isoxsuprine has been researched along with Pregnancy in 159 studies
Isoxsuprine: A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5% incidence of pulmonary edema was observed when the records of 1,407 patients treated with parenteral isoxsuprine over a 7-year interval were reviewed." | 7.67 | Pulmonary edema associated with isoxsuprine therapy. ( Cairns, J; Effer, S; Fallen, E; Nimrod, C; Rambihar, V, 1984) |
| " Intravenous injections of 133Xe were given to evaluate the effects of short-term administration of fenoterol (3 microgram/min) and isoxsuprine (150 migrogram/min) on the intervillous and myometrial blood flow in a series of 48 women during the last trimester of pregnancy." | 7.66 | Effect of fenoterol and isoxsuprine on myometrial and intervillous blood flow during late pregnancy. ( Kauppila, A; Kuikka, J; Tuimala, R, 1978) |
| "The uteroplacental blood flow was measured in 26 normal pregnant women between the 36-43 weeks of pregnancy before and after a short-term treatment of isoxsuprine." | 7.65 | [Uteroplacental blood flow in normal pregnancy before and after short-term treatment with (isoxsuprine) beta-sympathicomimetica (author's transl)]. ( Grönman, P; Luotola, H; Pitkänen, M; Pyörälä, T; Toivanen, J, 1977) |
| "Isoxsuprine was the only drug that elevated the blood flow volume in the AUM (P ≤ 0." | 5.40 | Effect of xylazine, isoxsuprine, and lidocaine on Doppler sonographic uterine and umbilical blood flow measurements in cows during the last month of pregnancy. ( Bleul, U; Waldvogel, D, 2014) |
| "Isoxsuprine therapy was begun with initial dose of 0." | 5.27 | Pulmonary edema occurring after isoxsuprine and dexamethasone treatment for preterm labor: Case report. ( Evron, S; Mor-Yosef, S; Rosen, E; Sadovsky, E; Samueloff, A, 1983) |
| " Taking a minimum birth weight of 2500 g as the criteria of successful treatment, the success rate in the placebo group was 71%, in the Nylidrin hydrochloride group 86%, the Isoxuprine hydrochloride group 75% and the alcohol group 70%." | 5.04 | Treatment of imminent premature labour. ( Castrén, O; Gummerus, M; Saarikoski, S, 1975) |
| "In this prospective, single-center, noncomparative study, patients (with preterm labor at gestational age of 24-37 weeks) were administered intravenous (IV) infusion of 40-mg isoxsuprine hydrochloride until uterine quiescence, followed by intramuscular (IM) injection of isoxsuprine hydrochloride 10 mg/4-hourly for first 24 hours and maintained with retard 40-mg sustained release capsule (two times a day) till the time of delivery or 37 completed weeks of pregnancy." | 4.02 | Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study. ( Jaju, PB, 2021) |
| "5% incidence of pulmonary edema was observed when the records of 1,407 patients treated with parenteral isoxsuprine over a 7-year interval were reviewed." | 3.67 | Pulmonary edema associated with isoxsuprine therapy. ( Cairns, J; Effer, S; Fallen, E; Nimrod, C; Rambihar, V, 1984) |
| "The potential association of intravenous isoxsuprine therapy for premature labor with pulmonary edema and an adult respiratory distress syndrome is demonstrated by 6 patients, 3 of whom became critically ill." | 3.66 | Pulmonary complications of isoxsuprine therapy in the gravida. ( Crenshaw, MC; Nagey, DA, 1982) |
| "The frequency of idiopathic respiratory distress (IRD) among premature offspring born of women who were given aminophylline before the thirty-fourth week of pregnancy was evaluated." | 3.66 | Antepartum aminophylline treatment for prevention of the respiratory distress syndrome in premature infants. ( Hadjigeorgiou, E; Kaskarelis, D; Kitsiou, S; Nicolopoulos, D; Psaroudakis, A; Segos, C, 1979) |
| " Intravenous injections of 133Xe were given to evaluate the effects of short-term administration of fenoterol (3 microgram/min) and isoxsuprine (150 migrogram/min) on the intervillous and myometrial blood flow in a series of 48 women during the last trimester of pregnancy." | 3.66 | Effect of fenoterol and isoxsuprine on myometrial and intervillous blood flow during late pregnancy. ( Kauppila, A; Kuikka, J; Tuimala, R, 1978) |
| "Estrogen concentrations in maternal plasma were determined in ten apparently normal patients attending clinic in the last trimester of pregnancy before, during, and after a maximum of four weeks isoxsuprine treatment." | 3.65 | The effect of isoxsuprine treatment of estrogen levels in maternal and umbilical cord plasma. ( Maughan, GB; Sybulski, S, 1975) |
| "Preterm labor is responsible for a majority of cases of perinatal morbidity and deaths." | 2.36 | Pharmacologic inhibition of preterm labor. ( Caritis, SN; Edelstone, DI; Mueller-Heubach, E, 1979) |
| "Isoxsuprine is a beta-agonist that can be used for growth promotion in cattle, but it is also used as registered veterinary medicine." | 1.38 | Veterinary treatment of cows with isoxsuprine for a caesarian section may temporarily lead to residues in hair of both cow and calf. ( Groot, MJ; Lasaroms, JJ; Nielen, MW; Van Hende, J, 2012) |
| " Duration of exposure to tocolysis was at least 30 days (30-180 days) with an oral dosage of 10 mg 3 times daily." | 1.28 | Transient electrocardiographic changes suggesting myocardial ischaemia in newborn infants following tocolysis with beta-sympathomimetics. ( Agnetti, A; De Luca, F; Di Pasquale, G; Gemelli, M; Leonardi, R; Mami, C; Manganaro, R; Rando, F, 1990) |
| " Preincubation with cocaine, 10(-5) M, shifted the inhibitory dose-response curves of Iso and Orc to the left, 16." | 1.27 | Mechanism of action of isoprenaline, isoxuprine, terbutaline and orciprenaline on gravid human isolated myometrium. Influence of the neuronal uptake process. ( Calixto, JB; Simas, CM, 1984) |
| "Isoxsuprine was more potent than the other two drugs and needed a long time for restoration." | 1.27 | [Effects of a beta 2-stimulant, ritodrine hydrochloride, on the fetuses and dams in the late stage of pregnancy: an experimental study using rabbits]. ( Akahane, M; Ikeda, S; Nebashi, Y, 1983) |
| "Isoxsuprine therapy was begun with initial dose of 0." | 1.27 | Pulmonary edema occurring after isoxsuprine and dexamethasone treatment for preterm labor: Case report. ( Evron, S; Mor-Yosef, S; Rosen, E; Sadovsky, E; Samueloff, A, 1983) |
