Page last updated: 2024-10-29

isradipine and Aging

isradipine has been researched along with Aging in 27 studies

Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The mean dosage was 1."6.67Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients. ( Correa-Nunes, A; Mariano-Pego, G; Moura, B; Pereira-Miguel, JM; Rocha-Gonçalves, F, 1994)
" The mean dosage was 1."2.67Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients. ( Correa-Nunes, A; Mariano-Pego, G; Moura, B; Pereira-Miguel, JM; Rocha-Gonçalves, F, 1994)
"Drug level monitoring during routine clinical visits in the course of phase III trials provides a means to document pharmacokinetic variability in a patient population."2.67Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine. ( Fertil, B; Jais, JP; Laplanche, R; Niederberger, W; Nüesch, E; Steimer, JL, 1991)
"Parkinson's disease is a common neurodegenerative disorder of unknown cause."2.44Calcium, ageing, and neuronal vulnerability in Parkinson's disease. ( Surmeier, DJ, 2007)
"There was very little significant difference between SAMR1 and SAMP8 in terms of the half-life (t(1/2)), total body clearance (CL(tot)), steady-state volume of distribution (Vd(ss))."1.31In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain. ( Deguchi, Y; Kimura, R; Uchida, S; Yamada, S; Yamamoto, M, 2000)
" In conclusion, the present study suggests that there is an altered Ca++ homeostasis in the SAMP8 brain that is effectively attenuated by chronic administration of nimodipine and nicardipine."1.29Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine. ( Kimura, R; Ohkura, T; Suzuki, M; Uchida, S; Yamada, S; Yamaguchi, M; Yamamoto, M, 1996)
" In anesthetized rats, isradipine inhibited the dose-response curves of norepinephrine on the blood pressure in 6- and 40-week-old animals more effectively than those in 10-week-old animals."1.29[Age-related alteration of inhibitory effects of isradipine on alpha 1-adrenoceptor mediated responses]. ( Ashikawa, N; Kanai, S; Satoh, M, 1996)
"The bioavailability of isradipine has been examined in 7- and 52-week-old rats after oral (12."1.28Bioavailability of isradipine in young and old rats: effect of mode of administration. ( Hassell, AE; Jaffe, JM; Schran, HF; Tse, FL, 1989)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19905 (18.52)18.7374
1990's16 (59.26)18.2507
2000's4 (14.81)29.6817
2010's2 (7.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chan, CS1
Gertler, TS1
Surmeier, DJ3
Guzman, JN1
Sanchez-Padilla, J1
Goldberg, JA1
Lopes, GS1
Smaili, SS1
Neto, AC1
Vladimirova, I1
Jurkiewicz, A1
Jurkiewicz, NH1
Bangalore, R1
Triggle, DJ2
Ikeda, S1
Amano, Y1
Adachi-Akahane, S1
Nagao, T1
Rocha-Gonçalves, F1
Moura, B1
Pereira-Miguel, JM1
Correa-Nunes, A1
Mariano-Pego, G1
Hoehner, PJ1
Kirsch, JR1
Helfaer, MA1
Ganunis, TF1
Murphy, MT1
Traystman, RJ1
Araki, T3
Kato, H3
Kanai, Y2
Kogure, K2
Shuto, K2
Ishida, Y1
Yoshida, M2
Latifpour, J2
Weiss, RM2
Yamada, S2
Uchida, S2
Ohkura, T1
Kimura, R2
Yamaguchi, M1
Suzuki, M1
Yamamoto, M2
Damiani, E1
Larsson, L1
Margreth, A1
Kanai, S1
Ashikawa, N1
Satoh, M1
Nagaki, S1
Fujiwara, T1
Itoyama, Y1
Deguchi, Y1
Tanaka, Y1
Ando, S1
Gałewski, S1
Skangiel-Kramska, J1
Pomorski, P1
Kossut, M1
Gu, XH2
Ou, RC1
Casley, DJ1
Daly, MJ1
Nayler, WG2
Galletti, F1
Rutledge, A1
Krogh, V1
Laplanche, R1
Fertil, B1
Nüesch, E1
Jais, JP1
Niederberger, W1
Steimer, JL1
Dillon, JS1
Tse, FL1
Jaffe, JM1
Hassell, AE1
Schran, HF1
Bode-Greuel, KM1
Singer, W1
Dooley, DJ1
Lickert, M1
Lupp, A1
Osswald, H1
Huguet, F1
Huchet, AM1
Gerard, P1
Narcisse, G1

Reviews

2 reviews available for isradipine and Aging

ArticleYear
The origins of oxidant stress in Parkinson's disease and therapeutic strategies.
    Antioxidants & redox signaling, 2011, Apr-01, Volume: 14, Issue:7

    Topics: Aging; Animals; Biological Clocks; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signa

2011
Calcium, ageing, and neuronal vulnerability in Parkinson's disease.
    The Lancet. Neurology, 2007, Volume: 6, Issue:10

    Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dopamine; Humans; Isradipine; N

2007

Trials

2 trials available for isradipine and Aging

ArticleYear
Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients.
    American journal of hypertension, 1994, Volume: 7, Issue:7 Pt 2

