Page last updated: 2024-08-21

isoxazoles and Rheumatoid Arthritis

isoxazoles has been researched along with Rheumatoid Arthritis in 572 studies

Research

Studies (572)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	45 (7.87)	18.2507
2000's	365 (63.81)	29.6817
2010's	157 (27.45)	24.3611
2020's	5 (0.87)	2.80

Authors

Authors	Studies
Aicha, BT; Hana, S; Ines, M; Issam, S; Kawther, BA; Leila, A; Leila, M; Lobna, BA; Mouna, BS; Olfa, S; Rawdha, T; Selma, B; Takoua, BB	1
Machaj, F; Malinowski, D; Olędzka, G; Pawlik, A; Rosik, J; Safranow, K; Szostak, B; Wiechec, E	1
Alothman, R; Amiri, N; Lepik, C; Waterman, E; Yeung, J	1
Kisiel, B; Tłustochowicz, ME; Tłustochowicz, W	1
Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y	1
Contreras, L; Flores, L; Núñez, P; Quera, R	1
Beck, E; Schaefer, C; Tissen-Diabaté, T; Weber-Schoendorfer, C	1
Eurich, DT; Hall, JJ; Katz, SJ; Keeling, SO; Maksymowych, WP; Schultz, M	1
de Silva, R; Fernandopulle, R; Galappatthy, P; Hart, M; Kelleher, P; Saravanamuttu, U; Senerath, U; Seneviratne, SL; Udagama, P; Weerasekera, LP; Wijayaratne, LS; Wijesinghe, H	1
Boulman, N; Kaly, L; Odeh, M; Raitter, R; Rimer, D; Rosner, I; Rozenbaum, M; Slobodin, G	1
Bananis, E; Chen, C; Curtis, JR; Fan, H; Hirose, T; Lindsey, S; Mendelsohn, AM; Nduaka, CI; Tanaka, Y; Valdez, H; Wang, L; Winthrop, KL; Yamaoka, K	1
Krüger, K	2
Baron, G; Combe, B; Constantin, A; Dernis, E; Dougados, M; Flipo, RM; Gottenberg, JE; Mariette, X; Morel, J; Ravaud, P; Rist, S; Saraux, A; Schaeverbeke, T; Sibilia, J; Soubrier, M; Vittecoq, O	1
Bae, SC; Lee, YH	1
Acevedo-Vásquez, EM; Alarcón-Riquelme, ME; Alvarellos, A; Babini, A; Ballesteros, F; Berbotto, G; Cardiel, MH; Catoggio, LJ; Citera, G; Eimon, A; Esquivel-Valerio, JA; García de la Torre, I; García, CG; Goñi, M; Graf, C; Maradiaga-Ceceña, MA; Marcos, JC; Messina, OD; Miranda, P; Moreno, JLC; Musuruana, JL; Nasswetter, G; Paira, S; Pellet, AC; Pons-Estel, BA; Quinteros, A; Sacnún, M; Sánchez, E; Scherbarth, H; Spindler, A; Strusberg, I; Tate, G; Toloza, S; Tusié-Luna, T	1
Hu, Y; Niu, H; Zhang, R	1
Lan, G; Lu, W; Sun, F; Wang, L; Xu, P; Yu, X; Zhang, L	1
Alfieri, DF; Costa, NT; de Medeiros, FA; de Sá, MC; Dichi, I; Iriyoda, TMV; Lozovoy, MAB; Maes, M; Micheletti, PL; Reiche, EMV; Scavuzzi, BM; Sekiguchi, BA; Simão, ANC	1
Colares, VLP; Fernandes, AMR; Fernandes, ES; Martins, MMRS; Mendes, SJF; Monteiro, CRAV; Muniz, TF; Pereira, DMS; Pereira, ICP; Silva, BLR; Sousa, NCF	1
Batty, K	1
Chen, Z; Li, XM; Li, XP; Li, ZJ; Xu, L	1
Conde, C; García, S; Gómez-Reino, JJ; González, A; Martínez, P; Orosa, B	1
Atukorala, I; Hunter, DJ	1
Li, WQ; Wang, ZM; Wu, Y	1
Conaghan, PG; Keen, HI; Tett, SE	1
Abásolo, L; Fernández-Gutierrez, B; Fontsere, O; Jover-Jover, JA; León, L; Peña-Blanco, RC; Rodriguez-Rodriguez, L	1
Nardi, AE; Ornelas, AC; Pinho de Oliveira Ribeiro, N; Pinho de Oliveira, CM; Rafael de Mello Schier, A; Silva, AC	1
Grzywa, M; Kadziela, M	1
Murdaca, G; Puppo, F; Spanò, F	1
Atzeni, F; Benucci, M; Boiardi, L; Sallì, S; Sarzi-Puttini, P	1
Bae, SC; Cho, SK; Choi, CB; Kwon, JM; Lee, EK; Sung, YK	1
Jiang, Y; Jiang, Z; Liu, B; Ma, L	1
Bartzatt, R	1
Bouret, AM; Frances, L; Guijarro, J; Leiva-Salinas, Mdel C; Marin, I	1
Cleland, LG; Flabouris, K; James, MJ; Lee, AT; Metcalf, RG; Proudman, SM; Rischmueller, M; Spargo, LD; Sullivan, TR; Wechalekar, MD	1
Gu, Y; Jin, B; Liu, W; Luo, Q; Qian, C; Shen, Y; Sun, Y; Tao, F; Wu, X; Xu, Q	1
Chen, DY; Chen, HH; Chen, YM; Chou, P; Chou, YJ; Huang, N; Lai, KL; Lin, CH	1
Arida, D; Silva, L; Skare, TL	1
Dudler, J; Forster, A; Handschin, T; Tuerk, R	1
Alasti, F; Aletaha, D; Smolen, JS	1
Bellosta Diago, E; Pascual Millán, LF; Santos Lasaosa, S; Velázquez Benito, A	1
El-Agha, S; El-Azkalany, GS; Shahin, AA	1
Arstila, L; Elfving, P; Kaipiainen-Seppänen, O; Kononoff, A; Koskela, H; Rutanen, J	1
Bussmann, A; Herzer, P; Listing, J; Richter, A; Strangfeld, A; Wilden, E; Zink, A	1
Biswas, M; Chatterjee, S; Ghosh, A; Ghosh, S; Sarkate, P	1
Ding, Y; Shen, Q; Wild, C; Ye, N; Zhou, J	1
Baba, H; Fukai, R; Ito, H; Katayama, K; Okubo, T; Sato, T	1
Cleland, LG; Foster, DJ; Hopkins, AM; O'Doherty, CE; Proudman, SM; Spargo, LD; Suppiah, V; Upton, RN; Wiese, MD	1
Choe, JY; Kim, SK	1
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Cui, Y; Luo, rQ; Yao, RY; Zhang, X; Zhou, H	1
Bilgici, A; Celenk, C; Kuru, O; Ulusoy, H	1
Agrawal, N; Eisen, GM; Goldstein, JL; Kent, JD; Stenson, WF; Verburg, KM	1
Brouwers, JR; Houtman, PM; Jansen, TL; Janssen, M; Keuper, R; van de Laar, MA; van Roon, EN; Yska, JP	1
Chikkamuniyappa, S	1
Edwards, JE; McQuay, HJ; Moore, AR	1
Emery, P; Suarez-Almazor, M	1
Andreev, SA; Batalov, AZ; Kuzmanova, SI; Russafov, PB; Solakov, PT; Staikova, ND	1
Cannon, GW; Dai, W; Holden, WL; Juhaeri, J; Scarazzini, L; Stang, P	1
Gan, BS; Harth, M; Lazarescu, A; Macdonald, J; Zhong, T	1
Chary-Valckenaere, I; Laborde, F; Loeuille, D	1
Armijo, JA; Gonzalez-Vilchez, F; Martinez-Taboada, VM; Rodriguez-Valverde, V	1
Kellner, H	1
Vandooren, AK; Verschueren, P; Westhovens, R	1
Dijkmans, BA; Jansen, G	1
Oliushin, IuA	1
Issa, SN; Ruderman, EM	1
Bingham, SJ; Buch, MH; Emery, P; Kerr, MA; Valadäo Barcelos, AT	1
Hartman, M; Laan, RF; Severens, JL; van Riel, PL; Welsing, PM	1
Creemers, MC; Flendrie, M; van Riel, PL; Welsing, PM	1
Kiely, PD	1
Ito, S; Sumida, T	1
Haneda, K; Iwamoto, M; Kamata, Y; Kamimura, T; Masuyama, J; Minota, S; Nara, H; Okazaki, H	1
Kiely, P; Kirkham, B; Lawson, T; Maddison, P; Moots, R; Proudfoot, D; Reece, R; Scott, D; Sword, R; Taggart, A; Thwaites, C; Williams, E	1
Large, SR; Ong, SL; Thomasset, SC	1
Jaeger, C; Jappe, U	1
Capriotti, T	1
Eisen, GM; Goldstein, JL; Hanna, DB; Rublee, DA	1
Dissemond, J; Goos, M; Knab, J	1
Berthelot, JM; de Quatrebarbes, J; Goëb, V; Joly, P; Le Loët, X; Mejjad, O; Reynaud-Hautin, C; Vittecoq, O	1
Lioté, H	1
Bégaud, B; Bentaberry, F; Dehais, J; Dumoulin, C; Haramburu, F; Lifermann, F; Longy-Boursier, M; Martin, K; Moore, N; Schaeverbeke, T	1
Bolten, W; Krüger, K	1
Ochi, T	1
Kawabata, D; Mimori, T	1
Nakajima, A; Yamanaka, H	1
Sugii, S	1
Cannon, GW; Crawford, B; Emery, P; Kalden, JR; Scott, DL; Smolen, JS; Strand, V; Tugwell, P	1
Amara, I; Koch, GG; Pincus, T	1
Bambery, P; Govindrajan, S; Khullar, M; Reddy, SV; Wanchu, A	1
Goldstein, JL; Mayne, TJ; Rabeneck, L; Rublee, DA; Vu, A	1
Fath, R	1
Burmester, GR	1
Derk, CT	1
Furst, DE; Ranganath, VK	2
Behrens, F; Kaltwasser, JP	1
Adachi, D; Akiba, H; Akiyama, Y; Hirano, M; Mimura, T; Takeishi, M	1
Ben Amor, G; Ben Miled, M; Ben Rhouma, S; Boussema, F; Chérif, O; Daoud, L; Kochbati, S; Ktari, S; Rokbani, L	1
Hochberg, MC	1
Balabanova, RM; Oliunin, IuA	1
Brodetskaia, KA; Chichasova, NV; Igolkina, EV; Imametdinova, GR	1
Hartmann, JT; Kanz, L; Kopp, HG; Moerike, K	1
Alvaro-Gracia, JM; Antoni, C; Combe, B; Emery, P; Kalden, JR; Kremer, JM; Smolen, JS; Strand, CV; Van Riel, P	1
Beneytout, JL; Bertin, P; Léger, DY; Liagre, B; Trèves, R; Vergne-Salle, P	1
Chan, V; Charles, BG; Tett, SE	1
Bernelot Moens, HJ; Brouwers, JR; Hoekstra, M; Jansen, TL; Tobi, H; van de Laar, MA; van Roon, EN	1
Gómez Rodríguez, N; Zulaica Garate, A	1
Urushibara, M	1
Balsa Criado, A; Cobo Ibáñez, T; Hernández Sanz, A; Martín Mola, E; Yehia Tayel, M	1
Cohen, SB; Dorrier, C; Elashoff, D; Emery, P; Furst, DE; Khanna, D; Park, GS; Paulus, HE; Simpson, KM	1
Balbir-Gurman, A; Guralnik, L; Keidar, Z; Nahir, AM; Rozenbaum, M; Rozin, A; Vlodavsky, E; Yigla, M	1
David-Bajar, KM; Elias, AR; Tam, CC	1
Capellino, S; Cutolo, M; Montagna, P; Seriolo, B; Sulli, A; Villaggio, B	1
Antoine, JC; Camu, W; Coudeyre, E; Gabelle, A; Hillaire-Buys, D	1
Michaud, K; Wolfe, F	1
Erzen, D; Hocevar, A; Lestan, B; Petric, V; Praprotnik, S; Rozman, B; Tomsic, M	1
Gupta, R; Gupta, SK	1
Andel, I; Leeb, BF; Rintelen, B; Sautner, J	1
Caplan, L; Michaud, K; Wolfe, F	1
Caspi, D; Elkayam, O; Kaufman, I; Levartovsky, D; Litinsky, I; Paran, D; Wigler, I; Yaron, I; Yaron, M	1
D'Amore, M; D'Amore, S; Minenna, G	1
Boyd, IW; Chapman, P; Highton, J; Savage, RL	1
Andrianakos, A; Antoniades, C; Charalambopoulos, D; Karanikolas, G; Katsilambros, N	1
Abruzzese, T; Aicher, WK; Alexander, D; Friedrich, B; Gondolph-Zink, B; Wülker, N	1
Hanna, FY	1
Jakob, A; Porstmann, R; Rompel, R	1
Ernst, P; Hudson, M; Suissa, S	1
Brocq, O; Cantagrel, A; Combe, B; Debiais, F; Deslandre, CJ; Kara-Terki, R; Kuntz, JL; Loet, XL; Mariette, X; Pavy, S; Perdriger, A	1
Brown, MT; Kivitz, AJ; Verburg, KM; Williams, GW	1
Liu, Y; Zhao, YX	1
De Keyser, F; De Rycke, L; Dendooven, A; Mielants, H; Verhelst, X; Veys, EM	1
Chonlahan, J; Halloran, MA; Hammonds, A	1
Aneja, R; Arya, V; Dhir, V; Galle, A; Grover, R; Kumar, A; Marwaha, V	1
Baumgärtel, K; Fuerst, M; Möhl, H; Rüther, W	1
Hirabayashi, Y; Kobayashi, N; Kudo, K; Shimizu, H	1
Bentaberry, F; Dehais, J; Dumoulin, C; Haramburu, F; Martin, K; Miremont-Salamé, G; Schaeverbeke, T	1
Antony, T; Jose, VM; Paul, BJ; Thomas, T	1
Bernatsky, S; Hudson, M; Suissa, S	1
Aleksandrova, EN; Balabanova, RM; Kashevarov, RIu; Oliunin, IuA; Smirnov, AV	1
Brazier, M; Clayssens, S; Daragon, A; Jouen, F; Klemmer, N; Le Loët, X; Lequerré, T; Mejjad, O; Ménard, JF; Tron, F; Vittecoq, O	1
Miller, R; Wardwell, NR; Ware, LB	1
Resman-Targoff, BH	1
Dimitrova, P; Ivanovska, N	1
Hagiyama, H; Harigai, M; Iwai, H; Miyasaka, N; Mizoguchi, F; Ochi, S; Oka, T	1
Combe, B	1
Hamamatsu, Y; Hitomi, K; Izaki, S; Sato, Y; Teraki, Y	1
Blanco, LP; Castro, JS; Chirinos, E; Esteva, MH; González, M; Granados, Y; Macgregor, EG; Marín, F; Mundaraín, L; Rodríguez, MA; Rosas, A; Sánchez, G; Sanoja, G; Snih, SA; Tristano, A; Zambrano-Marín, G	1
Kermode, AG; Kho, LK	1
Guerne, PA; Magne, D; Mézin, F; Palmer, G	1
Balakrishnan, C; Dasgupta, B	1
Berthelot, JM; Cantagrel, A; Combe, B; de Bandt, M; Fautrel, B; Flipo, RM; Guillemin, F; Le Loët, X; Lioté, F; Maillefert, JF; Meyer, O; Saraux, A; Wendling, D	1
Bleasel, JF; McGill, N; Richards, BL; Richards, GW; Spies, J; Vaile, J; Youssef, PP	1
Jakubicz, D; Wisłowska, M	1
Agrawal, S; Sharma, A	1
Allaart, CF; Breedveld, FC; de Vries-Bouwstra, JK; Dijkmans, BA; Gerards, AH; Goekoop-Ruiterman, YP; Hazes, JM; Kerstens, PJ; van der Kooij, SM; van Groenendael, JH; van Zeben, D	1
Aletaha, D; Kapral, T; Schoels, M; Smolen, JS; Stamm, T	1
Saito, E; Suwa, A; Suzuki, Y; Wakabayashi, T	1
Fiehn, C; Gao, I; Heilig, B; Jacki, S; Lampe, M; Richter, C; Rochel, E; Röther, E; Wiesmüller, G	1
Tłustochowicz, W	1
Choe, JY; Chung, SH; Ju, JH; Kim, HY; Kim, SI; Lee, J; Lee, JH; Lee, SI; Lee, SS; Lee, YH; Park, SH; Yoo, WH; Yoon, CH; Yoon, HJ	1
Innes, JA; Lambert, CM; Martin, N; Turnbull, CM; Wallace, WA	1
Matsuda, T; Ohtsubo, H	1
Suka, M; Yoshida, K	1
Assisi, A; Bertele', V; Di Muzio, V; Garattini, S; Renzo, D	1
Berger, M; Fiechtner, J; Gibofsky, A; Pan, S; Rodrigues, J	1
Wang, HJ; Wang, JP; Zhang, JH	1
Chambers, C; Johnson, D; Jones, KL; Koren, G; Tutuncu, ZN	1
Bachta, A; Dudek, A; Raczkiewicz-Papierska, A; Sułek, M; Tłustochowicz, M; Zawadyl, B	1
DeGroot, J; Hanemaaijer, R; Huizinga, TW; Kraan, MC; Tchetverikov, I; van El, B	1
Löwe, SH; Smeets, JG; Veraart, JC	1
Kingetsu, I; Kurosaka, D; Toyokawa, Y; Yamada, A; Yasuda, C; Yasuda, J; Yoshida, K	1
Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK	1
Bingham, CO; Miner, MM	1
Nakayamada, S; Ra, C; Saito, K; Sawamukai, N; Tanaka, Y; Yamaoka, K	1
Borm, GF; Fransen, J; Lemmens, WA	1
Akkoc, N; Dalkilic, E; Direskeneli, H; Duymaz-Tozkir, J; Erken, E; Fresko, I; Inanc, M; Inanc, N; Karaaslan, Y; Kinikli, G; Konice, M; Oksel, F; Pay, S; Saruhan-Direskeneli, G; Yazici, H; Yentür, SP; Yilmaz, V; Yucel, E	1
Harada, M; Inokuma, S; Koyama, T; Niiro, H; Ohtani, R; Otsuka, T; Yoshizawa, S	1
Dehler, S; Finckh, A; Gabay, C	1
Carloni, A; Giannakakis, K; Nori, G; Piciucchi, S; Poletti, V; Zobel, BB	1
Kaliterna, DM	1
Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M	1
Beuers, U; Budenhofer, U; Kremer, AE; Rust, C	1
Chopra, A; Lagu-Joshi, V; Saluja, M; Sarmukadam, S	1
Bohanec Grabar, P; Dolzan, V; Logar, D; Rozman, B; Suput, D; Tomsic, M	1
Campion, G; Dimitrijevic, M; Domljan, Z; Dordevic, J; Jajic, I; Mihajlovic, D; Mladenovic, V; Popovic, M; Rozman, B; Zivkovic, M	1
Jevtic, V; Presetnik, M; Rozman, B; Watt, I	1
Furst, DE	2
Bartlett, RR; Dimitrijevic, M	2
Bartlett, RR; Brendel, S; Schorlemmer, HU; Zielinski, T	1
Morris, RE; Silva Júnior, HT	1
Fox, RI	1
Rozman, B	2
Achsel, T; Kirschbaum, B; Laggerbauer, B; Lührmann, R; Müllner, S; Ortlepp, D	1
Pisetsky, D	1
Dimitrijevic, M; Glisic, B; Obradovic, S; Pejnovic, N; Popovic, M; Popovic, R; Stefanovic, D	1
Bartlett, RR; Schleyerbach, R; Schorlemmer, HU	1
Kalden, JR; Kvien, TK; Larsen, A; Loew-Friedrich, I; Oed, C; Rosenburg, R; Rozman, B; Scott, DL; Smolen, JS	1
Robb-Nicholson, C	1
Cherin, P	1
Robinson, DR	1
Badii, M	1
Bruyn, GA; Griep, EN; Korff, KJ	1
De Vita, S; Ferraccioli, GF	1
Arriola, ER; Lee, NP	1
Byrne, VM; Coblyn, JS; Helfgott, SM; Kaymakcian, MV; Kremer, JM; Maier, AL; Morrell, M; Strand, V; Weinblatt, ME	1
Yocum, DE	1
Bombardier, C; Crawford, B; Dorrier, C; Maetzel, A; Strand, V; Thompson, A; Tugwell, P; Wells, G	2
Fye, KH	1
Caldwell, J; Cannon, G; Cohen, S; Fleischmann, R; Fox, R; Furst, D; Hurley, F; Kaine, J; Loew-Friedrich, I; Moreland, L; Olsen, N; Schiff, M; Sharp, J; Strand, V; Weaver, A	1
Fox, RI; Frangou, CG; Herrmann, ML; Kirschbaum, BJ; Morris, RE; Strand, V; Wahl, GM	1
Kremer, JM; Olsen, NJ; Strand, V	1
Jarvis, B; Prakash, A	1
Breedveld, FC	2
Bartlett, RR; Kurrle, R; Schleyerbach, R; Schorlemmer, HU	1
Emery, P	2
Smolen, JS	1
Schiff, MH	1
Megeff, C; Schuna, AA	1
Strand, V	1
Kalden, JR	1
Hurley, F; Leung, H; Loew-Friedrich, I; Sharp, JT; Strand, V	1
Infante, R; Lahita, RG	1
Moder, KG	1
Chong, BS; Lowder, DM; Luong, BT	1
Herrmann, ML; Kirschbaum, BJ; Schleyerbach, R	1
Schattenkirchner, M	2
Bjorneboe, O; Breedveld, FC; Dahl, R; Dawes, PT; Emery, P; Gömör, B; Horslev-Petersen, K; Kaltwasser, JP; Lemmel, EM; Loew-Friedrich, I; Molloy, M; Nordström, D; Oed, C; Rodriguez De La Serna, A; Rosenburg, R; Tikly, M; Van Den Bosch, F	1
Goldenberg, MM	1
Carreño Pérez, L; González Fernández, CM; López Longo, FJ; Monteagudo Sáez, I	1
Breedveld, FC; de Koster, BM; Elferink, JG; Kraan, MC; Post, WJ; Tak, PP	1
Emery, P; Graninger, WB; Smolen, JS	1
Simon, LS	1
Naranjo Hernández, A	1
Barg, EC; Breedveld, FC; Emery, P; Farnell, J; Kraan, MC; Reece, RJ; Rosenburg, R; Smeets, TJ; Tak, PP; Veale, DJ	1
Dudler, M; So, A	1
Debroe, S; Hewitson, PJ; McBride, A; Milne, R	1
Allinger, S; Auer, J; Hinterreiter, M; Kirchgatterer, A; Knoflach, P	1
Simon, LS; Yocum, D	1
Emery, P; Smolen, JS	1
Andresen, PN; Hansen, G; Hørslev-Petersen, K	1
Breedveld, FC; Dayer, JM	1
Dixon, JA; Falchuk, KR; Weinblatt, ME	1
Mikuls, T; Moreland, L	1
Dahlager, J; Gam, AN; Horn, T; Kemp, E; Larsen, S; Nielsen, H; Olsen, S; Petersen, LJ	1
Davis, JS; Genovese, MC	1
Khan, W; Talip, F; Walker, N; Zimmermann, B	1
Laan, RF; van de Putte, LB; van Riel, PL	1
Alldred, A; Emery, P	1
Koren, G; Kozer, E; Moretti, ME	1
Coblyn, JS; Helfgott, S; Shadick, N	1
O'Dell, JR	1
Wolfe, F	1
Koh, ET	1
O'Dell, J	1
Kvien, TK; Larsen, A; Oed, C; Rau, R; Rosenburg, R; Rozman, B; Schattenkirchner, M; Scott, DL; Smolen, JS; Tikly, M; Westhovens, R	1
Petersson, I; Ringertz, B	1
Wasko, MC; Wildy, KS	1
Kucharz, EJ	1
Hughes, LB; Moreland, LW	1
Hu, Y; Liu, P; Tu, S	1
Jones, P; Kalden, JR; Kvien, TK; Oed, C; Rosenburg, R; Rozman, B; Schattenkirchner, M; Scott, DL; Smolen, JS; Williams, BD; Williams, RB	1
Hiida, M; Hoshi, K	1
Kalden, JR; Kvien, TK; Larsen, A; Loew-Friedrich, I; Nash, P; Oed, C; Schattenkirchner, M; Scott, DL; Smolen, JS; van de Putte, LB	1
Caldwell, J; Cannon, GW; Cohen, S; Fox, R; Furst, D; Kaine, J; Moreland, L; Olsen, N; Schiff, M; Sharp, J; Strand, V; Weaver, A	1
Cummins, G; Doyle, J; McLaughlin, T; Yazdani, C	1
Balslev, E; Holm, EA; Jemec, GB	1
Doyle, JJ	1
Calabrese, DC; Cannon, E; Casberg, JJ; Coleman, IC; Florentine, MJ; Harris, MR; Konop, R; Maves, TK; Meske, L; Orland, BI; Southwell, Y; Yoder, DM	1
Pisetsky, DS; St Clair, EW	1
Beaman, JM; Hackett, LP; Illett, KF; Luxton, G	1
Kaplan, MJ	1
Breedveld, FC; Emery, P; Gibbon, WW; Kraan, MC; O'Connor, PJ; Radjenovic, A; Reece, RJ; Ridgway, JP; Tak, PP; Veale, DJ	1
Johnsen, V; Kvien, TK; Rødevand, E	1
Flores, RH; Hochberg, MC; Tracy, JK	1
Aringer, M; Graninger, WB	1
Drosos, AA	1
Capell, HA; Madhok, R; McCarey, DW	1
Chambers, CD; Johnson, DL; Lyons Jones, K	1
Konttinen, YT; Nordström, DC	1
Wendling, D	1
Harisdangkul, V; Sanders, S	1
Accetto, R; Dolenc, P; Hojnik, M; Kos-Golja, M; Logar, D; Praprotnik, S; Rozman, B; Tomsic, M	1
Doyle, J; Huse, DM; Ollendorf, DA; Peterson, AN	1
McCoy, CM	1
Johnson, DM; Kiely, PD	1
Burgardt, C	1
Gromnica-Ihle, E; Reinhold-Keller, E	1
Choi, HK; Kuntz, KM; Seeger, JD	1
Jakez-Ocampo, J; Llorente, L; Richaud-Patin, Y; Simón, JA	1