| "Three cases of peripartum pulmonary edema associated with steroid administration are reported." | 1.27 | Pulmonary edema associated with the use of hydrocortisone and a tocolytic agent for the management of premature labor. ( O'Shaughnessy, R; Semchyshyn, S; Zuspan, FP, 1983) |
| "Isoxsuprine was used as the primary tocolytic agent in all the patients." | 1.27 | [The effect of amniocentesis on pregnancy prolongation in patients of threatened premature labor with intact membranes]. ( Hokanishi, H; Ikenoue, T; Kamitomo, M; Matsuda, Y; Matsumoto, T, 1988) |
| "Premature labor was diagnosed, and tocolytic treatment was initiated at a mean gestational age of 31." | 1.27 | Treatment of premature labor in insulin-dependent diabetic women. ( Holroyde, JC; Miodovnik, M; Peros, N; Siddiqi, TA, 1985) |
| "The terbutaline therapy was discontinued, and isoxsuprine hydrochloride infusion was started at 240 micrograms/min and gradually increased to 800 micrograms/min." | 1.26 | Pulmonary edema associated with the use of betamimetic agents in preterm labor. ( Gabert, HA; Guernsey, BG; Snyder, MD; Villarreal, Y, 1981) |
| " Thus, in utero treatment with isoxsuprine had no apparent adverse effect on newborn rats exposed to a prolonged O2 challenge." | 1.26 | Effect of prenatal isoxsuprine on pulmonary oxygen toxicity in the newborn rat. ( Frank, L; Massaro, D; Summerville, J, 1980) |
| "An obstetric alternative to premature labor is administration of isoxsuprine, an effective inhibitor of uterine contractions." | 1.26 | Effects of isoxsuprine on maternal and fetal acid-base balance and circulation. ( Ayromlooi, J; Desiderio, D; Tobias, M, 1981) |
| "The authors report two cases of severe non-obstructive cardiomyopathy presenting at the end of pregnancy in young women treated for long periods and at high dosage with beta 2-adrenoceptor stimulants, prescribed for threatened abortion or premature labour." | 1.26 | [Myocardiopathies during pregnancy. Possible role of beta-mimetics]. ( Bourdonnec, C; Daubert, JC; Gosse, P; Gouffault, J; Grall, JY; Pony, JC; Rio, M, 1978) |
| "Isoxsuprine was given intramuscularly for 24 hours to pregnant rabbits at 26 to 27 days' gestation." | 1.26 | Effect of maternal isoxsuprine on fetal rabbit lung biochemical maturation. ( Hayden, W; Olson, EB; Zachman, RD, 1977) |
| "A patient with acute polyhydramnios in two successive pregnancies is described." | 1.26 | Acute polyhydramnios recurrent in successive pregnancies. Management with multiple amniocenteses. ( Pitkin, RM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 140 (88.05) | 18.7374 |
| 1990's | 6 (3.77) | 18.2507 |
| 2000's | 3 (1.89) | 29.6817 |
| 2010's | 8 (5.03) | 24.3611 |
| 2020's | 2 (1.26) | 2.80 |
| Authors | Studies |
|---|---|
| Akbulut, NK | 1 |
| Kal, Y | 1 |
| Jaju, PB | 1 |
| Waldvogel, D | 1 |
| Bleul, U | 2 |
| Lopes, LM | 1 |
| Carrilho, MC | 1 |
| Francisco, RP | 1 |
| Lopes, MA | 1 |
| Krebs, VL | 1 |
| Zugaib, M | 3 |
| Yamasmit, W | 2 |
| Chaithongwongwatthana, S | 2 |
| Tolosa, JE | 2 |
| Limpongsanurak, S | 2 |
| Pereira, L | 2 |
| Lumbiganon, P | 2 |
| Kim-Egloff, C | 1 |
| Hässig, M | 1 |
| Bruckmaier, R | 1 |
| Giorgino, FL | 1 |
| Egan, CG | 1 |
| Groot, MJ | 1 |
| Lasaroms, JJ | 1 |
| Van Hende, J | 1 |
| Nielen, MW | 1 |
| Wex, J | 1 |
| Abou-Setta, AM | 1 |
| Clerici, G | 1 |
| Di Renzo, GC | 1 |
| TAUBERT, HD | 1 |
| HASKINS, AL | 1 |
| CHIERI, S | 1 |
| MAFFEO, G | 1 |
| HENDRICKS, CH | 1 |
| CIBILS, LA | 2 |
| POSE, SV | 1 |
| ESKES, TK | 2 |
| KARIM, M | 1 |
| Eriksson, G | 1 |
| Wiqvist, N | 2 |
| STANDER, RW | 1 |
| BARDEN, TP | 1 |
| THOMPSON, JF | 1 |
| PUGH, WR | 1 |
| WERTS, CE | 1 |
| CAMPBELL, C | 1 |
| ESKES, AB | 1 |
| RIKSSON, G | 1 |
| MURPHY, HS | 1 |
| Viswanathan, CL | 2 |
| Kodgule, MM | 1 |
| Chaudhari, AS | 2 |
| Cheynier, JM | 1 |
| Boutin, P | 1 |
| Whitworth, M | 1 |
| Quenby, S | 1 |
| Niebyl, JR | 1 |
| Johnson, JW | 1 |
| Alsat, E | 1 |
| Hauguel, S | 1 |
| Cedard, L | 1 |
| Schenken, RS | 1 |
| Hayashi, RH | 1 |
| Valenzuela, GV | 1 |
| Castillo, MS | 1 |
| Lewis, PJ | 1 |
| de Swiet, M | 1 |
| Boylan, P | 1 |
| Bulpitt, CJ | 1 |
| Jouppila, R | 2 |
| Kauppila, A | 5 |
| Tuimala, R | 5 |
| Pakarinen, A | 2 |
| Moilanen, K | 2 |
| Bremme, K | 2 |
| Eneroth, P | 2 |
| Brotanek, V | 1 |
| Brotanek, J | 1 |
| Guernsey, BG | 1 |
| Villarreal, Y | 1 |
| Snyder, MD | 1 |
| Gabert, HA | 1 |
| Martin, AJ | 1 |
| Karlsson, K | 1 |
| Suonio, S | 1 |
| Korenbrot, CC | 1 |
| Aalto, LH | 1 |
| Laros, RK | 2 |
| Calixto, JB | 1 |
| Simas, CM | 1 |
| Ikeda, S | 3 |
| Tamaoki, H | 2 |
| Hagenfeld, L | 1 |
| Hellgren, M | 1 |
| Akahane, M | 2 |
| Nebashi, Y | 2 |
| Cova, D | 1 |
| Colombo, R | 1 |
| Cellini, G | 1 |
| Pasargiklian, R | 1 |
| Monti, G | 1 |
| Bertulessi, C | 1 |
| Herczeg, J | 3 |
| Kovács, L | 2 |
| Keserü, T | 1 |
| Evron, S | 3 |
| Samueloff, A | 3 |
| Mor-Yosef, S | 1 |
| Rosen, E | 1 |
| Sadovsky, E | 3 |
| Curet, LB | 2 |
| Rao, AV | 1 |
| Zachman, RD | 2 |
| Morrison, JC | 1 |
| Burkett, G | 1 |
| Poole, WK | 1 |
| Bauer, C | 1 |
| Nimrod, C | 1 |
| Rambihar, V | 2 |
| Fallen, E | 1 |
| Effer, S | 1 |
| Cairns, J | 1 |
| Nimrod, CA | 1 |
| Beresford, P | 1 |
| Frais, M | 1 |
| Belenkie, I | 1 |
| Tyberg, J | 1 |
| Fremit, A | 1 |
| Smith, E | 1 |
| Ogburn, PL | 1 |
| Williams, PP | 1 |
| Johnson, SB | 1 |
| Holman, RT | 1 |
| Brazy, JE | 4 |
| Eckerman, CO | 1 |
| Gross, SJ | 1 |
| Semchyshyn, S | 2 |
| Zuspan, FP | 4 |
| O'Shaughnessy, R | 2 |
| Finke, C | 1 |
| Ogata, ES | 1 |
| Koroly, MV | 1 |
| Herron, MA | 1 |
| Katz, M | 2 |
| Creasy, RK | 3 |
| Coggiola, F | 1 |
| Scarrone, G | 1 |
| Cabiati, EG | 1 |
| Nagey, DA | 1 |
| Crenshaw, MC | 1 |
| Barrett, JM | 1 |
| Boehm, FH | 1 |
| Thomas, K | 1 |
| Vankrieken, L | 1 |
| Van Lierde, M | 1 |
| Monti, V | 1 |
| Tulli, AF | 1 |
| Carrera, F | 1 |
| Tamura, T | 1 |
| Yoshimura, K | 1 |
| Little, V | 2 |
| Grimm, J | 2 |
| Robertson, PA | 1 |
| Herron, M | 1 |
| Lefcourt, AM | 1 |
| Tabsh, K | 1 |
| Nuwayhid, B | 1 |
| Erkkola, R | 2 |
| Lieb, S | 1 |
| Ushioda, E | 1 |
| Brinkman, CR | 2 |
| Assali, NS | 2 |
| Pupkin, M | 1 |
| Horváth, G | 1 |
| Bacsfay, N | 1 |
| Nuwayhid, BS | 1 |
| Cabalum, MT | 1 |
| Lieb, SM | 1 |
| Tabsh, KM | 1 |