    Topics: Adolescent; Adult; Aged; Aging; Blood Pressure; Diastole; Dose-Response Relationship, Drug; Female;

1994
Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:1

    Topics: Adult; Aged; Aging; Analysis of Variance; Biological Availability; Body Height; Body Weight; Calcium

1991

Other Studies

23 other studies available for isradipine and Aging

ArticleYear
A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Volume: 25 Suppl 1

    Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal;

2010
Aging-induced decrease of cholinergic response and calcium sensitivity on rat jejunum contractions.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Volume: 62, Issue:3

    Topics: Adrenergic Agonists; Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Sig

2007
Age-dependent changes in voltage-gated calcium channels and ATP-dependent potassium channels in Fischer 344 rats.
    General pharmacology, 1995, Volume: 26, Issue:6

    Topics: Adenosine Triphosphate; Aging; Animals; Brain; Calcium; Calcium Channels; Glyburide; Heart Rate; Hip

1995
Binding of [3H](+)-PN200-110 to aortic membranes from normotensive and spontaneously hypertensive rats.
    European journal of pharmacology, 1994, Oct-24, Volume: 264, Issue:2

    Topics: Aging; Animals; Aorta, Abdominal; Aorta, Thoracic; Calcium Channels; Disease Models, Animal; Hyperte

1994
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
    Stroke, 1994, Volume: 25, Issue:10

    Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex;

1994
Selective changes of neurotransmitter receptors in middle-aged gerbil brain.
    Neurochemistry international, 1993, Volume: 23, Issue:6

    Topics: Adenosine; Aging; Animals; Autoradiography; Benzazepines; Brain; Dizocilpine Maleate; Gerbillinae; I

1993
Effect of vinconate against regional age-related changes in the gerbil brain.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:1

    Topics: Acetylcholine; Aging; Animals; Autoradiography; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Gerbi

1993
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract.
    European journal of pharmacology, 1993, Mar-02, Volume: 232, Issue:2-3

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Calcium Channel Agonists; Calcium Channels; Female; I

1993
Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Mice;

1996
Age-related abnormalities in regulation of the ryanodine receptor in rat fast-twitch muscle.
    Cell calcium, 1996, Volume: 19, Issue:1

    Topics: Aging; Animals; Antibiotics, Antineoplastic; Binding Sites; Caffeine; Calcium; Calcium Channel Block

1996
[Age-related alteration of inhibitory effects of isradipine on alpha 1-adrenoceptor mediated responses].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1996, Volume: 116, Issue:10

    Topics: Aging; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels

1996
Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats.
    Mechanisms of ageing and development, 1997, Volume: 95, Issue:1-2

    Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Calcium Channels; Carrier Proteins; Dizocilpi

1997
In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain.
    Pharmaceutical research, 2000, Volume: 17, Issue:7

    Topics: Aging; Animals; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Mice; Myocardiu

2000
Age-related changes in the subtypes of voltage-dependent calcium channels in rat brain cortical synapses.
    Neuroscience research, 2001, Volume: 39, Issue:2

    Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calci

2001
Voltage-dependent L-type calcium channels in the development and plasticity of mouse barrel cortex.
    Brain research. Developmental brain research, 1992, Jun-19, Volume: 67, Issue:2

    Topics: Aging; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; D

1992
Effect of age on endothelin-1 binding sites in rat cardiac ventricular membranes.
    Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:5

    Topics: Aging; Animals; Binding Sites; Binding, Competitive; Calcium; Dihydropyridines; Endothelin-1; Endoth

1992
Age-related changes in calcium antagonist receptors in rabbit ureter.
    Developmental pharmacology and therapeutics, 1992, Volume: 18, Issue:1-2

    Topics: Aging; Animals; Binding Sites; Body Weight; Calcium Channel Blockers; Female; Isradipine; Muscle, Sm

1992
Age related changes in Ca2+ channels in spontaneously hypertensive rats.
    General pharmacology, 1991, Volume: 22, Issue:1

    Topics: Aging; Animals; Body Weight; Brain; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques;

1991
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:2

    Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydrop

1989
Bioavailability of isradipine in young and old rats: effect of mode of administration.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:9

    Topics: Aging; Animals; Biological Availability; Diet; Injections, Intravenous; Isradipine; Kinetics; Male;

1989
Developmental changes of the distribution of binding sites for organic Ca2+-channel blockers in cat visual cortex.
    Experimental brain research, 1988, Volume: 70, Issue:2

    Topics: Aging; Animals; Autoradiography; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cats; Di

1988
Distribution of [125I]omega-conotoxin GVIA and [3H]isradipine binding sites in the central nervous system of rats of different ages.
    Neuroscience letters, 1988, Nov-11, Volume: 93, Issue:2-3

    Topics: Aging; Animals; Binding Sites; Calcium Channels; Central Nervous System; Electrophysiology; Iodine R

1988
Characterization of dihydropyridine binding sites in the rat brain: hypertension and age-dependent modulation of [3H](+)-PN 200-110 binding.
    Brain research, 1987, May-26, Volume: 412, Issue:1

    Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Hypertension; Isra

1987