isoxazoles has been researched along with Epilepsy in 190 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (5.26) | 18.7374 |
| 1990's | 30 (15.79) | 18.2507 |
| 2000's | 96 (50.53) | 29.6817 |
| 2010's | 54 (28.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takechi, K | 1 |
| Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J | 2 |
| Barary, MA; El-Yazbi, AF; Ibrahim, FA; Wagih, MM | 1 |
| Collinet, A; Sammut, V | 1 |
| Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B | 1 |
| Juhos, V | 1 |
| Ouyang, Y; Song, Z; Xiao, X; Zheng, W | 1 |
| Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R | 1 |
| Lossius, MI; Markhus, R; Nakken, KO; Sætre, E | 1 |
| Serrano-Castro, PJ; Villanueva, V | 1 |
| Chen, G; Jiang, D; Kong, S; Pitre, A; Sun, Y; Wang, Y; Wu, Z | 1 |
| Di Sabatino, F; Loiacono, G; Verrotti, A; Zaccara, G | 1 |
| Giorgi, L; Patten, A; Segieth, J; Trinka, E | 1 |
| Allaf, B; Biraben, A; Dupont, S; Lavernhe, G; Marquet, T | 1 |
| Ando, H; Fujimura, A; Matsubara, S; Oi, A; Suzuki, M; Usui, R | 1 |
| Cavanna, AE; Seri, S | 1 |
| Matar, KM | 1 |
| Fritsch, B; Gasior, M; Kaminski, RM; Reis, J; Rogawski, MA | 1 |
| Auvin, S; Cross, JH; Giorgi, L; Patten, A | 1 |
| Dahlin, M; Ohman, I; Wallander, KM | 1 |
| Andersen, H; Lindstrøm, P; Nakken, KO | 1 |
| Di Gennaro, G; Fattore, C; Femia, EA; Franco, V; Romigi, A; Vitrani, G | 1 |
| Ackermann, AL; Frank, LA; May, ER; McEntee, MF | 1 |
| Chen, TC; Chuang, YC; Dash, A; Huang, CW; Jou, SB; Kwan, SY | 1 |
| Belova, YA; Rudakova, IG | 1 |
| Bazil, CW; Jongeling, AC; Richins, RJ | 1 |
| Coelho, R; Gaspar, R; Lopes, J; Macedo, G; Rodrigues, S; Silva, R | 1 |
| Baulac, M; Hamer, H; Kockelmann, E; McMurray, R | 1 |
| Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H | 1 |
| Supuran, CT | 1 |
| Aburashed, R; Bhatt, A; Farooq, MU; Kassab, MY; Moore, PW | 1 |
| Bauer, J; Wellmer, J; Wellmer, S | 1 |
| Balestri, P; Coppola, G; Curatolo, P; Franzoni, E; Grosso, S; Iannetti, P; Luchetti, A; Mangano, S; Operto, FF; Parisi, P; Pascotto, A; Pelliccia, A; Verrotti, A | 1 |
| Rouvel-Tallec, A | 1 |
| Legido, A; Valencia, I | 1 |
| Kang, HC; Kim, HD; Lee, JS; Lee, YJ; Seo, JH | 1 |
| Pellock, JM | 1 |
| Dinapoli, L; Jandolo, B; Maschio, M; Saveriano, F | 1 |
| Perry, CM; Yang, LP | 1 |
| Carapella, CM; Dinapoli, L; Jandolo, B; Maschio, M; Pompili, A; Saveriano, F; Vidiri, A | 1 |
| Appleton, RE; Kneen, R; Martland, TR; Tan, HJ | 1 |
| Schulze-Bonhage, A | 1 |
| Albani, F; Baruzzi, A; Candela, C; Contin, M; Mohamed, S; Riva, R | 1 |
| Janszky, J | 1 |
| Bramanti, P; Calabrò, RS; Ferlazzo, E; Italiano, D | 1 |
| Fujita, Y; Hasegawa, M; Matsunaga, K; Murakami, K; Nabeshima, K; Nakai, S; Tomita, M; Yamakita, T | 1 |
| Brodie, MJ; Kelly, K; Parker, P; Stephen, LJ; Wilson, EA | 1 |
| Conant, KD; Dunne, IE; Linshaw, MA; Lyczkowski, DA; Paul, E; Pfeifer, HH; Thiele, EA | 1 |
| Beniak, TE; Birnbaum, AK; Leppik, IE; Marino, SE; Walczak, TS; White, JR | 1 |
| Li, JM; Li, Q; Peng, F; Yao, ZP; Zhou, D | 1 |
| Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J | 1 |
| Alfirevic, A; Jorgensen, A; Marson, AG; Mirza, NS; Pirmohamed, M | 1 |