| Frank, L | 1 |
| Summerville, J | 1 |
| Massaro, D | 1 |
| Iams, JD | 1 |
| Moynihan, V | 1 |
| Garfield, RE | 1 |
| Merrett, D | 1 |
| Grover, AK | 1 |
| Henderson, PA | 1 |
| Olson, RW | 1 |
| Schwartz, DB | 1 |
| Ayromlooi, J | 1 |
| Tobias, M | 1 |
| Desiderio, D | 1 |
| Plieth, M | 1 |
| Ache-Ebelt, H | 1 |
| Fitzner, R | 1 |
| Bein, G | 1 |
| Karkut, G | 1 |
| Pieterse, MC | 1 |
| Kisoka, R | 1 |
| Roy, UK | 1 |
| Pan, S | 1 |
| Feline, A | 1 |
| Quetin, AM | 1 |
| Koh, KS | 1 |
| Lammintausta, R | 1 |
| Katainen, P | 1 |
| Daubert, JC | 1 |
| Gosse, P | 1 |
| Rio, M | 1 |
| Grall, JY | 1 |
| Bourdonnec, C | 1 |
| Pony, JC | 1 |
| Gouffault, J | 1 |
| Caritis, SN | 1 |
| Edelstone, DI | 1 |
| Mueller-Heubach, E | 1 |
| Nair, GV | 1 |
| Ghosh, AK | 1 |
| Lewis, BV | 1 |
| Horowitz, JJ | 1 |
| Taeusch, W | 1 |
| Wyszogrodski, I | 2 |
| Bator, A | 1 |
| Robert, M | 1 |
| Carson, S | 1 |
| Avery, ME | 2 |
| Hayden, W | 1 |
| Olson, EB | 1 |
| Ylikorkala, O | 2 |
| Haapalahti, J | 2 |
| Karppanen, H | 2 |
| Viinikka, L | 2 |
| Johnson, WL | 1 |
| Harbert, GM | 1 |
| Martin, CB | 1 |
| Fanaroff, AA | 1 |
| Merkatz, IR | 1 |
| Merkus, JM | 1 |
| Roozen, PH | 1 |
| Verhoeven, AG | 1 |
| Kock, HC | 1 |
| Pupkin, MJ | 1 |
| Ehrenkranz, RA | 1 |
| Hamilton, LA | 1 |
| Brennan, SC | 1 |
| Oakes, GK | 1 |
| Walker, AM | 1 |
| Chez, RA | 1 |
| Schulman, H | 1 |
| Farine, K | 1 |
| Yannotti, S | 1 |
| Ginestet, D | 1 |
| Enhorning, G | 2 |
| Chamberlain, D | 2 |
| Contreras, C | 2 |
| Burgoyne, R | 2 |
| Robertson, B | 2 |
| Corbet, AJ | 1 |
| Flax, P | 1 |
| Rudolph, AJ | 1 |
| Hadjigeorgiou, E | 1 |
| Kitsiou, S | 1 |
| Psaroudakis, A | 1 |
| Segos, C | 1 |
| Nicolopoulos, D | 1 |
| Kaskarelis, D | 1 |
| Luotola, H | 1 |
| Grönman, P | 1 |
| Pitkänen, M | 1 |
| Toivanen, J | 1 |
| Pyörälä, T | 1 |
| Fuller, WE | 1 |
| Kuikka, J | 1 |
| Falkay, G | 1 |
| Pitkin, RM | 1 |
| Vandeplassche, M | 1 |
| Coryn, M | 1 |
| Spincemaille, J | 1 |
| Bouters, R | 1 |
| Bonte, P | 1 |
| Sybulski, S | 2 |
| Csapo, AI | 1 |
| Van Iddekinge, B | 1 |
| Hughes, EA | 1 |
| Caspi, E | 1 |
| Schreyer, P | 1 |
| Weinraub, Z | 1 |
| Reif, R | 1 |
| Levi, I | 1 |
| Mundel, G | 1 |
| Chung, HJ | 1 |
| Castrén, O | 3 |
| Gummerus, M | 2 |
| Saarikoski, S | 3 |
| Tomassini, A | 1 |
| Razzini, M | 1 |
| Zocchi, G | 1 |
| Caprioli, E | 1 |
| Doyle, LL | 1 |
| Peeters, G | 1 |
| Bruycker, RD | 1 |
| Polito, PM | 1 |
| De Palma, V | 1 |
| De Curtis, A | 1 |
| Maughan, GB | 1 |
| Mitsui, Y | 1 |
| Gemelli, M | 1 |
| De Luca, F | 1 |
| Manganaro, R | 1 |
| Leonardi, R | 1 |
| Rando, F | 1 |
| Agnetti, A | 1 |
| Mami, C | 1 |
| Di Pasquale, G | 1 |
| Kitterman, JA | 1 |
| Heilbron, DC | 1 |
| Cowan, RM | 1 |
| Tooley, WH | 1 |
| Matsuura, S | 1 |
| Hidaka, A | 2 |
| Komatani, M | 2 |
| Suzuki, Y | 1 |
| Sakamoto, H | 1 |
| Ikeda, H | 2 |
| Okada, K | 2 |
| Sugawa, T | 2 |
| Rasmusson, MG | 1 |
| Scott, JE | 1 |
| Oulton, MR | 1 |
| Matsuda, Y | 2 |
| Ikenoue, T | 2 |
| Kamitomo, M | 1 |
| Matsumoto, T | 1 |
| Hokanishi, H | 2 |
| Nakatsuka, T | 1 |
| Nagai, K | 1 |
| Tanaka, T | 1 |
| Tsuruta, K | 1 |
| Mori, N | 1 |
| Alba, E | 1 |
| Proserpio, D | 1 |
| Kitanaka, T | 1 |
| Miodovnik, M | 1 |
| Peros, N | 1 |
| Holroyde, JC | 1 |
| Siddiqi, TA | 1 |
| Sholl, JS | 1 |
| Hughey, MJ | 1 |
| Hirschmann, RA | 1 |
| Garzetti, GG | 1 |
| Rosati, P | 1 |
| Scambia, G | 1 |
| Guariglia, L | 1 |
| Iacobelli, S | 1 |
| Bellati, U | 1 |
| Moneta, E | 1 |
| Forcucci-Zulli, M | 1 |
| Moggian, G | 1 |
| Pini, PL | 1 |
| Fallen, EL | 1 |
| Tomich, PG | 1 |
| Kero, P | 2 |
| Hirvonen, T | 1 |
| Välimäki, I | 1 |
| Szönyi, G | 1 |
| Adám, J | 1 |
| Csáki, G | 1 |
| Ba, J | 1 |
| Landesman, R | 1 |
| Fuchs, F | 1 |
| Raij, K | 1 |
| Härkönen, M | 1 |
| Adlercreutz, H | 1 |
| Taeusch, HW | 1 |
| Singh, S | 1 |
| Singh, G | 1 |
| Gibbs, CE | 1 |
| Reynolds, JW | 1 |
| Soiva, K | 1 |
| Signorelli, I | 1 |
| Rella, R | 1 |
| Teubner, W | 1 |
| Gallier, J | 1 |
| Berger, C | 1 |
| Liska, G | 1 |
| Soutoul, JH | 1 |
| Di Grigoli, D | 1 |
| Candela, G | 1 |
| Jungmannová, C | 2 |
| Hodr, J | 2 |
| Zidovský, J | 2 |
| Boyd, IE | 1 |
| Chamberlain, GV | 1 |
| Fergusson, IL | 1 |
| Scillieri, P | 1 |
| Grossi, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients: a Double-blind Randomized Controlled Trial[NCT03348683] | Phase 2 | 240 participants (Actual) | Interventional | 2017-12-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time of latent labor defined as <6cm of cervical dilation. (NCT03348683)
Timeframe: average of 24 hours
| Intervention | hours (Mean) |
|---|---|
| Propranolol | 11.0 |
| Placebo | 11.2 |
Count of fetus with fetal bradycardia (<110bpm for >10 minutes within 30 minutes of study drug administration) (NCT03348683)
Timeframe: 30 minutes from drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 1 |
| Placebo | 0 |
Count of fetus with fetal heart rate decelerations within 30 minutes of study drug administration (NCT03348683)
Timeframe: 30 minutes from drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 15 |
| Placebo | 13 |
"Neonatal outcome - Number of neonates with hypoglycemia (blood glucose <50).~This population includes only the neonates who had heelsticks to check their blood glucose, which is not a universal practice and was not required by the protocol or IRB. The neonates included were those who met the nursery's risk-based protocol to check blood glucose after birth (ex: infants of diabetic mothers, fetal growth restriction, macrosomia, or symptoms suggestive of hypoglycemia)" (NCT03348683)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 11 |
| Placebo | 8 |
"Composite neonatal outcome score was for any of the following morbidity: Neonatal Intensive Care Unit (NICU) admission, respiratory support (CPAP, nasal cannula, intubation), culture proven sepsis, radiographically proven intracranial hemorrhage, necrotizing enterocolitis, hypoglycemia (for those infants who had sugar checked), and neonatal death.~The composite score was computed as a score of 1 for any indication of neonatal morbidity - neonates who experienced at least one morbidity and the components are given equal weights. Patients who had no evidence of the predefined neonatal morbidities are subsequently given a score of 0. The minimum is 0 and maximum is 1." (NCT03348683)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 21 |