Reviews

149 review(s) available for isoxazoles and Rheumatoid Arthritis

Article	Year
Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2 Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; 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Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea	2022
[Perioperative management of immunosuppressive treatment in patients undergoing joint surgery]. Zeitschrift fur Rheumatologie, 2017, Volume: 76, Issue:9 Topics: Adrenal Cortex Hormones; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Biological Products; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Perioperative Care; Risk Factors; Sulfasalazine; Surgical Wound Infection; Wound Healing	2017
Comparative efficacy and tolerability of monotherapy with leflunomide or tacrolimus for the treatment of rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials. Clinical rheumatology, 2018, Volume: 37, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Bendamustine Hydrochloride; Humans; Isoxazoles; Leflunomide; Network Meta-Analysis; Randomized Controlled Trials as Topic; Tacrolimus	2018
Valdecoxib : the rise and fall of a COX-2 inhibitor. Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:8 Topics: Animals; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Osteoarthritis; Sulfonamides; Treatment Outcome	2013
Safety evaluation of leflunomide in rheumatoid arthritis. Expert opinion on drug safety, 2013, Volume: 12, Issue:4 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Isoxazoles; Leflunomide	2013
Lung involvement and drug-induced lung disease in patients with rheumatoid arthritis. Expert review of clinical immunology, 2013, Volume: 9, Issue:7 Topics: Antibodies, Blocking; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Methotrexate; Patient Education as Topic; Rituximab; Tumor Necrosis Factor-alpha	2013
[Alopecia areata secondary to the use of leflunomide in patients with rheumatoid arthritis: a case report and literature review]. Medwave, 2015, Dec-30, Volume: 15, Issue:11 Topics: Adult; Alopecia Areata; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide	2015
Leflunomide Use and Risk of Lung Disease in Rheumatoid Arthritis: A Systematic Literature Review and Metaanalysis of Randomized Controlled Trials. The Journal of rheumatology, 2016, Volume: 43, Issue:5 Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases; Randomized Controlled Trials as Topic; Risk	2016
Challenges and treatment options for rheumatoid arthritis during pregnancy. Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:11 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Sulfasalazine; Treatment Outcome	2016
Diffuse alveolar damage in a patient with rheumatoid arthritis under prolonged leflunomide treatment: A Case Report and Literature Review. Medicine, 2016, Volume: 95, Issue:26 Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Pulmonary Alveoli; Time Factors	2016
Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs. British journal of clinical pharmacology, 2008, Volume: 66, Issue:2 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Quality of Life; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2008
DMARDS and infections in rheumatoid arthritis. Autoimmunity reviews, 2008, Volume: 8, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infections; Isoxazoles; Leflunomide; Methotrexate; Risk Factors	2008
[The efficacy and safety of the combination of leflunomide (Arava) and biological agents in treatment of rheumatoid arthritis]. Reumatizam, 2008, Volume: 55, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide	2008
[Antirheumatic agents for treatment of rheumatoid arthritis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2008, Oct-10, Volume: 97, Issue:10 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Pharmacogenetics; Randomized Controlled Trials as Topic; Remission Induction; Sulfasalazine; Time Factors	2008
[New ways in the management of rheumatoid arthritis in Hungary]. Lege artis medicinae : uj magyar orvosi hirmondo, 2007, Volume: 17, Issue:10 Topics: Abatacept; Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Azathioprine; Chloroquine; Cyclophosphamide; Cyclosporine; Diagnosis, Differential; Early Diagnosis; Etanercept; Humans; Hungary; Immunoconjugates; Immunoglobulin G; Immunologic Factors; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prognosis; Receptors, Tumor Necrosis Factor; Rituximab; Sulfasalazine; Tumor Necrosis Factor-alpha	2007
[Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis]. Clinical calcium, 2009, Volume: 19, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Disease Progression; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Penicillamine; Radiography; Randomized Controlled Trials as Topic; Sulfasalazine; Tacrolimus	2009
Clinical expression of leflunomide-induced pneumonitis. Rheumatology (Oxford, England), 2009, Volume: 48, Issue:9 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Pneumonia; Retrospective Studies; Tomography, X-Ray Computed	2009
Management of RA medications in pregnant patients. Nature reviews. Rheumatology, 2009, Volume: 5, Issue:7 Topics: Abatacept; Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Contraindications; Cyclosporine; Female; Gestational Age; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Rituximab; Sulfasalazine; Young Adult	2009
[Rituximab treatment of rheumatoid arthritis: new evidence]. Terapevticheskii arkhiv, 2009, Volume: 81, Issue:6 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide; Methotrexate; Rituximab	2009
Recurrent pneumothorax associated with pulmonary nodules after leflunomide therapy in rheumatoid arthritis: a case report and review of the literature. Rheumatology international, 2011, Volume: 31, Issue:7 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Multiple Pulmonary Nodules; Pneumothorax; Radiography; Recurrence	2011
Benefit-risk assessment of leflunomide: an appraisal of leflunomide in rheumatoid arthritis 10 years after licensing. Drug safety, 2009, Volume: 32, Issue:12 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Liver; Lung Diseases, Interstitial; Risk Assessment	2009
[Referring to an unusual case: pulmonary affection and rheumatoid arthritis]. Revue medicale suisse, 2009, Nov-11, Volume: 5, Issue:225 Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Dyspnea; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases; Middle Aged; Pleural Diseases; Pleurodesis; Pneumothorax; Pulmonary Emphysema; Radiography, Thoracic; Recurrence; Tetracycline; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2009
Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature. Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Rheumatoid; Etoricoxib; Female; Gram-Positive Bacterial Infections; Humans; Isoxazoles; Leflunomide; Leg; Leg Ulcer; Male; Methotrexate; Middle Aged; Prednisolone; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Retrospective Studies; Risk Factors; Sulfones	2010
New-onset psoriasis associated with etanercept therapy. The Journal of dermatology, 2010, Volume: 37, Issue:4 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Prednisolone; Psoriasis; Receptors, Tumor Necrosis Factor; Spondylitis, Ankylosing; Sulfasalazine; Tumor Necrosis Factor-alpha	2010
Pregnancy course and neonatal outcome after exposure to leflunomide--2 cases report and review of literature. Przeglad lekarski, 2009, Volume: 66, Issue:12 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Infant, Newborn; Isoxazoles; Leflunomide; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prenatal Exposure Delayed Effects	2009
Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases. Arzneimittel-Forschung, 2011, Volume: 61, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Autoimmune Diseases; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Humans; Inflammation; Isoxazoles; Leflunomide; Oxidoreductases Acting on CH-CH Group Donors; Randomized Controlled Trials as Topic; Structure-Activity Relationship	2011
Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011? Current opinion in rheumatology, 2011, Volume: 23, Issue:3 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha	2011
Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses. Current opinion in rheumatology, 2011, Volume: 23, Issue:3 Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Intercellular Adhesion Molecule-1; Isoxazoles; Leflunomide; Liver; Lung Diseases; Lymphocyte Function-Associated Antigen-1; Methotrexate; Neoplasms; Pharmacogenetics; Rituximab; Tumor Necrosis Factor-alpha	2011
[Systemic autoimmune disorders and pregnancy]. Orvosi hetilap, 2011, Oct-23, Volume: 152, Issue:43 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Administration Schedule; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Remission Induction; Sjogren's Syndrome; Sulfasalazine; Teratogens; Tumor Necrosis Factor-alpha	2011
[Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2011, Oct-10, Volume: 100, Issue:10 Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Molecular Targeted Therapy; Ribonucleosides	2011
Progressive multifocal leukoencephalopathy in autoimmune diseases. Joint bone spine, 2012, Volume: 79, Issue:4 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Comorbidity; Drug Therapy, Combination; Glucocorticoids; Humans; Infliximab; Isoxazoles; JC Virus; Leflunomide; Leukoencephalopathy, Progressive Multifocal; Lupus Erythematosus, Systemic; Rituximab; Virus Activation	2012
[ Bone and cartilage destruction in RA and its intervention. Disease-modifying antirheumatic drugs]. Clinical calcium, 2012, Volume: 22, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Cartilage; Clinical Trials as Topic; Cysteine; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Sulfasalazine; Tacrolimus	2012
Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials. Polskie Archiwum Medycyny Wewnetrznej, 2012, Volume: 122, Issue:1-2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome	2012
[Off-label therapy of rheumatoid arthritis and spondyloarthritis]. Zeitschrift fur Rheumatologie, 2012, Volume: 71, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Dose-Response Relationship, Drug; Drug Approval; Drug Costs; Drug Therapy, Combination; Germany; Humans; Insurance, Pharmaceutical Services; Isoxazoles; Leflunomide; Methotrexate; National Health Programs; Off-Label Use; Reimbursement Mechanisms; Spondylarthritis; Treatment Outcome; Tumor Necrosis Factor-alpha	2012
My treatment approach to rheumatoid arthritis. Mayo Clinic proceedings, 2012, Volume: 87, Issue:7 Topics: Abatacept; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Comorbidity; Diagnosis, Differential; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Immunoconjugates; Isoxazoles; Joints; Leflunomide; Methotrexate; Prednisone; Prognosis; Quality of Life; Randomized Controlled Trials as Topic; Referral and Consultation; Remission Induction; Rituximab; Severity of Illness Index; Sulfasalazine; Synovitis; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2012
Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis. Drugs, 2002, Volume: 62, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Hypertension; Isoenzymes; Isoxazoles; Leflunomide; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Risk Assessment; Tumor Necrosis Factor-alpha	2002
Severe skin reaction after leflunomide and etanercept in a patient with rheumatoid arthritis. Annals of the rheumatic diseases, 2002, Volume: 61, Issue:9 Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Erythema; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Pyrimidines; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha	2002
Valdecoxib. Reviews in gastroenterological disorders, 2002,Summer, Volume: 2, Issue:3 Topics: Arthritis, Rheumatoid; Cyclooxygenase 2; Enzyme Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sulfonamides	2002
[Gastrointestinal side effects in the therapy of rheumatologic diseases]. Zeitschrift fur Gastroenterologie, 2002, Volume: 40, Issue:11 Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Etanercept; Gastrointestinal Diseases; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Rheumatic Diseases; Stomach Ulcer; Sulfasalazine; Tumor Necrosis Factor-alpha	2002
[Efficacy of leflunomide]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:12 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Double-Blind Method; Humans; Isoxazoles; Leflunomide; Liver Diseases; Methotrexate; Mice; Sulfasalazine	2002
Leflunomide for treating rheumatoid arthritis. The Cochrane database of systematic reviews, 2003, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine	2003
Review article: The pharmacological properties and clinical use of valdecoxib, a new cyclo-oxygenase-2-selective inhibitor. Alimentary pharmacology & therapeutics, 2003, Feb-15, Volume: 17, Issue:4 Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Availability; Bone Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Dysmenorrhea; Female; Humans; Isoenzymes; Isoxazoles; Liver Diseases; Male; Membrane Proteins; Middle Aged; Mouth Diseases; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides	2003
Leflunomide. International journal of clinical practice, 2003, Volume: 57, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Product Surveillance, Postmarketing; Treatment Outcome	2003
Leflunomide for the treatment of rheumatoid arthritis. Expert opinion on pharmacotherapy, 2003, Volume: 4, Issue:6 Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Contraindications; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Practice Guidelines as Topic	2003
Leflunomide for the treatment of rheumatoid arthritis: a systematic review and metaanalysis. The Journal of rheumatology, 2003, Volume: 30, Issue:6 Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Randomized Controlled Trials as Topic	2003
Interpreting radiographic data in rheumatoid arthritis. Annals of the rheumatic diseases, 2003, Volume: 62, Issue:7 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Etanercept; Humans; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sialoglycoproteins; Treatment Outcome	2003
Valdecoxib: a review. Clinical therapeutics, 2003, Volume: 25, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Dysmenorrhea; Enzyme Inhibitors; Female; Humans; Isoxazoles; Male; Osteoarthritis; Pain, Postoperative; Sulfonamides; Treatment Outcome	2003
T-cell-activation inhibitors in rheumatoid arthritis. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2003, Volume: 17, Issue:4 Topics: Abatacept; Adjuvants, Immunologic; Arthritis, Rheumatoid; Double-Blind Method; Humans; Immunoconjugates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Signal Transduction; T-Lymphocytes	2003
[Current concepts of pharmacotherapy in rheumatoid arthritis]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:7 Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Cyclophosphamide; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Feasibility Studies; Female; Glucocorticoids; Humans; Ibuprofen; Immunosuppressive Agents; Isoxazoles; Ketoprofen; Leflunomide; Male; Methotrexate; Prednisolone; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Sulfasalazine; Time Factors	2003
[New drugs and treatment strategies for rheumatoid arthritis]. Recenti progressi in medicina, 2003, Volume: 94, Issue:9 Topics: Adalimumab; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Etanercept; Follow-Up Studies; Humans; Immunoglobulin G; Immunologic Factors; Infliximab; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoxazoles; Leflunomide; Middle Aged; Multicenter Studies as Topic; Placebos; Randomized Controlled Trials as Topic; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Time Factors; Tumor Necrosis Factor-alpha	2003
Is leflunomide as safe and effective in the treatment of rheumatoid arthritis as other DMARDs? American family physician, 2003, Sep-01, Volume: 68, Issue:5 Topics: Adjuvants, Immunologic; Antirheumatic Agents; Arthritis, Rheumatoid; Evidence-Based Medicine; Humans; Isoxazoles; Leflunomide; Practice Guidelines as Topic	2003
[Emergence of new therapeutic agents for collagen diseases and some of the problems]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2003, Oct-10, Volume: 92, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Approval; Drug Costs; Drug Design; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Tacrolimus	2003
[Clinical pharmacology of the selective COX-2 inhibitors]. Der Orthopade, 2003, Volume: 32, Issue:12 Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones	2003
Newer approaches to the treatment of rheumatoid arthritis. WMJ : official publication of the State Medical Society of Wisconsin, 2003, Volume: 102, Issue:7 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor	2003
[Collagen diseases and rheumatic diseases]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Mar-10, Volume: 93, Issue:3 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Drug Therapy, Combination; Genes, T-Cell Receptor delta; Humans; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Lymphocytes; Methotrexate; Prednisolone; Prognosis; Tumor Necrosis Factor-alpha	2004
New drugs for rheumatoid arthritis. The New England journal of medicine, 2004, May-20, Volume: 350, Issue:21 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Pregnancy; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Tumor Necrosis Factor-alpha	2004
Valdecoxib: a review of its use in the management of osteoarthritis, rheumatoid arthritis, dysmenorrhoea and acute pain. Drugs, 2004, Volume: 64, Issue:11 Topics: Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Drug Interactions; Dysmenorrhea; Female; Half-Life; Humans; Intestinal Absorption; Isoxazoles; Male; Osteoarthritis; Pain, Postoperative; Randomized Controlled Trials as Topic; Sulfonamides; Tissue Distribution; Treatment Outcome	2004
The efficacy of leflunomide monotherapy in rheumatoid arthritis: towards the goals of disease modifying antirheumatic drug therapy. The Journal of rheumatology. Supplement, 2004, Volume: 71 Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Maximum Tolerated Dose; Risk Factors; Severity of Illness Index; Treatment Outcome	2004
Leflunomide: a manageable safety profile. The Journal of rheumatology. Supplement, 2004, Volume: 71 Topics: Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Maximum Tolerated Dose; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Risk Assessment; Treatment Outcome	2004
Lefunomide in combination therapy. The Journal of rheumatology. Supplement, 2004, Volume: 71 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Randomized Controlled Trials as Topic; Risk Factors; Sulfasalazine; Treatment Outcome	2004
What I would like to know about leflunomide. The Journal of rheumatology, 2004, Volume: 31, Issue:6 Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide	2004
Safety overview of new disease-modifying antirheumatic drugs. Rheumatic diseases clinics of North America, 2004, Volume: 30, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Isoxazoles; Leflunomide; Treatment Outcome	2004
Overview of radiologic efficacy of new treatments. Rheumatic diseases clinics of North America, 2004, Volume: 30, Issue:2 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Progression; Etanercept; Humans; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sialoglycoproteins; Treatment Outcome	2004
Leflunomide. Rheumatic diseases clinics of North America, 2004, Volume: 30, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Monitoring; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Joints; Leflunomide; Liver; Methotrexate; Models, Animal	2004
[Diagnosis and therapy of rheumatoid arthritis]. Deutsche medizinische Wochenschrift (1946), 2004, Jun-04, Volume: 129, Issue:23 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty; Cyclooxygenase Inhibitors; Cyclosporine; Drug Therapy, Combination; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Methotrexate; Rheumatoid Factor; Sulfasalazine	2004
[Valdecoxib (Bextra)]. Revue medicale de Liege, 2004, Volume: 59, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Isoxazoles; Osteoarthritis; Pain, Postoperative; Prodrugs; Sulfonamides	2004
Leflunomide in the treatment of rheumatoid arthritis. Clinical therapeutics, 2004, Volume: 26, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Dihydroorotate Dehydrogenase; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Oxidoreductases Acting on CH-CH Group Donors; Protein-Tyrosine Kinases	2004
Reduced incidence of upper gastrointestinal ulcer complications with the COX-2 selective inhibitor, valdecoxib. Alimentary pharmacology & therapeutics, 2004, Sep-01, Volume: 20, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Multicenter Studies as Topic; Osteoarthritis; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Randomized Controlled Trials as Topic; Sulfonamides	2004
Efficacy and safety of valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. Pain, 2004, Volume: 111, Issue:3 Topics: Arthritis, Rheumatoid; Humans; Isoxazoles; Osteoarthritis; Randomized Controlled Trials as Topic; Sulfonamides	2004
Rheumatoid arthritis. Clinical evidence, 2003, Issue:9 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine	2003
Antimetabolites in the treatment of arthritis: current status of the use of antimetabolites. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Antimetabolites; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Methotrexate; Time Factors	2004
