isoxazoles has been researched along with Kahler Disease in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Imano, M; Ishizaka, T; Maekawa, S; Nishida, S; Satou, T; Tabata, M; Takeda, T; Tateishi, K; Tsubaki, M; Tsurushima, K | 1 |
| Allain, C; Boriack-Sjodin, AP; Chesworth, R; Copeland, RA; Drew, AE; Duncan, KW; Handler, JL; Jacques, SL; Jin, L; Kruger, RG; McCabe, MT; Mitchell, LH; Moradei, O; Moyer, MP; Ott, HM; Raimondi, A; Ribich, SA; Riera, T; Rioux, N; Scott, MP; Shapiro, G; Smith, J; Sneeringer, C; Waters, NJ | 1 |
| Boccarelli, A; Cabral, LM; de Pádula, M; Di Mauro, GD; Ferorelli, S; Fortuna, CG; Iaselli, M; Miciaccia, M; Pati, ML; Perrone, MG; Rodrigues Pereira da Silva, LC; Sathler, PC; Scilimati, A; Souza Domingos, TF; Vacca, A; Vitale, P | 1 |
| Aktoudianakis, V; Babaoglu, K; Bates, JG; Breckenridge, DG; Chen, X; Chin, G; Corkey, B; Du, J; Eisenberg, G; Elbel, K; Fung, W; Hung, M; Jiang, B; Jin, D; Jordan, K; Kan, E; Kobayashi, T; Kusam, S; Lad, L; Lansdon, E; Larson, N; Mackman, R; Martinez, R; Metobo, S; Mish, M; Neve, RM; Newby, ZER; Niedziela-Majka, A; Sapre, A; Shevick, SL; Sperandio, D; Tay, C; Webb, H; Yang, H; Zablocki, J | 1 |
| Das, S; Gu, Z; Levasseur, D; Shi, J; Tolomelli, G; Tricot, G; Wang, H; Xia, J; Xu, H; Yang, Y; Zhan, F; Zhou, W; Zhou, Y | 1 |
| Akimov, M; Alegre, A; Bargou, RC; Bladé, J; Fernandez-Ibarra, C; Goh, YT; Iyer, SP; Lu, H; Ottmann, OG; Pain, S; Seggewiss-Bernhardt, R; Spencer, A; Stewart, AK | 1 |
| Cooper, MR; Eda, H; Mertz, JA; Panaroni, C; Raje, N; Ramachandran, J; Santo, L; Sims Iii, RJ; Siu, KT; Yee, AJ | 1 |
| Adam, C; Baumann, P; Bumeder, I; Mandl-Weber, S; Oduncu, F; Schmidmaier, R; Völkl, A | 1 |
| Atadja, P; Garcia-Echeverria, C; Heider, U; Jensen, MR; Kaiser, M; Lamottke, B; Mieth, M; Quadt, C; Sezer, O; Türkmen, S; von Metzler, I | 1 |
| Andrulis, M; Bargou, RC; Beilhack, A; Bogen, B; Bumm, T; Chatterjee, M; Einsele, H; Heimberger, T; Riedel, S; Schraud, H; Stühmer, T | 1 |
| Bargou, RC; Chatterjee, M; Chène, P; Einsele, H; García-Echeverría, C; Grella, E; Jensen, MR; Knop, S; Kortüm, M; Quadt, C; Schoepfer, J; Siegmund, D; Stühmer, T; Unzicker, C; Wajant, H; Zöllinger, A | 1 |
| Ando, Y; Asai, S; Hotta, T; Kobayashi, H; Miyachi, H | 1 |
1 trial(s) available for isoxazoles and Kahler Disease
| Article | Year |
|---|---|
Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Multiple Myeloma; Resorcinols | 2015 |
11 other study(ies) available for isoxazoles and Kahler Disease
| Article | Year |
|---|---|
Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Melphalan; Morpholines; Multiple Myeloma; Resorcinols; Signal Transduction; src-Family Kinases; Unfolded Protein Response | 2020 |
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Topics: Animals; Antineoplastic Agents; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Isoxazoles; Male; Mice; Multiple Myeloma; Neoplasm Transplantation; Pyrimidines; Rats, Sprague-Dawley; Spiro Compounds | 2017 |
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Multiple Myeloma; Platelet Aggregation Inhibitors; Protein Binding; Structure-Activity Relationship | 2019 |
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Topics: Administration, Oral; Animals; Benzimidazoles; Biological Availability; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Humans; Isoxazoles; Mice; Molecular Structure; Multiple Myeloma; Neoplasms, Experimental; Protein Domains; Structure-Activity Relationship; Transcription Factors | 2019 |
RARα2 expression confers myeloma stem cell features.
Topics: Animals; Cell Line, Tumor; Cell Survival; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Isoxazoles; Itraconazole; Mice; Multidrug Resistance-Associated Proteins; Multiple Myeloma; Neoplastic Stem Cells; Plasma Cells; Prognosis; Proto-Oncogene Proteins c-bcl-2; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Signal Transduction; Sulfones; Syndecan-1; Veratrum Alkaloids; Wnt Proteins | 2013 |
Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma.
Topics: Animals; Benzazepines; Cell Cycle Proteins; G1 Phase Cell Cycle Checkpoints; Humans; Ikaros Transcription Factor; Interferon Regulatory Factors; Isoxazoles; Mice; Multiple Myeloma; Nuclear Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Transcription Factors | 2017 |
Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Cell Adhesion Molecules; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Culture Media; Dihydroorotate Dehydrogenase; Down-Regulation; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; G1 Phase; Humans; Isoxazoles; Leflunomide; Multiple Myeloma; Oxidoreductases Acting on CH-CH Group Donors; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytokine; Ribosomal Protein S6 Kinases, 70-kDa; Stromal Cells; Uridine | 2009 |
Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism; Histone Deacetylase Inhibitors; Histone Deacetylases; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Melphalan; Multiple Myeloma; Resorcinols | 2010 |
The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cells, Cultured; Diterpenes; DNA-Binding Proteins; Down-Regulation; Epoxy Compounds; Female; Gene Knockdown Techniques; Heat Shock Transcription Factors; Heat-Shock Proteins; Humans; Immunohistochemistry; Isoxazoles; Mice; Mice, Inbred BALB C; Multiple Myeloma; Neoplasm Transplantation; Phenanthrenes; Plasma Cells; Proteasome Endopeptidase Complex; Pyrazines; Resorcinols; RNA, Small Interfering; Transcription Factors; Transplantation, Heterologous | 2013 |
Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.
Topics: Apoptosis; Cell Line, Tumor; Coculture Techniques; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Multiple Myeloma; Resorcinols; Signal Transduction | 2008 |
Smoldering myeloma associated with zonisamide treatment.
Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy, Generalized; Humans; Immunoglobulin lambda-Chains; Intracranial Arteriovenous Malformations; Isoxazoles; Male; Multiple Myeloma; Myeloma Proteins; Subarachnoid Hemorrhage; Valproic Acid; Zonisamide | 2002 |