| Chung, HJ; Eom, S; Eun, BL; Eun, SH; Kang, HC; Kim, DW; Kim, HD; Kim, JS; Lee, IK; Lee, JS; Lee, YM; Moon, HK; Suh, ES | 1 |
| Bartolini, E; Bell, GS; Catarino, CB; Duncan, JS; Sander, JW; Yuen, AW | 1 |
| Cincotta, M; Tramacere, L; Zaccara, G | 1 |
| Muñana, KR; Olby, NJ; Schwartz, M | 1 |
| Holder, JL; Wilfong, AA | 1 |
| Kim, DW; Park, KS; Yoo, MW | 1 |
| Gekht, AB; Mil'chakova, LE | 1 |
| Ahn, JO; Chae, JS; Chung, JY; Hwang, CY; Kim, TH; Lee, SY; Seo, KW; Youn, HY | 1 |
| Ben-Menachem, E; Brodie, MJ; Chouette, I; Giorgi, L | 1 |
| Inoue, Y; Terada, K | 1 |
| Campistol, J; Darling, A; Perez-Duenas, B; Poo, P | 1 |
| Hayashi, K; Jo, K; Katsumori, H; Nagafuchi, H; Oguni, H; Osawa, M; Saito, Y; Yanagaki, S | 1 |
| Kurokawa, T | 1 |
| Sirven, JI | 1 |
| Alldredge, BK; Chen, JT; Garcia, PA | 1 |
| Bergin, AM; Connolly, M | 1 |
| Haginoya, K; Hirose, M; Iinuma, K; Yokoyama, H | 1 |
| Johannessen, SI; Perucca, E | 1 |
| Doi, T; Tokumaru, J; Ueda, Y; Willmore, LJ | 1 |
| Go, T | 1 |
| Fukuoka, N; Kimura, M; Morita, S; Tsukamoto, T; Uno, J | 2 |
| Hansen, SL; Sánchez, C; Sperling, BB | 1 |
| Iyo, M; Kobayashi, K; Noda, S; Ozawa, K | 1 |
| Fujiwara, T; Iinuma, K | 1 |
| Dubinsky, S; Newmark, ME | 1 |
| Hasegawa, H | 1 |
| Anthony, S; James, SP; Miller, GS; Montouris, G; Uthman, BM | 1 |
| Conry, JA | 1 |
| Larsson, OM; Sarup, A; Schousboe, A; White, HS | 1 |
| Garnett, WR; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Rosenfeld, W; Schmerler, M; Shah, J | 1 |
| Yagi, K | 1 |
| Seino, M | 1 |
| Miura, H | 3 |
| Haginoya, K; Iinuma, K | 1 |
| Kumagai, N; Maezawa, M; Seki, T | 1 |
| Aikawa, H; Yamauchi, T | 1 |
| Ohtahara, S; Yamatogi, Y | 2 |
| Willmore, LJ | 2 |
| Brodie, MJ | 1 |
| Bergen, D; Garnett, W; Grundy, JS; Levy, RH; Mather, G; Ragueneau-Majlessi, I; Rosenfeld, W; Shah, J | 1 |
| Wilfong, AA | 1 |
| Brodie, MJ; Levy, RH; Pan, WJ; Ragueneau-Majlessi, I; Shah, J; Smith, DF | 1 |
| Aldridge, J; Kim, HL; Rho, JM | 1 |
| Biton, V | 1 |
| Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D | 1 |
| Ohtahara, S | 1 |
| Zareba, G | 1 |
| Leppik, IE | 4 |
| Tisdell, J; Tosches, WA | 1 |
| Hamano, S; Imai, K; Motohashi, S; Sato, M; Yoshida, T | 1 |
| Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sobieszek, G | 1 |
| Arzimanoglou, A; Rahbani, A | 1 |
| Feuerstein, TJ; Stefan, H | 1 |
| Johannessen, SI; Tomson, T | 1 |
| Fukushima, K; Seino, M | 1 |
| Arinami, T; Hasegawa, M; Kamoda, T; Kanemoto, K; Kanemoto, N | 1 |
| Doi, T; Kato, T; Nikaido, K; Takayama, R | 1 |
| Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N | 1 |
| Matsuura, M | 1 |
| Brodie, M; Sills, G | 1 |
| Rambeck, B; Tipold, A; von Klopmann, T | 1 |
| Michael, CT; Starr, JL | 1 |
| Davenport, RD; Patel, NC | 1 |
| Wroe, S | 1 |
| Thöne, J; Wiemann, M | 1 |
| Bauer, J; Bös, M | 1 |
| Akechi, T; Azuma, H; Furukawa, TA; Hattori, M; Masayasu, T; Negi, A | 1 |
| Hwang, YH; Kwon, SH; Lee, BI; Lee, HW; Park, SP; Suh, CK | 1 |
| Kang, HC; Kim, HD; Ko, TS; Lee, HS; You, SJ | 1 |
| Appleton, RE; Macleod, S | 1 |
| Conry, JA; Pellock, JM; Shinnar, S | 1 |
| Leniger, T; Splettstösser, F; Thöne, J; Wiemann, M | 1 |