[Basic therapy of rheumatoid arthritis with leflunomide (review)]. Terapevticheskii arkhiv, 2004, Volume: 76, Issue:10 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Rats	2004
Damage control in rheumatoid arthritis. Hard-hitting, early treatment is crucial to curbing joint destruction. Postgraduate medicine, 2004, Volume: 116, Issue:5 Topics: Arthritis, Rheumatoid; Azathioprine; Disease Progression; Humans; Hydroxychloroquine; Immunologic Factors; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2004
The broadening use of leflunomide in clinical practice. Hospital medicine (London, England : 1998), 2004, Volume: 65, Issue:12 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide	2004
Leflunomide in rheumatoid arthritis: recommendations through a process of consensus. Rheumatology (Oxford, England), 2005, Volume: 44, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Tolerance; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Patient Compliance; Professional-Patient Relations	2005
The 'alphabet' of rheumatoid arthritis treatment. Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 2004, Volume: 13, Issue:6 Topics: Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arachidonic Acid; Arthritis, Rheumatoid; Cyclooxygenase 1; Cyclooxygenase 2; Drug Monitoring; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoxazoles; Leflunomide; Membrane Proteins; Methotrexate; Nurse's Role; Nursing Assessment; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor; Rituximab; Sialoglycoproteins; T-Lymphocytes; Tumor Necrosis Factor-alpha	2004
Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis. Alimentary pharmacology & therapeutics, 2005, Mar-01, Volume: 21, Issue:5 Topics: Abdominal Pain; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Dyspepsia; Female; Humans; Isoxazoles; Male; Middle Aged; Nausea; Osteoarthritis; Randomized Controlled Trials as Topic; Sulfonamides	2005
[Respiratory complications of new treatments for rheumatoid arthritis]. Revue des maladies respiratoires, 2004, Volume: 21, Issue:6 Pt 1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases; Methotrexate; Respiratory Tract Infections; Tumor Necrosis Factor-alpha	2004
[Guidelines for RA therapies]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Japan; Leflunomide; Methotrexate; Orthopedic Procedures; Practice Guidelines as Topic; Prednisolone	2005
[Disease modifying anti-rheumatic drugs (DMARDs): an overview]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benzopyrans; Cysteine; Evidence-Based Medicine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Meta-Analysis as Topic; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Sulfonamides	2005
[Leflunomide for therapy of rheumatoid arthritis]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Matrix Metalloproteinases; Oxidoreductases; T-Lymphocytes; Tumor Necrosis Factor-alpha	2005
[Adverse effects of DMARDs in treatment of rheumatoid arthritis]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Sodium Thiomalate; Hematologic Diseases; Humans; Isoxazoles; Kidney Diseases; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Reproduction; Sulfasalazine	2005
Modelling cost effectiveness and cost utility of sequential DMARD therapy including leflunomide for rheumatoid arthritis in Germany: II. The contribution of leflunomide to efficiency. PharmacoEconomics, 2005, Volume: 23, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Costs; Germany; Humans; Isoxazoles; Leflunomide; Models, Economic; Randomized Controlled Trials as Topic	2005
Rheumatoid arthritis: an update. Delaware medical journal, 2005, Volume: 77, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2005
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient. Clinics in geriatric medicine, 2005, Volume: 21, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome	2005
Leflunomide: long-term clinical experience and new uses. Expert opinion on pharmacotherapy, 2005, Volume: 6, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Industry; Humans; Isoxazoles; Leflunomide	2005
COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. Current topics in medicinal chemistry, 2005, Volume: 5, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cost-Benefit Analysis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Etoricoxib; Humans; Isoxazoles; Lactones; Membrane Proteins; Organic Chemicals; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Randomized Controlled Trials as Topic; Rheumatology; Sulfonamides; Sulfones; Treatment Outcome	2005
Use of combination of leflunomide with biological agents in treatment of rheumatoid arthritis. The Journal of rheumatology, 2005, Volume: 32, Issue:8 Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunologic Factors; Immunosuppressive Agents; Isoxazoles; Leflunomide	2005
[Disease modifying antirheumatic drugs with inhibitory effect on osteoclastogenesis]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63, Issue:9 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Differentiation; Humans; Isoxazoles; Leflunomide; Osteoclasts	2005
[Adverse events in rheumatoid arthritis patient with etanercept therapy: the appearance of osteomalacia]. Recenti progressi in medicina, 2005, Volume: 96, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Osteomalacia; Receptors, Tumor Necrosis Factor	2005
Leflunomide and warfarin interaction: case report and review of the literature. Pharmacotherapy, 2006, Volume: 26, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthritis, Rheumatoid; Atrial Fibrillation; Blood Coagulation; Drug Interactions; Female; Humans; International Normalized Ratio; Isoxazoles; Leflunomide; Middle Aged; Thromboembolism; Warfarin	2006
Medical therapy: where are we now? American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Sep-15, Volume: 63, Issue:18 Suppl 4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome	2006
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient. Rheumatic diseases clinics of North America, 2007, Volume: 33, Issue:1 Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Glomerular Filtration Rate; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2007
[Inhibition of radiographic progression in rheumatoid arthritis by anti-rheumatic drugs (DMARDs)]. Clinical calcium, 2007, Volume: 17, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclosporine; Disease Progression; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Radiography; Remission Induction; Sulfasalazine	2007
[Rational therapeutic approach in rheumatoid arthritis]. Annales Academiae Medicae Stetinensis, 2006, Volume: 52 Suppl 2 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Joint Prosthesis; Leflunomide; Methotrexate; Prostheses and Implants; Sulfasalazine	2006
[Effective combination therapy of TNF antagonists with DMARDs]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:7 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cysteine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Tumor Necrosis Factor-alpha	2007
[Economic evaluation of a new treatment for rheumatoid arthritis]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor	2007
Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study. Canadian family physician Medecin de famille canadien, 2007, Volume: 53, Issue:3 Topics: Abnormalities, Drug-Induced; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Incidence; Information Services; Isoxazoles; Leflunomide; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Risk Assessment; Sulfasalazine; Teratogens	2007
Treatment, management, and monitoring of established rheumatoid arthritis. The Journal of family practice, 2007, Volume: 56, Issue:10 Suppl R Topics: Abatacept; Adalimumab; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Therapy, Combination; Etanercept; Humans; Hydrotherapy; Hydroxychloroquine; Immunoconjugates; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Methotrexate; Physical Therapy Modalities; Primary Health Care; Prognosis; Quality of Life; Receptors, Tumor Necrosis Factor; Rituximab; Severity of Illness Index; Sulfasalazine; Treatment Outcome	2007
[Leflunomide (Arava) in the treatment of rheumatoid arthritis]. Reumatizam, 2007, Volume: 54, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide	2007
Innovative treatment approaches for rheumatoid arthritis. Cyclosporin, leflunomide and nitrogen mustard. Bailliere's clinical rheumatology, 1995, Volume: 9, Issue:4 Topics: Absorption; Alkylating Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Mechlorethamine; Tissue Distribution	1995
Leflunomide, an immunorestoring drug for the therapy of autoimmune disorders, especially rheumatoid arthritis. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Clinical Trials as Topic; Disease Models, Animal; Humans; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Mammals	1996
Leflunomide and malononitrilamides. The American journal of the medical sciences, 1997, Volume: 313, Issue:5 Topics: Aniline Compounds; Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Clinical Trials as Topic; Crotonates; Graft Rejection; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Molecular Structure; Nitriles; Organ Transplantation; Toluidines; Transplantation Immunology	1997
Mechanism of action of leflunomide in rheumatoid arthritis. The Journal of rheumatology. Supplement, 1998, Volume: 53 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Cycle; Dihydroorotate Dehydrogenase; Humans; Isoxazoles; Leflunomide; Lymphocyte Activation; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein-Tyrosine Kinases	1998
Clinical experience with leflunomide in rheumatoid arthritis. Leflunomide Investigators' Group. The Journal of rheumatology. Supplement, 1998, Volume: 53 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide	1998
[62nd Congress of the American College of Rheumatology, San Diego, 8-12 November 1998]. La Revue de medecine interne, 1999, Volume: 20, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Child, Preschool; Etanercept; Female; Humans; Immunoglobulin G; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Recombinant Proteins; Rheumatology; Societies, Medical; Sulfasalazine; Time Factors; Tumor Necrosis Factor-alpha	1999
Treatment advances in rheumatoid arthritis. The Western journal of medicine, 1999, Volume: 170, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Prognosis; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfonamides; Treatment Outcome	1999
Methotrexate and leflunomide: biochemical basis for combination therapy in the treatment of rheumatoid arthritis. Seminars in arthritis and rheumatism, 1999, Volume: 29, Issue:1 Topics: Adenosine; Arthritis, Rheumatoid; Cell Division; Cytokines; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Methotrexate; Molecular Structure; Purines; Pyrimidines; Treatment Outcome	1999
T cells: pathogenic cells and therapeutic targets in rheumatoid arthritis. Seminars in arthritis and rheumatism, 1999, Volume: 29, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Arthritis, Rheumatoid; Clone Cells; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Immunotherapy; Isoxazoles; Leflunomide; Lymphocyte Activation; T-Lymphocytes	1999
New treatments for rheumatoid arthritis. Available and upcoming slow-acting antirheumatic drugs. Postgraduate medicine, 1999, Oct-01, Volume: 106, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha	1999
Mechanism of action for leflunomide in rheumatoid arthritis. Clinical immunology (Orlando, Fla.), 1999, Volume: 93, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Enzyme Inhibitors; Humans; Isoxazoles; Leflunomide	1999
Leflunomide, mycophenolic acid and matrix metalloproteinase inhibitors. Rheumatology (Oxford, England), 1999, Volume: 38 Suppl 2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; Arthritis, Rheumatoid; Enzyme Inhibitors; Humans; Isoxazoles; Leflunomide; Metalloendopeptidases; Mycophenolic Acid	1999
Leflunomide: a review of its use in active rheumatoid arthritis. Drugs, 1999, Volume: 58, Issue:6 Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Pregnancy	1999
Investigational treatments in rheumatoid arthritis. Bailliere's best practice & research. Clinical rheumatology, 1999, Volume: 13, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drugs, Investigational; Genetic Therapy; Humans; Immunotherapy; Isoxazoles; Leflunomide; Tumor Necrosis Factor-alpha	1999
New drugs for the treatment of rheumatoid arthritis. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, Feb-01, Volume: 57, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoenzymes; Isoxazoles; Leflunomide; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor	2000
Recent advances in the treatment of rheumatoid arthritis. Clinical cornerstone, 1999, Volume: 2, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Immunosorbent Techniques; Infliximab; Isoxazoles; Leflunomide; Plasmapheresis; Receptors, Tumor Necrosis Factor	1999
Rheumatoid arthritis. New disease-modifying and anti-inflammatory drugs. Geriatrics, 2000, Volume: 55, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Lactones; Leflunomide; Male; Middle Aged; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfonamides; Sulfones	2000
New medications for use in patients with rheumatoid arthritis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 84, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Fees, Pharmaceutical; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor	2000
Treatment options for rheumatoid arthritis: celecoxib, leflunomide, etanercept, and infliximab. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Drug Interactions; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfonamides	2000
Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology, 2000, Volume: 47, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Autoimmune Diseases; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; T-Lymphocytes	2000
The use of leflunomide in the treatment of rheumatoid arthritis: an experimental and clinical review. Immunopharmacology, 2000, Volume: 47, Issue:2-3 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Crotonates; Drug Therapy, Combination; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Toluidines	2000
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis. Clinical therapeutics, 1999, Volume: 21, Issue:11 Topics: Adjuvants, Immunologic; Administration, Oral; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Randomized Controlled Trials as Topic; Safety; Treatment Outcome	1999
[Leflunomide: a new treatment for an old disease]. Revista clinica espanola, 2000, Volume: 200 Monog 1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	2000
DMARDs in the treatment of rheumatoid arthritis: current agents and future developments. International journal of clinical practice, 2000, Volume: 54, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Cyclosporins; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Methotrexate; Penicillamine; Treatment Outcome	2000
Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications. Journal of clinical pharmacy and therapeutics, 2000, Volume: 25, Issue:4 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Disease Progression; Drug Costs; Humans; Isoxazoles; Leflunomide; Pain; Treatment Outcome	2000
New and future drug therapies for rheumatoid arthritis. Rheumatology (Oxford, England), 2000, Volume: 39 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; CD40 Antigens; Celecoxib; Etanercept; Forecasting; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfonamides	2000
Leflunomide for rheumatoid arthritis. Drug and therapeutics bulletin, 2000, Volume: 38, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Randomized Controlled Trials as Topic	2000
[Leflunomide for active rheumatoid arthritis]. Ugeskrift for laeger, 2000, Sep-25, Volume: 162, Issue:39 Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Randomized Controlled Trials as Topic	2000
Leflunomide: mode of action in the treatment of rheumatoid arthritis. Annals of the rheumatic diseases, 2000, Volume: 59, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Division; Dihydroorotate Oxidase; DNA; Humans; Interleukin-1; Isoxazoles; Leflunomide; Lymphocytes; NF-kappa B; Protein-Tyrosine Kinases; Pyrimidines; Tumor Necrosis Factor-alpha	2000
The treatment of rheumatoid arthritis: a review of recent clinical trials. Current rheumatology reports, 1999, Volume: 1, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Prognosis; Prospective Studies; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome	1999
Therapy of rheumatoid arthritis: new developments and trends. Current rheumatology reports, 1999, Volume: 1, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Prognosis; Severity of Illness Index; Treatment Outcome	1999
Rational use of new and existing disease-modifying agents in rheumatoid arthritis. Annals of internal medicine, 2001, Apr-17, Volume: 134, Issue:8 Topics: Adjuvants, Immunologic; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Costs; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Risk Factors; Sulfasalazine	2001
Leflunomide and methotrexate. Current opinion in rheumatology, 2001, Volume: 13, Issue:3 Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Treatment Outcome	2001
Leflunomide: a novel DMARD for the treatment of rheumatoid arthritis. Expert opinion on pharmacotherapy, 2001, Volume: 2, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Costs and Cost Analysis; Female; Half-Life; Humans; Isoxazoles; Leflunomide; Male; Pregnancy; Treatment Outcome	2001
How is it best to treat early rheumatoid arthritis patients? Best practice & research. Clinical rheumatology, 2001, Volume: 15, Issue:1 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Prognosis; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha	2001
New disease modifying agents in adult rheumatoid arthritis. Annals of the Academy of Medicine, Singapore, 2001, Volume: 30, Issue:2 Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha	2001
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis. Hand clinics, 2001, Volume: 17, Issue:2 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Digestive System; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Lactones; Leflunomide; Methotrexate; Osteoarthritis; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfasalazine; Sulfonamides; Sulfones	2001
[Rheumatic pain]. Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59, Issue:9 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Cytokines; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Neoplasm Proteins; Pain; Pain Management; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Steroids; Tumor Necrosis Factor Decoy Receptors	2001
Economic and quality-of-life impact of rheumatoid arthritis. Managed care (Langhorne, Pa.), 2001, Volume: 10, Issue:7 Suppl Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost of Illness; Humans; Isoxazoles; Leflunomide; Managed Care Programs; Quality of Life; Treatment Outcome; United States	2001
Progress in the treatment of rheumatoid arthritis. JAMA, 2001, Dec-12, Volume: 286, Issue:22 Topics: Analgesics; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclosporine; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine	2001
Leflunomide Aventis Pharma. Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:2 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Contraindications; Humans; Isoxazoles; Leflunomide; Structure-Activity Relationship	2001
[Leflunomide--a new disease modifying anti-rheumatic agent]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001, Nov-10, Volume: 121, Issue:27 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Drug Interactions; Humans; Isoxazoles; Leflunomide; Prospective Studies; Randomized Controlled Trials as Topic	2001
"Stepping-up" from methotrexate: a systematic review of randomised placebo controlled trials in patients with rheumatoid arthritis with an incomplete response to methotrexate. Annals of the rheumatic diseases, 2001, Volume: 60 Suppl 3 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Maximum Tolerated Dose; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome	2001
Treating rheumatoid arthritis with new disease modifying drugs. Acta medica Austriaca, 2002, Volume: 29, Issue:1 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Tumor Necrosis Factor-alpha	2002
Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy. Drugs, 2002, Volume: 62, Issue:6 Topics: Animals; Arthritis, Rheumatoid; Cyclosporine; Cytokines; Gene Expression Regulation; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mitogen-Activated Protein Kinases; Mycophenolic Acid; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Sirolimus; Tacrolimus	2002
[New drug treatments for rheumatoid arthritis]. Duodecim; laaketieteellinen aikakauskirja, 2000, Volume: 116, Issue:11 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha	2000
[Leflunomide in the treatment of rheumatoid arthritis]. Annales de medecine interne, 2002, Volume: 153, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Isoxazoles; Leflunomide; Middle Aged; Rabbits; Rats; T-Lymphocytes	2002
Leflunomide for the treatment of rheumatoid arthritis and autoimmunity. The American journal of the medical sciences, 2002, Volume: 323, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Autoimmune Diseases; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide	2002
Advances in the medical management of rheumatoid arthritis. Hospital medicine (London, England : 1998), 2002, Volume: 63, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Steroids; Sulfasalazine; Treatment Outcome	2002

