isradipine has been researched along with Brain Ischemia in 18 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The L-type calcium channel blocker isradipine was devoid of neuroprotective activity in focal and global models of cerebral ischemia in three species of normotensive animals." | 7.69 | Failure of isradipine to reduce infarct size in mouse, gerbil, and rat models of cerebral ischemia. ( Bailey, SJ; Hamilton, TC; Harrison, DC; Hunter, AJ; King, PD; Roberts, JC; Rothaul, AL; Samson, NA; Wood, NI, 1995) |
| "We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [3H]dopamine release in a canine model of global cerebral ischemia/reperfusion." | 7.69 | Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. ( Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL, 1994) |
| " One dihydropyridine calcium antagonist (isradipine), given in doses which have been reported to ameliorate ischemic damage due to stroke, failed to reduce damage incurred by 30 min of hypoglycemic coma, or 15 min of transient forebrain ischemia." | 7.68 | The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis. ( Ohta, S; Siesjö, BK; Smith, ML, 1991) |
| " No change in functional deficit was seen with isradipine with either dosing paradigm at 24 h post-MCA occlusion." | 5.30 | Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. ( Campbell, CA; Hadingham, SJ; Hamilton, TC; King, PD; Mackay, KB; Patel, S; Stretton, JL, 1997) |
| " Dihydropyridine-class calcium channel antagonists, such as isradipine, show promise as therapeutic agents for preventing cocaine-induced cerebral ischemia." | 4.81 | Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonists. ( Ait-Daoud, N; Devous, MD; Johnson, BA; Ruiz, P, 2001) |
| "The L-type calcium channel blocker isradipine was devoid of neuroprotective activity in focal and global models of cerebral ischemia in three species of normotensive animals." | 3.69 | Failure of isradipine to reduce infarct size in mouse, gerbil, and rat models of cerebral ischemia. ( Bailey, SJ; Hamilton, TC; Harrison, DC; Hunter, AJ; King, PD; Roberts, JC; Rothaul, AL; Samson, NA; Wood, NI, 1995) |
| "We investigated the relationships among N-methyl-D-aspartate, glycine, L-type voltage-dependent calcium channels, and [3H]dopamine release in a canine model of global cerebral ischemia/reperfusion." | 3.69 | Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion. ( Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL, 1994) |
| " One dihydropyridine calcium antagonist (isradipine), given in doses which have been reported to ameliorate ischemic damage due to stroke, failed to reduce damage incurred by 30 min of hypoglycemic coma, or 15 min of transient forebrain ischemia." | 3.68 | The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis. ( Ohta, S; Siesjö, BK; Smith, ML, 1991) |
| " No change in functional deficit was seen with isradipine with either dosing paradigm at 24 h post-MCA occlusion." | 1.30 | Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. ( Campbell, CA; Hadingham, SJ; Hamilton, TC; King, PD; Mackay, KB; Patel, S; Stretton, JL, 1997) |
| " An initial dose-response study using neurological deficit scores and estimates of protection from brain infarction (by histology) showed that isradipine reduced cortical infarctions compared to vehicle-treated animals at most doses (between 1." | 1.30 | Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia. ( Barone, FC; Chandra, S; Coatney, RW; Everding, D; Feuerstein, GZ; Sarkar, SK; White, RF, 1999) |
| " Using this model, dose-response curves for infarct size, measured by magnetic resonance imaging, and biochemical markers of infarction were obtained for various calcium antagonists." | 1.28 | Cerebrovascular, biochemical, and cytoprotective effects of isradipine in laboratory animals. ( Hof, RP; Rudin, M; Sauter, A; Wiederhold, KH, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 14 (77.78) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Liu, J | 1 |
| Li, D | 1 |
| Zhang, C | 1 |
| Liu, M | 1 |
| Bailey, SJ | 1 |
| Wood, NI | 1 |
| Samson, NA | 1 |
| Rothaul, AL | 1 |
| Roberts, JC | 1 |
| King, PD | 2 |
| Hamilton, TC | 2 |
| Harrison, DC | 1 |
| Hunter, AJ | 1 |
| Nakane, H | 1 |
| Ooboshi, H | 2 |
| Ibayashi, S | 2 |
| Yao, H | 2 |
| Sadoshima, S | 2 |
| Fujishima, M | 2 |
| Dmitriev, VV | 1 |
| Kurkova, KS | 1 |
| Arabidze, GG | 1 |
