Page last updated: 2024-08-21

isoxazoles and Neoplasm Metastasis

isoxazoles has been researched along with Neoplasm Metastasis in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's0 (0.00)18.2507
2000's4 (16.67)29.6817
2010's12 (50.00)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Ahirwar, DK; Charan, M; Chatterjee, N; Das, S; Ganju, RK; Kaul, K; Mishra, S; Misri, S; Satoskar, AR; Varikuti, S1
Abel, L; Baschnagel, AM; Clark, PA; Elnaggar, JH; Kaushik, S; Kimple, RJ; Kromke, AC; Leal, TA; Longhurst, CA; Nickel, KP; Skiba, JH; VanBeek, HJ; Zhao, SG1
Feng, Z; Zheng, J; Zhu, J1
Ballinari, D; Brasca, MG; Casale, E; Ciomei, M; De Ponti, A; Degrassi, A; Donati, D; Felder, E; Fogliatto, G; Galvani, A; Germani, M; Gianellini, L; Guanci, M; Isacchi, A; Mantegani, S; Paolucci, M; Pesenti, E; Polucci, P; Russo, M; Sola, F; Valsasina, B; Visco, C; Zuccotto, F1
Abdel-Latif, A; Morris, AJ; Ratajczak, MZ; Schneider, G; Sellers, ZP1
Bhagat, S; Fullerton, SL; Kenner, DJ1
Liu, S; Parajuli, KR; You, Z; Zhang, Q1
Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A1
Benítez, S; Cabiscol, E; Dolcet, X; Domingo, M; Maiques, O; Marti, RM; Martinez, M; Matias-Guiu, X; Ribera, J; Santacana, M; Valls, J; Vea, A; Vilella, R; Yeramian, A1
Aglietta, M; Ahmed, S; Akimov, M; Alba, E; Armstrong, AC; Beck, JT; Biganzoli, L; Campone, M; Hsu Schmitz, SF; Kong, A; Lee, SC; Lefebvre, C; López López, R; Rea, D1
Hedley, D; Krzyzanowska, MK; Moore, MJ; Renouf, DJ; Schmuck, M; Wang, L1
Im, DS; Ishii, S; Kimura, T; Komachi, M; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T; Yanagida, K1
Abel, U; Deuschle, U; Kinzel, O; Kremoser, C; Schlüter, T; Schüler, J; Schulz, A1
Chen, G; Gong, ZC; Jia, J; Lin, ZQ; Liu, H; Sun, ZJ; Wang, FQ; Zhang, W; Zhao, YF; Zhu, JY1
Ikeya, T; Im, DS; Kimura, T; Komachi, M; Kuwabara, A; Malchinkhuu, E; Morishita, Y; Ogawa, T; Ohta, H; Ohwada, S; Okajima, F; Sato, K; Tamoto, K; Tanahashi, Y; Tobo, M; Tomura, H; Yamada, T; Yanagita, Y1
Bloemendaal, AL; Borel Rinkes, IH; Kranenburg, O; Smakman, N; van Diest, P; Vogten, JM1
Bordet, JC; Boucharaba, A; Clézardin, P; Guglielmi, J; Peyruchaud, O; Serre, CM1
Aherne, W; Barril, X; Box, G; Boxall, F; Boxall, K; Brough, PA; Cansfield, JE; Cheung, KM; de Haven Brandon, A; Drysdale, MJ; Dymock, B; Eccles, SA; Finch, H; Gowan, S; Hayes, A; Howes, R; Hubbard, RE; James, K; Jones, K; Kalusa, A; Martins, V; Massey, A; Matthews, TP; McDonald, E; Patterson, L; Pearl, L; Prodromou, C; Raynaud, FI; Rowlands, M; Sharp, SY; Surgenor, A; Urban, F; Valenti, M; Webb, P; Wood, M; Workman, P; Wright, L1
Bodey, G; Fleishman, G; Murphy, WK; Yap, HY1
Ansbacher, R1
Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE1
Chang, YC; Falkson, G; Knuiman, MW; Pandya, KJ; Skeel, RT; Willson, JK; Wolter, JM1
Booth, BW; Budman, D; Ellison, RR; Khojasteh, A; Korzun, AH; Weiss, RB; Wood, W1
Adolphson, CC; Ajani, JA; Barlogie, B; Bedikian, AY; Bodey, GP; Korinek, J; Stroehlein, JR1

Trials

5 trial(s) available for isoxazoles and Neoplasm Metastasis

ArticleYear
Effect of preintravenous injection of parecoxib, combined with transversus abdominis plane block in strategy of enhanced recovery after radical resection of colorectal cancer.
    Journal of cancer research and therapeutics, 2018, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Female; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pain Measurement; Pain, Postoperative; Tomography, X-Ray Computed; Treatment Outcome; Young Adult

2018
Phase 1B/2 study of the HSP90 inhibitor AUY922 plus trastuzumab in metastatic HER2-positive breast cancer patients who have progressed on trastuzumab-based regimen.
    Oncotarget, 2016, Jun-21, Volume: 7, Issue:25

    Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Breast Neoplasms; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Kaplan-Meier Estimate; Middle Aged; Neoplasm Metastasis; Receptor, ErbB-2; Resorcinols; Trastuzumab; Treatment Outcome

2016
A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer.
    Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Disease-Free Survival; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Middle Aged; Neoplasm Metastasis; Resorcinols; Survival Rate; Treatment Outcome