| Placebo | 28 |
"Composite maternal morbidity score consists of a count of postpartum hemorrhage, transfusion, hysterectomy, placental abruption, chorioamnionitis, shoulder dystocia, episiotomy, higher order laceration, and ICU admission.~The composite score was computed as a score of 1 for any indication of maternal morbidity, that is the participant experienced at least one maternal morbidity, and the components are given equal weights. Participants who had no evidence of the predefined maternal morbidities are subsequently given a score of 0. The minimum is 0 and maximum is 1." (NCT03348683)
Timeframe: average of 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 35 |
| Placebo | 49 |
Greater than 500cc of blood expelled during a vaginal delivery or greater than 1000cc of blood expelled during a cesarean section (NCT03348683)
Timeframe: 30 minutes from drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 15 |
| Placebo | 26 |
The time of induction (based on time of foley balloon placement for cervical ripening or misoprostol administration) to the time of delivery of the infant. (NCT03348683)
Timeframe: average of 24 hours
| Intervention | hours (Mean) |
|---|---|
| Propranolol | 13.8 |
| Placebo | 14.3 |
Number of various mode of delivery - count of Vaginal delivery, vacuum assisted vaginal delivery, forceps assisted vaginal delivery, cesarean section (NCT03348683)
Timeframe: average of 24 hours
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Spontaneous vaginal delivery | Vacuum assisted vaginal delivery | Forceps assisted vaginal delivery | Cesarean section | |
| Placebo | 61 | 10 | 8 | 40 |
| Propranolol | 64 | 3 | 8 | 46 |
12 reviews available for isoxsuprine and Pregnancy
| Article | Year |
|---|---|
Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Albuterol; Female; Fenoterol; Fetal Membranes | 2015 |
Use of isoxsuprine hydrochloride as a tocolytic agent in the treatment of preterm labour: a systematic review of previous literature.
Topics: Abortion, Spontaneous; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Isoxsuprine; O | 2010 |
Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects.
Topics: Adrenergic beta-Agonists; Cost-Benefit Analysis; Female; Humans; Isoxsuprine; Italy; Obstetric Labor | 2011 |
Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Albuterol; Female; Fenoterol; Gestational Age | 2012 |
Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies.
Topics: Administration, Oral; Adrenergic beta-Agonists; Female; Humans; Isoxsuprine; Obstetric Labor, Premat | 2008 |
Inhibition of preterm labor.
Topics: Adrenergic beta-Agonists; Bed Rest; Cervix Uteri; Diazoxide; Ethanol; Female; Gestational Age; Human | 1980 |
Severe unwanted effects associated with betasympathomimetics when used in the treatment of premature labour: causes, incidence and preventative measures.
Topics: Adrenergic beta-Agonists; Albuterol; Female; Fenoterol; Humans; Isoxsuprine; Obstetric Labor, Premat | 1981 |
Premature labour.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Amnion; Anti-Bacterial Agents; Bacteri | 1976 |
Pharmacologic inhibition of preterm labor.
Topics: Adrenergic beta-Agonists; Diazoxide; Ethanol; Female; Humans; Infant, Newborn; Isoxsuprine; Magnesiu | 1979 |
Modern obstetrical management of the low birth weight infant.
Topics: Breech Presentation; Cesarean Section; Delivery, Obstetric; Ethanol; Female; Fetal Heart; Fetal Memb | 1977 |
Control of uterine activity and prevention of premature birth.
Topics: Adrenergic beta-Antagonists; Aspirin; Blood Pressure; Diazoxide; Epinephrine; Ethanol; Female; Fetal | 1974 |
The use of drugs in influencing human fetal metabolism.
Topics: Adrenocortical Hyperfunction; Animals; Blood Transfusion, Intrauterine; Congenital Hypothyroidism; E | 1974 |
5 trials available for isoxsuprine and Pregnancy
| Article | Year |
|---|---|
[Clenbuterol in the treatment of premature labor].
Topics: Adult; Clenbuterol; Drug Evaluation; Ethanolamines; Female; Humans; Isoxsuprine; Obstetric Labor, Pr | 1983 |
Surfactant in the amniotic fluid and bromhexine metabolite VIII.
Topics: Ambroxol; Amniotic Fluid; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Gestati | 1978 |
Treatment of imminent premature labour.
Topics: Birth Weight; Clinical Trials as Topic; Ethanol; Female; Follow-Up Studies; Gestational Age; Humans; | 1975 |
[Interpretative analysis of 50 cases of tocolysis treated with isoxsuprine].
Topics: Abortion, Threatened; Clinical Trials as Topic; Female; Humans; Isoxsuprine; Obstetric Labor, Premat | 1975 |
Arresting premature labour: orciprenaline and other drugs.
Topics: Clinical Trials as Topic; Female; Humans; Infusions, Parenteral; Isoxsuprine; Labor, Obstetric; Meta | 1973 |
142 other studies available for isoxsuprine and Pregnancy
| Article | Year |
|---|---|
Effects of tocolytic drugs (isoxsuprine hydrochloride) during the implantation period in pregnant sheep.
Topics: Animals; Calcium; Female; Hydrocortisone; Isoxsuprine; Pregnancy; Progesterone; Sheep; Tocolytic Age | 2022 |
Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study.
Topics: Adult; Female; Gestational Age; Humans; India; Infant, Newborn; Injections, Intramuscular; Isoxsupri | 2021 |
Effect of xylazine, isoxsuprine, and lidocaine on Doppler sonographic uterine and umbilical blood flow measurements in cows during the last month of pregnancy.
Topics: Adrenergic beta-Agonists; Anesthetics, Local; Animals; Blood Flow Velocity; Cattle; Female; Hypnotic | 2014 |
Fetal ductus arteriosus constriction and closure: analysis of the causes and perinatal outcome related to 45 consecutive cases.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Caffeine; Central N | 2016 |
Doppler sonographic examination of uterine and placental perfusion in cows in the last month of gestation and effects of epidural anesthesia and isoxsuprine.
Topics: Anesthesia, Epidural; Animals; Blood Flow Velocity; Cattle; Female; Gestational Age; Isoxsuprine; Pl | 2016 |
Veterinary treatment of cows with isoxsuprine for a caesarian section may temporarily lead to residues in hair of both cow and calf.