| Kaleyias, J; Kothare, SV | 1 |
| Berent, S; Donofrio, PD; Sackellares, JC; Sakmar, E; Wagner, JG | 1 |
| Kakegawa, N; Seino, M | 1 |
| Dam, M; Jensen, I; Petersen, HR | 1 |
| Hori, M; Ito, T; Masuda, Y; Shimizu, M; Yoshida, K | 1 |
| Peters, DH; Sorkin, EM | 1 |
| Pimentel, J; Pinto, F | 1 |
| Patsalos, PN; Sander, JW | 1 |
| Hashimoto, Y; Hori, R; Odani, A; Okuno, T; Tanigawara, Y; Yasuhara, M | 1 |
| Hirai, K; Kumagai, N; Seki, T; Takuma, Y; Yamada, T | 1 |
| Shields, WD | 1 |
| Fromm, G; Homan, RW; Leppik, IE; Lesser, RP; Oommen, KJ; Penry, JK; Sackellares, JC; Smith, DB; Wallace, JD; Willmore, LJ | 1 |
| Kito, M; Maehara, M; Watanabe, K | 1 |
| Ito, T; Kurokawa, M; Masuda, Y; Shimizu, M; Uno, H | 1 |
| Akita, M; Hasegawa, M; Hasegawa, T; Nabeshima, T; Shinoda, M | 1 |
| Chadwick, DW; Kadir, ZA; Marson, AG | 1 |
| Chadwick, DW; Kadir, Z; Marson, T | 1 |
| Amano, Y; Egawa, I; Kaneko, S; Kondo, T | 1 |
| Grippo, J | 1 |
| Eguchi, T; Fujita, N; Kishi, T; Ueda, K | 1 |
| Dejima, S; Hara, T; Maeoka, Y; Takeshita, K | 1 |
| Kato, H; Matsuishi, T; Ohnishi, A; Satoi, M; Shimizu, T; Togo, A; Wada, N; Yamashita, Y | 1 |
| Chadwick, DW; Hutton, JL; Kadir, ZA; Marson, AG | 1 |
| Cho, K; Iinuma, K; Kajii, N; Minami, T; Tachi, N | 1 |
| Perucca, E | 1 |
| Kohsaka, M; Koyama, T; Miyamoto, T | 1 |
| Vajda, FJ | 1 |
| Hayakawa, F; Ishihara, N; Kato, T; Kuno, K; Okumura, A; Watanabe, K | 1 |
| Hiramatsu, M; Komatsu, M; Willmore, LJ | 1 |
| Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M | 3 |
| Jain, KK | 1 |
| Fatope, MO | 1 |
| Biederman, TS; McAuley, JW; Moore, JL; Smith, JC | 1 |
| Fujioka, T; Hakui, T; Hanada, K; Kondou, T; Mine, M; Seike, E; Sitaya, M; Tounou, S | 1 |
| Ishii, M; Isobe, K; Itoh, S; Kawada, K; Kusaka, T | 1 |
| Wheless, JW | 1 |
| Glauser, TA; Pellock, JM | 1 |
| Amano, S; Ihara, N; Miura, Y; Torii, R | 1 |
| Seino, M; Yagi, K | 1 |
| Fukuchi, H; Harada, Y; Kimura, M; Kimura, Y; Kitaura, T; Miyake, K; Tanaka, N | 1 |
| Hara, M; Hashimoto, R; Hirai, K; Kimiya, S; Kumagai, N; Seki, T; Suzuki, N; Takuma, Y; Yamada, T; Yamawaki, H | 1 |
| Ito, T; Miyazaki, H; Seino, M | 1 |
| Fujimoto, Y; Ikoma, R; Shimizu, A; Shimizu, T | 1 |
| Hasegawa, H; Wada, Y; Yamaguchi, N | 1 |
| Hasegawa, H; Okuda, H; Wada, Y; Yamaguchi, N | 1 |
| Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M | 1 |
| Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
| Löscher, W | 1 |
| Kawasaki, T; Shimizu, A; Tanaka, M; Yamada, Y; Yamamoto, J | 1 |
| Hammond, EJ; McLean, JR; Perchalski, RJ; Wilder, BJ | 1 |
| Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ | 1 |
61 review(s) available for isoxazoles and Epilepsy
| Article | Year |
|---|---|
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxazoles; Kindling, Neurologic; Membrane Proteins; Mental Disorders; Mice; Nerve Tissue Proteins; Pentylenetetrazole; Piriform Cortex; Psychomotor Performance; Pyrrolidines; Quality of Life; Receptors, Nicotinic; Seizures; Social Behavior | 2019 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Network Meta-Analysis; Oxcarbazepine; Phenobarbital; Phenytoin; Piracetam; Remission Induction; Topiramate; Triazines; Valproic Acid; Zonisamide | 2017 |
