isoxazoles has been researched along with Seizures in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (21.78) | 18.7374 |
| 1990's | 16 (15.84) | 18.2507 |
| 2000's | 24 (23.76) | 29.6817 |
| 2010's | 38 (37.62) | 24.3611 |
| 2020's | 1 (0.99) | 2.80 |
| Authors | Studies |
|---|---|
| Takechi, K | 1 |
| Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J | 2 |
| Lee, JW; Nicolas, J; Sarkis, RA | 1 |
| Doğan, EA; Erdoğan, Ç; Genç, BO; Genç, E | 1 |
| Collinet, A; Sammut, V | 1 |
| Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B | 1 |
| Heo, K; Ki, CS; Kim, KH; Park, CW; Song, JS | 1 |
| Assenza, G; Di Pino, G; Pellegrino, G; Tombini, M | 1 |
| Greenhalgh, J; Marson, AG; Pulman, J | 1 |
| Lossius, MI; Markhus, R; Nakken, KO; Sætre, E | 1 |
| Chen, G; Jiang, D; Kong, S; Pitre, A; Sun, Y; Wang, Y; Wu, Z | 1 |
| Conway, C; Cristancho, P; Jewkes, D; Mon, T | 1 |
| Allaf, B; Biraben, A; Dupont, S; Lavernhe, G; Marquet, T | 1 |
| Khan, SA; Malik, S | 1 |
| Fritsch, B; Gasior, M; Kaminski, RM; Reis, J; Rogawski, MA | 1 |
| Baldelli, P; Benfenati, F; Ferrea, E; Greco, B; Medrihan, L | 1 |
| Ahuja, P; Khan, SA; Malik, S; Sahu, K | 1 |
| Gudausky, TM; Kovach, J; Loomba, RS; Singh, AK | 1 |
| Khongkhatithum, C; Thampratankul, L; Visudtibhan, A | 1 |
| Cheng, L; Dargham, RA; Kong, S; Liu, X; Ren, W; Wan, L; Wang, Y; Wu, Z | 1 |
| Greenhalgh, J; Marson, AG; Weston, J | 1 |
| Dęborska-Materkowska, D; Durlik, M; Komuda-Leszek, E; Mikołajczyk, N; Miszewska-Szyszkowska, D; Świder, R; Szmidt, J; Wieczorek-Godlewska, R | 1 |
| Horvath, R; Janszky, J; Komoly, S | 1 |
| Baulac, M; Hamer, H; Kockelmann, E; McMurray, R | 1 |
| Araki, H; Kiyoi, T; Suemaru, K; Takechi, K; Tanaka, A | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Merlin, LR; Shen, H; Smith, SS; Yang, L | 1 |
| Madsen, KK; Schousboe, A | 1 |
| Bell, WL; Oles, KS | 1 |
| Lizer, MH; Schneider, RA | 1 |
| Aksamit, AJ; Deen, HG; Dickson, DW; Dominik, J; Freeman, WD; Rahmlow, M; Robles, HA; Shuster, EA | 1 |
| Barbaud, A; Schmutz, JL; Tréchot, P | 1 |
| Dinapoli, L; Jandolo, B; Maschio, M; Saveriano, F | 1 |
| Gogtay, NJ; Lahiri, KR; Muranjan, MN; Shaikh, AY | 1 |
| Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y | 1 |
| Mareš, P | 1 |
| Chiang, KT; Liang, CS; Yang, FW | 1 |
| Clausen, RP; Danbolt, NC; Guo, C; Holen, T; Holmseth, S; Hua, R; Laake, P; Lehre, AC; Madsen, KK; Olofsson, AM; Poblete-Naredo, I; Rowley, NM; Rusakov, DA; Schousboe, A; White, HS; Zhou, Y | 1 |
| Citraro, R; Constanti, A; De Fazio, S; De Sarro, G; Di Paola, ED; Perrota, I; Perrotta, I; Russo, E; Scicchitano, F | 1 |
| Arai, H; Iimura, Y; Nakajima, M; Sugano, H | 1 |
| Cho, YW; Heo, K; Kim, KS; Kim, OJ; Kim, SE; Kim, SH; Lee, BI; Lee, JH; Lee, SJ; Park, SP; Shin, DJ; Song, HK; Yi, SD | 1 |
| Dupont, S; Stefan, H | 1 |
| Araki, H; Hidaka, N; Kato, Y; Suemaru, K | 1 |
| Butcher, RJ; Cooke, N; Cox, DS; Edafiogho, IO; Eddington, ND; Goodwin, AM; Roberts, RR; Scott, KR; Smith, CA; Stables, JP | 1 |
| De Micheli, C; De Sarro, A; De Sarro, G; Ferreri, G; Grasso, S; Micale, N; Puja, G; Toma, L; Zappalà, M | 1 |
| Araki, H; Futagami, K; Gomita, Y; Hashimoto, Y; Kawasaki, H | 1 |
| Fukuda, F; Ijiri, Y; Inoue, T; Kobayashi, T; Shibahara, N; Suzuki, K; Takenaka, H; Tanaka, K | 1 |
| Brotherton, T; Santos, CC | 1 |
| Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Song, HK; Won, MH | 1 |