Topics: Animals; Animals, Newborn; Cattle; Cesarean Section; Female; Hair; Isoxsuprine; Male; Pregnancy; Tim | 2012 |
The effect of isoxsuprine hydrochloride upon the contractility of the human uterus in labor.
Topics: Female; Humans; Isoxsuprine; Labor, Obstetric; Muscle Contraction; Muscle Relaxants, Central; Phenet | 1961 |
[The use of isoxsuprine hydrochloride in the therapy of threatened abortion].
Topics: Abortion, Induced; Abortion, Spontaneous; Abortion, Threatened; Female; Humans; Isoxsuprine; Muscle | 1962 |
The pharmacologic control of excessive uterine activity with isoxsuprine.
Topics: Abortion, Induced; Abortion, Spontaneous; Female; Humans; Isoxsuprine; Phenethylamines; Pregnancy; U | 1961 |
ISOXSUPRINE AND THE HUMAN PARTURIENT UTERUS. A CLINICAL AND TOKOGRAPHIC STUDY.
Topics: Abortion, Induced; Blood Pressure; Female; Fetal Heart; Heart Rate; Humans; Isoxsuprine; Labor Prese | 1963 |
THE EFFECT OF ISOXSUPRINE ON THE PREGNANT HUMAN UTERUS.
Topics: Abortion, Induced; Abortion, Legal; Abortion, Spontaneous; Female; Humans; Hypertonic Solutions; Iso | 1964 |
PROGESTERONE OR ISOXSUPRINE IN PREMATURE LABOUR.
Topics: Cardiovascular Agents; Female; Humans; Isoxsuprine; Muscle Relaxants, Central; Obstetric Labor Compl | 1964 |
FETAL CARDIAC EFFECTS OF MATERNAL ISOXSUPRINE INFUSION.
Topics: Blood Pressure; Computers; Electrocardiography; Electronic Data Processing; Female; Fetal Heart; Hum | 1964 |
OBSTETRICAL COMPLICATIONS FOLLOWING INTRAVENOUS ISOXSUPRINE IN THE ACTIVE PHASE OF LABOR.
Topics: Drug Therapy; Female; Humans; Isoxsuprine; Labor, Obstetric; Muscle Relaxants, Central; Obstetric La | 1965 |
[COMPARISON OF THE EFFICACY OF PROGESTERONE AND DUVADILAN AS UTERINE RELAXANTS].
Topics: Cardiovascular Agents; Female; Humans; Isoxsuprine; Labor, Obstetric; Muscle Relaxants, Central; Obs | 1964 |
ACTION OF ISOXSUPRINE AND ITS (+) ISOMER ON THE PREGNANT HUMAN UTERUS; AN EXPERIMENTAL STUDY.
Topics: Abortion, Induced; Abortion, Spontaneous; Abortion, Therapeutic; Angiotensins; Blood Pressure; Femal | 1965 |
Management of leg cramps in pregnancy with isoxsuprine hydrochloride.
Topics: Disease Management; Female; Humans; Isoxsuprine; Leg; Muscle Cramp; Phenethylamines; Pregnancy; Preg | 1962 |
Design, synthesis and evaluation of racemic 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl]amino-1-propanol hydrochlorides as novel uterine relaxants.
Topics: 1-Propanol; Animals; Cardiotonic Agents; Cyclic AMP; Drug Design; Female; Isoxsuprine; Muscle Relaxa | 2005 |
Synthesis and evaluation of uterine relaxant activity for a novel series of substituted p-hydroxyphenylethanolamines.
Topics: Animals; Cardiotonic Agents; Chromatography, Thin Layer; Cyclic AMP; Dogs; Dose-Response Relationshi | 2006 |
[Present means to prevent premature birth].
Topics: Adrenergic beta-Agonists; Anti-Infective Agents; Bed Rest; Cerclage, Cervical; Female; Humans; Infan | 1973 |
The effect of isoproterenol and beta-sympathomimetic drugs on human placental glycogen metabolism.
Topics: Adrenergic beta-Agonists; Albuterol; Enzyme Induction; Female; Glycogen; Glycogen Synthase; Humans; | 1980 |
Treatment of premature labor with beta sympathomimetics: results with isoxsuprine.
Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Female; Gestational Age; Heart Rate; Humans; Infant | 1980 |
How obstetricians in the United Kingdom manage preterm labour.
Topics: Adrenergic beta-Agonists; Albuterol; Ampicillin; Anti-Bacterial Agents; Female; Glucocorticoids; Hum | 1980 |
Maternal, fetal and neonatal effects of beta-adrenergic stimulation in connection with cesarean section.
Topics: Acid-Base Equilibrium; Adolescent; Adrenergic beta-Agonists; Adult; Blood Glucose; Blood Pressure; C | 1980 |
Serum estriol levels during beta-receptor agonist infusion in the third trimester of pregnancy.
Topics: Adrenergic beta-Agonists; Estriol; Female; Humans; Infusions, Parenteral; Isoxsuprine; Obstetric Lab | 1981 |
Assessment of uteroplacental perfusion in preeclampsia using beta-adrenergic drugs.
Topics: Adrenergic beta-Agonists; Female; Humans; Isoxsuprine; Pre-Eclampsia; Pregnancy; Propanolamines; Reg | 1981 |
Maternal, fetal and aminiotic fluid ACTH, cortisol and prolactin in association with medical beta-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Adrenocorticotropic Hormone; Amniotic Fluid; Female; Fenoterol; Fetal Bloo | 1981 |
Pulmonary edema associated with the use of betamimetic agents in preterm labor.
Topics: Adrenergic beta-Agonists; Adult; Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy; | 1981 |
Beta-receptor agonists in pregnancy: long term effects in preterm children.
Topics: Adrenergic beta-Agonists; Female; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Isox | 1982 |
Maternal placental blood flow in hypertensive pregnancy and the effect of beta-mimetic drugs on it.
Topics: Adrenergic beta-Agonists; Bed Rest; Birth Weight; Female; Humans; Hypertension; Isoxsuprine; Organ S | 1982 |
The cost effectiveness of stopping preterm labor with beta-adrenergic treatment.
Topics: Adrenergic beta-Agonists; Ambulatory Care; California; Cost-Benefit Analysis; Fees, Medical; Female; | 1984 |
Mechanism of action of isoprenaline, isoxuprine, terbutaline and orciprenaline on gravid human isolated myometrium. Influence of the neuronal uptake process.
Topics: Adrenergic beta-Agonists; Adult; Cocaine; Depression, Chemical; Dose-Response Relationship, Drug; Fe | 1984 |
Pharmacological investigation of ritodrine hydrochloride, a beta 2-adrenoceptor stimulant.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Carbachol; Cyclic AMP; Female; Guinea Pigs; Heart Rate; | 1984 |
Changes in maternal serum aldosterone, potassium and prolactin levels during beta-receptor agonist treatment in third trimester pregnancies.
Topics: Adult; Aldosterone; Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Potassium; Pregnancy; P | 1982 |
Effects of ritodrine hydrochloride, a beta 2-adrenoceptor stimulant, on uterine motilities in late pregnancy.
Topics: Anesthesia; Animals; Blood Pressure; Female; Heart Rate; Isoproterenol; Isoxsuprine; Oxytocin; Pregn | 1984 |
Determination of isoxsuprine in human plasma by gas chromatography with electron capture detection.
Topics: Chromatography, Gas; Electrons; Female; Fetal Blood; Humans; Infant, Newborn; Isoxsuprine; Mass Spec | 1983 |
Premature labor and coincident acute appendicitis not resolved by betamimetic but surgical treatment.
Topics: Adult; Appendicitis; Female; Humans; Infant, Newborn; Isoxsuprine; Obstetric Labor, Premature; Pregn | 1983 |
[Effects of a beta 2-stimulant, ritodrine hydrochloride, on the fetuses and dams in the late stage of pregnancy: an experimental study using rabbits].
Topics: Animals; Blood Pressure; Female; Fetal Heart; Fetus; Heart Rate; Isoproterenol; Isoxsuprine; Placent | 1983 |
Pulmonary edema occurring after isoxsuprine and dexamethasone treatment for preterm labor: Case report.
