isoxazoles has been researched along with Pancreatic Neoplasms in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, B; Li, D; Liu, Y; Song, Y; Wang, Q; Yang, S; Zhang, Y; Zhu, C | 1 |
| Bristow, CA; Carbone, F; Carugo, A; Deem, AK; Draetta, GF; Feng, N; Genovese, G; Heffernan, TP; Huang, JK; Inoue, A; Lissanu Deribe, Y; Maitra, A; Msaouel, P; Perelli, L; Poggetto, ED; Robinson, FS; Rose, JL; Soeung, M; Takeda, M; Tannir, NM; Tomihara, H; Viale, A | 1 |
| Fu, X; He, J; Qiu, Y; Song, T; Tang, N; Xu, S | 1 |
| Eshleman, JR; Gulla, A; Kazlauskas, E; Liang, H; Matulis, D; Petrauskas, V; Strupas, K | 1 |
| Cheng, X; Lu, M; Luo, C; Wang, X | 1 |
| Chen, X; Du, T; Ji, M; Jin, J; Lai, F; Liu, D; Xue, N; Yan, C; Yu, X; Zhang, S | 1 |
| Ailer, G; Auernhammer, CJ; Beuschlein, F; Göke, B; Maurer, J; Spoettl, G; Vlotides, G; Zitzmann, K | 1 |
| Chen, X; Jin, J; Liu, D; Xue, N; Yan, R; Yu, X; Zhang, S | 1 |
| Bartsch, DK; Fendrich, V; L-Lopez, C; Lang, SA; Lauth, M; Rexin, P; Schlitt, HJ; Waldmann, J; Wichmann, S; Wiese, D | 1 |
| Im, DS; Kimura, T; Komachi, M; Kurose, H; Kuwabara, A; Malchinkhuu, E; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T | 1 |
| Arkema, E; Askling, J; Davies, R; Hyrich, K; Listing, J; Neovius, M; Simard, J; Strangfeld, A; Symmons, D; Watson, K; Zink, A | 1 |
| Im, DS; Ishii, S; Kimura, T; Komachi, M; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T; Yanagida, K | 1 |
| Geissler, EK; Hackl, C; Lang, SA; Moser, C; Scheiffert, E; Schlitt, HJ; Stoeltzing, O; Wagner, C | 1 |
| Almahariq, M; Chen, H; Cheng, X; Mei, FC; Sastry, SK; Schwede, F; Tsalkova, T; Zhou, J | 1 |
| Brunner, TB; Charlton, PA; Cornelissen, B; Fokas, E; Gillies McKenna, W; Hammond, EM; Muschel, RJ; Olcina, MM; Pollard, JR; Prevo, R; Reaper, PM; Vallis, KA | 1 |
| Ikeya, T; Im, DS; Kimura, T; Komachi, M; Kuwabara, A; Malchinkhuu, E; Morishita, Y; Ogawa, T; Ohta, H; Ohwada, S; Okajima, F; Sato, K; Tamoto, K; Tanahashi, Y; Tobo, M; Tomura, H; Yamada, T; Yanagita, Y | 1 |
| Allen, L; Meck, R; Yunis, A | 1 |
| Allen, LM; Clubb, KJ; Meck, RA; Yunis, AA | 1 |
18 other study(ies) available for isoxazoles and Pancreatic Neoplasms
| Article | Year |
|---|---|
MIF inhibitor, ISO-1, attenuates human pancreatic cancer cell proliferation, migration and invasion in vitro, and suppresses xenograft tumour growth in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biological Assay; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diffusion Chambers, Culture; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pancreatic Neoplasms; RNA, Messenger; Signal Transduction; Transcription Factor RelA; Tumor Burden; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2020 |
Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Proliferation; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Mice; Mice, Nude; Pancreatic Neoplasms; Prognosis; Resorcinols; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Fluorouracil; Humans; Imidazoles; Irinotecan; Isoxazoles; Kaplan-Meier Estimate; Leucovorin; Mice; Mice, Nude; Oxaliplatin; Pancreatic Neoplasms; RNA Interference; RNA, Small Interfering; Transplantation, Heterologous; Ubiquitin-Protein Ligases; Wnt Signaling Pathway | 2021 |
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; Benzamides; Benzoquinones; Carcinoma, Pancreatic Ductal; Cell Culture Techniques, Three Dimensional; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Molecular Structure; Pancreatic Neoplasms; Resorcinols; Rifabutin; Triazoles | 2021 |
Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclic AMP; Drug Synergism; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Humans; Hydrazones; Isoxazoles; Lithium Chloride; Pancreatic Neoplasms; Pyridines; Pyrimidines | 2017 |
Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer.
Topics: Adenine; Amino Acid Sequence; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lysosomal-Associated Membrane Protein 2; Lysosomes; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Resorcinols; RNA Interference; RNA, Small Interfering; Sequence Alignment; Signal Transduction | 2019 |
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Carcinoid Tumor; Carcinoma, Neuroendocrine; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; M Phase Cell Cycle Checkpoints; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidines; Receptor, ErbB-2; Receptor, IGF Type 1; Resorcinols; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction | 2013 |
Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drugs, Investigational; G2 Phase; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; MAP Kinase Signaling System; Mice, Nude; Molecular Targeted Therapy; Neoplasm Proteins; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyridones; Random Allocation; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Insulin; Islets of Langerhans; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Resorcinols; RNA, Messenger | 2014 |
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
Topics: Ascites; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoxazoles; Laminin; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Proteoglycans; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; RNA, Small Interfering | 2009 |
Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Cohort Studies; Female; Germany; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Pancreatic Neoplasms; Registries; Risk Factors; Sweden; United Kingdom; White People | 2011 |
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays | 2012 |
Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.
Topics: Animals; Cell Communication; Cell Growth Processes; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neovascularization, Pathologic; Pancreatic Neoplasms; Random Allocation; Resorcinols; Signal Transduction; Xenograft Model Antitumor Assays | 2012 |
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Movement; Cyclic AMP; Guanine Nucleotide Exchange Factors; Humans; Hydrazones; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoxazoles; Molecular Docking Simulation; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; rap1 GTP-Binding Proteins | 2013 |
Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; DNA Damage; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazines; Radiation Tolerance; Radiation-Sensitizing Agents | 2012 |
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
Topics: Adult; Animals; Ascites; Blotting, Northern; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Humans; Isoxazoles; Lipids; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Middle Aged; Monoacylglycerol Lipases; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection | 2004 |
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
Topics: Antibiotics, Antineoplastic; Cells, Cultured; gamma-Glutamyltransferase; Glycine; Half-Life; Humans; Isoxazoles; Oxazoles; Pancreatic Neoplasms; Time Factors | 1980 |
Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501).
Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Interphase; Isoxazoles; Kinetics; Male; Oxazoles; Pancreatic Neoplasms; Time Factors | 1981 |