[The role of zonisamide in the treatment of women with epilepsy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Zonisamide | 2016 |
[Epilepsy in the elderly].
Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Quality of Life; Seizures; Triazines; Zonisamide | 2013 |
[Zonisamide in the epilepsy treatment: a literature review from add-on therapy to monotherapy].
Topics: Adult; Animals; Anorexia; Anticonvulsants; Antioxidants; Carbonic Anhydrase Inhibitors; Child; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Europe; Fatigue; Headache; Humans; Ion Channels; Isoxazoles; Multicenter Studies as Topic; Neurotransmitter Agents; Randomized Controlled Trials as Topic; United States; Zonisamide | 2013 |
The adverse event profile of zonisamide: a meta-analysis.
Topics: Anticonvulsants; Clinical Trials as Topic; Databases, Factual; Epilepsy; Humans; Isoxazoles; Zonisamide | 2013 |
Zonisamide in the management of epilepsy in the elderly.
Topics: Aged; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Zonisamide | 2015 |
[New possibilities of monotherapy of symptomatic and cryptogenic partial epilepsy].
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Isoxazoles; Zonisamide | 2015 |
Therapeutic role of zonisamide in neuropsychiatric disorders.
Topics: Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Psychotic Disorders; Retrospective Studies; Zonisamide | 2008 |
[Role of monotherapy with new antiepileptic drugs in the treatment of childhood epilepsy].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Topiramate; Triazines; Zonisamide | 2009 |
New pharmacotherapies for pediatric seizures.
Topics: Adolescent; Amines; Animals; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Pediatrics; Piracetam; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 2004 |
Zonisamide in the treatment of epilepsy.
Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Compassionate Use Trials; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Europe; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Syndrome; Treatment Outcome; Zonisamide | 2010 |
[Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases].
Topics: Anticonvulsants; Bipolar Disorder; Calcium Channels, T-Type; Cholinergic Agents; Dopamine Agents; Dyskinesias; Epilepsy; Excitatory Amino Acid Agents; Feeding and Eating Disorders; GABA Agents; Humans; Isoxazoles; Migraine Disorders; Nerve Tissue Proteins; Nervous System Diseases; Neuroprotective Agents; Obesity; Parkinson Disease; Randomized Controlled Trials as Topic; Sodium Channels; Treatment Outcome; Voltage-Gated Sodium Channel beta-2 Subunit; Zonisamide | 2009 |
Drug safety evaluation of zonisamide for the treatment of epilepsy.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Isoxazoles; Kidney Calculi; Mental Disorders; Randomized Controlled Trials as Topic; Zonisamide | 2011 |
Zonisamide in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Epilepsy; Humans; Isoxazoles; Sodium Channel Blockers; Zonisamide | 2011 |
[New drugs in the treatment of adult patients with refractery epilepsy].