Topics: Adult; Dexamethasone; Drug Therapy, Combination; Female; Hemodynamics; Humans; Isoxsuprine; Obstetri | 1983 |
[Pulmonary edema occurring after isoxsuprine treatment for preterm labor].
Topics: Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy; Pulmonary Edema | 1983 |
Association between ruptured membranes, tocolytic therapy, and respiratory distress syndrome.
Topics: Amniotic Fluid; Female; Fetal Membranes, Premature Rupture; Humans; Infant, Newborn; Isoxsuprine; Ob | 1984 |
Fetal movements in isoxsuprine-treated patients.
Topics: Female; Fetus; Humans; Isoxsuprine; Movement; Obstetric Labor, Premature; Pregnancy; Uterine Contrac | 1984 |
Pulmonary edema associated with isoxsuprine therapy.
Topics: Adult; Female; Fluid Therapy; Humans; Infusions, Parenteral; Isoxsuprine; Obstetric Labor, Premature | 1984 |
Hemodynamic observations on pulmonary edema associated with a beta-mimetic agent. A report of two cases.
Topics: Adult; Betamethasone; Drug Therapy, Combination; Female; Fetal Organ Maturity; Hemodynamics; Humans; | 1984 |
Serum free fatty acid and arachidonic acid response to successful inhibition of premature labor with isoxsuprine.
Topics: Arachidonic Acid; Arachidonic Acids; Fatty Acids, Nonesterified; Female; Humans; Isoxsuprine; Obstet | 1981 |
Follow-up of infants of less than 1500 gm birth weight with antenatal isoxsuprine exposure.
Topics: Adult; Black People; Child Development; Female; Fetal Blood; Follow-Up Studies; Gestational Age; Hum | 1983 |
Pulmonary edema associated with the use of hydrocortisone and a tocolytic agent for the management of premature labor.
Topics: Adolescent; Adult; Female; Humans; Hydrocortisone; Isoxsuprine; Magnesium Sulfate; Obstetric Labor, | 1983 |
[Suspected mineralization disorders in the deciduous dentition after Duvadilan use during pregnancy (case reports)].
Topics: Child, Preschool; Female; Humans; Isoxsuprine; Pregnancy; Prenatal Exposure Delayed Effects; Tooth C | 1982 |
Isoxsuprine infusion in the rat: alterations in maternal, fetal and neonatal glucose homeostasis.
Topics: Animals; Animals, Newborn; Blood Glucose; Female; Fetus; Homeostasis; Insulin; Isoxsuprine; Liver Gl | 1981 |
Isoxsuprine as a tocolytic agent: use in a community hospital.
Topics: Adolescent; Adult; Female; Hospitals, Community; Humans; Isoxsuprine; New Jersey; Obstetric Labor, P | 1982 |
Evaluation of a preterm birth prevention program: preliminary report.
Topics: Female; Gestational Age; Humans; Isoxsuprine; Obstetric Labor, Premature; Patient Education as Topic | 1982 |
[3 cases of acute pulmonary edema in pregnant women treated with tocolytics and betamethasone].
Topics: Abortion, Threatened; Adult; Betamethasone; Female; Humans; Isoxsuprine; Metaproterenol; Pregnancy; | 1982 |
Pulmonary complications of isoxsuprine therapy in the gravida.
Topics: Adolescent; Adult; Blood Pressure; Female; Heart Rate; Humans; Isoxsuprine; Obstetric Labor, Prematu | 1982 |
Comparison of aggressive and conservative management of premature rupture of fetal membranes.
Topics: Adolescent; Adult; Betamethasone; Birth Weight; Female; Fetal Membranes, Premature Rupture; Gestatio | 1982 |
Characterization of ritodrine radioimmunoassay. Standard curves, cross-reactions and serum levels in women.
Topics: Adolescent; Adult; Albuterol; Cross Reactions; Female; Fenoterol; Humans; Isoxsuprine; Obstetric Lab | 1982 |
[Fetal motor activity after "accidental ingestion" of beta-mimetics in the early stages of pregnancy].
Topics: Adult; Female; Fetal Diseases; Fetus; Humans; Isoxsuprine; Pregnancy; Pregnancy Complications; Risk; | 1982 |
[Premature labor and its management--palliative treatment].
Topics: Adult; Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy; Terbutaline | 1982 |
Isoxsuprine in the perinatal period. II. Relationships between neonatal symptoms, drug exposure, and drug concentration at the time of birth.
Topics: Administration, Oral; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Infusions, Pa | 1981 |
Maternal morbidity associated with isoxsuprine and terbutaline tocolysis.
Topics: Adult; Cardiovascular Diseases; Female; Fetus; Humans; Isoxsuprine; Obstetric Labor, Premature; Preg | 1981 |
Rhythmic contractions of the teat sphincter in bovines: an expulsion mechanism.
Topics: Animals; Cattle; Epinephrine; Female; Isoxsuprine; Lactation; Mammary Glands, Animal; Milk Ejection; | 1982 |
Hemodynamic responses of the pelvic vascular bed to vasoactive stimuli in pregnant sheep.
Topics: Angiotensin II; Animals; Catecholamines; Female; Hemodynamics; Isoxsuprine; Models, Biological; Nitr | 1981 |
Risk:benefit considerations for the use of isoxsuprine in the treatment of premature labor.
Topics: Female; Fetal Blood; Fetal Membranes, Premature Rupture; Humans; Isoxsuprine; Maternal-Fetal Exchang | 1981 |
Experiences with the use of a uterine muscle relaxant preparation (Hanegif inj, ad us. vet.)..
Topics: Animals; Cattle; Cattle Diseases; Cesarean Section; Dystocia; Female; Injections, Intramuscular; Iso | 1981 |
Hemodynamic effects of isoxsuprine and terbutaline in pregnant and nonpregnant sheep.
Topics: Animals; Blood Pressure; Cardiac Output; Female; Heart Rate; Hemodynamics; Iliac Artery; Isoxsuprine | 1980 |
Effect of prenatal isoxsuprine on pulmonary oxygen toxicity in the newborn rat.
Topics: Animals; Animals, Newborn; Body Weight; DNA; Dose-Response Relationship, Drug; Environment, Controll | 1980 |
Blood pressure response in hypertensive pregnancies treated with cortisol.
Topics: Adolescent; Adult; Blood Pressure; Drug Therapy, Combination; Ethanol; Female; Humans; Hydralazine; | 1980 |
Gap junction formation and regulation in myometrium.
Topics: Animals; Culture Techniques; Cycloheximide; Female; Intercellular Junctions; Isoxsuprine; Myometrium | 1980 |
The treatment of premature labor with isoxsuprine.
Topics: Female; Humans; Injections, Intravenous; Isoxsuprine; Obstetric Labor, Premature; Pregnancy | 1980 |
Effects of isoxsuprine on maternal and fetal acid-base balance and circulation.
Topics: Acid-Base Equilibrium; Animals; Blood Circulation; Female; Fetal Heart; Heart Rate; Hemoglobins; Iso | 1981 |
[Examination of cardiac function following long-term tocolysis with fenoterol and isoxsuprine in newborn (author's transl)].
Topics: Cardiomyopathies; Clinical Enzyme Tests; Creatine Kinase; Echocardiography; Electrocardiography; Eth | 1980 |
[Uterus relaxants in the cow].
Topics: Animals; Cattle; Clenbuterol; Delivery, Obstetric; Female; Isoxsuprine; Pregnancy; Uterine Contracti | 1995 |
[Separate birth 30 days after a premature delivery in a twin pregnancy. A case report].
Topics: Adult; Female; Fetal Monitoring; Gestational Age; Humans; Infant, Newborn; Isoxsuprine; Male; Obstet | 1994 |
Use of calcium antagonist (nifedipine) in premature labour.
