isradipine has been researched along with Alzheimer Disease in 7 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isradipine is a Federal Drug Administration-approved dihydropyridine calcium channel blocker that binds selectively to Ca(v)1." | 2.47 | Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine. ( Anekonda, TS; Quinn, JF, 2011) |
| "Isradipine was the most potent blocker, preventing APP CTF neurotoxicity at nanomolar concentrations." | 1.37 | L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease. ( Anekonda, TS; Frahler, K; Harris, C; Quinn, JF; Wadsworth, TL; Woltjer, RL, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Wickline, JL | 1 |
| Smith, S | 1 |
| Shin, R | 1 |
| Odfalk, K | 1 |
| Sanchez, J | 1 |
| Javors, M | 1 |
| Ginsburg, B | 1 |
| Hopp, SC | 1 |
| Gholami Pourbadie, H | 1 |
| Naderi, N | 1 |
| Janahmadi, M | 1 |
| Mehranfard, N | 1 |
| Motamedi, F | 1 |
| Anekonda, TS | 3 |
| Quinn, JF | 3 |
| Harris, C | 1 |
| Frahler, K | 1 |
| Wadsworth, TL | 2 |
| Woltjer, RL | 2 |
| Copenhaver, PF | 1 |
| Musashe, D | 1 |
| Robinson, KM | 1 |
| Ramaker, JM | 1 |
| Swanson, TL | 1 |
| Kretzschmar, D | 1 |
| Sen, AP | 1 |
| Boksa, P | 1 |
| Quirion, R | 1 |
| Ikeda, M | 1 |
| Dewar, D | 1 |
| McCulloch, J | 1 |
1 review available for isradipine and Alzheimer Disease
| Article | Year |
|---|---|
Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine.
Topics: Alzheimer Disease; Animals; Autophagy; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; | 2011 |
6 other studies available for isradipine and Alzheimer Disease
| Article | Year |
|---|---|
L-type calcium channel antagonist isradipine age-dependently decreases plaque associated dystrophic neurites in 5XFAD mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium Channel B | 2023 |
Calcium channel blockade attenuates abnormal synaptic transmission in the dentate gyrus elicited by entorhinal amyloidopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Channel Blockers; Dentate Gyrus; Entorhin | 2016 |
L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line, Tumor; Fe | 2011 |
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Assay; Calcium Channels, L-Type; Cell | 2011 |
Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases.
Topics: Aged; Alzheimer Disease; Autopsy; Binding Sites; Brain; Calcium; Calcium Channels; Dihydropyridines; | 1993 |
A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channels; Choline O-Acetyltransferase; Female; H | 1992 |