isradipine and Aging
isradipine has been researched along with Aging in 27 studies
Isradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The mean dosage was 1." | 6.67 | Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients. ( Correa-Nunes, A; Mariano-Pego, G; Moura, B; Pereira-Miguel, JM; Rocha-Gonçalves, F, 1994) |
| " The mean dosage was 1." | 2.67 | Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients. ( Correa-Nunes, A; Mariano-Pego, G; Moura, B; Pereira-Miguel, JM; Rocha-Gonçalves, F, 1994) |
| "Drug level monitoring during routine clinical visits in the course of phase III trials provides a means to document pharmacokinetic variability in a patient population." | 2.67 | Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine. ( Fertil, B; Jais, JP; Laplanche, R; Niederberger, W; Nüesch, E; Steimer, JL, 1991) |
| "Parkinson's disease is a common neurodegenerative disorder of unknown cause." | 2.44 | Calcium, ageing, and neuronal vulnerability in Parkinson's disease. ( Surmeier, DJ, 2007) |
| "There was very little significant difference between SAMR1 and SAMP8 in terms of the half-life (t(1/2)), total body clearance (CL(tot)), steady-state volume of distribution (Vd(ss))." | 1.31 | In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain. ( Deguchi, Y; Kimura, R; Uchida, S; Yamada, S; Yamamoto, M, 2000) |
| " In conclusion, the present study suggests that there is an altered Ca++ homeostasis in the SAMP8 brain that is effectively attenuated by chronic administration of nimodipine and nicardipine." | 1.29 | Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine. ( Kimura, R; Ohkura, T; Suzuki, M; Uchida, S; Yamada, S; Yamaguchi, M; Yamamoto, M, 1996) |
| " In anesthetized rats, isradipine inhibited the dose-response curves of norepinephrine on the blood pressure in 6- and 40-week-old animals more effectively than those in 10-week-old animals." | 1.29 | [Age-related alteration of inhibitory effects of isradipine on alpha 1-adrenoceptor mediated responses]. ( Ashikawa, N; Kanai, S; Satoh, M, 1996) |
| "The bioavailability of isradipine has been examined in 7- and 52-week-old rats after oral (12." | 1.28 | Bioavailability of isradipine in young and old rats: effect of mode of administration. ( Hassell, AE; Jaffe, JM; Schran, HF; Tse, FL, 1989) |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 16 (59.26) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chan, CS | 1 |
| Gertler, TS | 1 |
| Surmeier, DJ | 3 |
| Guzman, JN | 1 |
| Sanchez-Padilla, J | 1 |
| Goldberg, JA | 1 |
| Lopes, GS | 1 |
| Smaili, SS | 1 |
| Neto, AC | 1 |
| Vladimirova, I | 1 |
| Jurkiewicz, A | 1 |
| Jurkiewicz, NH | 1 |
| Bangalore, R | 1 |
| Triggle, DJ | 2 |
| Ikeda, S | 1 |
| Amano, Y | 1 |
| Adachi-Akahane, S | 1 |
| Nagao, T | 1 |
| Rocha-Gonçalves, F | 1 |
| Moura, B | 1 |
| Pereira-Miguel, JM | 1 |
| Correa-Nunes, A | 1 |
| Mariano-Pego, G | 1 |
| Hoehner, PJ | 1 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Ganunis, TF | 1 |
| Murphy, MT | 1 |
| Traystman, RJ | 1 |
| Araki, T | 3 |
| Kato, H | 3 |
| Kanai, Y | 2 |
| Kogure, K | 2 |
| Shuto, K | 2 |
| Ishida, Y | 1 |
| Yoshida, M | 2 |
| Latifpour, J | 2 |
| Weiss, RM | 2 |
| Yamada, S | 2 |
| Uchida, S | 2 |
| Ohkura, T | 1 |
| Kimura, R | 2 |
| Yamaguchi, M | 1 |
| Suzuki, M | 1 |
| Yamamoto, M | 2 |
| Damiani, E | 1 |
| Larsson, L | 1 |
| Margreth, A | 1 |
| Kanai, S | 1 |
| Ashikawa, N | 1 |
| Satoh, M | 1 |
| Nagaki, S | 1 |
| Fujiwara, T | 1 |
| Itoyama, Y | 1 |
| Deguchi, Y | 1 |
| Tanaka, Y | 1 |
| Ando, S | 1 |
| Gałewski, S | 1 |
| Skangiel-Kramska, J | 1 |
| Pomorski, P | 1 |
| Kossut, M | 1 |
| Gu, XH | 2 |
| Ou, RC | 1 |
| Casley, DJ | 1 |
| Daly, MJ | 1 |
| Nayler, WG | 2 |
| Galletti, F | 1 |
| Rutledge, A | 1 |
| Krogh, V | 1 |
| Laplanche, R | 1 |
| Fertil, B | 1 |
| Nüesch, E | 1 |
| Jais, JP | 1 |
| Niederberger, W | 1 |
| Steimer, JL | 1 |
| Dillon, JS | 1 |
| Tse, FL | 1 |
| Jaffe, JM | 1 |
| Hassell, AE | 1 |
| Schran, HF | 1 |
| Bode-Greuel, KM | 1 |
| Singer, W | 1 |
| Dooley, DJ | 1 |
| Lickert, M | 1 |
| Lupp, A | 1 |
| Osswald, H | 1 |
| Huguet, F | 1 |
| Huchet, AM | 1 |
| Gerard, P | 1 |
| Narcisse, G | 1 |
Reviews
2 reviews available for isradipine and Aging
| Article | Year |
|---|---|
The origins of oxidant stress in Parkinson's disease and therapeutic strategies.