Topics: Adult; Female; Humans; Isoxsuprine; Nifedipine; Obstetric Labor, Premature; Pregnancy; Tocolysis; Ut | 1993 |
[Letter: An undesirable effect of beta-stimulating agents? Outbreak of an acute psychiatric symptomatology in mental patients].
Topics: Acute Disease; Adrenergic beta-Agonists; Adult; Albuterol; Depression; Female; Hallucinations; Human | 1975 |
Effect of intravenous infusion of betasympathomimetic agents on plasma renin activity during pregnancy.
Topics: Adrenergic beta-Agonists; Female; Glucose; Humans; Isoxsuprine; Pregnancy; Pregnancy Trimester, Thir | 1978 |
[Myocardiopathies during pregnancy. Possible role of beta-mimetics].
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Cardiomyopathies; Female; Hemodynamics; Humans; Isoxsupr | 1978 |
Letter: Bowel distension during treatment of premature labour with beta-receptor agonists.
Topics: Adult; Female; Flatulence; Humans; Isoxsuprine; Metaproterenol; Obstetric Labor, Premature; Pregnanc | 1976 |
Allergic dermatitis associated with administration of isoxsuprine during premature labor.
Topics: Adult; Drug Eruptions; Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy | 1978 |
Pharmacologic regulation of alveolar surfactant in fetal and newborn rabbits: ACTH, heroin, isoxsuprine, and glucocorticoid.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Female; Fetus; Glucocorticoids; Heroin; Isox | 1975 |
Effect of maternal isoxsuprine on fetal rabbit lung biochemical maturation.
Topics: Animals; Diacylglycerol Cholinephosphotransferase; Female; Isoxsuprine; Lung; Maternal-Fetal Exchang | 1977 |
Effects of intravenous isoxsuprine and ritodrine, with and without concomitant dexamethasone, on fetoplacental and pituitary hormones and cyclic adenosine monophosphate during late pregnancy.
Topics: Adult; Cyclic AMP; Dexamethasone; Estradiol; Estriol; Female; Follicle Stimulating Hormone; Growth H | 1978 |
Effects of ritodrine and isoxsuprine with and without dexamethasone during late pregnancy.
Topics: Adolescent; Adult; Blood Glucose; Cyclic AMP; Dexamethasone; Female; Humans; Insulin; Iron; Isoxsupr | 1978 |
Pharmacologic control of uterine contractility. In vitro human and in vivo monkey studies.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Fenoprofen; Fetu | 1975 |
Effects of maternal isoxsuprine administration on preterm infants.
Topics: Adult; Female; Fetus; Humans; Hypocalcemia; Hypoglycemia; Hypotension; Infant, Newborn; Infant, Prem | 1979 |
Effects of salbutamol and isoxsuprine on uterine and umbilical blood flow in pregnant sheep.
Topics: Albuterol; Animals; Dose-Response Relationship, Drug; Female; Fenoterol; Fetal Blood; Isoxsuprine; M | 1977 |
The comparative actions of uterine inhibiting drugs.
Topics: Animals; Depression, Chemical; Electric Stimulation; Female; Humans; Isoproterenol; Isoxsuprine; Myo | 1978 |
[Preliminary report on the neuropsychological study of women treated by beta-mimetic drugs in a gynecological clinic].
Topics: Abortion, Threatened; Adult; Albuterol; Basal Ganglia Diseases; Female; Humans; Isoxsuprine; Pregnan | 1977 |
Isoxsuprine-induced release of pulmonary surfactant in the rabbit fetus.
Topics: Amniotic Fluid; Animals; Body Weight; Epithelium; Female; Fetus; Isoxsuprine; Organ Size; Phosphatid | 1977 |
Role of autonomic nervous system controlling surface tension in fetal rabbit lungs.
Topics: Animals; Autonomic Nervous System; Female; Isoxsuprine; Lung; Muscarine; Phenylephrine; Pilocarpine; | 1977 |
Isoxsuprine infusion to the pregnant rabbit and its effect on fetal lung surfactant.
Topics: Animals; Body Fluids; Female; Heart Rate; Infusions, Parenteral; Isoxsuprine; Lung; Maternal-Fetal E | 1979 |
Antepartum aminophylline treatment for prevention of the respiratory distress syndrome in premature infants.
Topics: Aminophylline; Delivery, Obstetric; Extraembryonic Membranes; Female; Gestational Age; Humans; Infan | 1979 |
[Uteroplacental blood flow in normal pregnancy before and after short-term treatment with (isoxsuprine) beta-sympathicomimetica (author's transl)].
Topics: Adult; Female; Fetus; Humans; Isoxsuprine; Maternal-Fetal Exchange; Placenta; Pregnancy; Regional Bl | 1977 |
Management of premature labor.
Topics: Aspirin; Bed Rest; Betamethasone; Estrogens; Ethanol; Female; Fetal Membranes, Premature Rupture; Gl | 1978 |
Effect of fenoterol and isoxsuprine on myometrial and intervillous blood flow during late pregnancy.
Topics: Ethanolamines; Female; Fenoterol; Heart Rate; Humans; Isoxsuprine; Myometrium; Placenta; Pregnancy; | 1978 |
Effect of beta-mimetic isoxsuprine on prostaglandin biosynthesis in pregnant human myometrium in vitro.
Topics: Epinephrine; Female; Humans; In Vitro Techniques; Isoxsuprine; Microsomes; Myometrium; Pregnancy; Pr | 1978 |
Acute polyhydramnios recurrent in successive pregnancies. Management with multiple amniocenteses.
Topics: Acute Disease; Adult; Amniocentesis; Delivery, Obstetric; Female; Humans; Hyaline Membrane Disease; | 1976 |
[Prevention of abortion and premature labor in cattle and horses].
Topics: Abortion, Habitual; Animals; Cattle; Cattle Diseases; Female; Horse Diseases; Horses; Isoxsuprine; O | 1976 |
Umbilical cord plasma cortisol levels in association with pregnancy complications.
Topics: Congenital Abnormalities; Female; Fetal Blood; Humans; Hydrocortisone; Infant, Newborn; Isoxsuprine; | 1977 |
Arrest of premature labor by isoxsuprine.
Topics: Administration, Oral; Birth Weight; Blood Pressure; Drug Evaluation; Female; Fetal Heart; Gestationa | 1977 |
The effect of intrauterine fetal transfusion and a beta-sympathomimetic substance on the lecithin/sphingomyelin ratio in human amniotic fluid.
Topics: Amniotic Fluid; Blood Transfusion, Intrauterine; Erythroblastosis, Fetal; Female; Gestational Age; H | 1977 |
Prevention of the respiratory distress syndrome in premature infants by antepartum glucocorticoid therapy.
Topics: Amniotic Fluid; Apgar Score; Dexamethasone; Female; Gestational Age; Humans; Infant, Newborn; Isoxsu | 1976 |
Arresting premature labor.
Topics: Ethanol; Female; Humans; Infusions, Parenteral; Isoxsuprine; Obstetric Labor, Premature; Obstetric N | 1976 |
Hormone-releasing silicone-rubber intrauterine contraceptive devices. Effect of incorporation of various compounds on intrauterine contraceptive devices in rats.
Topics: Acetates; Animals; Copper; Female; Gonanes; Hormones; Hydroxysteroids; Intrauterine Devices; Isoxsup | 1975 |
Influence of sympathomimetic drugs on the motility of bovine teat muscles.
Topics: Animals; Cattle; Epinephrine; Female; Isoproterenol; Isoxsuprine; Mammary Glands, Animal; Muscle Con | 1975 |
[The use of isoxsuprine in threatened premature labor].
Topics: Adult; Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy; Uterine Contraction | 1975 |
The effect of isoxsuprine treatment of estrogen levels in maternal and umbilical cord plasma.
Topics: Estradiol; Estrogens; Female; Fetal Blood; Humans; Infant, Newborn; Isoxsuprine; Maternal-Fetal Exch | 1975 |
[Study on measurement and significance of erythrocyte deformability by electron spin resonance (ESR) method].
