Page last updated: 2024-08-21

isoxazoles and Prostatic Neoplasms

isoxazoles has been researched along with Prostatic Neoplasms in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.52)18.2507
2000's3 (14.29)29.6817
2010's13 (61.90)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Huang, C; Li, J; Shen, H; Wu, X; Xiang, Q; Xu, Y; Zhang, C; Zhang, M; Zhang, Y; Zhao, L; Zhu, R; Zhuang, X1
Liu, ZX; Wang, C; Wu, C; Wu, TB; Xiang, QP; Xiao, LJ; Xu, Y; Zhang, C; Zhang, MF; Zhang, Y1
Armstrong, HK; Brooks, DA; Butler, LM; Centenera, MM; Chin, MY; Gillis, JL; Johnson, IRD; Levrier, C; Lynn, DJ; Moldovan, M; Nassar, ZD; Sadowski, MC; Selth, LA; Tarulli, G; Tomlinson Guns, ES1
Cronauer, M; Taubert, H; Wach, S1
Bilen, CY; Dikmen, AU; Kiliccioglu, I; Konac, E; Sozen, S1
Honkakoski, P; Huhtala, T; Jääskeläinen, T; Juvonen, RO; Kaikkonen, S; Küblbeck, J; Laatikainen, R; Närvänen, A; Palvimo, JJ; Peräkylä, M; Petsalo, A; Poutiainen, PK; Pulkkinen, JT; Raunio, H1
Clézardin, P; David, M; Descotes, F; Leblanc, R; Mege, F; Peyruchaud, O; Ribeiro, J; Sahay, D1
Avanzo, RE; Carabelos, MN; D'Accorso, NB; Fascio, ML; Gueron, G; Schuster, F; Vazquez, E1
Aleksic, T; Esashi, F; Gao, S; Lodhia, KA; Macaulay, VM1
Liu, S; Parajuli, KR; You, Z; Zhang, Q2
Aliev, G; Arunasree, KM; Bishayee, A; Dhananjaya, BL; Dharmapuri, G; Pedada, SR; Philip, GH; Putta, S; Rangaiah, G; Tambade, PJ; Yarla, NS1
Bushman, LR; Chen, P; Hail, N1
Gibbs, TC; Knoepp, SM; Meier, KE; Park, JJ; Rubio, MV; Snider, AJ; Um, T; Xie, Y; Zhang, Z1
Butler, LM; Centenera, MM; Gillis, JL; Hanson, AR; Jindal, S; Knudsen, KE; Raj, GV; Risbridger, GP; Scher, HI; Sutherland, PD; Taylor, RA; Tilley, WD; Yeadon, T1
Annadanam, A; Armour, E; Aziz, K; Cades, JA; Chettiar, ST; DeWeese, TL; Gajula, RP; Gandhi, N; Hales, RK; Herman, JM; Kato, Y; Schaeffer, EM; Song, D; Tran, PT; Wild, AT; Williams, RD; Zhang, Y1
Bucala, R; Iczkowski, KA; Leng, L; Meyer-Siegler, KL; Vera, PL1
Pickhardt, PA; Ripple, MO; Wilding, G1
Berens, ME; Chen, H; Chu, L; Germain, L; Hersh, E; Hirth, KP; Jacobs, JS; Longhi, M; Mann, E; McMahon, G; Meredith, S; Powell, TJ; Schwartz, DP; Shawver, LK; Tang, C; Taylorson, L; Tsai, J; Ullrich, A1
Balk, SP; Bubley, GJ; Chachoua, A; DePaoli, A; Hannah, A; Kabbinavar, F; Ko, YJ; Reese, D; Small, EJ; Taneja, S1
George, D1

Reviews

2 review(s) available for isoxazoles and Prostatic Neoplasms

ArticleYear
Role of androgen receptor splice variants, their clinical relevance and treatment options.
    World journal of urology, 2020, Volume: 38, Issue:3

    Topics: Alternative Splicing; Androgen Antagonists; Androstadienes; Antineoplastic Agents, Hormonal; Benzamides; Benzhydryl Compounds; Benzimidazoles; Benzoquinones; Binding Sites; Chlorohydrins; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Male; Niclosamide; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Protein Domains; Protein Isoforms; Proteins; Receptors, Androgen; Resorcinols; RNA, Messenger

2020
Platelet-derived growth factor receptors: a therapeutic target in solid tumors.
    Seminars in oncology, 2001, Volume: 28, Issue:5 Suppl 17

    Topics: Antineoplastic Agents; Benzamides; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Imatinib Mesylate; Isoxazoles; Leflunomide; Ligands; Male; Piperazines; Platelet-Derived Growth Factor; Prostatic Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Signal Transduction

2001

Trials

1 trial(s) available for isoxazoles and Prostatic Neoplasms

ArticleYear
A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:4

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Humans; Immunohistochemistry; Isoxazoles; Leflunomide; Male; Middle Aged; Pain Measurement; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Platelet-Derived Growth Factor; Time Factors; Treatment Outcome

2001

Other Studies

18 other study(ies) available for isoxazoles and Prostatic Neoplasms

ArticleYear
Rational design, synthesis and biological evaluation of benzo[d]isoxazole derivatives as potent BET bivalent inhibitors for potential treatment of prostate cancer.
    Bioorganic chemistry, 2023, Volume: 135

    Topics: Cell Proliferation; Humans; Isoxazoles; Male; Prostatic Neoplasms; Protein Domains; Transcription Factors

2023
Y06014 is a selective BET inhibitor for the treatment of prostate cancer.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:12

