new calcium antagonist with strong vasodilatory but negligible cardiodepressive effects.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Femal | 1990 |
Myocardial properties of the new dihydropyridine calcium antagonist isradipine compared to nifedipine with or without additional beta blockade in coronary artery disease.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Disease; Drug Therapy, Combination; | 1989 |
Cardioprotection by the calcium antagonist PN 200-110 in the absence and presence of cardiodepression.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; In Vitro Techn | 1985 |