Topics: Adult; Anticonvulsants; Dibenzazepines; Epilepsy; Humans; Isoxazoles; Zonisamide | 2011 |
Zonisamide: its pharmacology, efficacy and safety in clinical trials.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 2012 |
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Child, Preschool; Dopamine; Dopamine Antagonists; Down Syndrome; Dyskinesia, Drug-Induced; Dystonic Disorders; Electroencephalography; Epilepsy; Female; Fragile X Syndrome; Humans; Intellectual Disability; Isoxazoles; Male; Methotrimeprazine; Ocular Motility Disorders; Paliperidone Palmitate; Piperazines; Pyrimidines; Quinolones; Risperidone; Substance Withdrawal Syndrome; Translocation, Genetic; Valproic Acid | 2013 |
Antiepileptic drug therapy for adults: when to initiate and how to choose.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Recurrence; Risk Factors; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
New antiepileptic drug therapies.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Phenytoin; Piracetam; Propylene Glycols; Thiazines; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2003 |
[Clinical guidelines for treatment of epilepsy in children].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Isoxazoles; Life Style; Magnetic Resonance Imaging; Phenytoin; Practice Guidelines as Topic; Temporal Lobe; Valproic Acid; Zonisamide | 2004 |
Pharmacologic treatment of the catastrophic epilepsies.
Topics: Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Epilepsy; Fructose; Humans; Infant; Isoxazoles; Lamotrigine; Spasms, Infantile; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 2004 |
Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy.
Topics: Animals; Anticonvulsants; Carrier Proteins; Epilepsy; GABA Plasma Membrane Transport Proteins; Humans; Isoxazoles; Membrane Transport Modulators | 2004 |
Review of zonisamide development in Japan.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Japan; Product Surveillance, Postmarketing; Zonisamide | 2004 |
Zonisamide overview of the United States experience.
Topics: Anticonvulsants; Epilepsy; Humans; Isoxazoles; Retrospective Studies; United States; Zonisamide | 2004 |
Zonisamide: newer antiepileptic agent with multiple mechanisms of action.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Epilepsy; Follow-Up Studies; History, 20th Century; History, 21st Century; Humans; Isoxazoles; Neuroprotective Agents; Zonisamide | 2004 |
Antiepileptic drugs and neuroprotection: current status and future roles.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Fructose; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Neuroprotective Agents; Piracetam; Seizures; Topiramate; Triazines; Zonisamide | 2005 |
Zonisamide in the management of epilepsy--Japanese experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Japan; Zonisamide | 2006 |
Zonisamide: review of its use in epilepsy therapy.
Topics: Animals; Anticonvulsants; Biological Availability; Child; Child, Preschool; Drug Interactions; Epilepsy; Half-Life; Humans; Infant; Isoxazoles; Migraine Disorders; Pain; Parkinson Disease; Randomized Controlled Trials as Topic; Tissue Distribution; Zonisamide | 2005 |
Practical prescribing and long-term efficacy and safety of zonisamide.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 2006 |
Zonisamide for the treatment of epilepsy.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Practice Patterns, Physicians'; Treatment Outcome; Zonisamide | 2006 |
Novel anticonvulsant drugs.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Piracetam; Pregabalin; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2007 |
Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Monitoring; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Pregabalin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2006 |
[Newer antiepileptic drugs].
Topics: Amines; Animals; Anti-Anxiety Agents; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Approval; Drug Design; Drug Interactions; Epilepsy; Felbamate; Fructose; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Neuroprotective Agents; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Sodium Channel Blockers; Topiramate; Triazines; Zonisamide | 2007 |
Pharmacokinetics and drug interactions with zonisamide.
Topics: Anticonvulsants; Contraceptives, Oral; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Epilepsy; Half-Life; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 2007 |
The new antiepileptic drugs.
Topics: Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsies, Partial; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Pregabalin; Topiramate; Triazines; Vigabatrin; Zonisamide | 2007 |
Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Brain Diseases; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Mental Disorders; Treatment Outcome; Zonisamide | 2008 |
Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Zonisamide | 1993 |
[New antiepileptic medications].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Triazines; Vigabatrin; Zonisamide | 1995 |
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Topics: Acetamides; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Piracetam; Propylene Glycols; Risk Factors; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1994 |
Antiepileptic drugs in development: prospects for the near future.
Topics: Acetates; Adult; Amines; Aminocaproates; Animals; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Drug Design; Drugs, Investigational; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Triazines; Vigabatrin; Zonisamide | 1994 |
Investigational antiepileptic drugs for the treatment of childhood seizure disorders: a review of efficacy and safety.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child; Clinical Trials as Topic; Clobazam; Drug Design; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Triazines; Zonisamide | 1994 |
[Research and development of zonisamide, a new type of antiepileptic drug].