| Willmore, LJ | 1 |
| Doi, T; Nagatomo, K; Nakajima, A; Tokumaru, J; Ueda, Y | 1 |
| Masumizu, T; Mori, A; Noda, Y; Packer, L | 1 |
| Davenport, RD; Patel, NC | 1 |
| Anderson, NJ; Cremers, TI; Ebert, B; Fahey, JM; Rasmussen, S; Sánchez, C; Vogel, V | 1 |
| Conry, JA; Pellock, JM; Shinnar, S | 1 |
| Conry, JA; Murphy, JV; Vossler, DG | 1 |
| Amamiya, S; Araki, A; Fujieda, K; Kajihama, A; Ohinata, J; Sugai, R; Suzuki, N; Takahashi, S; Tanaka, H | 1 |
| Bialer, M; Shimshoni, JA; Yagen, B | 1 |
| Minchin, MC; Nutt, DJ | 1 |
| Breese, GR; Frye, GD; McCown, TJ | 1 |
| Frey, HH; Löscher, W; Reiche, R; Schultz, D | 1 |
| Fariello, RG; Golden, GT | 1 |
| Horton, R; Meldrum, B | 1 |
| Johnson, DD; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS | 1 |
| Kamei, C; Masuda, Y; Oka, M; Shimizu, M; Yoshida, K | 1 |
| Hori, M; Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Yoshida, K | 1 |
| Garant, DS; Moshé, SL; Sperber, EF; Xu, SG | 2 |
| Fujita, T; Nakai, H; Takano, K; Tanaka, T; Yonemasu, Y | 1 |
| Jenkinson, SG; Lawrence, RA; Morgan, JA; Peacock, MD; Schenk, DA | 1 |
| Brioni, JD; Buckley, MJ; Decker, MW; Giardina, WJ; Kang, CH; Kim, DJ; Radek, RJ; Raszkiewicz, JL; Sullivan, JP; Wasicak, JT | 1 |
| Karasawa, T; Masuda, Y; Noguchi, H | 1 |
| Fukushima, Y; Hirano, T; Kaneko, S; Kondo, T; Okada, M; Otani, K | 1 |
| Falch, E; Hunt, J; Krogsgaard-Larsen, P; Schousboe, A; Swinyard, EA; White, HS; Wolf, HH | 1 |
| Steppuhn, KG; Turski, L | 1 |
| Arnt, J; Krogsgaard-Larsen, P; Lenz, SM; Madsen, U; Sánchez, C | 1 |
| Akasaki, Y; Nagase, F; Nagatomo, I; Nomaguchi, M; Takigawa, M | 1 |
| Buchanan, RA; Kochak, GM; Padgett, CS; Page, JG; Peters, R | 1 |
| Akasaki, Y; Kuchiiwa, S; Nagatomo, I; Nakagawa, S; Takigawa, M; Uchida, M | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Stensbøl, TB | 1 |
| Faingold, CL; N'Gouemo, P | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M | 1 |
| Miyamoto, A; Okamoto, T; Oki, J; Shirai, M; Sugai, R | 1 |
| Akaike, K; Fukumoto, S; Imamura, S; Takigawa, M; Tanaka, S; Tojo, H | 1 |
| Ben-Ari, Y; Cossart, R; Hirsch, J; Khalilov, I | 1 |
| Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K | 1 |
| Gorecki, DK; Peesker, SJ; Wood, JD | 1 |
| Ito, T; Shimizu, M; Yoshida, K | 1 |
| Awouters, F; Janssen, PA; Megens, AA; Niemegeers, CJ | 1 |
| Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Meldrum, BS | 1 |
| Bagri, A; Di Scala, G; Sandner, G | 1 |
| Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N | 1 |
| Löscher, W; Schwark, WS | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA | 1 |
| Chweh, AY; Lin-Michell, E; Swinyard, EA | 1 |
| Löscher, W | 1 |
| Karasawa, T; Masuda, M; Oka, M; Shimizu, M; Yoshida, K | 1 |
12 review(s) available for isoxazoles and Seizures
| Article | Year |
|---|---|
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxazoles; Kindling, Neurologic; Membrane Proteins; Mental Disorders; Mice; Nerve Tissue Proteins; Pentylenetetrazole; Piriform Cortex; Psychomotor Performance; Pyrrolidines; Quality of Life; Receptors, Nicotinic; Seizures; Social Behavior | 2019 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2020 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Postoperative Complications; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2018 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2013 |
[Epilepsy in the elderly].
Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Quality of Life; Seizures; Triazines; Zonisamide | 2013 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized Controlled Trials as Topic; Seizures; Valproic Acid; Zonisamide | 2015 |
[ZONISAMIDE: FIRST CHOICE AMONG THE FIRST-LINE ANTIEPILEPTIC DRUGS IN FOCAL EPILEPSY].
Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Approval; Drug Prescriptions; Electroencephalography; Encephalitis; Epilepsies, Partial; Humans; Hungary; Isoxazoles; Levetiracetam; Magnetic Resonance Imaging; Medication Adherence; Obesity; Phenytoin; Piracetam; Risk Assessment; Risk Factors; Seizures; Stroke; Weight Loss; Young Adult; Zonisamide | 2015 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Delineation of the Role of Astroglial GABA Transporters in Seizure Control.
Topics: Animals; Anticonvulsants; Astrocytes; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Humans; Isoxazoles; Seizures | 2017 |
Zonisamide in clinical practice.
Topics: Anticonvulsants; Epilepsies, Partial; Humans; Isoxazoles; Quality of Life; Seizures; Treatment Outcome; Zonisamide | 2012 |
Antiepileptic drugs and neuroprotection: current status and future roles.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Neuroprotective Agents; Piracetam; Seizures; Topiramate; Triazines; Zonisamide | 2005 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; Hypoxia; Imidazoles; Isoxazoles; Mice; Mice, Inbred DBA; Muscimol; Myoclonus; Neurotransmitter Agents; Papio; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
4 trial(s) available for isoxazoles and Seizures
| Article | Year |
|---|---|
Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: a multicenter open-label single-arm trial in Korean patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsies, Partial; Female; Humans; Isoxazoles; Korea; Male; Middle Aged; Seizures; Young Adult; Zonisamide | 2012 |
Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Female; Humans; Isoxazoles; Male; Pancreatitis; Seizures; Severity of Illness Index; Sweating; Time Factors; Treatment Outcome; Vertigo; Zonisamide | 2009 |
Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Myoclonic Epilepsies, Progressive; Seizures; Zonisamide | 2008 |
Steady-state pharmacokinetics of zonisamide, an antiepileptic agent for treatment of refractory complex partial seizures.
Topics: Anticonvulsants; Half-Life; Humans; Isoxazoles; Metabolic Clearance Rate; Seizures; Zonisamide | 1998 |
85 other study(ies) available for isoxazoles and Seizures
| Article | Year |
|---|---|
Tolerability of lacosamide or zonisamide in elderly patients with seizures.
Topics: Acetamides; Aged; Anticonvulsants; Dizziness; Female; Gait; Humans; Isoxazoles; Lacosamide; Male; Postural Balance; Retrospective Studies; Seizures; Zonisamide | 2017 |
Efficacy, tolerability, and retention rates of zonisamide in older adult patients with focal-onset epilepsy: Experiences from two tertiary epilepsy centers.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsies, Partial; Female; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Seizures; Treatment Outcome; Weight Loss; Zonisamide | 2017 |
Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Diagnosis, Differential; Drug Hypersensitivity; Epilepsy; Isoxazoles; Male; Seizures; Zonisamide | 2017 |
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammation; Isoxazoles; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Seizures; Zonisamide | 2018 |
First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea.
