isoxicam and Spondylitis--Ankylosing

1 Isoxicam, 200 mg once daily, was compared to ketoprofen, 100 mg three times daily, in 19 patients (16 males, three females) with ankylosing spondylitis in a 30-day, double-blind study conducted in two centres. 2 Improvements from baseline to final assessment were noted after both isoxicam and ketoprofen in most clinical variables, with isoxicam, in general, being more effective than ketoprofen. 3 Isoxicam was significantly superior to ketoprofen in reducing pain and was judged by both patients and physicians to be superior overall to ketoprofen. 4 Of the 13 patients who expressed a preference, 10 preferred isoxicam. 5 Typical NSAID side effects were encountered with both drugs.

Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ketoprofen; Male; Middle Aged; Pain Measurement; Phenylpropionates; Piroxicam; Random Allocation; Sleep; Spondylitis, Ankylosing

Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Osteoarthritis; Piroxicam; Spondylitis, Ankylosing; Thiazines

Topics: Adolescent; Adult; Aged; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Interactions; Humans; Kinetics; Middle Aged; Osteoarthritis; Piroxicam; Spondylitis, Ankylosing; Thiazines