Topics: Electron Spin Resonance Spectroscopy; Erythrocyte Deformability; Female; Hematocrit; Humans; Isoxsup | 1991 |
Transient electrocardiographic changes suggesting myocardial ischaemia in newborn infants following tocolysis with beta-sympathomimetics.
Topics: Adrenergic beta-Agonists; Coronary Disease; Electrocardiography; Female; Fetus; Heart; Humans; Infan | 1990 |
Outcome of very-low-birth-weight infants exposed to beta-sympathomimetics in utero.
Topics: Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Isoxsuprine; Longitudinal Studies; Pregna | 1991 |
[Indications and management of tocolytic treatment].
Topics: Adrenergic beta-Agonists; Female; Fenoterol; Fetal Distress; Humans; Isoxsuprine; Obstetric Labor, P | 1985 |
[Effects of uterine contraction and a beta-stimulant on placental and fetal brain blood flow in correlation with fetal heart rate changes].
Topics: Adrenergic beta-Agonists; Animals; Cerebrovascular Circulation; Female; Fetus; Heart Rate, Fetal; Is | 1987 |
Beta-adrenergic-induced surfactant synthesis, secretion, and reutilization in fetal rabbit lung and isolated differentiating type II alveolar cells.
Topics: Adrenergic beta-Agonists; Animals; Cell Differentiation; Female; Isoxsuprine; Lung; Pregnancy; Pulmo | 1988 |
[The effect of amniocentesis on pregnancy prolongation in patients of threatened premature labor with intact membranes].
Topics: Adult; Amniocentesis; Female; Fetal Membranes, Premature Rupture; Humans; Isoxsuprine; Obstetric Lab | 1988 |
Role of myometrial constriction in the induction of wavy ribs in rat fetuses.
Topics: Amniotic Fluid; Animals; Embryonic and Fetal Development; Female; Furosemide; Isoxsuprine; Myometriu | 1988 |
Regulation of placental 15-hydroxyprostaglandin dehydrogenase activity by obstetric drugs.
Topics: Actihaemyl; Estrogens; Female; Humans; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Isoxsuprin | 1987 |
[Premature rupture of the membranes. Therapy and materno-neonatal prognosis. Our case series].
Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Apgar Score; Female; Fetal Membranes, Prematu | 1987 |
A comparative study of intrauterine fetal resuscitation by beta-stimulant and O2 inhalation.
Topics: Female; Fetal Distress; Humans; Isoxsuprine; Labor, Obstetric; Oxygen Inhalation Therapy; Pregnancy | 1987 |
[The perinatal factors associated with the development of neonatal RDS in cases of placenta previa].
Topics: Abruptio Placentae; Asphyxia Neonatorum; Female; Humans; Infant, Newborn; Isoxsuprine; Obstetric Lab | 1986 |
Treatment of premature labor in insulin-dependent diabetic women.
Topics: Administration, Oral; Adult; Birth Weight; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; | 1985 |
Myotonic muscular dystrophy associated with ritodrine tocolysis.
Topics: Adult; Amniocentesis; Apgar Score; Cesarean Section; Female; Humans; Infant, Newborn; Isoxsuprine; M | 1985 |
Effects of intra-amniotic isoxsuprine on amino acid placental transfer in rats.
Topics: Amino Acids; Amnion; Animals; Female; Injections; Isoxsuprine; Maternal-Fetal Exchange; Methionine; | 1985 |
[Interactions between beta-mimetics and indices of feto-placental function].
Topics: Abortion, Threatened; Adolescent; Adult; Drug Interactions; Estriol; Female; Humans; Isoxsuprine; Pl | 1985 |
Isoxsuprine and pulmonary edema.
Topics: Cardiac Output; Female; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy; Pregnancy Compli | 1985 |
Prolonged use of tocolytic agents in the expectant management of placenta previa.
Topics: Birth Weight; Costs and Cost Analysis; Female; Gestational Age; Humans; Infant, Low Birth Weight; In | 1985 |
Prenatal and postnatal isoxsuprine and respiratory-distress syndrome.
Topics: Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Isoxsuprine; Maternal-Fetal Exchange | 1973 |
Pharmacologic control of premature labor.
Topics: Adrenergic beta-Agonists; Drug Therapy, Combination; Epinephrine; Ethanol; Extraembryonic Membranes; | 1973 |
[The use of beta adrenergic receptor stimulants in the prevention of premature labor and abortion].
Topics: Abortion, Threatened; Adrenergic beta-Agonists; Female; Fetal Death; Gestational Age; Humans; Isoxsu | 1974 |
Urinary cyclic AMP excretion in toxaemia of pregnancy.
Topics: Cyclic AMP; Cyclohexanes; Diazepam; Estriol; Female; Furosemide; Heterocyclic Compounds; Humans; Hyd | 1973 |
Premature labor: its management and therapy.
Topics: Adrenergic beta-Agonists; Dilatation; Ethanol; Ethisterone; Female; Fetus; Humans; Infections; Injec | 1972 |
Isoxsuprine-induced alterations of pulmonary pressure-volume relationships in premature rabbits.
Topics: Animals; Animals, Newborn; Cesarean Section; Female; Fetus; Gestational Age; Injections, Intramuscul | 1974 |
Role of uterine contraction in producing hemorrhages in rat fetuses after amniocentesis.
Topics: Amniocentesis; Animals; Female; Fetal Diseases; Gestational Age; Hemorrhage; Isoxsuprine; Limb Defor | 1974 |
Diagnosis and treatment of uterine conditions that may cause permaturity.
Topics: Abortion, Spontaneous; Extraction, Obstetrical; Female; Humans; Hydroxyprogesterones; Hysterectomy; | 1973 |
Heart rate variation in infants with the respiratory distress syndrome.
Topics: Age Factors; Autonomic Nervous System; Birth Weight; Cesarean Section; Decerebrate State; Diagnosis, | 1974 |
[Effect of beta-sympathicomimetics during labour on the adaption on the newborn infant].
Topics: Acidosis; Adaptation, Physiological; Apgar Score; Asphyxia Neonatorum; Cesarean Section; Female; Ges | 1972 |
[Use of isoxsuprine in the obstetrical pathology].
Topics: Abortion, Threatened; Administration, Oral; Adult; Female; Humans; Injections, Intramuscular; Isoxsu | 1972 |
[Isoxsuprine (Vasoplex). Review of literature on the experimental and clinical results].
Topics: Adult; Aged; Animals; Arterial Occlusive Diseases; Diabetic Angiopathies; Dogs; Drug Evaluation; Dys | 1972 |
[Limits in prolonged treatments with utero-relaxants of threatened premature labor. Apropos of a series of cases].
Topics: Adult; Female; Fetus; Humans; Isoxsuprine; Obstetric Labor, Premature; Pregnancy; Time Factors; Uter | 1972 |
[Antispastic action of isoxsuprine in the evaluation of tubal patency].
Topics: Fallopian Tubes; Female; Humans; Hysterosalpingography; Infertility, Female; Isoxsuprine; Muscle, Sm | 1973 |
[Effect of Vasodilan on placental blood vessels in vitro].
Topics: Blood Pressure; Female; Humans; In Vitro Techniques; Infant, Newborn; Isoxsuprine; Norepinephrine; O | 1973 |
The oxytocin stress test and the isoxsuprine placental transfer test in the management of suspected placental insufficiency.
Topics: Adult; Apgar Score; Birth Weight; Female; Fetal Heart; Gestational Age; Humans; Isoxsuprine; Methods | 1974 |
[Effectiveness of Vasodilan R on placental vessels in vitro].
Topics: Abortion, Threatened; Blood Vessels; Catecholamines; Culture Techniques; Female; Humans; Isoxsuprine | 1972 |
[Treatment of threatened abortion and premature labor with isoxsuprine hydrochloride].
Topics: Abortion, Threatened; Adult; Amino Alcohols; Female; Humans; Isoxsuprine; Obstetric Labor, Premature | 1971 |