Topics: Adult; Anticonvulsants; Blotting, Southern; Cystatin B; Female; Genetic Predisposition to Disease; Humans; Isoxazoles; Levetiracetam; Piracetam; Republic of Korea; Seizures; Treatment Outcome; Unverricht-Lundborg Syndrome; Valproic Acid; Zonisamide | 2018 |
Zonisamide for seizures in Parkinson's disease with dementia.
Topics: Aged; Anticonvulsants; Dementia; Humans; Isoxazoles; Male; Parkinson Disease; Seizures; Zonisamide | 2013 |
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission | 2013 |
Successful use of right unilateral ECT for catatonia: a case series.
Topics: Adolescent; Adult; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Catatonia; Depressive Disorder, Major; Electroconvulsive Therapy; Female; GABA Modulators; Humans; Isoxazoles; Lorazepam; Lupus Erythematosus, Systemic; Male; Paliperidone Palmitate; Psychotic Disorders; Pyrimidines; Schizophrenia, Catatonic; Seizures; Treatment Outcome; Young Adult | 2014 |
Management and monitoring of patients treated with zonisamide: the OZONE study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Collection; Data Interpretation, Statistical; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Monitoring, Physiologic; Quality of Life; Seizures; Treatment Outcome; Young Adult; Zonisamide | 2013 |
Design and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents.
Topics: Administration, Oral; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Electroshock; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Molecular Structure; Rats; Rats, Wistar; Seizures; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Triazines | 2014 |
Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.
Topics: Amygdala; Animals; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Isoxazoles; Mice; Mice, Knockout; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures | 2014 |
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neurons; Seizures; Synapsins | 2015 |
Design and synthesis of new of 3-(benzo[d]isoxazol-3-yl)-1-substituted pyrrolidine-2, 5-dione derivatives as anticonvulsants.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Design; Electroshock; Isoxazoles; Mice; Molecular Structure; Motor Activity; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Structure-Activity Relationship; Succinimides | 2014 |
Lacosamide-induced atrial tachycardia in a child with hypoplastic left-heart syndrome: the importance of assessing additional proarrhythmic risks.
Topics: Acetamides; Anticonvulsants; Arrhythmias, Cardiac; Child, Preschool; Comorbidity; Humans; Hypoplastic Left Heart Syndrome; Isoxazoles; Lacosamide; Levetiracetam; Male; Piracetam; Seizures; Tachycardia, Sinus; Treatment Outcome; Zonisamide | 2015 |
Efficacy and safety of zonisamide in Thai children and adolescents with intractable seizures.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Isoxazoles; Male; Retrospective Studies; Seizures; Thailand; Zonisamide | 2015 |
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Membrane Potentials; Neurons; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2014 |
Severe cytomegalovirus infection in a second kidney transplant recipient treated with ganciclovir, leflunomide, and immunoglobulins, with complications including seizures, acute HCV infection, drug-induced pancytopenia, diabetes, cholangitis, and multi-or
Topics: Adult; Antiviral Agents; Cholangitis; Cytomegalovirus Infections; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Ganciclovir; Hepatitis C; Humans; Immunoglobulins, Intravenous; Isoxazoles; Kidney Transplantation; Leflunomide; Multiple Organ Failure; Pancytopenia; Reoperation; Seizures; Transplant Recipients; Viral Load | 2015 |
Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Seizures; Treatment Outcome; Young Adult; Zonisamide | 2016 |
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Models, Animal; Isoxazoles; Kindling, Neurologic; Male; Mice, Inbred ICR; Motor Activity; Nicotinic Agonists; Pentylenetetrazole; Psychomotor Performance; Pyrrolidines; Receptors, Nicotinic; Rotarod Performance Test; Seizures; Social Behavior | 2016 |
Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus.
Topics: Age Factors; Animals; Benzamides; CA1 Region, Hippocampal; Cations, Monovalent; Evoked Potentials; Female; GABA-A Receptor Agonists; Imidazoles; In Vitro Techniques; Isoxazoles; Mice, Inbred C57BL; Models, Neurological; Potassium; Receptors, GABA-A; Seizures; Sexual Maturation | 2016 |
Zonisamide concentrations during pregnancy.