Topics: Aging; Animals; Biological Clocks; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signa | 2011 |
Calcium, ageing, and neuronal vulnerability in Parkinson's disease.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dopamine; Humans; Isradipine; N | 2007 |
Trials
2 trials available for isradipine and Aging
| Article | Year |
|---|---|
Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients.
Topics: Adolescent; Adult; Aged; Aging; Blood Pressure; Diastole; Dose-Response Relationship, Drug; Female; | 1994 |
Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine.
Topics: Adult; Aged; Aging; Analysis of Variance; Biological Availability; Body Height; Body Weight; Calcium | 1991 |
Other Studies
23 other studies available for isradipine and Aging
| Article | Year |
|---|---|
A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; | 2010 |
Aging-induced decrease of cholinergic response and calcium sensitivity on rat jejunum contractions.
Topics: Adrenergic Agonists; Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Sig | 2007 |
Age-dependent changes in voltage-gated calcium channels and ATP-dependent potassium channels in Fischer 344 rats.
Topics: Adenosine Triphosphate; Aging; Animals; Brain; Calcium; Calcium Channels; Glyburide; Heart Rate; Hip | 1995 |
Binding of [3H](+)-PN200-110 to aortic membranes from normotensive and spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta, Abdominal; Aorta, Thoracic; Calcium Channels; Disease Models, Animal; Hyperte | 1994 |
Dihydropyridine ligand binding decreases earlier in adolescent than in infant swine after global cerebral ischemia.
Topics: Aging; Animals; Blood Pressure; Brain Ischemia; Calcium Channels; Caudate Nucleus; Cerebral Cortex; | 1994 |
Selective changes of neurotransmitter receptors in middle-aged gerbil brain.
Topics: Adenosine; Aging; Animals; Autoradiography; Benzazepines; Brain; Dizocilpine Maleate; Gerbillinae; I | 1993 |
Effect of vinconate against regional age-related changes in the gerbil brain.
Topics: Acetylcholine; Aging; Animals; Autoradiography; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Gerbi | 1993 |
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Calcium Channel Agonists; Calcium Channels; Female; I | 1993 |
Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Mice; | 1996 |
Age-related abnormalities in regulation of the ryanodine receptor in rat fast-twitch muscle.
Topics: Aging; Animals; Antibiotics, Antineoplastic; Binding Sites; Caffeine; Calcium; Calcium Channel Block | 1996 |
[Age-related alteration of inhibitory effects of isradipine on alpha 1-adrenoceptor mediated responses].
Topics: Aging; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels | 1996 |
Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Calcium Channels; Carrier Proteins; Dizocilpi | 1997 |
In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain.
Topics: Aging; Animals; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Mice; Myocardiu | 2000 |
Age-related changes in the subtypes of voltage-dependent calcium channels in rat brain cortical synapses.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calci | 2001 |
Voltage-dependent L-type calcium channels in the development and plasticity of mouse barrel cortex.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; D | 1992 |
Effect of age on endothelin-1 binding sites in rat cardiac ventricular membranes.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Calcium; Dihydropyridines; Endothelin-1; Endoth | 1992 |
Age-related changes in calcium antagonist receptors in rabbit ureter.
Topics: Aging; Animals; Binding Sites; Body Weight; Calcium Channel Blockers; Female; Isradipine; Muscle, Sm | 1992 |
Age related changes in Ca2+ channels in spontaneously hypertensive rats.
Topics: Aging; Animals; Body Weight; Brain; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques; | 1991 |
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydrop | 1989 |
Bioavailability of isradipine in young and old rats: effect of mode of administration.
Topics: Aging; Animals; Biological Availability; Diet; Injections, Intravenous; Isradipine; Kinetics; Male; | 1989 |
Developmental changes of the distribution of binding sites for organic Ca2+-channel blockers in cat visual cortex.
Topics: Aging; Animals; Autoradiography; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cats; Di | 1988 |
Distribution of [125I]omega-conotoxin GVIA and [3H]isradipine binding sites in the central nervous system of rats of different ages.
Topics: Aging; Animals; Binding Sites; Calcium Channels; Central Nervous System; Electrophysiology; Iodine R | 1988 |
Characterization of dihydropyridine binding sites in the rat brain: hypertension and age-dependent modulation of [3H](+)-PN 200-110 binding.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Hypertension; Isra | 1987 |