Trials

93 trial(s) available for isoxazoles and Rheumatoid Arthritis

Article	Year
Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2 Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea	2022
Leflunomide is equally efficacious and safe compared to low dose rituximab in refractory rheumatoid arthritis given in combination with methotrexate: results from a randomized double blind controlled clinical trial. BMC musculoskeletal disorders, 2017, Jul-19, Volume: 18, Issue:1 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Lymphocytes; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome	2017
[Rheumatoid arthritis treated with acupoint application of Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2016, Jul-12, Volume: 36, Issue:7 Topics: Acupuncture Points; Antirheumatic Agents; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Humans; Isoxazoles; Leflunomide; Meridians; Treatment Outcome	2016
MRI assessment of erosion repair in patients with long-standing rheumatoid arthritis receiving double-filtration plasmapheresis in addition to leflunomide and methotrexate: a randomized controlled trial. Clinical rheumatology, 2018, Volume: 37, Issue:4 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Female; Humans; Isoxazoles; Joints; Leflunomide; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Plasmapheresis; Treatment Outcome	2018
Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. International immunopharmacology, 2013, Volume: 15, Issue:3 Topics: Adolescent; Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Cytoprotection; Drug Therapy, Combination; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Liver; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Paeonia; Plant Roots; Young Adult	2013
[Effects of leflunomide in treating patients with rheumatoid arthritis of different Chinese medical syndrome patterns]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2013, Volume: 33, Issue:1 Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Medicine, Chinese Traditional; Middle Aged; Yin Deficiency; Young Adult	2013
Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Annals of the rheumatic diseases, 2015, Volume: 74, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Docosahexaenoic Acids; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Eicosapentaenoic Acid; Female; Fish Oils; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome	2015
Methotrexate in combination with other DMARDs is not superior to methotrexate alone for remission induction with moderate-to-high-dose glucocorticoid bridging in early rheumatoid arthritis after 16 weeks of treatment: the CareRA trial. Annals of the rheumatic diseases, 2015, Volume: 74, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Early Medical Intervention; Female; Glucocorticoids; Humans; Induction Chemotherapy; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Risk Assessment; Severity of Illness Index; Sulfasalazine; Treatment Outcome	2015
Efficacy and safety of weekly leflunomide for the treatment of early rheumatoid arthritis: a randomized, multi-center study. International journal of rheumatic diseases, 2016, Volume: 19, Issue:7 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Chi-Square Distribution; China; Drug Administration Schedule; Early Diagnosis; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Pain Measurement; Predictive Value of Tests; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome	2016
Total glucosides of paeony can reduce the hepatotoxicity caused by Methotrexate and Leflunomide combination treatment of active rheumatoid arthritis. International immunopharmacology, 2015, Volume: 28, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Paeonia; Treatment Outcome; Young Adult	2015
[Treatment of Refractory Rheumatoid Arthritis by Huayu Tongbi Recipe Combined Methotrexate]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015, Volume: 35, Issue:11 Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Humans; Isoxazoles; Leflunomide; Methotrexate; Phytotherapy; Treatment Outcome	2015
Effectiveness of methotrexate with step-down glucocorticoid remission induction (COBRA Slim) versus other intensive treatment strategies for early rheumatoid arthritis in a treat-to-target approach: 1-year results of CareRA, a randomised pragmatic open-la Annals of the rheumatic diseases, 2017, Volume: 76, Issue:3 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Remission Induction; Risk Factors; Severity of Illness Index; Sulfasalazine	2017
Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate, or leflunomide, or cyclosporin-A monotherapy: a 48-week, comparative, prospective study. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:9 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome	2008
The changes in serum chemokines following leflunomide therapy in patients with rheumatoid arthritis. Clinical rheumatology, 2009, Volume: 28, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemokine CCL2; Chemokine CCL5; Chemokines; Health Status; Humans; Interleukin-6; Isoxazoles; Joints; Leflunomide; Middle Aged; Severity of Illness Index	2009
Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction. Musculoskeletal care, 2009, Volume: 7, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Counseling; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Patient Compliance; Patient Satisfaction; Pilot Projects; Sulfasalazine; Young Adult	2009
Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha. Clinical rheumatology, 2010, Volume: 29, Issue:5 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Disease Progression; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Risk; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2010
Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study. Clinical rheumatology, 2010, Volume: 29, Issue:8 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation; Diarrhea; Female; Headache; Humans; Hypertension; Incidence; Isoxazoles; Leflunomide; Male; Middle Aged; Nausea; Prospective Studies; Treatment Outcome	2010
Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients. Modern rheumatology, 2011, Volume: 21, Issue:4 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Diarrhea; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Nausea; Severity of Illness Index; Social Class; Treatment Outcome	2011
Leflunomide in Pakistani patients with rheumatoid arthritis: prospective study in daily rheumatology practice. International journal of rheumatic diseases, 2011, Volume: 14, Issue:1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Pakistan; Practice Patterns, Physicians'; Prospective Studies; Remission Induction; Rheumatology; Severity of Illness Index; Treatment Outcome	2011
Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients. Arzneimittel-Forschung, 2011, Volume: 61, Issue:5 Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Risk	2011
Lack of association between CAG repeat polymorphism in the androgen receptor gene and the outcome of rheumatoid arthritis treatment with leflunomide. European journal of clinical pharmacology, 2012, Volume: 68, Issue:4 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Polymorphism, Genetic; Receptors, Androgen; Treatment Outcome	2012
Effects of double filtration plasmapheresis, leflunomide, and methotrexate on inflammatory changes found through magnetic resonance imaging in early rheumatoid arthritis. The Journal of rheumatology, 2012, Volume: 39, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Disability Evaluation; Early Diagnosis; Female; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Plasmapheresis; Quality of Life; Recovery of Function	2012
Etanercept normalises left ventricular mass in patients with rheumatoid arthritis. Annals of the rheumatic diseases, 2013, Volume: 72, Issue:6 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Echocardiography; Etanercept; Female; Humans; Hypertrophy, Left Ventricular; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Pulse Wave Analysis; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha; Vascular Stiffness	2013
Efficacy and safety of leflunomide in DMARD-naive patients with early rheumatoid arthritis: comparison of a loading and a fixed-dose regimen. Rheumatology (Oxford, England), 2013, Volume: 52, Issue:6 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Treatment Outcome	2013
The effects of disease-modifying anti-rheumatic drugs on the Health Assessment Questionnaire score. Lessons from the leflunomide clinical trials database. Rheumatology (Oxford, England), 2002, Volume: 41, Issue:8 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Follow-Up Studies; Health Status; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Placebos; Sulfasalazine; Surveys and Questionnaires; Time Factors	2002
Efficacy and safety of valdecoxib in treating the signs and symptoms of rheumatoid arthritis: a randomized, controlled comparison with placebo and naproxen. Rheumatology (Oxford, England), 2002, Volume: 41, Issue:9 Topics: Administration, Oral; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Health Status; Humans; Isoxazoles; Joints; Male; Middle Aged; Naproxen; Pain Measurement; Self-Examination; Severity of Illness Index; Sulfonamides; Treatment Outcome	2002
Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial. Annals of internal medicine, 2002, Nov-05, Volume: 137, Issue:9 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Arthritis, Rheumatoid; Diarrhea; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Liver Function Tests; Male; Methotrexate; Middle Aged; Placebos; Quality of Life; Surveys and Questionnaires; Treatment Outcome	2002
An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in Arthritis and rheumatism, 2003, Volume: 48, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Pain; Pain Measurement; Placebos; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome	2003
The efficacy and safety of leflunomide in patients with active rheumatoid arthritis: a five-year followup study. Arthritis and rheumatism, 2003, Volume: 48, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Female; Follow-Up Studies; Health Status; Humans; International Cooperation; Isoxazoles; Leflunomide; Male; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome	2003
Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial. Rheumatology (Oxford, England), 2003, Volume: 42, Issue:10 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Middle Aged; Pain Measurement; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Treatment Outcome	2003
A comparison of the upper gastrointestinal mucosal effects of valdecoxib, naproxen and placebo in healthy elderly subjects. Alimentary pharmacology & therapeutics, 2003, Jul-01, Volume: 18, Issue:1 Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Isoxazoles; Naproxen; Osteoarthritis; Pain; Risk Factors; Sulfonamides	2003
Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial. Chinese medical journal, 2003, Volume: 116, Issue:8 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Growth Inhibitors; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged	2003
Economic evaluation of oral valdecoxib versus diclofenac in the treatment of patients with rheumatoid arthritis in a randomized clinical trial. Rheumatology (Oxford, England), 2003, Volume: 42 Suppl 3 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cohort Studies; Cost Savings; Cost-Benefit Analysis; Diclofenac; Drug Costs; Female; Health Resources; Hospitalization; Humans; Isoxazoles; Male; Middle Aged; Peptic Ulcer; Sulfonamides	2003
Efficacy and safety of leflunomide and predisposing factors for treatment response in patients with active rheumatoid arthritis: RELIEF 6-month data. The Journal of rheumatology, 2003, Volume: 30, Issue:12 Topics: Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Enzyme Inhibitors; Female; Health Status; Humans; International Cooperation; Isoxazoles; Joints; Leflunomide; Male; Middle Aged; Severity of Illness Index; Treatment Outcome	2003
Rheumatoid arthritis treatment with weekly leflunomide: an open-label study. The Journal of rheumatology, 2004, Volume: 31, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Treatment Outcome	2004
Efficacy and safety of leflunomide 10 mg versus 20 mg once daily in patients with active rheumatoid arthritis: multinational double-blind, randomized trial. Rheumatology (Oxford, England), 2004, Volume: 43, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Severity of Illness Index; Treatment Outcome	2004
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:9 Topics: Adult; Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Crotonates; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Hydroxybutyrates; Immunosuppressive Agents; Interferon-gamma; Interleukin-6; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Nitriles; Toluidines	2004
Long term evaluation of radiographic disease progression in a subset of patients with rheumatoid arthritis treated with leflunomide beyond 2 years. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Progression; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Long-Term Care; Radiography; Treatment Outcome	2004
When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide? Annals of the rheumatic diseases, 2005, Volume: 64, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Sulfasalazine; Treatment Failure; Treatment Outcome	2005
Therapeutic interchange involving replacement of rofecoxib or celecoxib with valdecoxib. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2004, Jul-01, Volume: 61, Issue:13 Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Celecoxib; Chronic Disease; Cost Savings; Cyclooxygenase 2; Drug Utilization Review; Endpoint Determination; Female; Hospitals, Veterans; Humans; Isoenzymes; Isoxazoles; Lactones; Male; Membrane Proteins; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Therapeutic Equivalency	2004
Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial. The Journal of rheumatology, 2004, Volume: 31, Issue:8 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Retreatment; Treatment Outcome	2004
Leflunomide in the treatment of refractory rheumatoid arthritis. Folia medica, 2003, Volume: 45, Issue:3 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Female; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Male; Middle Aged; Prospective Studies; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome	2003
Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis. International immunopharmacology, 2005, Volume: 5, Issue:6 Topics: Adult; Arthritis, Rheumatoid; Biomarkers; Citrulline; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Nitric Oxide	2005
Valdecoxib is associated with improved dyspepsia-related health compared with nonspecific NSAIDs in patients with osteoarthritis or rheumatoid arthritis. The American journal of gastroenterology, 2005, Volume: 100, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Dyspepsia; Female; Humans; Ibuprofen; Isoxazoles; Male; Middle Aged; Naproxen; Osteoarthritis; Pain Measurement; Patient Satisfaction; Placebos; Quality of Life; Sulfonamides; Treatment Outcome; Upper Gastrointestinal Tract	2005
[Leflunomide in the treatment of rheumatoid arthritis]. La Tunisie medicale, 2005, Volume: 83, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Prospective Studies; Treatment Outcome	2005
[Evaluation of rheumatoid arthritis activity in clinical practice]. Terapevticheskii arkhiv, 2005, Volume: 77, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Treatment Outcome	2005
[Experience in long-term therapy of active rheumatoid arthritis with leflunomide]. Terapevticheskii arkhiv, 2005, Volume: 77, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Treatment Outcome	2005
Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. Arthritis and rheumatism, 2005, Volume: 52, Issue:10 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Hematinics; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Treatment Outcome	2005
Leflunomide/chloroquin combination therapy in rheumatoid arthritis: a pilot study. Clinical rheumatology, 2006, Volume: 25, Issue:4 Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Pilot Projects; Severity of Illness Index	2006
The effects of leflunomide on clinical parameters and serum levels of IL-6, IL-10, MMP-1 and MMP-3 in patients with resistant rheumatoid arthritis. Cytokine, 2006, Jan-21, Volume: 33, Issue:2 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Interleukin-10; Interleukin-6; Isoxazoles; Leflunomide; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Middle Aged	2006
Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis. The Journal of rheumatology, 2006, Volume: 33, Issue:3 Topics: Adjuvants, Immunologic; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Isoxazoles; Joints; Leflunomide; Severity of Illness Index; Treatment Outcome	2006
A comparison of valdecoxib and naproxen in the treatment of rheumatoid arthritis symptoms. Clinical therapeutics, 2006, Volume: 28, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Naproxen; Sulfonamides; Treatment Outcome	2006
[Clinical observation on effects of leflunomid and total glucosides of paeony on rheumatoid arthritis]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26, Issue:4 Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Paeonia; Phytotherapy; Treatment Outcome	2006
Leflunomide and methotrexate combination therapy in daily clinical practice. Annals of the rheumatic diseases, 2006, Volume: 65, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Isoxazoles; Leflunomide; Methotrexate	2006
Efficacy and safety of leflunomide alone and in combination with methotrexate in the treatment of refractory rheumatoid arthritis. Indian journal of medical sciences, 2006, Volume: 60, Issue:8 Topics: Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Treatment Outcome	2006
[An antidestructive effect of leflunomide in early rheumatoid arthritis]. Terapevticheskii arkhiv, 2006, Volume: 78, Issue:6 Topics: Adjuvants, Immunologic; Adult; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Severity of Illness Index; Treatment Outcome	2006
Effect of leflunomide on the peripheral nerves in rheumatoid arthritis. Internal medicine journal, 2007, Volume: 37, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Neuritis; Peripheral Nerves; Prospective Studies	2007
Preliminary evaluation in rheumatoid arthritis activity in patients treated with TNF-alpha blocker plus methotrexate versus methotrexate or leflunomide alone. Rheumatology international, 2007, Volume: 27, Issue:7 Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Pilot Projects; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha	2007
Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:10 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Sulfasalazine; Treatment Failure; Treatment Outcome	2007
Eight versus 16-week re-evaluation period in rheumatoid arthritis patients treated with leflunomide or methotrexate accompanied by moderate dose prednisone. Rheumatology international, 2007, Volume: 27, Issue:10 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intramuscular; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome	2007
Efficacy and tolerability of valdecoxib in treating the signs and symptoms of severe rheumatoid arthritis: a 12-week, multicenter, randomized, double-blind, placebo-controlled study. Clinical therapeutics, 2007, Volume: 29, Issue:6 Topics: Activities of Daily Living; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Naproxen; Pain Measurement; Patient Satisfaction; Placebos; Severity of Illness Index; Sulfonamides; Time Factors; Treatment Outcome	2007
[Clinical study on effect of total panax notoginseng saponins on immune related inner environment imbalance in rheumatoid arthritis patients]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2007, Volume: 27, Issue:7 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Isoxazoles; Leflunomide; Male; Middle Aged; Panax notoginseng; Phytotherapy; Prednisone; Rheumatoid Factor; Saponins; Treatment Outcome; Young Adult	2007
[Leflunomide as a second choice treatment in patients with rheumatoid arthritis]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2007, Volume: 22, Issue:132 Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome	2007
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients. Annals of the rheumatic diseases, 2008, Volume: 67, Issue:1 Topics: Aged; alpha-Macroglobulins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Down-Regulation; Enzyme Inhibitors; Female; Humans; Isoxazoles; Leflunomide; Male; Matrix Metalloproteinases; Methotrexate; Middle Aged; Multiprotein Complexes; Phenylalanine; Statistics, Nonparametric; Thiophenes	2008
The role of HLA-DRB1 shared epitope alleles in predicting short-term response to leflunomide in rheumatoid arthritis. Rheumatology (Oxford, England), 2007, Volume: 46, Issue:12 Topics: Adult; Alleles; Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Epitopes; Female; Follow-Up Studies; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome	2007
Leflunomide (Arava) is a useful DMARD in Indian (Asian) patients: a clinic-based observational study of 1-year treatment. Clinical rheumatology, 2008, Volume: 27, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; India; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Prospective Studies; Treatment Outcome	2008
Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study. Arthritis and rheumatism, 1995, Volume: 38, Issue:11 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Single-Blind Method; Treatment Outcome	1995
Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of peripheral blood and synovial fluid mononuclear cells in rheumatoid arthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:11 Topics: Adjuvants, Immunologic; Antigens, CD; Arthritis, Rheumatoid; Cell Adhesion; Cell Aggregation; Female; Humans; Isoxazoles; Leflunomide; Male; Monocytes; Single-Blind Method; Synovial Fluid	1996
Comparative study of the clinical efficacy of four DMARDs (leflunomide, methotrexate, cyclosporine, and levamisole) in patients with rheumatoid arthritis. Transplantation proceedings, 1998, Volume: 30, Issue:8 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Levamisole; Male; Methotrexate; Middle Aged	1998
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. Lancet (London, England), 1999, Jan-23, Volume: 353, Issue:9149 Topics: Algorithms; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Placebos; Radiography; Statistics, Nonparametric; Sulfasalazine; Treatment Outcome	1999
Leflunomide for active rheumatoid arthritis. Lancet (London, England), 1999, May-29, Volume: 353, Issue:9167 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Vasculitis, Leukocytoclastic, Cutaneous	1999
Leflunomide for active rheumatoid arthritis. Lancet (London, England), 1999, May-29, Volume: 353, Issue:9167 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	1999
Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis and rheumatism, 1999, Volume: 42, Issue:7 Topics: Adult; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspartate Aminotransferases; Diarrhea; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Liver; Male; Methotrexate; Middle Aged; Nausea; Patient Compliance; Treatment Outcome	1999
Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. Arthritis and rheumatism, 1999, Volume: 42, Issue:9 Topics: Adjuvants, Immunologic; Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Placebos; Quality of Life	1999
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Archives of internal medicine, 1999, Nov-22, Volume: 159, Issue:21 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Transaminases; Treatment Outcome	1999
Disease modification in rheumatoid arthritis with leflunomide. Scandinavian journal of rheumatology. Supplement, 1999, Volume: 112 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Time Factors	1999
Efficacy and safety of the new DMARD leflunomide: comparison to placebo and sulfasalazine in active rheumatoid arthritis. Scandinavian journal of rheumatology. Supplement, 1999, Volume: 112 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Radiography; Safety; Time Factors	1999
Leflunomide improves quality of life in rheumatoid arthritis. Scandinavian journal of rheumatology. Supplement, 1999, Volume: 112 Topics: Activities of Daily Living; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Quality of Life; Sulfasalazine	1999
Leflunomide versus methotrexate: a comparison of the European and American experience. Scandinavian journal of rheumatology. Supplement, 1999, Volume: 112 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Europe; Female; Folic Acid; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; United States	1999
Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. Arthritis and rheumatism, 2000, Volume: 43, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Isoxazoles; Leflunomide; Methotrexate; Placebos; Radiography; Sulfasalazine	2000
Clinical improvement as reflected in measures of function and health-related quality of life following treatment with leflunomide compared with methotrexate in patients with rheumatoid arthritis: sensitivity and relative efficiency to detect a treatment e Arthritis and rheumatism, 2000, Volume: 43, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Quality of Life; Treatment Outcome	2000
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology (Oxford, England), 2000, Volume: 39, Issue:6 Topics: Adolescent; Adult; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Outcome Assessment, Health Care; Radiography; Treatment Outcome	2000
Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis and rheumatism, 2000, Volume: 43, Issue:7 Topics: Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Crotonates; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hydroxybutyrates; Immunosuppressive Agents; In Vitro Techniques; Interleukin-8; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Prospective Studies; Toluidines	2000
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine Arthritis and rheumatism, 2000, Volume: 43, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Immunohistochemistry; Isoxazoles; Leflunomide; Metalloendopeptidases; Prospective Studies; Synovial Membrane; Synovitis; Therapeutic Equivalency	2000
Slowing of disease progression in rheumatoid arthritis patients during long-term treatment with leflunomide or sulfasalazine. Scandinavian journal of rheumatology, 2001, Volume: 30, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Radiography; Sulfasalazine; Treatment Outcome	2001
A randomized, controlled, single-blind trial of leflunomide in the treatment of rheumatoid arthritis. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 2001, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Oxaprozin; Propionates; Single-Blind Method	2001
Improved functional ability in patients with rheumatoid arthritis--longterm treatment with leflunomide versus sulfasalazine. European Leflunomide Study Group. The Journal of rheumatology, 2001, Volume: 28, Issue:9 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Long-Term Care; Male; Middle Aged; Pain Measurement; Patient Satisfaction; Probability; Prognosis; Range of Motion, Articular; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome	2001
Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. Annals of the rheumatic diseases, 2001, Volume: 60, Issue:10 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Confidence Intervals; Disability Evaluation; Disease Progression; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Logistic Models; Male; Middle Aged; Radiography; Rheumatoid Factor; Statistics, Nonparametric; Sulfasalazine; Treatment Outcome	2001
Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis and rheumatism, 2001, Volume: 44, Issue:9 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome	2001
Economic comparison of leflunomide and methotrexate in patients with rheumatoid arthritis: an evaluation based on a 1-year randomised controlled trial. PharmacoEconomics, 2002, Volume: 20, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Economics, Pharmaceutical; Health Care Costs; Humans; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Ontario; Treatment Outcome	2002
Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. Arthritis and rheumatism, 2002, Volume: 46, Issue:2 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prospective Studies; Synovitis; Treatment Outcome	2002
Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. Rheumatology (Oxford, England), 2002, Volume: 41, Issue:6 Topics: Adult; Aged; Anaphylaxis; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Combined Modality Therapy; Diarrhea; Drug Eruptions; Female; Humans; Hypertension; Immunosuppressive Agents; Infections; Infliximab; Isoxazoles; Leflunomide; Liver; Male; Middle Aged; Oral Ulcer; Pilot Projects; Tumor Necrosis Factor-alpha	2002
Weekly dose of leflunomide for the treatment of refractory rheumatoid arthritis: an open pilot comparative study. Joint bone spine, 2002, Volume: 69, Issue:3 Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged; Pilot Projects; Treatment Outcome	2002