Topics: Adult; Anticonvulsants; Female; Humans; Isoxazoles; Myoclonic Epilepsy, Juvenile; Pregnancy; Pregnancy Complications; Seizures; Zonisamide | 2008 |
Apparent seizure and atrial fibrillation associated with paliperidone.
Topics: Antipsychotic Agents; Atrial Fibrillation; Bipolar Disorder; Humans; Isoxazoles; Male; Middle Aged; Paliperidone Palmitate; Pyrimidines; Seizures | 2008 |
Leflunomide-associated progressive multifocal leukoencephalopathy.
Topics: Arthritis, Rheumatoid; Biopsy; Brain; Cytarabine; Humans; Immunosuppressive Agents; Injections, Intravenous; Isoxazoles; Leflunomide; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Middle Aged; Seizures; Staining and Labeling | 2008 |
[Leflunomide and Lyell syndrome].
Topics: Adult; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Seizures; Stevens-Johnson Syndrome | 2009 |
Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on.
Topics: Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Epilepsy; Erectile Dysfunction; Humans; Isoxazoles; Male; Seizures; Zonisamide | 2011 |
Possible mechanism for zonisamide-induced hyperammonemia in a child with citrullinemia type 1.
Topics: Anticonvulsants; Child; Citrullinemia; Humans; Hyperammonemia; Isoxazoles; Male; Seizures; Zonisamide | 2009 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Generalized; Frontal Lobe; Hippocampus; Isoxazoles; Kindling, Neurologic; Male; Olfactory Bulb; Rats; Rats, Wistar; Seizures; Valproic Acid; Zonisamide | 2010 |
Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Incidence; Isoxazoles; Male; Rats; Rats, Wistar; Reaction Time; Seizures; Zonisamide | 2010 |
Paliperidone-associated seizure after discontinuation of sodium valproate: a case report.
Topics: Adult; Humans; Isoxazoles; Male; Paliperidone Palmitate; Pyrimidines; Seizures; Valproic Acid | 2011 |
Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.
Topics: Animals; Anticonvulsants; Convulsants; Crosses, Genetic; Dose-Response Relationship, Drug; Electroshock; Exons; Female; GABA Plasma Membrane Transport Proteins; Isoxazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nipecotic Acids; Pentylenetetrazole; RNA, Messenger; Seizures; Tiagabine | 2011 |
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Ethosuximide; Isoxazoles; Levetiracetam; Male; Piracetam; Rats; Rats, Wistar; Seizures; Zonisamide | 2011 |
Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.
Topics: Anticonvulsants; Cognition Disorders; Corpus Callosum; Cortical Synchronization; Drug Resistance; Electroencephalography; Functional Laterality; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Myoclonus; Neurosurgical Procedures; Seizures; Syncope; Valproic Acid; Young Adult; Zonisamide | 2012 |
Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats.
Topics: Animals; Electric Stimulation; Electroshock; Isoxazoles; Male; Memory Disorders; Memory, Short-Term; Pyrrolidines; Rats; Rats, Wistar; Receptors, Nicotinic; Recurrence; Seizures | 2013 |
Synthesis and anticonvulsant activity of enaminones. 4. Investigations on isoxazole derivatives.
Topics: Amines; Animals; Anticonvulsants; Brain; Crystallography, X-Ray; Isoxazoles; Male; Mice; Molecular Structure; Motor Activity; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures; Sodium Channels; Structure-Activity Relationship | 2002 |
Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cerebellum; Dioxoles; Excitatory Amino Acid Antagonists; Isoxazoles; Kainic Acid; Male; Mice; Mice, Inbred DBA; Models, Molecular; Motor Activity; Neurons; Patch-Clamp Techniques; Phenylacetates; Propionates; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Semicarbazones; Structure-Activity Relationship | 2002 |
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Phenytoin; Prosencephalon; Seizures; Time Factors; Valproic Acid; Zonisamide | 2003 |
Dialyzability of the antiepileptic drug zonisamide in patients undergoing hemodialysis.