| Shklovskiĭ, VM | 1 |
| Rogova, AN | 1 |
| Metelitsa, TV | 1 |
| Vizel', TG | 1 |
| Hoehner, PJ | 3 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Ganunis, TF | 1 |
| Murphy, MT | 1 |
| Traystman, RJ | 1 |
| Werling, LL | 1 |
| Hurt, KJ | 1 |
| Fox, LG | 1 |
| Blanck, TJ | 2 |
| Rosenthal, RE | 2 |
| Fiskum, G | 2 |
| Uchimura, H | 1 |
| Sauter, A | 2 |
| Rudin, M | 2 |
| Campbell, CA | 1 |
| Mackay, KB | 1 |
| Patel, S | 1 |
| Stretton, JL | 1 |
| Hadingham, SJ | 1 |
| Chandra, S | 1 |
| White, RF | 1 |
| Everding, D | 1 |
| Feuerstein, GZ | 1 |
| Coatney, RW | 1 |
| Sarkar, SK | 1 |
| Barone, FC | 1 |
| Johnson, BA | 1 |
| Devous, MD | 1 |
| Ruiz, P | 1 |
| Ait-Daoud, N | 1 |
| Roy, R | 1 |
| Kato, H | 1 |
| Araki, T | 1 |
| Hara, H | 1 |
| Kogure, K | 2 |
| Ohta, S | 1 |
| Smith, ML | 1 |
| Siesjö, BK | 1 |
| Bentahila, S | 1 |
| Atkinson, J | 1 |
| Capdeville, C | 1 |
| Azcona, A | 1 |
| Lataste, X | 1 |
| Wiederhold, KH | 1 |
| Hof, RP | 1 |
| Abe, K | 1 |
| Watanabe, T | 1 |
2 reviews available for isradipine and Brain Ischemia
| Article | Year |
|---|---|
Calcium antagonists for acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Calcium; Calcium Channel Blockers; Fe | 2019 |
Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonists.
Topics: Brain Ischemia; Calcium Channel Blockers; Cocaine-Related Disorders; Dihydropyridines; Humans; Israd | 2001 |
2 trials available for isradipine and Brain Ischemia
| Article | Year |
|---|---|
[Lomir for the treatment of patients with essential hypertension and for the rehabilitation of patients with a history of cerebral circulatory disorder].
Topics: Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Chronic Disease; Circadian Rhythm; Fema | 1994 |
Isradipine in patients with acute ischaemic cerebral infarction. An overview of the ASCLEPIOS Programme.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Doubl | 1990 |
14 other studies available for isradipine and Brain Ischemia
| Article | Year |
|---|---|
Failure of isradipine to reduce infarct size in mouse, gerbil, and rat models of cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Disease Models, Animal; Gerb | 1995 |
Isradipine, a calcium channel blocker, attenuates the ischemia-induced release of dopamine but not glutamate in rats.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascul | 1995 |
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex; | 1994 |
Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Calcium Channels; Dogs; Dopamine; Female; Glycine; Isradipine; N-Methylaspa | 1994 |
Isradipine attenuates the ischemia-induced release of dopamine in the striatum of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circula | 1993 |
Failure of isradipine in cerebral ischemia models.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Gerbillinae; Isradipine; Mice; | 1996 |
Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Behavior, Animal; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Calcium Channel Block | 1997 |
Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationshi | 1999 |
Alteration of voltage-dependent calcium channels in canine brain during global ischemia and reperfusion.
Topics: Animals; Binding Sites; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; | 1992 |
Sequential changes in muscarinic acetylcholine, adenosine A1 and calcium antagonist binding sites in the gerbil hippocampus following repeated brief ischemia.
Topics: Adenosine; Animals; Autoradiography; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Dih | 1991 |
The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis.
Topics: Animals; Brain Diseases; Brain Ischemia; Calcium Channel Blockers; Coma; Hypoglycemia; Isradipine; M | 1991 |
Protective effects of antihypertensive treatment with isradipine on the consequences of cerebral ischaemia in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Hydralazine; Hypertension; Isradipine; Male; Motor | 1991 |
Cerebrovascular, biochemical, and cytoprotective effects of isradipine in laboratory animals.
Topics: Animals; Antihypertensive Agents; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; | 1989 |
Prevention of ischemic and postischemic brain edema by a novel calcium antagonist (PN200-110).
Topics: Animals; Autoradiography; Brain Edema; Brain Ischemia; Calcium; Calcium Channel Blockers; Isradipine | 1988 |