Other Studies

331 other study(ies) available for isoxazoles and Rheumatoid Arthritis

Article	Year
Therapeutic drug monitoring of teriflunomide: do plasma concentrations predict response to leflunomide in patients with rheumatoid arthritis? Drug metabolism and personalized therapy, 2023, 03-01, Volume: 38, Issue:1 Topics: Arthritis, Rheumatoid; Drug Monitoring; Humans; Isoxazoles; Leflunomide; Treatment Outcome	2023
The association between CYB5A gene rs1790834 polymorphism and clinical improvement after 6 months of leflunomide treatment in women with rheumatoid arthritis. Clinical rheumatology, 2023, Volume: 42, Issue:9 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cytochromes b5; Female; Humans; Isoxazoles; Leflunomide; Polymorphism, Genetic; Treatment Outcome	2023
Leflunomide exposure through second trimester of pregnancy: A case report. Birth defects research, 2023, 10-01, Volume: 115, Issue:16 Topics: Arthritis, Rheumatoid; Cholestyramine Resin; Female; Humans; Isoxazoles; Leflunomide; Pregnancy; Pregnancy Trimester, Second	2023
Quality of life and clinical outcomes in Polish patients with high activity rheumatoid arthritis treated with leflunomide (Arava®) in Therapeutic Program: A retrospective analysis of data from the PLUS study. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2019, Volume: 28, Issue:11 Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Poland; Quality of Life; Retrospective Studies; Treatment Outcome	2019
Leflunomide as a cause of collagenous colitis: an entity to consider. Revista espanola de enfermedades digestivas, 2021, Volume: 113, Issue:10 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Colitis, Collagenous; Humans; Isoxazoles; Leflunomide	2021
Leflunomide - A human teratogen? A still not answered question. An evaluation of the German Embryotox pharmacovigilance database. Reproductive toxicology (Elmsford, N.Y.), 2017, Volume: 71 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Antirheumatic Agents; Arthritis, Rheumatoid; Esophageal Atresia; Female; Germany; Humans; Infant, Newborn; Isoxazoles; Leflunomide; Male; Maternal-Fetal Exchange; Pharmacovigilance; Pregnancy; Pregnancy Trimester, First; Teratogens; Tracheoesophageal Fistula; Young Adult	2017
Clinical effectiveness and safety of leflunomide in inflammatory arthritis: a report from the RAPPORT database with supporting patient survey. Clinical rheumatology, 2017, Volume: 36, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Health Surveys; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Remission Induction; Retrospective Studies; Treatment Outcome; Young Adult	2017
[SUSTAINABILITY OF RITUXIMAB IN CONCOMMITANT TREATMENT WITH METHOTREXATE OR LEFLUNOMIDE IN PATIENTS WITH RHEUMATOID ARTHRITIS]. Harefuah, 2017, Volume: 156, Issue:7 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Prospective Studies; Rituximab; Treatment Outcome	2017
Herpes Zoster and Tofacitinib: Clinical Outcomes and the Risk of Concomitant Therapy. Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:10 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Clinical Trials as Topic; Databases, Factual; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Herpes Zoster; Humans; Incidence; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multivariate Analysis; Piperidines; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors	2017
Risk factors of serious infections in patients with rheumatoid arthritis treated with tocilizumab in the French Registry REGATE. Rheumatology (Oxford, England), 2017, 10-01, Volume: 56, Issue:10 Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Drug Therapy, Combination; Female; France; Humans; Incidence; Isoxazoles; Leflunomide; Leukocyte Count; Male; Middle Aged; Neutrophils; Opportunistic Infections; Peptides, Cyclic; Proportional Hazards Models; Registries; Risk Factors	2017
Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis. The Journal of rheumatology, 2017, Volume: 44, Issue:12 Topics: Adult; Age Factors; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Argentina; Arthritis, Rheumatoid; Chile; Female; Genotype; Humans; Indians, North American; Indians, South American; Isoxazoles; Leflunomide; Male; Methotrexate; Mexico; Middle Aged; Peru; Radiography; Rheumatoid Factor; Sex Factors; Sulfasalazine	2017
Metabolic syndrome and the decreased levels of uric acid by leflunomide favor redox imbalance in patients with rheumatoid arthritis. Clinical and experimental medicine, 2018, Volume: 18, Issue:3 Topics: Adolescent; Adult; Advanced Oxidation Protein Products; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Case-Control Studies; Disease Progression; Female; Gene Expression; Humans; Isoxazoles; Leflunomide; Lipid Peroxides; Male; Metabolic Syndrome; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Sex Factors; Uric Acid	2018
Treatment with either leflunomide or adalimumab reduces anaemia in patients with rheumatoid arthritis. Anais da Academia Brasileira de Ciencias, 2018, Volume: 90, Issue:2 suppl 1 Topics: Adalimumab; Adult; Anemia; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Treatment Outcome	2018
No live vaccines for people being treated with leflunomide. Internal medicine journal, 2018, Volume: 48, Issue:10 Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Vaccines	2018
Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis. Annals of the rheumatic diseases, 2014, Volume: 73, Issue:1 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Osteoblasts; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid; Synovitis	2014
Leflunomide discontinuation in rheumatoid arthritis and influence of associated disease-modifying anti-rheumatic drugs: a survival analysis. Scandinavian journal of rheumatology, 2013, Volume: 42, Issue:6 Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Withholding Treatment	2013
Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Comprehensive psychiatry, 2013, Volume: 54, Issue:8 Topics: Adult; Aged; Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Comorbidity; Depression; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Psychiatric Status Rating Scales; Suicidal Ideation	2013
[The conversion of hypothyroidism into hyperthyroidism during leflunomide with povidone iodine treatment of rheumatoid arthritis]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2013, Volume: 34, Issue:204 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Combinations; Female; Humans; Hyperthyroidism; Hypothyroidism; Isoxazoles; Leflunomide; Middle Aged; Povidone-Iodine	2013
Use of leflunomide plus TNF-α inhibitors in rheumatoid arthritis. Expert opinion on drug safety, 2013, Volume: 12, Issue:6 Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Tumor Necrosis Factor-alpha	2013
Development of an algorithm for identifying rheumatoid arthritis in the Korean National Health Insurance claims database. Rheumatology international, 2013, Volume: 33, Issue:12 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Coding; Databases, Factual; Drug Therapy, Combination; Female; Humans; Insurance Claim Reporting; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; National Health Programs; Reproducibility of Results; Republic of Korea; Young Adult	2013
Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis. Clinical rheumatology, 2014, Volume: 33, Issue:2 Topics: Adult; Aged; Antibodies; Antigens, CD1d; Arthritis, Rheumatoid; B-Lymphocytes, Regulatory; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Separation; Female; Flow Cytometry; Forkhead Transcription Factors; Hepatitis A Virus Cellular Receptor 1; Humans; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Male; Membrane Glycoproteins; Methotrexate; Middle Aged; Peptides, Cyclic; Plant Extracts; Receptors, Virus	2014
Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization. Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2014, Volume: 13, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Computer Simulation; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Design; Humans; Isoxazoles; Models, Molecular; Neoplasms; Pain; Sulfonamides	2014
Multiple eruptive keratoacanthomas associated with leflunomide. Dermatology online journal, 2013, Jul-14, Volume: 19, Issue:7 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carcinoma, Squamous Cell; Drug Eruptions; Female; Humans; Isoxazoles; Keratoacanthoma; Leflunomide; Skin Neoplasms	2013
A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide. Journal of immunology (Baltimore, Md. : 1950), 2013, Nov-15, Volume: 191, Issue:10 Topics: Adaptor Proteins, Signal Transducing; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chromones; Collagen; I-kappa B Kinase; Inflammation; Interleukin-17; Isoxazoles; Leflunomide; Male; Methotrexate; Mice; Mice, Inbred DBA; Phosphorylation; Signal Transduction; Sulfonamides; Synovial Membrane; TNF Receptor-Associated Factor 5	2013
Periodontitis and etanercept discontinuation risk in anti-tumor necrosis factor-naive rheumatoid arthritis patients: a nationwide population-based cohort study. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2013, Volume: 19, Issue:8 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Periodontitis; Receptors, Tumor Necrosis Factor; Retrospective Studies; Risk Assessment; Risk Factors; Sulfasalazine; Tumor Necrosis Factor-alpha	2013
The hypouricemiant effect of leflunomide. Joint bone spine, 2014, Volume: 81, Issue:3 Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Uric Acid	2014
RAISE - rheumatoid arthritis independent Swiss treatment expectations and outcome: results for the abatacept subpopulation. Swiss medical weekly, 2013, Volume: 143 Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Switzerland; Treatment Outcome	2013
Chronicity of rheumatoid arthritis affects the responsiveness of physical function, but not of disease activity measures in rheumatoid arthritis clinical trials. Annals of the rheumatic diseases, 2015, Volume: 74, Issue:3 Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Disease Progression; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha	2015
[Acute sensory-motor axonal neuropathy (Guillain-Barre syndrome) following vertebroplasty]. Medicina clinica, 2014, Sep-15, Volume: 143, Issue:6 Topics: Accidental Falls; Arthritis, Rheumatoid; Female; Guillain-Barre Syndrome; Humans; Immunocompromised Host; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged; Osteoporosis; Postoperative Complications; Prednisone; Spinal Fractures; Thoracic Vertebrae; Vertebroplasty	2014
The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients. Clinical rheumatology, 2014, Volume: 33, Issue:7 Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Corneal Ulcer; Dry Eye Syndromes; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Models, Statistical; Severity of Illness Index; Sjogren's Syndrome; Treatment Outcome; Young Adult	2014
Five cases of interstitial lung disease after leflunomide was combined with methotrexate therapy. Scandinavian journal of rheumatology, 2014, Volume: 43, Issue:3 Topics: Aged; Arthritis, Rheumatoid; Disease Progression; Drug Interactions; Drug Therapy, Combination; Female; Finland; Humans; Incidence; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Prognosis; Risk Assessment; Sampling Studies; Survival Rate	2014
Sustainability of rituximab therapy in different treatment strategies: results of a 3-year followup of a German biologics register. Arthritis care & research, 2014, Volume: 66, Issue:11 Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Germany; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Registries; Retrospective Studies; Rituximab; Treatment Outcome	2014
Early, structured disease modifying anti-rheumatic drug (DMARD) therapy reduces cardiovascular risk in rheumatoid arthritis--a single centre study using non-biologic drugs. The Journal of the Association of Physicians of India, 2013, Volume: 61, Issue:8 Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cholesterol; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Middle Aged; Severity of Illness Index; Sulfasalazine; Triglycerides; Young Adult	2013
Small molecule inhibitors targeting activator protein 1 (AP-1). Journal of medicinal chemistry, 2014, Aug-28, Volume: 57, Issue:16 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzophenones; Biological Products; Humans; Inflammation; Isoxazoles; Maleimides; Molecular Targeted Therapy; Neoplasms; Organic Chemicals; Quinazolines; Signal Transduction; Small Molecule Libraries; Transcription Factor AP-1; Transcription Factors	2014
Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice. Modern rheumatology, 2015, Volume: 25, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Foot Joints; Hand Joints; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Retrospective Studies; Tacrolimus; Treatment Outcome	2015
The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity. Journal of clinical pharmacy and therapeutics, 2014, Volume: 39, Issue:5 Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Polymorphism, Genetic; Proportional Hazards Models; Protein Tyrosine Phosphatase, Non-Receptor Type 22; South Australia; Treatment Outcome; White People	2014
Association between serum uric acid and inflammation in rheumatoid arthritis: perspective on lowering serum uric acid of leflunomide. Clinica chimica acta; international journal of clinical chemistry, 2015, Jan-01, Volume: 438 Topics: Aged; Arthritis, Rheumatoid; Female; Glomerular Filtration Rate; Humans; Inflammation; Isoxazoles; Leflunomide; Male; Middle Aged; Uric Acid	2015
Ascidian tunicate extracts attenuate rheumatoid arthritis in a collagen-induced murine model. Natural product communications, 2014, Volume: 9, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Collagen; Isoxazoles; Leflunomide; Mice; Tissue Extracts; Urochordata	2014
Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade. Arthritis research & therapy, 2014, Oct-02, Volume: 16, Issue:5 Topics: Aged; Aged, 80 and over; Animals; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cytokines; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Humans; Inflammation Mediators; Isoxazoles; Leukocytes; Lysophospholipids; Middle Aged; Propionates; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Synovial Membrane	2014
Treatment of rheumatoid arthritis with methotrexate alone and in combination with other conventional DMARDs using the T2T strategy. A cohort study. Clinical rheumatology, 2015, Volume: 34, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cohort Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisolone; Retrospective Studies; Sulfasalazine; Treatment Outcome; Young Adult	2015
[Acute interstitial pneumonia in patient with rheumatoid arthritis treated with leflunomide]. Pneumonologia i alergologia polska, 2014, Volume: 82, Issue:6 Topics: Acute Disease; Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Idiopathic Interstitial Pneumonias; Isoxazoles; Leflunomide; Male; Middle Aged	2014
Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. PloS one, 2014, Volume: 9, Issue:11 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Synergism; Drug Therapy, Combination; Isoxazoles; Leflunomide; Male; Mice; Severity of Illness Index; Sulfonamides; Treatment Outcome	2014
Rheumatoid arthritis: Methotrexate and bridging glucocorticoids in early RA. Nature reviews. Rheumatology, 2014, Volume: 10, Issue:12 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Isoxazoles; Male; Methotrexate; Prednisone; Sulfasalazine	2014
Factors influencing ultrasonographic remission in patients with rheumatoid arthritis. Rheumatology international, 2015, Volume: 35, Issue:3 Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Delayed Diagnosis; Etanercept; Female; Hand Joints; Humans; Isoxazoles; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Remission Induction; Rituximab; Severity of Illness Index; Sulfasalazine; Synovitis; Tenosynovitis; Time Factors; Ultrasonography, Doppler	2015
Seroconversion in patients with rheumatic diseases treated with immunomodulators or immunosuppressants, who were inadvertently revaccinated against yellow fever. Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:2 Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Child; Contraindications; Female; Humans; Immunity, Innate; Immunization, Secondary; Immunologic Factors; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Middle Aged; Retrospective Studies; Rheumatic Diseases; Rituximab; Scleroderma, Systemic; Yellow Fever; Yellow Fever Vaccine; Young Adult	2015
[Pleuro-pericarditis developed under a leflunomide therapy]. Revue de pneumologie clinique, 2015, Volume: 71, Issue:1 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Pericarditis; Pleurisy	2015
[Subacute cutaneous lupus erythematosus induced by golimumab]. Medicina clinica, 2015, Sep-07, Volume: 145, Issue:5 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; Middle Aged; Tumor Necrosis Factor-alpha	2015
69-year-old woman with rheumatoid arthritis presents with shortness of breath and cough. Annals of the American Thoracic Society, 2014, Volume: 11, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bronchoalveolar Lavage; Bronchoscopy; Cough; Diagnosis, Differential; Dyspnea; Female; Humans; Isoxazoles; Leflunomide; Pulmonary Disease, Chronic Obstructive; Pulmonary Eosinophilia; Tomography, X-Ray Computed	2014
Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis. Pharmacological reports : PR, 2015, Volume: 67, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Hindlimb; Isoxazoles; Leflunomide; Liver Cirrhosis; Male; Methotrexate; Rats; Rats, Wistar; Spleen	2015
Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts. Annals of the rheumatic diseases, 2015, Volume: 74, Issue:5 Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Cohort Studies; Disease Progression; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Proportional Hazards Models; Remission Induction; Sulfasalazine; Time-to-Treatment; Treatment Outcome	2015
Leflunomide-induced acute interstitial pneumonia in a patient treated for rheumatoid arthritis. Pneumonologia i alergologia polska, 2015, Volume: 83, Issue:1 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Fatal Outcome; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Middle Aged; Radiography, Thoracic	2015
Comparative effectiveness of tocilizumab with either methotrexate or leflunomide in the treatment of rheumatoid arthritis. PloS one, 2015, Volume: 10, Issue:4 Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Neutropenia; Retrospective Studies; Treatment Outcome	2015
On the interactions of leflunomide and teriflunomide within receptor cavity--NMR studies and energy calculations. Journal of molecular modeling, 2015, Volume: 21, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Binding Sites; Crotonates; Dihydroorotate Dehydrogenase; Energy Metabolism; Humans; Hydrogen Bonding; Hydroxybutyrates; Isoxazoles; Leflunomide; Magnetic Resonance Spectroscopy; Models, Molecular; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Toluidines	2015
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study. Clinical rheumatology, 2015, Volume: 34, Issue:6 Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha	2015
Topical delivery of leflunomide for rheumatoid arthritis treatment: evaluation of local tissue deposition of teriflunomide and its anti-inflammatory effects in an arthritis rat model. Drug development and industrial pharmacy, 2016, Volume: 42, Issue:2 Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Crotonates; Drug Delivery Systems; Guinea Pigs; Hydroxybutyrates; Isoxazoles; Leflunomide; Mice; Mice, Hairless; Mice, Inbred BALB C; Nitriles; Rats; Rats, Sprague-Dawley; Skin Absorption; Swine; Swine, Miniature; Tissue Distribution; Toluidines; Transdermal Patch	2016
Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis? BMC musculoskeletal disorders, 2015, Jun-23, Volume: 16 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Bone Density; Disease Progression; Female; Germany; Hand Joints; Humans; Isoxazoles; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Radiographic Image Interpretation, Computer-Assisted; Retrospective Studies; Time Factors; Treatment Outcome	2015
Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis. British journal of clinical pharmacology, 2016, Volume: 81, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Crotonates; Cytochrome P-450 CYP1A2; Female; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Male; Middle Aged; Nitriles; Polymorphism, Single Nucleotide; Toluidines	2016
Safety and retention of combination triple disease-modifying anti-rheumatic drugs in new-onset rheumatoid arthritis. Internal medicine journal, 2015, Volume: 45, Issue:12 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Sulfasalazine; Treatment Outcome; United States	2015
Quantitation of Teriflunomide in Human Serum/Plasma Across a 40,000-Fold Concentration Range by LC/MS/MS. Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1383 Topics: Arthritis, Rheumatoid; Chromatography, Liquid; Crotonates; Dihydroorotate Dehydrogenase; Drug Monitoring; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Limit of Detection; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Prodrugs; Tandem Mass Spectrometry; Toluidines	2016
Changes in Body Mass Related to the Initiation of Disease-Modifying Therapies in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:8 Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Body Weight; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Tumor Necrosis Factor-alpha	2016
Examining Time to Initiation of Biologic Disease-modifying Antirheumatic Drugs and Medication Adherence and Persistence Among Texas Medicaid Recipients With Rheumatoid Arthritis. Clinical therapeutics, 2016, Volume: 38, Issue:3 Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Hispanic or Latino; Humans; Isoxazoles; Leflunomide; Male; Medicaid; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Texas; United States; Young Adult	2016
Effectiveness of treatment with biologic- and disease-modifying antirheumatic drugs in rheumatoid arthritis patients in Colombia. International journal of clinical practice, 2016, Volume: 70, Issue:6 Topics: Abatacept; Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Child; Child, Preschool; Chloroquine; Cohort Studies; Colombia; Etanercept; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Young Adult	2016
Proteome Analysis of Rheumatoid Arthritis Gut Mucosa. Journal of proteome research, 2017, 01-06, Volume: 16, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Colon; Epithelial Cells; Female; Gene Expression Regulation; Humans; Intestinal Mucosa; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Proteome; Tetrahydrofolate Dehydrogenase	2017
Cost-effectiveness Analysis of Treatment Sequence Initiating With Etanercept Compared With Leflunomide in Rheumatoid Arthritis: Impact of Reduced Etanercept Cost With Patent Expiration in South Korea. Clinical therapeutics, 2016, Volume: 38, Issue:11 Topics: Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Cost-Benefit Analysis; Drug Costs; Etanercept; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Republic of Korea	2016
Primary cardiac B cell lymphoma: Manifestation of Felty's syndrome or TNFα antagonist. Pathology, research and practice, 2016, Volume: 212, Issue:12 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Felty Syndrome; Female; Heart Neoplasms; Humans; Infliximab; Isoxazoles; Leflunomide; Lymphoma, B-Cell; Myocardium; Tumor Necrosis Factor-alpha	2016
Putting recommendations into practice: Australian rheumatologists' opinions on leflunomide use in rheumatoid arthritis. Clinical rheumatology, 2017, Volume: 36, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Disease Management; Humans; Isoxazoles; Leflunomide; Rheumatologists; Rheumatology; Societies, Medical; Surveys and Questionnaires	2017
Risk and severity of herpes zoster in patients with rheumatoid arthritis receiving different immunosuppressive medications: a case-control study in Asia. BMJ open, 2017, 01-05, Volume: 7, Issue:1 Topics: Abatacept; Adalimumab; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Case-Control Studies; Etanercept; Female; Herpes Zoster; Herpes Zoster Ophthalmicus; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Odds Ratio; Risk Factors; Rituximab; Severity of Illness Index; Sulfasalazine; Taiwan; Time Factors; Tumor Necrosis Factor-alpha; Young Adult	2017
IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide. Scientific reports, 2017, 01-24, Volume: 7 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Interleukin-22; Interleukins; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; T-Lymphocytes, Helper-Inducer; Treatment Outcome	2017
The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1. Journal of translational medicine, 2017, 02-13, Volume: 15, Issue:1 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Differentiation; Crotonates; Forkhead Transcription Factors; Heme Oxygenase-1; Humans; Hydroxybutyrates; Inflammation; Isoxazoles; Jurkat Cells; Leflunomide; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitriles; Oxidative Stress; Signal Transduction; Spleen; Th17 Cells; Toluidines; Tyrosine	2017
Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis. Modern rheumatology, 2008, Volume: 18, Issue:5 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Japan; Leflunomide; Lung Injury; Male; Middle Aged; Odds Ratio; Practice Guidelines as Topic; Retrospective Studies	2008
[Persistent diarrhea and loss of weight during therapy with leflunomide]. Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:34-35 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Colitis, Lymphocytic; Diabetes Mellitus, Type 1; Diarrhea; Female; Hashimoto Disease; Humans; Hypertension; Isoxazoles; Leflunomide; Middle Aged; Weight Loss	2008
Rheumatoid arthritis, alcohol, leflunomide and methotrexate. Can changes to the BSR guidelines for leflunomide and methotrexate on alcohol consumption be justified? Musculoskeletal care, 2008, Volume: 6, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Depressants; Contraindications; Databases, Factual; Ethanol; Female; Health Care Surveys; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Surveys and Questionnaires	2008
Effects of leflunomide and methotrexate in rheumatoid arthritis detected by digital X-ray radiogrammetry and computer-aided joint space analysis. Rheumatology international, 2009, Volume: 29, Issue:3 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Female; Finger Joint; Humans; Image Interpretation, Computer-Assisted; Isoxazoles; Leflunomide; Longitudinal Studies; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Radiography	2009
Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. Journal of immunology (Baltimore, Md. : 1950), 2008, Oct-01, Volume: 181, Issue:7 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Cell Line, Tumor; Cyclooxygenase 2; Cytokines; Dinoprostone; Enzyme Induction; Fibroblasts; Humans; Inflammation Mediators; Isoxazoles; Lysophospholipids; Propionates; Receptors, Lysophosphatidic Acid; Synovial Fluid	2008
Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis. Joint bone spine, 2008, Volume: 75, Issue:5 Topics: Adjuvants, Immunologic; Adult; Arthritis, Rheumatoid; Cholestyramine Resin; Female; Glucocorticoids; Humans; Ion Exchange Resins; Isoxazoles; Leflunomide; Prednisolone; Stevens-Johnson Syndrome	2008
Leflunomide-associated progressive multifocal leukoencephalopathy. Archives of neurology, 2008, Volume: 65, Issue:11 Topics: Arthritis, Rheumatoid; Biopsy; Brain; Cytarabine; Humans; Immunosuppressive Agents; Injections, Intravenous; Isoxazoles; Leflunomide; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Middle Aged; Seizures; Staining and Labeling	2008
Preliminary study on the immunologic background of good clinical outcome in rheumatoid arthritis patients after one month therapy with leflunomide. Rheumatology international, 2009, Volume: 29, Issue:8 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Case-Control Studies; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Female; Follow-Up Studies; Humans; Immunity, Innate; Isoxazoles; Killer Cells, Natural; Leflunomide; Male; Middle Aged; Monocytes; T-Lymphocyte Subsets; Time Factors; Treatment Outcome	2009
Comparative effectiveness of tumour necrosis factor alpha inhibitors in combination with either methotrexate or leflunomide. Annals of the rheumatic diseases, 2009, Volume: 68, Issue:12 Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult	2009
Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide. Annals of the rheumatic diseases, 2010, Volume: 69, Issue:1 Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Cohort Studies; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Young Adult	2010
[Leflunomide in combination with TNF-blockers for Methotrexate intolerance]. Zeitschrift fur Rheumatologie, 2009, Volume: 68, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor Inhibitors	2009
Disease-modifying antirheumatic drugs. The Journal of hand surgery, 2009, Volume: 34, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2009
The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide. Pharmacogenomics, 2009, Volume: 10, Issue:2 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Carrier State; Conserved Sequence; Dihydroorotate Dehydrogenase; DNA Primers; Exons; Female; Genotype; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Oxidoreductases Acting on CH-CH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide	2009
Leflunomide use in New Zealand. A national prospective post-marketing study. Internal medicine journal, 2009, Volume: 39, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; New Zealand; Product Surveillance, Postmarketing; Prospective Studies; Registries; Young Adult	2009
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide. Arthritis and rheumatism, 2009, Volume: 60, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biopsy; Case-Control Studies; Drug Resistance, Multiple; Endothelial Cells; Humans; Isoxazoles; Leflunomide; Macrophages; Methotrexate; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Synovial Membrane	2009
Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis. Rheumatology (Oxford, England), 2009, Volume: 48, Issue:9 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Weight; Female; Humans; Isoxazoles; Japan; Leflunomide; Lung Diseases, Interstitial; Male; Middle Aged; Prevalence; Product Surveillance, Postmarketing; Risk Factors; Smoking	2009
Measure of function in rheumatoid arthritis: individualised or classical scales? Annals of the rheumatic diseases, 2010, Volume: 69, Issue:1 Topics: Activities of Daily Living; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Prospective Studies; Psychometrics; Reproducibility of Results; Severity of Illness Index; Treatment Outcome	2010
An elderly man with rheumatoid arthritis and dyspnea. Chest, 2009, Volume: 135, Issue:4 Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Male; Pneumonia; Pulmonary Alveoli	2009
[Leflunomide and Lyell syndrome]. Annales de dermatologie et de venereologie, 2009, Volume: 136, Issue:4 Topics: Adult; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Seizures; Stevens-Johnson Syndrome	2009
Leflunomide-induced polymyositis in a patient with rheumatoid arthritis. Modern rheumatology, 2009, Volume: 19, Issue:4 Topics: Adjuvants, Immunologic; Alanine Transaminase; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Muscle, Skeletal; Polymyositis; Prednisolone; Treatment Outcome	2009
Leflunomide and the lung. Rheumatology (Oxford, England), 2009, Volume: 48, Issue:9 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases	2009
Leflunomide treatment in elderly patients with rheumatoid or psoriatic arthritis: retrospective analysis of safety and adherence to treatment. Drugs & aging, 2009, Volume: 26, Issue:5 Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Isoxazoles; Italy; Leflunomide; Male; Medication Adherence; Middle Aged; Retrospective Studies; Severity of Illness Index; Survival Rate; Treatment Outcome	2009
Prevalence of positive ppd in a cohort of rheumatoid arthritis patients. Rheumatology international, 2010, Volume: 30, Issue:5 Topics: Adult; Aged; Antirheumatic Agents; Argentina; Arthritis, Rheumatoid; Biological Products; Cross-Sectional Studies; Female; Humans; Isoxazoles; Latent Tuberculosis; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Risk Assessment; Risk Factors; Steroids; Treatment Outcome; Tuberculin Test; Tumor Necrosis Factor-alpha	2010
Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; Aryl Hydrocarbon Hydroxylases; Crotonates; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Female; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Male; Middle Aged; Nitriles; Polymorphism, Genetic; Synovial Membrane; Toluidines	2009
Long-term efficacy of leflunomide on disease activity and inhibition of joint damage: retrospective comparison with methotrexate for Japanese rheumatoid arthritis patients. Modern rheumatology, 2009, Volume: 19, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Chi-Square Distribution; Disease Progression; Drug Therapy, Combination; Female; Finger Joint; Humans; Isoxazoles; Japan; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Retrospective Studies; Severity of Illness Index; Statistics, Nonparametric; Toe Joint; Treatment Outcome; Wrist Joint	2009
Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis. Annals of the rheumatic diseases, 2009, Volume: 68, Issue:8 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP1A2; Dihydroorotate Dehydrogenase; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Oxidoreductases Acting on CH-CH Group Donors; Polymorphism, Genetic	2009
Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis. Rheumatology (Oxford, England), 2009, Volume: 48, Issue:10 Topics: Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Crotonates; Female; Humans; Hydroxybutyrates; Hypoxia; Isoxazoles; Japan; Leflunomide; Lung Diseases, Interstitial; Lung Injury; Male; Middle Aged; Nitriles; Product Surveillance, Postmarketing; Prognosis; Respiration, Artificial; Risk Factors; Serum Albumin; Toluidines	2009
[Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia]. Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:1 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Colombia; Diagnostic Services; Direct Service Costs; Disease Management; Drug Costs; Drug Therapy, Combination; Etanercept; Health Care Costs; Hospital Costs; Hospitals, University; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Thiazines; Thiazoles	2009
Pseudo-pseudo Meigs syndrome developed under the leflunomide therapy. Rheumatology international, 2011, Volume: 31, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; CA-125 Antigen; Diagnosis, Differential; Female; Humans; Isoxazoles; Leflunomide; Meigs Syndrome; Middle Aged	2011
[Security of the combined treatment of methotrexate and leflunomide in patients with rheumatoid arthritis]. Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2007, Volume: 64, Issue:4 Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Injections, Intramuscular; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome	2007
Successful treatment of leflunomide-induced acute pneumonitis with cholestyramine wash-out therapy. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2009, Volume: 15, Issue:8 Topics: Adult; Alveolitis, Extrinsic Allergic; Anion Exchange Resins; Antirheumatic Agents; Arthritis, Rheumatoid; Cholestyramine Resin; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial	2009
Rituximab and concomitant leflunomide for the treatment of rheumatoid arthritis. Rheumatology international, 2010, Volume: 30, Issue:5 Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Recurrence; Retrospective Studies; Rituximab; Severity of Illness Index; Time Factors; Treatment Outcome	2010
Severe aplastic anaemia following leflunomide therapy. Rheumatology (Oxford, England), 2010, Volume: 49, Issue:5 Topics: Adult; Anemia, Aplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide	2010
Disseminated cutaneous and visceral Kaposi sarcoma in a woman with rheumatoid arthritis receiving leflunomide. Rheumatology international, 2012, Volume: 32, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Sarcoma, Kaposi	2012
Birth outcomes in women who have taken leflunomide during pregnancy. Arthritis and rheumatism, 2010, Volume: 62, Issue:5 Topics: Adult; Anticholesteremic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Birth Weight; Body Size; Cholestyramine Resin; Congenital Abnormalities; Female; Gestational Age; Humans; Infant, Newborn; Isoxazoles; Leflunomide; Linear Models; Multivariate Analysis; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Risk Factors	2010
Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admission. Arthritis care & research, 2010, Volume: 62, Issue:5 Topics: Adverse Drug Reaction Reporting Systems; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Episode of Care; Female; Glucocorticoids; Hospitalization; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Compliance; Product Surveillance, Postmarketing; Retrospective Studies; Tennessee	2010
Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment. Annals of the New York Academy of Sciences, 2010, Volume: 1193 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Gene Expression Profiling; Gene Expression Regulation; Glucocorticoids; Humans; Inflammation; Isoxazoles; Leflunomide; Leukocytes, Mononuclear; Male; Microarray Analysis; Middle Aged; Prednisone; RNA, Messenger; Time Factors; Treatment Outcome	2010
Comment on: Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis. Rheumatology (Oxford, England), 2010, Volume: 49, Issue:8 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cause of Death; Humans; Isoxazoles; Japan; Leflunomide; Lung Diseases, Interstitial; Lung Injury; Risk Factors	2010
Leflunomide in combination therapy for rheumatoid arthritis. Drug safety, 2010, Jun-01, Volume: 33, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Infections; Isoxazoles; Leflunomide; Methotrexate; New Zealand; Pancytopenia; Pneumonia	2010
Pharmacotherapy: Is there a place for leflunomide in the treatment of RA? Nature reviews. Rheumatology, 2010, Volume: 6, Issue:7 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	2010
Macrophage activation syndrome after leflunomide treatment in an adult rheumatoid arthritis patient. Rheumatology (Oxford, England), 2010, Volume: 49, Issue:10 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Macrophage Activation Syndrome; Male; Middle Aged	2010
[Combined therapy in a patient with generalized aggressive periodontitis and rheumatoid arthritis: a 15-year follow up case]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2010, Volume: 45, Issue:5 Topics: Adult; Aggressive Periodontitis; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Dental Scaling; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Metronidazole; Periodontal Splints; Root Canal Therapy; Spiramycin	2010
A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammatory disease patients screened for latent tuberculosis prior to the initiation of a first tumor necrosis factor α inhibitor. Clinical rheumatology, 2011, Volume: 30, Issue:4 Topics: Arthritis, Rheumatoid; Azathioprine; Biological Assay; CD4-Positive T-Lymphocytes; Female; Glucocorticoids; Humans; Immunity, Cellular; Interferon-gamma; Isoxazoles; Latent Tuberculosis; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Tuberculin Test; Tumor Necrosis Factor-alpha	2011
Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers. Rheumatology (Oxford, England), 2011, Volume: 50, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Cohort Studies; Female; Germany; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Pancreatic Neoplasms; Registries; Risk Factors; Sweden; United Kingdom; White People	2011
Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens. Congenital anomalies, 2011, Volume: 51, Issue:1 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antidepressive Agents; Arthritis, Rheumatoid; Carbamazepine; Case-Control Studies; Cohort Studies; Female; Fever; Fluoxetine; Humans; Isoxazoles; Leflunomide; Maternal Exposure; Neural Tube Defects; Physical Examination; Pregnancy; Prospective Studies; Research Design; Teratogens; Tretinoin	2011
Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients. Rheumatology international, 2012, Volume: 32, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; India; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Time Factors	2012
The effect of ESR1 and ESR2 gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide. Pharmacogenomics, 2011, Volume: 12, Issue:1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Genotype; Humans; Isoxazoles; Leflunomide; Middle Aged; Polymorphism, Single Nucleotide; Treatment Outcome	2011
Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:5 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Benzophenones; Cytochrome P-450 Enzyme System; Glucuronides; Glucuronosyltransferase; Haplorhini; Humans; Hydrolysis; Intestinal Mucosa; Intestines; Isoenzymes; Isoxazoles; Liver; Microsomes; Microsomes, Liver; Rats; Recombinant Proteins; Transcription Factor AP-1	2011
Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective. Rheumatology (Oxford, England), 2011, Volume: 50, Issue:7 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cost of Illness; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Markov Chains; Methotrexate; Middle Aged; Netherlands; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha	2011
A series of complications after third molar osteotomy in a pancytopenia patient and spontaneous healing after bone marrow transplantation. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2011, Volume: 69, Issue:10 Topics: Adult; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Transplantation; Clindamycin; Cutaneous Fistula; Dental Care for Chronically Ill; Female; Focal Infection, Dental; Humans; Immunocompromised Host; Isoxazoles; Leflunomide; Mandibular Diseases; Molar, Third; Mucormycosis; Negative-Pressure Wound Therapy; Osteomyelitis; Osteotomy; Pancytopenia; Platelet Transfusion; Pneumonia; Tooth Extraction	2011
Photodistributed eruption with rhabdomyolisis due to leflunomide. Photodermatology, photoimmunology & photomedicine, 2011, Volume: 27, Issue:4 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Photosensitivity Disorders; Rhabdomyolysis; Sjogren's Syndrome	2011
A case of eczematous and vesicular dermatitis during anti-TNFalpha therapy for rheumatoid arthritis. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2011, Volume: 146, Issue:4 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnostic Errors; Drug Eruptions; Drug Synergism; Drug Therapy, Combination; Eczema; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Pruritus; Psoriasis; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Skin Diseases, Vesiculobullous; Tumor Necrosis Factor-alpha	2011
Comparative effectiveness of rituximab in combination with either methotrexate or leflunomide in the treatment of rheumatoid arthritis. Seminars in arthritis and rheumatism, 2011, Volume: 41, Issue:3 Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome	2011
[Treatment of rheumatoid and psoriatic arthritis--review of leflunomide]. Reumatizam, 2010, Volume: 57, Issue:2 Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	2010
Efficacy of leflunomide addition in relation to prognostic factors for patients with active early rheumatoid arthritis failing to methotrexate in daily practice. Clinical rheumatology, 2012, Volume: 31, Issue:1 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Female; Humans; Isoxazoles; Joints; Leflunomide; Male; Methotrexate; Middle Aged; Prognosis; Range of Motion, Articular; Retrospective Studies; Severity of Illness Index; Treatment Outcome	2012
Interstitial lung disease in rheumatoid arthritis: response to IL-6R blockade. Scandinavian journal of rheumatology, 2011, Volume: 40, Issue:5 Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Drug Therapy, Combination; Dyspnea; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Methotrexate; Middle Aged; Peptides, Cyclic; Radiography; Receptors, Interleukin-6; Rheumatoid Factor; Steroids	2011
Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: results of a 1-year follow-up study from the CERERRA collaboration. Annals of the rheumatic diseases, 2012, Volume: 71, Issue:3 Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Rituximab; Treatment Outcome	2012
Leflunomide in clinical practice. A retrospective observational study on use of leflunomide in New Zealand. International journal of rheumatic diseases, 2011, Volume: 14, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Male; Middle Aged; New Zealand; Retrospective Studies; Young Adult	2011
Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis. Arthritis care & research, 2011, Volume: 63, Issue:10 Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Narcotics; Retrospective Studies; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2011
Leflunomide-induced pulmonary hypertension in a young woman with rheumatoid arthritis: a case report. Cardiovascular toxicology, 2012, Volume: 12, Issue:2 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Leflunomide; Ultrasonography	2012
Differential drug retention between anti-TNF agents and alternative biological agents after inadequate response to an anti-TNF agent in rheumatoid arthritis patients. Annals of the rheumatic diseases, 2012, Volume: 71, Issue:6 Topics: Abatacept; Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Proportional Hazards Models; Registries; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha	2012
[Sulphasalazine in patients with rheumatoid arthritis in China: a cross-sectional study]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2012, Apr-18, Volume: 44, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; China; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Sulfasalazine; Surveys and Questionnaires	2012
A case of severe staphylococcal septicaemia: septic arthritis and a mediastinal abscess following leflunamide therapy for rheumatoid arthritis. BMJ case reports, 2010, Aug-19, Volume: 2010 Topics: Abscess; Adrenal Cortex Hormones; Anti-Bacterial Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Bacteremia; Drainage; Female; Follow-Up Studies; Humans; Immunocompromised Host; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged; Risk Assessment; Severity of Illness Index; Streptococcal Infections; Treatment Outcome	2010
Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis. Arthritis research & therapy, 2012, Jul-12, Volume: 14, Issue:4 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cytochrome P-450 CYP2C19; Diarrhea; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Polymorphism, Single Nucleotide; Retrospective Studies; Withholding Treatment	2012
Risk factors of severe infections in patients with rheumatoid arthritis treated with leflunomide. Modern rheumatology, 2013, Volume: 23, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Retrospective Studies; Risk Factors	2013
Tumour necrosis factor-alpha inhibitor-induced hepatic injury in patients with rheumatoid arthritis: two case reports and an analysis of the laboratory data from the Slovenian national biologicals registry. Rheumatology international, 2013, Volume: 33, Issue:11 Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Registries; Slovenia; Sulfasalazine; Tumor Necrosis Factor-alpha	2013
Pulmonary aspergillosis in chronic leflunomide treatment. Surgical infections, 2012, Volume: 13, Issue:4 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lung; Pulmonary Aspergillosis; Radiography, Thoracic	2012
Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis. Pharmacogenomics, 2012, Volume: 13, Issue:12 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dihydroorotate Dehydrogenase; Female; Haplotypes; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Oxidoreductases Acting on CH-CH Group Donors; Polymorphism, Single Nucleotide; Young Adult	2012
Treatment of early rheumatoid arthritis in a multinational inception cohort of Latin American patients: the GLADAR experience. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2012, Volume: 18, Issue:7 Topics: Adult; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Management; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Isoxazoles; Latin America; Leflunomide; Male; Methotrexate; Middle Aged; Registries; Sulfasalazine; Treatment Outcome	2012
Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate. Arthritis research & therapy, 2012, Oct-29, Volume: 14, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Elasticity Imaging Techniques; Female; Humans; Isoxazoles; Leflunomide; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Multivariate Analysis; Risk Factors	2012
Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort. Arthritis research & therapy, 2012, Nov-19, Volume: 14, Issue:6 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Cohort Studies; Disease Progression; Female; Humans; Isoxazoles; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Outcome Assessment, Health Care; Peptides, Cyclic; Prognosis; Radiography	2012
Leflunomide in dialysis patients with rheumatoid arthritis--a pharmacokinetic study. Clinical rheumatology, 2013, Volume: 32, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Crotonates; Female; Humans; Hydroxybutyrates; Isoxazoles; Kidney Failure, Chronic; Leflunomide; Male; Middle Aged; Models, Biological; Nitriles; Renal Dialysis; Retrospective Studies; Toluidines	2013
Therapeutic efficacy and safety of methotrexate + leflunomide in Colombian patients with active rheumatoid arthritis refractory to conventional treatment. Revista brasileira de reumatologia, 2012, Volume: 52, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Child; Colombia; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Young Adult	2012
A predictive model for remission and low disease activity in patients with established rheumatoid arthritis receiving TNF blockers. Clinical rheumatology, 2013, Volume: 32, Issue:5 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Prednisolone; Prospective Studies; Remission Induction; Rheumatoid Factor; Surveys and Questionnaires; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2013
The SMILE study -- safety of methotrexate in combination with leflunomide in rheumatoid arthritis. The Journal of rheumatology, 2013, Volume: 40, Issue:3 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome	2013
A biologic pharmacosurveillance program for rheumatoid arthritis: a single-center experience. Clinical rheumatology, 2013, Volume: 32, Issue:6 Topics: Adrenal Cortex Hormones; Alberta; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Registries; Remission Induction; Severity of Illness Index	2013
Leflunomide-induced chronic cough in a rheumatoid arthritis patient with pulmonary tuberculosis. BMJ case reports, 2013, Feb-01, Volume: 2013 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; Arthritis, Rheumatoid; Cough; Female; Humans; Isoxazoles; Leflunomide; Tuberculosis, Pulmonary	2013
Physician treatment preferences in rheumatoid arthritis of differing disease severity and activity: the impact of cost on first-line therapy. Arthritis and rheumatism, 2002, Jun-15, Volume: 47, Issue:3 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Costs and Cost Analysis; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Pilot Projects; Practice Patterns, Physicians'; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Tumor Necrosis Factor-alpha	2002
Peripheral neuropathy: an unwanted effect of leflunomide? Rheumatology (Oxford, England), 2002, Volume: 41, Issue:8 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; Isoxazoles; Leflunomide; Male; Peripheral Nervous System Diseases	2002
Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden. Annals of the rheumatic diseases, 2002, Volume: 61, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Clinical Protocols; Etanercept; Feasibility Studies; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Middle Aged; Monitoring, Physiologic; Product Surveillance, Postmarketing; Prospective Studies; Pyrimidines; Receptors, Tumor Necrosis Factor; Sweden; Treatment Outcome; Tumor Necrosis Factor-alpha	2002
Alopecia areata in a patient with rheumatoid arthritis treated with leflunomide. The Journal of rheumatology, 2002, Volume: 29, Issue:8 Topics: Alopecia Areata; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged	2002
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis and rheumatism, 2002, Volume: 47, Issue:4 Topics: Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Radiography, Thoracic; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Rheumatoid Nodule; Tomography, X-Ray Computed; Treatment Outcome; Vasculitis	2002
[2 years data of controlled trials with leflunomide vs. methotrexate and leflunomide vs. sulfasalazine]. Zeitschrift fur Rheumatologie, 2002, Volume: 61, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine	2002
