Page last updated: 2024-08-21

isoxazoles and Pancreatic Neoplasms

isoxazoles has been researched along with Pancreatic Neoplasms in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's0 (0.00)18.2507
2000's2 (11.11)29.6817
2010's10 (55.56)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Cheng, B; Li, D; Liu, Y; Song, Y; Wang, Q; Yang, S; Zhang, Y; Zhu, C1
Bristow, CA; Carbone, F; Carugo, A; Deem, AK; Draetta, GF; Feng, N; Genovese, G; Heffernan, TP; Huang, JK; Inoue, A; Lissanu Deribe, Y; Maitra, A; Msaouel, P; Perelli, L; Poggetto, ED; Robinson, FS; Rose, JL; Soeung, M; Takeda, M; Tannir, NM; Tomihara, H; Viale, A1
Fu, X; He, J; Qiu, Y; Song, T; Tang, N; Xu, S1
Eshleman, JR; Gulla, A; Kazlauskas, E; Liang, H; Matulis, D; Petrauskas, V; Strupas, K1
Cheng, X; Lu, M; Luo, C; Wang, X1
Chen, X; Du, T; Ji, M; Jin, J; Lai, F; Liu, D; Xue, N; Yan, C; Yu, X; Zhang, S1
Ailer, G; Auernhammer, CJ; Beuschlein, F; Göke, B; Maurer, J; Spoettl, G; Vlotides, G; Zitzmann, K1
Chen, X; Jin, J; Liu, D; Xue, N; Yan, R; Yu, X; Zhang, S1
Bartsch, DK; Fendrich, V; L-Lopez, C; Lang, SA; Lauth, M; Rexin, P; Schlitt, HJ; Waldmann, J; Wichmann, S; Wiese, D1
Im, DS; Kimura, T; Komachi, M; Kurose, H; Kuwabara, A; Malchinkhuu, E; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T1
Arkema, E; Askling, J; Davies, R; Hyrich, K; Listing, J; Neovius, M; Simard, J; Strangfeld, A; Symmons, D; Watson, K; Zink, A1
Im, DS; Ishii, S; Kimura, T; Komachi, M; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T; Yanagida, K1
Geissler, EK; Hackl, C; Lang, SA; Moser, C; Scheiffert, E; Schlitt, HJ; Stoeltzing, O; Wagner, C1
Almahariq, M; Chen, H; Cheng, X; Mei, FC; Sastry, SK; Schwede, F; Tsalkova, T; Zhou, J1
Brunner, TB; Charlton, PA; Cornelissen, B; Fokas, E; Gillies McKenna, W; Hammond, EM; Muschel, RJ; Olcina, MM; Pollard, JR; Prevo, R; Reaper, PM; Vallis, KA1
Ikeya, T; Im, DS; Kimura, T; Komachi, M; Kuwabara, A; Malchinkhuu, E; Morishita, Y; Ogawa, T; Ohta, H; Ohwada, S; Okajima, F; Sato, K; Tamoto, K; Tanahashi, Y; Tobo, M; Tomura, H; Yamada, T; Yanagita, Y1
Allen, L; Meck, R; Yunis, A1
Allen, LM; Clubb, KJ; Meck, RA; Yunis, AA1

Other Studies

18 other study(ies) available for isoxazoles and Pancreatic Neoplasms

ArticleYear
MIF inhibitor, ISO-1, attenuates human pancreatic cancer cell proliferation, migration and invasion in vitro, and suppresses xenograft tumour growth in vivo.
    Scientific reports, 2020, 04-21, Volume: 10, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biological Assay; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diffusion Chambers, Culture; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Pancreatic Neoplasms; RNA, Messenger; Signal Transduction; Transcription Factor RelA; Tumor Burden; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2020
Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress.
    Cancer research, 2021, 01-15, Volume: 81, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Proliferation; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Mice; Mice, Nude; Pancreatic Neoplasms; Prognosis; Resorcinols; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2021
Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer.
    Cell proliferation, 2021, Volume: 54, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Fluorouracil; Humans; Imidazoles; Irinotecan; Isoxazoles; Kaplan-Meier Estimate; Leucovorin; Mice; Mice, Nude; Oxaliplatin; Pancreatic Neoplasms; RNA Interference; RNA, Small Interfering; Transplantation, Heterologous; Ubiquitin-Protein Ligases; Wnt Signaling Pathway

