isoxicam and Arthritis

isoxicam has been researched along with Arthritis* in 6 studies

Trials

2 trial(s) available for isoxicam and Arthritis

Article	Year
Compared effects of isoxicam and indomethacin on the urinary excretion of prostaglandins in degenerative articular diseases. Prostaglandins, leukotrienes, and essential fatty acids, 1989, Volume: 38, Issue:2 The effects of a 7 day-treatment with isoxicam (200 mg/24 h) on the urinary excretion of prostaglandins (PG) were compared to those of indomethacin (150 mg/24 h) in a double-blind randomized study conducted in 18 patients with degenerative arthritic disease and normal renal function. Indomethacin decreased the urinary excretion of PGF2 alpha by about 70% and 6-keto-PGF1 alpha and thromboxane (Tx)B2, the stable break-down products of prostacyclin and TxA2 respectively, by about 40%. Isoxicam effects on urinary PG did not significantly differ from those of indomethacin. During both treatments, urinary gamma-glutamyl transferase and N- acetyl-glucosaminidase remained stable and none of the changes in the urinary excretion of PGs could be related to either plasma or urinary drug concentrations. In conclusion, chronic administration of isoxicam inhibited the renal PG biosynthesis to a similar extent than indomethacin which suggests that non steroidal anti-inflammatory drugs of the oxicam group ought also be used cautiously in patients with renal impairment. Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Dinoprost; Double-Blind Method; Female; Humans; Indomethacin; Kidney Diseases; Male; Middle Aged; Piroxicam; Prostaglandins; Thromboxane B2	1989
[Efficacy and tolerance of isoxicam in outpatients with gonarthrosis and coxarthrosis. Comparison with another non-steroid antirheumatic agent]. Die Medizinische Welt, 1983, Nov-11, Volume: 34, Issue:45 Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Arthritis; Drug Tolerance; Hip Joint; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Piroxicam; Thiazines	1983

Article

Year

Compared effects of isoxicam and indomethacin on the urinary excretion of prostaglandins in degenerative articular diseases.

Prostaglandins, leukotrienes, and essential fatty acids, 1989, Volume: 38, Issue:2

The effects of a 7 day-treatment with isoxicam (200 mg/24 h) on the urinary excretion of prostaglandins (PG) were compared to those of indomethacin (150 mg/24 h) in a double-blind randomized study conducted in 18 patients with degenerative arthritic disease and normal renal function. Indomethacin decreased the urinary excretion of PGF2 alpha by about 70% and 6-keto-PGF1 alpha and thromboxane (Tx)B2, the stable break-down products of prostacyclin and TxA2 respectively, by about 40%. Isoxicam effects on urinary PG did not significantly differ from those of indomethacin. During both treatments, urinary gamma-glutamyl transferase and N- acetyl-glucosaminidase remained stable and none of the changes in the urinary excretion of PGs could be related to either plasma or urinary drug concentrations. In conclusion, chronic administration of isoxicam inhibited the renal PG biosynthesis to a similar extent than indomethacin which suggests that non steroidal anti-inflammatory drugs of the oxicam group ought also be used cautiously in patients with renal impairment.

Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Dinoprost; Double-Blind Method; Female; Humans; Indomethacin; Kidney Diseases; Male; Middle Aged; Piroxicam; Prostaglandins; Thromboxane B2

1989

[Efficacy and tolerance of isoxicam in outpatients with gonarthrosis and coxarthrosis. Comparison with another non-steroid antirheumatic agent].

Die Medizinische Welt, 1983, Nov-11, Volume: 34, Issue:45

Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Arthritis; Drug Tolerance; Hip Joint; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Piroxicam; Thiazines

1983

Other Studies

4 other study(ies) available for isoxicam and Arthritis

Article	Year
[The effect of estro-progesterones on the inflammatory episodes of hand arthroses. Apropos of a case]. Revue du rhumatisme et des maladies osteo-articulaires, 1989, Volume: 56, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Estradiol; Estrogen Replacement Therapy; Female; Finger Joint; Hand; Humans; Menopause; Middle Aged; Piroxicam; Progesterone	1989
[Lyell's syndrome induced by Vectren]. Dermatologica, 1986, Volume: 172, Issue:5 While treated with isoxicam, a middle-aged lady developed first diffuse maculopapules and afterwards a syndrome of Lyell; similar observations of bimodal toxicodermatitis have been reported in the literature. Topics: Arthritis; Female; Humans; Middle Aged; Piroxicam; Psoriasis; Stevens-Johnson Syndrome; Thiazines	1986
[Clinical study of isoxicam in psoriatic arthritis]. La Clinica terapeutica, 1986, Sep-15, Volume: 118, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis; Drug Evaluation; Female; Humans; Male; Middle Aged; Piroxicam; Psoriasis	1986
Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats. Research communications in chemical pathology and pharmacology, 1978, Volume: 19, Issue:3 Isoxicam at 25 mg/kg/day x 28 days significantly inhibited the multiple alterations with the developing polyarthritis. In rats, this drug did not induce any changes in the relative liver weights or serum SGPT, AP, or BUN in polyarthritic rats. Isoxicam absorption was similar in normal and arthritic rats. Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis; Arthritis, Experimental; Blood Urea Nitrogen; Isoxazoles; Male; Organ Size; Oxazoles; Piroxicam; Rats; Thiazines	1978