isradipine has been researched along with Cerebral Infarction in 7 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The L-type calcium channel blocker isradipine was devoid of neuroprotective activity in focal and global models of cerebral ischemia in three species of normotensive animals." | 7.69 | Failure of isradipine to reduce infarct size in mouse, gerbil, and rat models of cerebral ischemia. ( Bailey, SJ; Hamilton, TC; Harrison, DC; Hunter, AJ; King, PD; Roberts, JC; Rothaul, AL; Samson, NA; Wood, NI, 1995) |
| "The L-type calcium channel blocker isradipine was devoid of neuroprotective activity in focal and global models of cerebral ischemia in three species of normotensive animals." | 3.69 | Failure of isradipine to reduce infarct size in mouse, gerbil, and rat models of cerebral ischemia. ( Bailey, SJ; Hamilton, TC; Harrison, DC; Hunter, AJ; King, PD; Roberts, JC; Rothaul, AL; Samson, NA; Wood, NI, 1995) |
| " Using this model, dose-response curves for infarct size, measured by magnetic resonance imaging, and biochemical markers of infarction were obtained for various calcium antagonists." | 1.28 | Cerebrovascular, biochemical, and cytoprotective effects of isradipine in laboratory animals. ( Hof, RP; Rudin, M; Sauter, A; Wiederhold, KH, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bailey, SJ | 1 |
| Wood, NI | 1 |
| Samson, NA | 1 |
| Rothaul, AL | 1 |
| Roberts, JC | 1 |
| King, PD | 1 |
| Hamilton, TC | 1 |
| Harrison, DC | 1 |
| Hunter, AJ | 1 |
| Sauter, A | 5 |
| Rudin, M | 5 |
| Reese, T | 1 |
| Pórszász, R | 1 |
| Baumann, D | 1 |
| Bochelen, D | 1 |
| Boumezbeur, F | 1 |
| McAllister, KH | 1 |
| Bjelke, B | 1 |
| Azcona, A | 1 |
| Lataste, X | 1 |
| Wiederhold, KH | 1 |
| Hof, RP | 1 |
1 trial available for isradipine and Cerebral Infarction
| Article | Year |
|---|---|
Isradipine in patients with acute ischaemic cerebral infarction. An overview of the ASCLEPIOS Programme.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Doubl | 1990 |
6 other studies available for isradipine and Cerebral Infarction
| Article | Year |
|---|---|
Failure of isradipine to reduce infarct size in mouse, gerbil, and rat models of cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Disease Models, Animal; Gerb | 1995 |
Failure of isradipine in cerebral ischemia models.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Gerbillinae; Isradipine; Mice; | 1996 |
Cytoprotection does not preserve brain functionality in rats during the acute post-stroke phase despite evidence of non-infarction provided by MRI.
Topics: Adenosine Triphosphate; Animals; Blood Volume; Brain; Cerebral Infarction; Cerebrovascular Circulati | 2000 |
In vivo NMR in pharmaceutical research.
Topics: Animals; Brain; Cerebral Infarction; Cerebrovascular Circulation; Drug Evaluation, Preclinical; Isra | 1992 |
Treatment of hypertension with isradipine reduces infarct size following stroke in laboratory animals.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarction; Hypertension; Israd | 1989 |
Cerebrovascular, biochemical, and cytoprotective effects of isradipine in laboratory animals.
Topics: Animals; Antihypertensive Agents; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; | 1989 |