Fatal hepatitis with leflunomide and itraconazole. The American journal of medicine, 2002, Volume: 113, Issue:4 Topics: Aged; Antifungal Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury, Chronic; Diagnosis, Differential; Drug Administration Schedule; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Isoxazoles; Itraconazole; Leflunomide; Mycoses; Otitis Media	2002
Summaries for patients. Combination therapy for rheumatoid arthritis. Annals of internal medicine, 2002, Nov-05, Volume: 137, Issue:9 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Arthritis, Rheumatoid; Diarrhea; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Liver Function Tests; Male; Methotrexate; Middle Aged; Treatment Outcome	2002
Leflunomide can potentiate the anticoagulant effect of warfarin. BMJ (Clinical research ed.), 2002, Dec-07, Volume: 325, Issue:7376 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthritis, Rheumatoid; Drug Synergism; Hematuria; Humans; International Normalized Ratio; Isoxazoles; Leflunomide; Male; Middle Aged; Warfarin	2002
Pancytopenia associated with leflunomide and methotrexate. The Annals of pharmacotherapy, 2003, Volume: 37, Issue:1 Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Pancytopenia	2003
Life-threatening reversible bone marrow toxicity in a rheumatoid arthritis patient switched from leflunomide to infliximab. Rheumatology (Oxford, England), 2003, Volume: 42, Issue:1 Topics: Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Pancytopenia; Steroids	2003
Cost effectiveness of adding leflunomide to a 5-year strategy of conventional disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Arthritis and rheumatism, 2002, Dec-15, Volume: 47, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Cost-Benefit Analysis; Decision Trees; Drug Therapy, Combination; Economics, Pharmaceutical; Health Care Costs; Humans; Isoxazoles; Leflunomide; Models, Statistical; Probability	2002
Unproven hypothesis that leflunomide is better than methotrexate as measured by magnetic resonance imaging: comment on the article by Reece et al. Arthritis and rheumatism, 2003, Volume: 48, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Magnetic Resonance Imaging; Methotrexate	2003
The use of disease modifying antirheumatic drugs in women with rheumatoid arthritis of childbearing age: a survey of practice patterns and pregnancy outcomes. The Journal of rheumatology, 2003, Volume: 30, Issue:2 Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Data Collection; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Receptors, Tumor Necrosis Factor; Risk Factors	2003
[Evidence-based treatment of methotrexate-resistant rheumatoid arthritis. Combinations of conventional disease-modifying antirheumatic agents]. Deutsche medizinische Wochenschrift (1946), 2003, Jan-24, Volume: 128, Issue:4 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Placebos; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors	2003
A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology (Oxford, England), 2003, Volume: 42, Issue:2 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Clinical Trials, Phase III as Topic; Disease Progression; Female; Follow-Up Studies; Health Status Indicators; Humans; Isoxazoles; Joints; Leflunomide; Linear Models; Male; Middle Aged; Pain Measurement; Severity of Illness Index; Treatment Outcome	2003
Aminotransferase levels during treatment of rheumatoid arthritis with leflunomide in clinical practice. Annals of the rheumatic diseases, 2003, Volume: 62, Issue:4 Topics: Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged; Prospective Studies	2003
FDA officials argue over safety of new arthritis drug. BMJ (Clinical research ed.), 2003, Mar-15, Volume: 326, Issue:7389 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug and Narcotic Control; Humans; Isoxazoles; Leflunomide; United States; United States Food and Drug Administration	2003
Anti-glomerular basement membrane antibody-associated renal failure in a patient with leflunomide-treated rheumatoid arthritis. Arthritis and rheumatism, 2003, Volume: 48, Issue:4 Topics: Arthritis, Rheumatoid; Basement Membrane; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Isoxazoles; Kidney Glomerulus; Leflunomide; Middle Aged; Renal Insufficiency	2003
Brain abscess in rheumatoid arthritis. Annals of the rheumatic diseases, 2003, Volume: 62, Issue:7 Topics: Arthritis, Rheumatoid; Brain; Brain Abscess; Emergencies; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Magnetic Resonance Imaging; Male; Middle Aged; Tomography, X-Ray Computed	2003
[Can a combination therapy with leflunomide be recommended for patients with active rheumatoid arthritis?]. Zeitschrift fur Rheumatologie, 2003, Volume: 62, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Treatment Outcome	2003
Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis. Clinical and experimental immunology, 2003, Volume: 133, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemokine CCL17; Chemokine CCL2; Chemokine CCL22; Chemokines; Chemokines, CC; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Statistics, Nonparametric	2003
Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography. Biomedical chromatography : BMC, 2003, Volume: 17, Issue:4 Topics: Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Crotonates; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Nitriles; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Toluidines	2003
[Drug hypersensitivity syndrome induced by leflunomide]. Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:5 Topics: Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged	2003
[Lichenoid drug reaction to leflunomide]. Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lichenoid Eruptions; Middle Aged; Patch Tests; Skin	2003
Toward a definition and method of assessment of treatment failure and treatment effectiveness: the case of leflunomide versus methotrexate. The Journal of rheumatology, 2003, Volume: 30, Issue:8 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Patient Satisfaction; Predictive Value of Tests; Severity of Illness Index; Surveys and Questionnaires; Treatment Failure	2003
Is the recommended dose of leflunomide the best regimen to treat rheumatoid arthritis patients? Rheumatology (Oxford, England), 2003, Volume: 42, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Retrospective Studies	2003
[Tolerable pain therapy in rheumatism saves long-term costs. Despite this most COX-2 candidates receive conventional NSAID therapy]. MMW Fortschritte der Medizin, 2003, Jul-24, Volume: 145, Issue:29-30 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost Savings; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Germany; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; National Health Programs; Prostaglandin-Endoperoxide Synthases; Sulfonamides	2003
Survival and effectiveness of leflunomide compared with methotrexate and sulfasalazine in rheumatoid arthritis: a matched observational study. Annals of the rheumatic diseases, 2003, Volume: 62, Issue:10 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Chi-Square Distribution; Databases, Factual; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Statistics, Nonparametric; Sulfasalazine; Time Factors; Treatment Failure	2003
Correlation between clinical response to treatment and radiographic progression: comment on the article by Strand and Sharp. Arthritis and rheumatism, 2003, Volume: 48, Issue:10 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Radiography	2003
Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide. Dermatology (Basel, Switzerland), 2003, Volume: 207, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Erythema Multiforme; Female; Humans; Isoxazoles; Leflunomide; Middle Aged	2003
Leflunomide use during the first 33 months after food and drug administration approval: experience with a national cohort of 3,325 patients. Arthritis and rheumatism, 2003, Dec-15, Volume: 49, Issue:6 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Databases, Factual; Drug Approval; Drug Therapy, Combination; Female; Hospitals, Veterans; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Military Medicine; Product Surveillance, Postmarketing; Treatment Failure; United States; United States Department of Veterans Affairs	2003
Leflunomide (Arava)-induced cystoid macular oedema. Rheumatology (Oxford, England), 2004, Volume: 43, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Macular Edema; Male; Middle Aged	2004
Weekly leflunomide as monotherapy for recent-onset rheumatoid arthritis. Arthritis and rheumatism, 2004, Feb-15, Volume: 51, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Joints; Leflunomide; Male; Outpatients; Pain; Treatment Outcome	2004
Japan deaths spark concerns over arthritis drug. Lancet (London, England), 2004, Feb-07, Volume: 363, Issue:9407 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cause of Death; Drug Approval; Humans; Isoxazoles; Japan; Leflunomide; Lung Diseases, Interstitial; Treatment Outcome	2004
Leflunomide-induced acute hepatitis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2004, Volume: 36, Issue:1 Topics: Adjuvants, Immunologic; Aged; Anion Exchange Resins; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestyramine Resin; Female; Humans; Isoxazoles; Leflunomide; Liver	2004
[Contribution of leflunomide to the cost effectiveness of sequential DMARD therapy of rheumatoid arthritis in Germany]. Zeitschrift fur Rheumatologie, 2004, Volume: 63, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Germany; Humans; Isoxazoles; Leflunomide; Mathematical Computing; Models, Economic; National Health Programs; Quality of Life; Quality-Adjusted Life Years	2004
[Development and/or increase of rheumatoid nodules in RA patients following leflunomide therapy]. Zeitschrift fur Rheumatologie, 2004, Volume: 63, Issue:1 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Elbow; Female; Follow-Up Studies; Hand; Humans; Isoxazoles; Leflunomide; Male; Rheumatoid Factor; Rheumatoid Nodule	2004
Patient preferences for treatment of rheumatoid arthritis. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Computer Simulation; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Organogold Compounds; Patient Satisfaction; Receptors, Tumor Necrosis Factor; Risk	2004
The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1. Arthritis and rheumatism, 2004, Volume: 50, Issue:3 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Carrier Proteins; Cell Differentiation; DNA-Binding Proteins; Humans; Isoxazoles; Leflunomide; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Nuclear Proteins; Osteoclasts; Pyrimidines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; T-Lymphocytes; Transcription Factors	2004
The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. Arthritis and rheumatism, 2004, Apr-15, Volume: 51, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Hospitalization; Humans; Infections; Infliximab; Isoxazoles; Leflunomide; Male; Middle Aged; Retrospective Studies; Treatment Outcome	2004
Interstitial lung disease and disease modifying anti-rheumatic drugs. Lancet (London, England), 2004, Apr-10, Volume: 363, Issue:9416 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial	2004
Chronic overdose of leflunomide inducing interstitial nephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Overdose; Humans; Isoxazoles; Kidney; Leflunomide; Male; Nephritis, Interstitial	2004
Subacute cutaneous lupus erythematosus associated with leflunomide. Clinical and experimental dermatology, 2004, Volume: 29, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; Male; Middle Aged	2004
Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy. Dermatology (Basel, Switzerland), 2004, Volume: 208, Issue:3 Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lichen Planus, Oral; Middle Aged; Photosensitivity Disorders; Rhabdomyolysis	2004
Dose escalation of leflunomide (LEF) to 40 mg once daily in patients with rheumatoid arthritis and insufficient response to standard dose LEF. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:6 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Prospective Studies; Treatment Outcome	2004
Leflunomide in active rheumatoid arthritis: a prospective study in daily practice. British journal of clinical pharmacology, 2004, Volume: 57, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Prospective Studies; Treatment Outcome	2004
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2004, Volume: 53, Issue:6 Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Dexamethasone; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Interleukin-1; Isoenzymes; Isoxazoles; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Synovial Membrane; Time Factors	2004
Leflunomide-induced aseptic meningitis. Joint bone spine, 2004, Volume: 71, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Male; Meningitis, Aseptic; Middle Aged	2004
Peripheral neuropathy in patients on leflunomide. Rheumatology (Oxford, England), 2004, Volume: 43, Issue:7 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Peripheral Nervous System Diseases	2004
Extraarticular rheumatoid arthritis and drug-induced syndromes: understanding the role of tumor necrosis factor inhibitors. The Journal of rheumatology, 2004, Volume: 31, Issue:7 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Isoxazoles; Leflunomide; Tumor Necrosis Factor-alpha; Vasculitis	2004
[Changes in indices of inflammatory activity in patients with rheumatoid arthritis during early stages of basic therapy with leflunomide]. Terapevticheskii arkhiv, 2004, Volume: 76, Issue:5 Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Quality of Life; Severity of Illness Index; Treatment Outcome	2004
Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis. The American journal of medicine, 2004, Jul-15, Volume: 117, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Liver; Liver Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Severity of Illness Index; Treatment Outcome; United States	2004
Leflunomide in active rheumatoid arthritis: a prospective study in daily practice. British journal of clinical pharmacology, 2004, Volume: 58, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Prospective Studies; Treatment Outcome; Withholding Treatment	2004
[Methotrexate combined with leflunomide or hydroxychloroquine in the treatment of rheumatoid arteritis]. Zhonghua yi xue za zhi, 2004, Jun-17, Volume: 84, Issue:12 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged	2004
Pulmonary abscess due to leflunomide use in rheumatoid arthritis: a case report. Rheumatology international, 2005, Volume: 25, Issue:2 Topics: Adult; Ampicillin; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lung Abscess; Sulbactam; Tomography, X-Ray Computed	2005
Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis. Annals of the rheumatic diseases, 2005, Volume: 64, Issue:4 Topics: Aged; Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Crotonates; Drug Monitoring; Female; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Male; Middle Aged; Nitriles; Prodrugs; ROC Curve; Severity of Illness Index; Toluidines; Treatment Outcome	2005
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. Dermatology online journal, 2004, Jul-15, Volume: 10, Issue:1 Topics: Accidental Falls; Adrenal Cortex Hormones; Aged; Amputation, Surgical; Anti-Bacterial Agents; Antirheumatic Agents; Arm; Arthritis, Rheumatoid; Cellulitis; Combined Modality Therapy; Debridement; Diagnosis, Differential; Drug Therapy, Combination; Elbow Injuries; Fasciitis, Necrotizing; Humans; Hydroxychloroquine; Immunocompromised Host; Isoxazoles; Leflunomide; Male; Shock, Septic; Staphylococcal Scalded Skin Syndrome; Streptococcus pyogenes	2004
Adverse events with disease modifying antirheumatic drugs (DMARD): a cohort study of leflunomide compared with other DMARD. The Journal of rheumatology, 2004, Volume: 31, Issue:10 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Retrospective Studies	2004
Vasculitis associated with the use of leflunomide. The Journal of rheumatology, 2004, Volume: 31, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Treatment Outcome; Vasculitis	2004
Life-threatening hypertriglyceridemia during leflunomide therapy in a patient with rheumatoid arthritis. Arthritis and rheumatism, 2004, Volume: 50, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Hypertriglyceridemia; Isoxazoles; Leflunomide; Middle Aged	2004
Pulmonary hypertension in a patient with rheumatoid arthritis treated with leflunomide. Rheumatology (Oxford, England), 2004, Volume: 43, Issue:11 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Leflunomide	2004
[Current EULAR data on valdecoxib. New study results of gastrointestinal safety and "cost effectiveness"]. Krankenpflege Journal, 2004, Volume: 42, Issue:5-6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Drug Costs; Germany; Humans; Isoxazoles; Osteoarthritis; Peptic Ulcer; Product Surveillance, Postmarketing; Risk Factors; Sulfonamides	2004
Debilitating diarrhoea and weight loss due to colitis in two RA patients treated with leflunomide. Clinical rheumatology, 2005, Volume: 24, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Colitis; Colon; Colonoscopy; Diagnosis, Differential; Diarrhea; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Middle Aged; Weight Loss	2005
Induction of antinuclear antibodies in patients with rheumatoid arthritis treated with infliximab and leflunomide. Arthritis and rheumatism, 2004, Volume: 50, Issue:12 Topics: Adjuvants, Immunologic; Antibodies, Antinuclear; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Leflunomide	2004
Modeling the 5-year cost effectiveness of treatment strategies including tumor necrosis factor-blocking agents and leflunomide for treating rheumatoid arthritis in the Netherlands. Arthritis and rheumatism, 2004, Dec-15, Volume: 51, Issue:6 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Female; Humans; Isoxazoles; Leflunomide; Male; Markov Chains; Middle Aged; Models, Economic; Netherlands; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational study. Rheumatology (Oxford, England), 2005, Volume: 44, Issue:4 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Middle Aged; Severity of Illness Index	2005
Interstitial lung disease associated with leflunomide. Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:12 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial	2004
Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:12 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Middle Aged	2004
Post-coronary artery bypass graft liver failure: a possible association with leflunomide. The Annals of thoracic surgery, 2005, Volume: 79, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Coronary Artery Bypass; Fatal Outcome; Female; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Leflunomide; Liver Failure	2005
Valdecoxib-induced systemic contact dermatitis confirmed by positive patch test. Contact dermatitis, 2005, Volume: 52, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dermatitis, Allergic Contact; Drug Eruptions; Exanthema; Humans; Isoxazoles; Male; Patch Tests; Sulfonamides	2005
Successful treatment of a leg ulcer occurring in a rheumatoid arthritis patient under leflunomide therapy. Journal of the European Academy of Dermatology and Venereology : JEADV, 2005, Volume: 19, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Cholestyramine Resin; Debridement; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Leg Ulcer; Skin Transplantation; Vasculitis; Wound Healing	2005
Leflunomide-induced subacute cutaneous lupus erythematosus. Rheumatology (Oxford, England), 2005, Volume: 44, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; Middle Aged	2005
Neuropathy associated with leflunomide: a case series. Annals of the rheumatic diseases, 2005, Volume: 64, Issue:4 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Peripheral Nervous System Diseases	2005
[Treatment with leflunomide in rheumatoid arthritis]. Zeitschrift fur Rheumatologie, 2005, Volume: 64, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Europe; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome	2005
Physical function and health related quality of life: analysis of 2-year data from randomized, controlled studies of leflunomide, sulfasalazine, or methotrexate in patients with active rheumatoid arthritis. The Journal of rheumatology, 2005, Volume: 32, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Disability Evaluation; Double-Blind Method; Female; Health Status; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Sulfasalazine; Surveys and Questionnaires	2005
Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria. Arthritis and rheumatism, 2005, Volume: 52, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Health Status; Humans; Isoxazoles; Leflunomide; Methotrexate; Pain Measurement; Placebos; Randomized Controlled Trials as Topic; Rheumatology; Severity of Illness Index; Societies, Medical; Treatment Outcome; United States	2005
Modelling cost effectiveness and cost utility of sequential DMARD therapy including leflunomide in rheumatoid arthritis in Germany: I. Selected DMARDs and patient-related costs. PharmacoEconomics, 2005, Volume: 23, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Drug Costs; Germany; Humans; Isoxazoles; Leflunomide; Models, Economic	2005
[When to begin rheumatism treatment? Initial combination therapy helps fastest]. MMW Fortschritte der Medizin, 2004, Sep-09, Volume: 146, Issue:37 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
[Three joints swollen, blood sedimentation increased. Methotrexate to be given immediately?]. MMW Fortschritte der Medizin, 2004, Sep-09, Volume: 146, Issue:37 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
Leflunomide induced acute interstitial pneumonia. The Journal of rheumatology, 2005, Volume: 32, Issue:6 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Cholestyramine Resin; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Middle Aged; Prednisolone; Radiography, Thoracic; Treatment Outcome	2005
Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide. Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:1 Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Administration Schedule; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Isoxazoles; Leflunomide; Male; Peripheral Nervous System Diseases; Polyneuropathies; Rectal Neoplasms; Tegafur; Time Factors; Uracil	2005
Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005, Sep-07, Volume: 31, Issue:5 Topics: Active Transport, Cell Nucleus; Aniline Compounds; Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Crotonates; Cyclooxygenase 2; Cytokines; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxybutyrates; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-10; Interleukin-11; Interleukin-8; Isoxazoles; Leflunomide; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor, Type I; Sialoglycoproteins; Synovial Fluid; Time Factors; Toluidines; Trypsin	2005
Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis. British journal of clinical pharmacology, 2005, Volume: 60, Issue:3 Topics: Adjuvants, Immunologic; Adult; Aged; Aniline Compounds; Arthritis, Rheumatoid; Cross-Sectional Studies; Crotonates; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Male; Middle Aged; Nitriles; Toluidines	2005
Leflunomide in the treatment of rheumatoid arthritis. An analysis of predictors for treatment continuation. British journal of clinical pharmacology, 2005, Volume: 60, Issue:3 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Netherlands; Time Factors	2005
[Development of dermatomyositis in a woman with rheumatoid arthritis treated with leflunomide]. Anales de medicina interna (Madrid, Spain : 1984), 2005, Volume: 22, Issue:6 Topics: Arthritis, Rheumatoid; Dermatomyositis; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged	2005
Safety and efficacy of leflunomide and infliximab versus methotrexate and infliximab combination therapy in rheumatoid arthritis. Rheumatology (Oxford, England), 2005, Volume: 44, Issue:11 Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged	2005
Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. Clinical rheumatology, 2006, Volume: 25, Issue:3 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases; Male; Osteoarthropathy, Secondary Hypertrophic; Radionuclide Imaging; Radiopharmaceuticals; Rheumatoid Nodule; Technetium Tc 99m Medronate	2006
Subacute cutaneous lupus erythematosus associated with leflunomide. Cutis, 2005, Volume: 76, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; Middle Aged	2005
Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients. Annals of the rheumatic diseases, 2006, Volume: 65, Issue:6 Topics: Analysis of Variance; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blotting, Western; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Drug Therapy, Combination; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Intercellular Adhesion Molecule-1; Isoxazoles; Jurkat Cells; Leflunomide; Macrophages; Membrane Proteins; Methotrexate; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; T-Lymphocytes	2006
[Leflunomide-related severe axonal neuropathy]. Revue neurologique, 2005, Volume: 161, Issue:11 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Axons; Cranial Nerve Diseases; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Severity of Illness Index	2005
Towards an epidemiology of rheumatoid arthritis outcome with respect to treatment: randomized controlled trials overestimate treatment response and effectiveness. Rheumatology (Oxford, England), 2005, Volume: 44 Suppl 4 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bias; Epidemiologic Studies; Humans; Infliximab; Isoxazoles; Leflunomide; Models, Statistical; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome	2005
Leflunomide-associated tuberculosis? Rheumatology (Oxford, England), 2006, Volume: 45, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Opportunistic Infections; Tuberculosis, Pulmonary	2006
Severe hepatotoxicity in a rheumatoid arthritis patient switched from leflunomide to methotrexate. MedGenMed : Medscape general medicine, 2005, Sep-06, Volume: 7, Issue:3 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Severity of Illness Index	2005
Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy. Arthritis and rheumatism, 2006, Volume: 54, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Hospitalization; Humans; Immunocompromised Host; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Pneumonia; Prednisone; Risk Factors; Tumor Necrosis Factor-alpha	2006
Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports. Internal medicine journal, 2006, Volume: 36, Issue:3 Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Australia; Cohort Studies; Female; Follow-Up Studies; Humans; Incidence; Isoxazoles; Leflunomide; Male; Middle Aged; Pneumonia; Radiography; Respiratory Function Tests; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Distribution; Survival Rate	2006
The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2006, Volume: 17, Issue:1-2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Female; Fibroblasts; Gene Expression; Humans; In Vitro Techniques; Interleukin-17; Isoxazoles; Leflunomide; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Middle Aged; Oligonucleotide Array Sequence Analysis; Osteoarthritis; Recombinant Proteins; RNA, Messenger; Synovial Membrane; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha	2006
Disease modifying treatment for feline rheumatoid arthritis. Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 2005, Volume: 18, Issue:2 Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Breeding; Cat Diseases; Cats; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Isoxazoles; Leflunomide; Male; Methotrexate; Radiography; Treatment Outcome	2005
[Skin ulceration after leflunomide treatment in two patients with rheumatoid arthritis]. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2006, Volume: 4, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Skin Ulcer	2006
Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritis. Arthritis and rheumatism, 2006, Volume: 54, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Middle Aged; Risk Factors	2006
Safety of infliximab used in combination with leflunomide or azathioprine in daily clinical practice. The Journal of rheumatology, 2006, Volume: 33, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome	2006
Severe infections following leflunomide therapy for rheumatoid arthritis. Rheumatology (Oxford, England), 2006, Volume: 45, Issue:7 Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged; Opportunistic Infections; Tuberculosis, Spinal	2006
Leflunomide increases the risk of early healing complications in patients with rheumatoid arthritis undergoing elective orthopedic surgery. Rheumatology international, 2006, Volume: 26, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Orthopedics; Postoperative Complications; Risk; Surgical Wound Infection; Wound Healing	2006
Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis. Internal medicine (Tokyo, Japan), 2006, Volume: 45, Issue:10 Topics: Adjuvants, Immunologic; Aged; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lung; Pneumonia; Radiography; Radionuclide Imaging	2006
Peripheral neuropathy associated with leflunomide: is there a risk patient profile? Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Complications; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Neurologic Examination; Peripheral Nervous System Diseases; Rheumatoid Factor; Risk Assessment; Vasculitis	2007
Antirheumatic drug use and the risk of acute myocardial infarction. Arthritis and rheumatism, 2006, Aug-15, Volume: 55, Issue:4 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Myocardial Infarction; Random Allocation; Treatment Outcome	2006
Autoantibodies, metalloproteinases and bone markers in rheumatoid arthritis patients are unable to predict their responses to infliximab. Rheumatology (Oxford, England), 2007, Volume: 46, Issue:3 Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Bone Resorption; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Metalloproteases; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Rheumatoid Factor; Tumor Necrosis Factor-alpha	2007
Pulmonary alveolar proteinosis associated with a disease-modifying antirheumatoid arthritis drug. Respirology (Carlton, Vic.), 2006, Volume: 11, Issue:5 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Male; Pulmonary Alveolar Proteinosis	2006
Influence of leflunomide on gastrointestinal Candida albicans infection induced in naive and arthritic newborn mice. International immunopharmacology, 2006, Volume: 6, Issue:11 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Candida albicans; Candidiasis; Collagen; Colony Count, Microbial; Female; Gastrointestinal Diseases; Hypersensitivity, Delayed; Immunoglobulin G; Interferon-gamma; Interleukin-4; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred ICR; Spleen; Th1 Cells; Th2 Cells	2006
Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage. Modern rheumatology, 2006, Volume: 16, Issue:5 Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Autopsy; Cholestyramine Resin; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Methylprednisolone; Pulmonary Alveoli; Tomography, X-Ray Computed	2006
Leflunomide combined with conventional disease-modifying antirheumatic drugs or biologics in patients with rheumatoid arthritis. Joint bone spine, 2006, Volume: 73, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide	2006
Leflunomide-induced toxic epidermal necrolysis. International journal of dermatology, 2006, Volume: 45, Issue:11 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; Stevens-Johnson Syndrome	2006
Durability of treatment with methotrexate in Venezuelan patients with rheumatoid arthritis. Rheumatology international, 2007, Volume: 27, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Venezuela	2007
Leflunomide-induced peripheral neuropathy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2007, Volume: 14, Issue:2 Topics: Adjuvants, Immunologic; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Peripheral Nervous System Diseases	2007
The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:11 Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Crotonates; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Humans; Hydroxybutyrates; Interleukin-1beta; Isoxazoles; Jurkat Cells; Leflunomide; Nitriles; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Synovial Membrane; Toluidines; Tumor Necrosis Factor-alpha; Uridine	2006
Pulmonary adverse events with leflunomide--myth or reality? Rheumatology (Oxford, England), 2007, Volume: 46, Issue:2 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases; Male; Middle Aged	2007
Clinical practice format for choosing a second-line disease modifying anti-rheumatic drug in early rheumatoid arthritis after failure of 6 months' first-line DMARD therapy. Joint bone spine, 2007, Volume: 74, Issue:1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Decision Support Techniques; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Practice Guidelines as Topic; Radiography; Receptors, Tumor Necrosis Factor; Rheumatoid Factor; Sulfasalazine; Treatment Failure	2007
Dual mycobacterial infection in the setting of leflunomide treatment for rheumatoid arthritis. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:2 Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycobacterium leprae; Mycobacterium tuberculosis; Tuberculosis	2007
Step-up combination versus switching of non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a retrospective observational study. Annals of the rheumatic diseases, 2007, Volume: 66, Issue:8 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Retrospective Studies; Sulfasalazine; Treatment Failure	2007
Risk of interstitial lung disease associated with leflunomide treatment in Korean patients with rheumatoid arthritis. Arthritis and rheumatism, 2007, Volume: 56, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Korea; Leflunomide; Lung Diseases, Interstitial; Male; Middle Aged; Risk Factors	2007
Hypersensitivity pneumonitis associated with leflunomide therapy. The Journal of rheumatology, 2007, Volume: 34, Issue:9 Topics: Aged; Alveolitis, Extrinsic Allergic; Arthritis, Rheumatoid; Biopsy; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Tomography, X-Ray Computed	2007
New antirheumatic drugs: any real added value? A critical overview of regulatory criteria for their marketing approval. European journal of clinical pharmacology, 2007, Volume: 63, Issue:9 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Drug Approval; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Italy; Leflunomide; Legislation, Drug; Marketing; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Time Factors	2007
Cutaneous infections with Stenotrophomonas maltophilia in patients using immunosuppressive medication. Journal of the European Academy of Dermatology and Venereology : JEADV, 2007, Volume: 21, Issue:9 Topics: Adjuvants, Immunologic; Adult; Aged; Arthritis, Rheumatoid; Cross Infection; Cyclophosphamide; Female; Gram-Negative Bacterial Infections; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Skin Diseases, Infectious; Stenotrophomonas maltophilia	2007
Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. Modern rheumatology, 2007, Volume: 17, Issue:5 Topics: Aged; Anemia, Macrocytic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Pancytopenia; Radiography, Thoracic; Time Factors; Tomography, X-Ray Computed; Treatment Outcome	2007
Leflunomide-associated infections in rheumatoid arthritis. The Journal of rheumatology, 2007, Volume: 34, Issue:11 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cellulitis; Female; Hospitalization; Humans; Infections; Isoxazoles; Leflunomide; Male; Middle Aged; New Zealand; Sepsis; Staphylococcal Infections; Tuberculosis, Hepatic	2007
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. Journal of immunology (Baltimore, Md. : 1950), 2007, Nov-15, Volume: 179, Issue:10 Topics: Aniline Compounds; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Chronic Disease; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxybutyrates; Immunosuppressive Agents; Inflammation Mediators; Isoxazoles; Leflunomide; Mast Cells; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Synovial Membrane; Synovitis; Toluidines; Uridine	2007
A simple sample size formula for analysis of covariance in randomized clinical trials. Journal of clinical epidemiology, 2007, Volume: 60, Issue:12 Topics: Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Randomized Controlled Trials as Topic; Research Design; Sample Size; Sulfasalazine; Treatment Outcome	2007
Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease. Modern rheumatology, 2008, Volume: 18, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Lymphocyte Count; Middle Aged; Pulmonary Fibrosis	2008
The effectiveness of leflunomide as a co-therapy of tumour necrosis factor inhibitors in rheumatoid arthritis: a population-based study. Annals of the rheumatic diseases, 2009, Volume: 68, Issue:1 Topics: Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Confounding Factors, Epidemiologic; Disease Progression; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha	2009
Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. Journal of thoracic imaging, 2008, Volume: 23, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differential; Dyspnea; Hemoptysis; Hemorrhage; Humans; Isoxazoles; Kidney; Leflunomide; Lung; Lung Diseases; Male; Methylprednisolone; Muscle Weakness; Pleural Effusion; Pulmonary Alveoli; Tomography, X-Ray Computed	2008
Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. Pathology oncology research : POR, 2008, Volume: 14, Issue:1 Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases; Multiple Pulmonary Nodules; Rheumatoid Nodule; Sjogren's Syndrome; Thoracoscopy	2008
[A 47-year-old dog breeder with chronic polyarthritis, weight loss and high fever]. Zeitschrift fur Gastroenterologie, 2008, Volume: 46, Issue:5 Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Diagnosis, Differential; Disease Progression; Fever of Unknown Origin; Humans; Immunologic Deficiency Syndromes; Isoxazoles; Leflunomide; Male; Middle Aged; Polymerase Chain Reaction; Risk Factors; Systemic Inflammatory Response Syndrome; Tropheryma; Weight Loss; Whipple Disease	2008
Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. European journal of clinical pharmacology, 2008, Volume: 64, Issue:9 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cytochrome P-450 CYP1A2; Diarrhea; Dose-Response Relationship, Drug; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Nausea; Pharmacogenetics; Pilot Projects; Polymorphism, Genetic; Pruritus; Vomiting	2008
Use of contrast enhanced MRI in the assessment of therapeutic response to a disease-modifying antirheumatic drug. Case study of a patient with rheumatoid arthritis--6- and 24-month follow up. British journal of rheumatology, 1995, Volume: 34, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Monitoring; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Magnetic Resonance Imaging; Metacarpophalangeal Joint; Middle Aged; Prospective Studies; Radiography; Single-Blind Method; Treatment Outcome	1995
Leflunomide, a novel immunomodulating drug, inhibits homotypic adhesion of mononuclear cells in rheumatoid arthritis. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Antigens, CD; Arthritis, Rheumatoid; Cell Aggregation; Cells, Cultured; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Synovial Fluid; Tetradecanoylphorbol Acetate	1996
The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis. RNA (New York, N.Y.), 1998, Volume: 4, Issue:8 Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Compartmentation; Cell Line; Cell Nucleus; Cloning, Molecular; DEAD-box RNA Helicases; Drug Resistance; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Molecular Sequence Data; RNA Helicases; RNA Nucleotidyltransferases; RNA Precursors; RNA Splicing; RNA Splicing Factors; RNA, Messenger; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Spliceosomes	1998
New treatments for rheumatoid arthritis. Health news (Waltham, Mass.), 1998, Nov-20, Volume: 4, Issue:14 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor	1998
Leflunomide approved for rheumatoid arthritis; other drugs nearing approval. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Nov-01, Volume: 55, Issue:21 Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	1998
New drugs for rheumatoid arthritis. The Medical letter on drugs and therapeutics, 1998, Nov-20, Volume: 40, Issue:1040 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diarrhea; Drug Interactions; Etanercept; Fees, Pharmaceutical; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha	1998
Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis. Transplantation proceedings, 1998, Volume: 30, Issue:8 Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibodies, Antinuclear; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Disease Models, Animal; Female; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Mutant Strains; Nitriles; Rats; Rats, Inbred Lew	1998
Rheumatoid arthritis drugs show promise. Mayo Clinic health letter (English ed.), 1999, Volume: 17, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor	1999
I have rheumatoid arthritis and have been taking methotrexate. I'm interested in the new drugs that have been in the news lately. Just how effective are they? Harvard women's health watch, 1999, Volume: 6, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor	1999
Clinical therapeutics. Current opinion in rheumatology, 1999, Volume: 11, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Leflunomide; Rheumatic Diseases; Tumor Necrosis Factor-alpha	1999
National Meeting of the American College of Rheumatology. November 8-12, 1998, San Diego, California. Clinical and investigative medicine. Medecine clinique et experimentale, 1999, Volume: 22, Issue:2 Topics: Aniline Compounds; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Crotonates; Etanercept; Humans; Hydroxybutyrates; Immunoglobulin G; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Infliximab; Isoxazoles; Leflunomide; Nitriles; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Toluidines; Tumor Necrosis Factor-alpha; United States	1999
Leflunomide for the treatment of rheumatoid arthritis. Bulletin on the rheumatic diseases, 1999, Volume: 48, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Isoxazoles; Leflunomide	1999
Disease-modifying activity of malononitrilamides, derivatives of leflunomide's active metabolite, on models of rheumatoid arthritis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 2 Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Crotonates; Dose-Response Relationship, Drug; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred Lew; Toluidines	1999
Changing the course of rheumatoid arthritis. Introduction. Scandinavian journal of rheumatology. Supplement, 1999, Volume: 112 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	1999
[Rheumatoid arthritis: a new basic therapy. Proliferating T-cells controlled]. MMW Fortschritte der Medizin, 2000, Apr-27, Volume: 142, Issue:17 Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; T-Lymphocytes	2000
Leflunomide, a new disease-modifying anti-rheumatic drug and the never ending rheumatoid arthritis story. Rheumatology (Oxford, England), 2000, Volume: 39, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy; Humans; Isoxazoles; Leflunomide	2000
[Treatment of rheumatoid arthritis]. Medicina clinica, 2000, May-27, Volume: 114, Issue:20 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Decision Making; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Patient Education as Topic	2000
Leflunomide: a new DMARD for rheumatoid arthritis. Hospital medicine (London, England : 1998), 2000, Volume: 61, Issue:5 Topics: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged	2000
[Recent progress in the treatment of rheumatoid polyarthritis]. Revue medicale de la Suisse romande, 2000, Volume: 120, Issue:7 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Switzerland; Treatment Outcome	2000
Severe pancytopenia after leflunomide in rheumatoid arthritis. Acta medica Austriaca, 2000, Volume: 27, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bone Marrow; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Isoxazoles; Leflunomide; Middle Aged; Pancytopenia; Recombinant Proteins	2000
Efficacy and safety of leflunomide in active rheumatoid arthritis. Rheumatology (Oxford, England), 2000, Volume: 39 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome	2000
Serious liver disease in a patient receiving methotrexate and leflunomide. Arthritis and rheumatism, 2000, Volume: 43, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Severity of Illness Index	2000
Newer immunomodulating drugs in rheumatoid arthritis may precipitate glomerulonephritis. Clinical nephrology, 2001, Volume: 55, Issue:1 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Glomerulonephritis; Humans; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Receptors, Tumor Necrosis Factor	2001
Current management of rheumatoid arthritis. Hospital practice (1995), 2001, Feb-15, Volume: 36, Issue:2 Topics: Adjuvants, Immunologic; Adult; Aged; Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Case Management; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged	2001
Treatment of Felty's syndrome with leflunomide. The Journal of rheumatology, 2001, Volume: 28, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Felty Syndrome; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged	2001
Leflunomide: new antirheumatic drug. Effect on pregnancy outcomes. Canadian family physician Medecin de famille canadien, 2001, Volume: 47 Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Half-Life; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Pregnancy; Pregnancy Complications	2001
Leflunomide-associated weight loss in rheumatoid arthritis. Arthritis and rheumatism, 2001, Volume: 44, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Oxidative Phosphorylation; Weight Loss	2001
Which HAQ is best? A comparison of the HAQ, MHAQ and RA-HAQ, a difficult 8 item HAQ (DHAQ), and a rescored 20 item HAQ (HAQ20): analyses in 2,491 rheumatoid arthritis patients following leflunomide initiation. The Journal of rheumatology, 2001, Volume: 28, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disability Evaluation; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Sensitivity and Specificity; Surveys and Questionnaires; Treatment Outcome	2001
Conventional DMARD options for patients with a suboptimal response to methotrexate. The Journal of rheumatology. Supplement, 2001, Volume: 62 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine	2001
[Chronic polyarthritis]. MMW Fortschritte der Medizin, 2001, May-24, Volume: 143, Issue:21 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome	2001
[Leflunomide--the first specific disease-modifying drug against rheumatoid arthritis]. Lakartidningen, 2001, Feb-07, Volume: 98, Issue:6 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	2001
[Application of leflunomide in the treatment of patients with rheumatoid arthritis]. Polskie Archiwum Medycyny Wewnetrznej, 2001, Volume: 105, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	2001
New therapeutic approaches to the management of rheumatoid arthritis. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2001, Volume: 15, Issue:6 Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Staphylococcal Protein A; Tumor Necrosis Factor-alpha	2001
[Leflunomide plus methotrexate. Hope for patients with rheumatoid arthritis]. MMW Fortschritte der Medizin, 2001, Aug-23, Volume: 143, Issue:33-34 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate	2001
Comparison of rheumatoid arthritis care costs in patients starting therapy with leflunomide versus etanercept. The American journal of managed care, 2001, Volume: 7, Issue:13 Suppl Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cost of Illness; Etanercept; Female; Health Care Costs; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Middle Aged; Receptors, Tumor Necrosis Factor; United States	2001
Is there a place for leflunomide in the treatment of rheumatoid arthritis? Lancet (London, England), 2001, Oct-13, Volume: 358, Issue:9289 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic	2001
Vasculitis occurring during leflunomide therapy. Dermatology (Basel, Switzerland), 2001, Volume: 203, Issue:3 Topics: Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Middle Aged; Vasculitis, Leukocytoclastic, Cutaneous	2001
Leflunomide and rheumatoid arthritis: new preparation. Neither the safest nor the most effective slow-acting antirheumatic drug. Prescrire international, 2001, Volume: 10, Issue:52 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; France; Humans; Isoxazoles; Methotrexate; Treatment Outcome	2001
Discussion. Treatment algorithm: managing rheumatoid arthritis. Managed care (Langhorne, Pa.), 2001, Volume: 10, Issue:7 Suppl Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Deductibles and Coinsurance; Disease Management; Drug Costs; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Medicare; Methotrexate; Patient Compliance; Primary Health Care; Quality of Life; Rheumatology; United States; Workforce	2001
Effect of hemodialysis on leflunomide plasma concentrations. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biotransformation; Chromatography, High Pressure Liquid; Female; Humans; Isoxazoles; Kidney Failure, Chronic; Leflunomide; Renal Dialysis	2002
Severe liver damage with leflunomide. Prescrire international, 2001, Volume: 10, Issue:55 Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Liver Cirrhosis; Liver Failure	2001
[New basic therapeutic drugs from the viewpoint of evidence-based therapy]. Zeitschrift fur Rheumatologie, 2001, Volume: 60, Issue:6 Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Etanercept; Evidence-Based Medicine; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Receptors, Tumor Necrosis Factor; Treatment Outcome	2001
Leflunomide in treatment of rheumatoid arthritis. Lancet (London, England), 2002, Mar-30, Volume: 359, Issue:9312 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide	2002
Monitoring leflunomide (Arava) as a new potential teratogen. Teratology, 2002, Volume: 65, Issue:5 Topics: Abnormalities, Drug-Induced; Arthritis, Rheumatoid; Female; Humans; Infant, Newborn; Isoxazoles; Leflunomide; Pregnancy; Teratogens	2002
Valdecoxib (Bextra)--a new cox-2 inhibitor. The Medical letter on drugs and therapeutics, 2002, Apr-29, Volume: 44, Issue:1129 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; Isoxazoles; Kidney Diseases; Osteoarthritis; Peptic Ulcer; Sulfonamides	2002
Leflunomide and hypertension. Annals of the rheumatic diseases, 2002, Volume: 61, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Hypertension; Isoxazoles; Leflunomide; Prospective Studies	2002
Impact of leflunomide versus biologic agents on the costs of care for rheumatoid arthritis in a managed care population. The American journal of managed care, 2002, Volume: 8, Issue:7 Suppl Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cost of Illness; Drug Costs; Etanercept; Female; Health Care Costs; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Managed Care Programs; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine; United States	2002
Leflunomide-associated skin ulceration. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:6 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Skin Ulcer	2002
[Drug therapy and malpractice exemplified by combination leflunomide and methotrexate therapy]. Zeitschrift fur Rheumatologie, 2002, Volume: 61, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Drug Interactions; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Malpractice; Methotrexate; Treatment Outcome	2002
[Leflunomide + methotrexate combination therapy from the physician's viewpoint]. Zeitschrift fur Rheumatologie, 2002, Volume: 61, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Drug Interactions; Drug Therapy, Combination; Germany; Humans; Isoxazoles; Leflunomide; Malpractice; Methotrexate	2002
A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis. The Journal of rheumatology, 2002, Volume: 29, Issue:6 Topics: Analysis of Variance; Arthritis, Rheumatoid; Cohort Studies; Cost-Benefit Analysis; Decision Making; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Pain Measurement; Probability; Prospective Studies; Receptors, Tumor Necrosis Factor; Sensitivity and Specificity; Sulfasalazine; Treatment Outcome; United States	2002
Clinical pharmacokinetics of leflunomide. Clinical pharmacokinetics, 2002, Volume: 41, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Availability; Biotransformation; Drug Interactions; Humans; Intestinal Absorption; Isoxazoles; Leflunomide; Tissue Distribution	2002