    Topics: Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Indoles; Isoxazoles; Male; Molecular Docking Simulation; Molecular Structure; Prostatic Neoplasms; Protein Binding; Protein Domains; Small Molecule Libraries; Structure-Activity Relationship; Transcription Factors

2021
Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion.
    Scientific reports, 2018, 02-01, Volume: 8, Issue:1

    Topics: Aged; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cytoskeleton; Endosomes; Fibronectins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Middle Aged; Neoplasm Invasiveness; Prostatic Neoplasms; Resorcinols; Secretory Pathway

2018
Hsp-27 and NF-κB pathway is associated with AR/AR-V7 expression in prostate cancer cells.
    Gene, 2019, May-20, Volume: 697

    Topics: Anisoles; Apoptosis; Cell Line, Tumor; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; I-kappa B Kinase; Isoxazoles; Male; Molecular Chaperones; NF-kappa B; Nitriles; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Sulfones

2019
Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.
    Molecular and cellular endocrinology, 2014, Apr-25, Volume: 387, Issue:1-2

    Topics: Aged; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; COS Cells; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Male; Mice; Mice, Inbred DBA; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Tosyl Compounds; Xenograft Model Antitumor Assays

2014
Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Heparin-binding EGF-like Growth Factor; Humans; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Propionates; Prostatic Neoplasms; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction; Xenograft Model Antitumor Assays

2014
Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:7

    Topics: Alkenes; Antineoplastic Agents; Carbohydrates; Cell Line, Tumor; Cell Survival; G1 Phase Cell Cycle Checkpoints; Humans; Isoxazoles; Male; Prostatic Neoplasms; Resting Phase, Cell Cycle; Triazoles

2014
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
    International journal of cancer, 2015, Jun-15, Volume: 136, Issue:12

    Topics: Blotting, Western; Boron Compounds; BRCA1 Protein; BRCA2 Protein; CDC2 Protein Kinase; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Repair; Histones; Homologous Recombination; Humans; Isoxazoles; Male; Microscopy, Fluorescence; Phosphorylation; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Quinolines; Rad51 Recombinase; Receptor, IGF Type 1; RNA Interference; Thiazoles

2015
Aminomethylphosphonic acid and methoxyacetic acid induce apoptosis in prostate cancer cells.
    International journal of molecular sciences, 2015, May-22, Volume: 16, Issue:5

    Topics: Acetates; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Male; Organophosphonates; Prostate; Prostatic Neoplasms; Tetrazoles

2015
Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model.
    Oncotarget, 2016, Mar-01, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cyclin D1; Disease Models, Animal; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; Isoxazoles; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphonates; Prostatic Neoplasms; Tetrazoles; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2016
Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents.
    European journal of medicinal chemistry, 2016, Apr-13, Volume: 112

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indoles; Isoxazoles; Male; Mice; Models, Molecular; Phospholipases A2, Secretory; Prostatic Neoplasms; Rats, Wistar

2016
Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention.
    Neoplasia (New York, N.Y.), 2010, Volume: 12, Issue:6

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Caspases; Cell Line, Transformed; Cytochromes c; Dose-Response Relationship, Drug; Epithelial Cells; Flow Cytometry; Humans; Immunoblotting; Isoxazoles; Leflunomide; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxygen Consumption; Prostate; Prostatic Neoplasms; Reactive Oxygen Species; Time Factors; Tumor Cells, Cultured

2010
Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells.
    The Prostate, 2012, Volume: 72, Issue:15

    Topics: Adenocarcinoma; Animals; Calpain; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Screening Assays, Antitumor; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Ionomycin; Isoxazoles; Lysophospholipids; Male; Paxillin; Phosphorylation; Propionates; Prostatic Neoplasms; Proteolysis; Rats; Thapsigargin

2012
Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jul-01, Volume: 18, Issue:13

    Topics: Aged; Antineoplastic Agents; Apoptosis; Benzoquinones; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; G2 Phase Cell Cycle Checkpoints; Gene Expression; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lactams, Macrocyclic; Male; Middle Aged; Molecular Targeted Therapy; Prostatic Neoplasms; Pyridones; Pyrimidines; Resorcinols; Tissue Culture Techniques; Tumor Cells, Cultured

2012
Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.
    Cancer biology & therapy, 2013, Volume: 14, Issue:4

    Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Growth Processes; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Down-Regulation; G2 Phase; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Mice; Mice, Transgenic; Prostatic Neoplasms; Radiation-Sensitizing Agents; Random Allocation; Resorcinols; Signal Transduction; Xenograft Model Antitumor Assays

2013
Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Dec-15, Volume: 177, Issue:12

    Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line, Tumor; Cell Proliferation; Histocompatibility Antigens Class II; Humans; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Prostatic Neoplasms; Signal Transduction; Transplantation, Heterologous

2006
Alteration in gamma-glutamyl transpeptidase activity and messenger RNA of human prostate carcinoma cells by androgen.
    Cancer research, 1997, Jun-15, Volume: 57, Issue:12

    Topics: Androgens; Borates; Cell Division; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Glycylglycine; Humans; Immunohistochemistry; Isoxazoles; Male; Prostatic Neoplasms; RNA, Messenger; Serine; Tumor Cells, Cultured

1997
Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:7

    Topics: 3T3 Cells; Animals; Brain Neoplasms; Cell Survival; Epidermal Growth Factor; Female; Glioma; Growth Inhibitors; Humans; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Ovarian Neoplasms; Platelet-Derived Growth Factor; Prostatic Neoplasms; Rats; Receptor, Platelet-Derived Growth Factor beta; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured

1997