2016
Phase II clinical trial of acivicin in advanced breast cancer: an Eastern Cooperative Oncology Group Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1986
Phase II trial of acivicin in advanced breast carcinoma: a Cancer and Leukemia Group B Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Brain Diseases; Breast Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1986

Other Studies

19 other study(ies) available for isoxazoles and Neoplasm Metastasis

ArticleYear
Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer.
    Cell death & disease, 2020, 09-17, Volume: 11, Issue:9

    Topics: Animals; Apoptosis; Caspases; Cell Movement; Cell Survival; Cytochromes c; Disease Progression; Enzyme Activation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Inflammation; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Morpholines; Neoplasm Metastasis; Neoplasm Transplantation; Treatment Outcome; Triple Negative Breast Neoplasms; Wound Healing

2020
ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts.
    Molecular cancer therapeutics, 2021, Volume: 20, Issue:11

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Female; Heterografts; Humans; Isoxazoles; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Pyrazines; Treatment Outcome

2021
NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jul-01, Volume: 19, Issue:13

    Topics: Animals; Antineoplastic Agents; Binding Sites; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Isoxazoles; Mice; Molecular Conformation; Molecular Docking Simulation; Neoplasm Metastasis; Organ Specificity; Protein Binding; Proteolysis; Tumor Burden; Xenograft Model Antitumor Assays

2013
Bioactive lipids, LPC and LPA, are novel prometastatic factors and their tissue levels increase in response to radio/chemotherapy.
    Molecular cancer research : MCR, 2014, Volume: 12, Issue:11

    Topics: Animals; Bone Marrow; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chemotactic Factors; Drug Resistance, Neoplasm; Gamma Rays; Humans; Isoxazoles; Lysophosphatidylcholines; Lysophospholipids; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, SCID; Neoplasm Metastasis; Propionates; Receptors, G-Protein-Coupled; Rhabdomyosarcoma; Tumor Microenvironment; Vincristine

2014
Daily subcutaneous parecoxib injection for cancer pain: an open label pilot study.
    Journal of palliative medicine, 2015, Volume: 18, Issue:4

    Topics: Analgesics, Opioid; Analysis of Variance; Bone Neoplasms; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Hospital Units; Humans; Injections, Subcutaneous; Isoxazoles; Male; Neoplasm Metastasis; Pain Management; Pain Measurement; Palliative Care; Pilot Projects; Treatment Outcome; Victoria

2015
Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model.
    Oncotarget, 2016, Mar-01, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cyclin D1; Disease Models, Animal; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; Isoxazoles; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphonates; Prostatic Neoplasms; Tetrazoles; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2016
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
    Nature communications, 2016, Feb-08, Volume: 7

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles

2016
2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels.
    Pigment cell & melanoma research, 2016, Volume: 29, Issue:3

    Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Glutathione; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Isoxazoles; MAP Kinase Signaling System; Melanoma; Mice, SCID; Neoplasm Metastasis; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Resorcinols; RNA, Messenger; Skin; Sulfonamides; Xenograft Model Antitumor Assays

2016
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
    Cancer science, 2012, Volume: 103, Issue:6

    Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays

2012
FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Animals; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Humans; Isoxazoles; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasm Metastasis; Protein Binding; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Burden; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2012
Overexpression of macrophage migration inhibitory factor in adenoid cystic carcinoma: correlation with enhanced metastatic potential.
    Journal of cancer research and clinical oncology, 2013, Volume: 139, Issue:2

    Topics: Carcinoma, Adenoid Cystic; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Gene Expression; Humans; Isoxazoles; Macrophage Migration-Inhibitory Factors; MAP Kinase Kinase 4; Neoplasm Metastasis; Salivary Gland Neoplasms

2013
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Adult; Animals; Ascites; Blotting, Northern; Cell Adhesion; Cell Division; Cell Line, Tumor; Cell Movement; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Humans; Isoxazoles; Lipids; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Middle Aged; Monoacylglycerol Lipases; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection

2004
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jan-01, Volume: 11, Issue:1

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Genes, ras; Image Processing, Computer-Assisted; Immunohistochemistry; Isoxazoles; Ki-67 Antigen; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microcirculation; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA Interference; Time Factors

2005
The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jun-20, Volume: 103, Issue:25

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Mice; Neoplasm Metastasis; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid

2006
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
    Cancer research, 2008, Apr-15, Volume: 68, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Cycle; Cell Division; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Resorcinols; Transplantation, Heterologous

2008
Phase II trial of acivicin in advanced metastatic breast cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:9

    Topics: Adult; Breast Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1983
Treatment of endometriosis with Danazol.
    American journal of obstetrics and gynecology, 1975, Jan-15, Volume: 121, Issue:2

    Topics: Adult; Castration; Endometriosis; Ethisterone; Fallopian Tubes; Female; Humans; Hysterectomy; Isoxazoles; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ovarian Neoplasms; Oxazoles; Uterine Neoplasms

1975
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
    Investigational new drugs, 1988, Volume: 6, Issue:2

    Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine

1988
Phase II trial of acivicin in patients with advanced colorectal carcinoma.
    American journal of clinical oncology, 1986, Volume: 9, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Leukopenia; Male; Middle Aged; Nausea; Neoplasm Metastasis; Oxazoles; Rectal Neoplasms; Vomiting

1986