2021
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
    Pancreas, 2021, 04-01, Volume: 50, Issue:4

    Topics: Adenosine Triphosphatases; Antineoplastic Agents; Benzamides; Benzoquinones; Carcinoma, Pancreatic Ductal; Cell Culture Techniques, Three Dimensional; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Molecular Structure; Pancreatic Neoplasms; Resorcinols; Rifabutin; Triazoles

2021
Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival.
    Acta biochimica et biophysica Sinica, 2017, Jul-01, Volume: 49, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclic AMP; Drug Synergism; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Humans; Hydrazones; Isoxazoles; Lithium Chloride; Pancreatic Neoplasms; Pyridines; Pyrimidines

2017
Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer.
    Cellular and molecular life sciences : CMLS, 2019, Volume: 76, Issue:17

    Topics: Adenine; Amino Acid Sequence; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lysosomal-Associated Membrane Protein 2; Lysosomes; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Resorcinols; RNA Interference; RNA, Small Interfering; Sequence Alignment; Signal Transduction

2019
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
    International journal of oncology, 2013, Volume: 43, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Carcinoid Tumor; Carcinoma, Neuroendocrine; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; M Phase Cell Cycle Checkpoints; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidines; Receptor, ErbB-2; Receptor, IGF Type 1; Resorcinols; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction

2013
Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways.
    Current cancer drug targets, 2014, Volume: 14, Issue:7

    Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drugs, Investigational; G2 Phase; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; MAP Kinase Signaling System; Mice, Nude; Molecular Targeted Therapy; Neoplasm Proteins; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyridones; Random Allocation; Tumor Burden; Xenograft Model Antitumor Assays

2014
Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms.
    Neuroendocrinology, 2014, Volume: 100, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Insulin; Islets of Langerhans; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Resorcinols; RNA, Messenger

2014
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
    Carcinogenesis, 2009, Volume: 30, Issue:3

    Topics: Ascites; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoxazoles; Laminin; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Proteoglycans; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; RNA, Small Interfering

2009
Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers.
    Rheumatology (Oxford, England), 2011, Volume: 50, Issue:1

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Cohort Studies; Female; Germany; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Pancreatic Neoplasms; Registries; Risk Factors; Sweden; United Kingdom; White People

2011
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
    Cancer science, 2012, Volume: 103, Issue:6

    Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays

2012
Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.
    Anticancer research, 2012, Volume: 32, Issue:7

    Topics: Animals; Cell Communication; Cell Growth Processes; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neovascularization, Pathologic; Pancreatic Neoplasms; Random Allocation; Resorcinols; Signal Transduction; Xenograft Model Antitumor Assays

2012
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
    Molecular pharmacology, 2013, Volume: 83, Issue:1

    Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Movement; Cyclic AMP; Guanine Nucleotide Exchange Factors; Humans; Hydrazones; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoxazoles; Molecular Docking Simulation; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; rap1 GTP-Binding Proteins

2013
Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.
    Cell death & disease, 2012, Dec-06, Volume: 3

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; DNA Damage; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazines; Radiation Tolerance; Radiation-Sensitizing Agents

2012
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Adult; Animals; Ascites; Blotting, Northern; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Humans; Isoxazoles; Lipids; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Middle Aged; Monoacylglycerol Lipases; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection

2004
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
    Research communications in chemical pathology and pharmacology, 1980, Volume: 27, Issue:1

    Topics: Antibiotics, Antineoplastic; Cells, Cultured; gamma-Glutamyltransferase; Glycine; Half-Life; Humans; Isoxazoles; Oxazoles; Pancreatic Neoplasms; Time Factors

1980
Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501).
    Cancer research, 1981, Volume: 41, Issue:11 Pt 1

    Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Interphase; Isoxazoles; Kinetics; Male; Oxazoles; Pancreatic Neoplasms; Time Factors

1981