Topics: Adult; Anticonvulsants; Anuria; Comorbidity; Drug Administration Schedule; Female; Hemodialysis Solutions; Humans; Isoxazoles; Kidney Failure, Chronic; Lupus Erythematosus, Systemic; Middle Aged; Protein Binding; Renal Dialysis; Seizures; Zonisamide | 2004 |
Use of zonisamide in pediatric patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Seizures; Zonisamide | 2005 |
Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil.
Topics: Animals; Anticonvulsants; Gerbillinae; Hippocampus; In Situ Hybridization; Isoxazoles; Neuropeptide Y; Seizures; Vigabatrin; Zonisamide | 2005 |
In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.
Topics: Animals; Anticonvulsants; Electron Spin Resonance Spectroscopy; Hippocampus; Isoxazoles; Kainic Acid; Male; Microdialysis; Nitrogen Oxides; Oxidation-Reduction; Rats; Rats, Wistar; Seizures; Zonisamide | 2005 |
Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Free Radicals; Hippocampus; Isoxazoles; Kainic Acid; Male; Manganese Compounds; Mice; Oxides; Seizures; Zonisamide | 2005 |
Zonisamide as treatment for seizures.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Isoxazoles; Seizures; Zonisamide | 2007 |
Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing.
Topics: Anesthetics; Animals; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Electrodes, Implanted; Electroencephalography; GABA Antagonists; Hypnotics and Sedatives; Isoxazoles; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sleep | 2008 |
Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: a successful use of zonisamide for controlling the seizures.
Topics: Anticonvulsants; Biological Transport; Child; DNA Mutational Analysis; Erythrocytes; Female; Glucose; Glucose Transporter Type 1; Humans; Isoxazoles; Male; Methylgalactosides; Seizures; Zonisamide | 2008 |
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mice; Motor Activity; Rats; Seizures; Sulfonamides; Urea; Valproic Acid; Zonisamide | 2008 |
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds | 1984 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disease Susceptibility; Ethanol; Forelimb; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Tremor | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid | 1983 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Penicillins; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Taurine; Time Factors | 1984 |
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors | 1980 |
Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO.
Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Anticonvulsants; Chickens; Cyclohexanecarboxylic Acids; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Seizures; Transaminases | 1983 |
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nipecotic Acids; Pentylenetetrazole; Seizures | 1983 |
Effects of 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810) and some antiepileptics on the kindled seizures in the neocortex, hippocampus and amygdala in rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; Hippocampus; Isoxazoles; Male; Oxazoles; Rats; Seizures; Zonisamide | 1981 |
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile.
Topics: Animals; Anticonvulsants; Barbiturates; Carbonic Anhydrase Inhibitors; Dogs; Electroshock; Isoxazoles; Motor Activity; Oxazoles; Rabbits; Rats; Seizures; Sleep; Species Specificity; Time Factors; Zonisamide | 1980 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Microinjections; Muscimol; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1995 |
Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Electroencephalography; Glucose; Isoxazoles; Kainic Acid; Limbic System; Rats; Rats, Wistar; Seizures; Status Epilepticus; Zonisamide | 1995 |
Elimination of glutathione-induced protection from hyperbaric hyperoxia by acivicin.
Topics: Animals; Brain; Brain Chemistry; gamma-Glutamyltransferase; Glutathione; Hyperbaric Oxygenation; Isoxazoles; Kidney; Lung; Male; Oxygen; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.
Topics: Alzheimer Disease; Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Behavior, Animal; Body Temperature; Brain; Cerebrovascular Circulation; Cognition; Electroencephalography; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nociceptors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cholinergic; Seizures; Vomiting | 1994 |
Evidence against a significant implication of carbonic anhydrase inhibitory activity of zonisamide in its anticonvulsive effects.
Topics: Animals; Anticonvulsants; Brain; Carbonic Anhydrase Inhibitors; Electroshock; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred Strains; Rats; Seizures; Zonisamide | 1994 |
Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vivo, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade of seizure spread.
Topics: Adenosine; Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Culture Techniques; Dopamine; Evoked Potentials; Hippocampus; Isoxazoles; Male; Rats; Rats, Wistar; Seizures; Serotonin; Synaptic Transmission; Zonisamide | 1993 |
Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Seizures | 1993 |
Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants.
Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Drug Administration Routes; Isoxazoles; Kainic Acid; Male; Mice; N-Methylaspartate; Propionates; Receptors, Glutamate; Seizures | 1993 |
Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Convulsants; Cues; Discrimination Learning; Discrimination, Psychological; Excitatory Amino Acid Agonists; Isoxazoles; Ligands; Male; Mice; N-Methylaspartate; Propionates; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Female; Isoxazoles; Male; Mice; Mice, Mutant Strains; Phenobarbital; Seizures; Time Factors; Zonisamide | 1996 |
Influence of dietary zinc on convulsive seizures and hippocampal NADPH diaphorase-positive neurons in seizure susceptible EL mouse.
Topics: Animals; Anticonvulsants; Cell Count; Diet; Genetic Predisposition to Disease; Hippocampus; Isoxazoles; Mice; Mice, Mutant Strains; NADPH Dehydrogenase; Neurons; Seizures; Zinc; Zonisamide | 1998 |
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Topics: Animals; Convulsants; Excitatory Amino Acid Agonists; Isoxazoles; Mice; Pyrroles; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Structure-Activity Relationship | 1998 |
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Isoxazoles; Male; Microinjections; Naloxone; Narcotic Antagonists; Nerve Net; Periaqueductal Gray; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Seizures | 1999 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Agonists; Isoxazoles; Kainic Acid; Mice; Mice, Inbred DBA; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Phthalazines; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship | 2000 |
Urine stone formation during treatment with zonisamide.
Topics: Anticonvulsants; Child; Encephalitis, Viral; Epstein-Barr Virus Infections; Female; Hematuria; Herpesvirus 4, Human; Humans; Isoxazoles; Pyuria; Seizures; Urinary Calculi; Zonisamide | 2000 |
Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures.
Topics: Animals; Anticonvulsants; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Injections, Intraventricular; Isoxazoles; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Seizures; Zonisamide | 2001 |
Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors.
Topics: Animals; Animals, Newborn; Anticonvulsants; Hippocampus; Interneurons; Isoxazoles; Neural Inhibition; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Seizures | 2002 |
Relationships between plasma concentrations of diphenylhydantoin, phenobarbital, carbamazepine, and 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810), a new anticonvulsant agent, and their anticonvulsant or neurotoxic effects in experimental animals.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Dogs; Dose-Response Relationship, Drug; Haplorhini; Isoxazoles; Male; Mice; Motor Skills; Oxazoles; Phenobarbital; Phenytoin; Rabbits; Rats; Seizures; Species Specificity | 1979 |
3-Isoxazolidone--an inhibitor of GABA metabolism.
Topics: Aminobutyrates; Animals; Brain; Chickens; Depression, Chemical; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Oxazolidinones; Rats; Seizures; Time Factors | 1976 |
Effect of 1,2-benzisoxazole-3-acetamidoxime on caudato-thalamo-cortical system in cats.
Topics: Animals; Cats; Caudate Nucleus; Cerebral Cortex; Electroencephalography; Female; Isoxazoles; Male; Oxazoles; Oximes; Seizures; Thalamus | 1976 |
The proconvulsant effect of nigral infusions of THIP on flurothyl-induced seizures in rat pups.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Flurothyl; Infusions, Parenteral; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Substantia Nigra | 1992 |
Functional interaction between serotonin-S2 and dopamine-D2 neurotransmission as revealed by selective antagonism of hyper-reactivity to tryptamine and apomorphine.
Topics: Animals; Antipsychotic Agents; Apomorphine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Injections, Intravenous; Isoxazoles; Male; Piperidines; Rats; Rats, Inbred Strains; Risperidone; Ritanserin; Seizures; Serotonin; Serotonin Antagonists; Synaptic Transmission; Tryptamines | 1990 |
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neuroglia; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1989 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazoles; Male; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Strychnine | 1988 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Seizures | 1985 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, Neurologic; Muscimol; Muscle Relaxation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1985 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures | 1986 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Nervous System; Pentylenetetrazole; Receptors, GABA-A; Seizures | 1986 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1985 |
1,2-Benzisoxazole-3-acetamidoxime hydrochloride, a new psychotropic agent.
Topics: Acetamides; Aggression; Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Female; Humans; Ileum; In Vitro Techniques; Isoxazoles; Norepinephrine; Oxazoles; Oximes; Reserpine; Seizures; Sleep; Tranquilizing Agents | 1974 |