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Dogs; Drug Design; Electroencephalography; Epilepsy; Humans; Isoxazoles; Mice; Rabbits; Rats; Structure-Activity Relationship; Zonisamide | 1996 |
New antiepileptic drugs: a systematic review of their efficacy and tolerability.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cross-Over Studies; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Male; Middle Aged; Nipecotic Acids; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 1996 |
Clinical administration of new antiepileptic drugs: an overview of safety and efficacy.
Topics: Acetates; Amines; Anticonvulsants; Confidence Intervals; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Odds Ratio; Placebos; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 1996 |
[Treatment of the epilepsy: new drugs].
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Topiramate; Triazines; Vigabatrin; Zonisamide | 1996 |
The new antiepileptic drugs: a systematic review of their efficacy and tolerability.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Male; Middle Aged; Randomized Controlled Trials as Topic; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 1997 |
Zonisamide.
Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 1999 |
The clinical pharmacokinetics of the new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Zonisamide | 1999 |
New antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
An assessment of zonisamide as an anti-epileptic drug.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Female; Humans; Isoxazoles; Middle Aged; Pregnancy; Zonisamide | 2000 |
Soretolide (Laboratoires Biocodex).
Topics: Animals; Anticonvulsants; Contraindications; Epilepsy; Humans; Isoxazoles; Structure-Activity Relationship | 2001 |
Newer therapies in the drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Piracetam; Zonisamide | 2002 |
Three new drugs for epilepsy: levetiracetam, oxcarbazepine, and zonisamide.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Piracetam; Treatment Outcome; Zonisamide | 2002 |
Using the new antiepilepsy drugs in children.
Topics: Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Piracetam; Treatment Outcome; Zonisamide | 2002 |
Zonisamide in pediatric epilepsy: review of the Japanese experience.
Topics: Adult; Anticonvulsants; Child; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Japan; Treatment Outcome; Zonisamide | 2002 |
Zonisamide.
Topics: Animals; Anticonvulsants; Brain; Drugs, Investigational; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Isoxazoles; Zonisamide | 1991 |
GABA uptake inhibitors: relevance to antiepileptic drug research.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Oxazoles | 1987 |
Neuropharmacology of zonisamide, a new antiepileptic drug.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbonic Anhydrase Inhibitors; Drug Interactions; Epilepsy; Isoxazoles; Kinetics; Oxazoles; Zonisamide | 1987 |
25 trial(s) available for isoxazoles and Epilepsy
| Article | Year |
|---|---|
Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Tolerance; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Italy; Magnetic Resonance Imaging; Male; Neurologic Examination; Statistics, Nonparametric; Young Adult; Zonisamide | 2009 |
Efficacy and tolerability of adjunctive therapy with zonisamide in childhood intractable epilepsy.
Topics: Adolescent; Anticonvulsants; Chemotherapy, Adjuvant; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Severity of Illness Index; Spasms, Infantile; Treatment Outcome; Zonisamide | 2010 |
Comparative trial of low- and high-dose zonisamide as monotherapy for childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Humans; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2011 |
Zonisamide monotherapy for idiopathic epilepsy in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Isoxazoles; Zonisamide | 2012 |
Zonisamide monotherapy in a multi-group clinic.
Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Humans; Isoxazoles; Male; Patient Care Team; Zonisamide | 2004 |
Safety of 25- and 50-mg capsules in the initiation of zonisamide therapy in patients with epilepsy: an uncontrolled, open-label study.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Isoxazoles; Male; United States; Zonisamide | 2004 |
Lack of a clinically significant effect of zonisamide on phenytoin steady-state pharmacokinetics in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Metabolic Clearance Rate; Middle Aged; Phenytoin; Zonisamide | 2004 |
Zonisamide monotherapy with once-daily dosing in children with cryptogenic localization-related epilepsies: clinical effects and pharmacokinetic studies.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2004 |
Clinical efficacy of zonisamide in childhood epilepsy after long-term treatment: a postmarketing, multi-institutional survey.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Disability Evaluation; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Male; Product Surveillance, Postmarketing; Severity of Illness Index; Time; Treatment Outcome; Zonisamide | 2004 |
Effects of zonisamide monotherapy in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Electroencephalography; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Severity of Illness Index; Treatment Outcome; Tuberous Sclerosis; Zonisamide | 2004 |
Efficacy of zonisamide: our experience.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Product Surveillance, Postmarketing; Prospective Studies; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
Zonisamide clinical trials: European experience.
Topics: Adult; Anticonvulsants; Demography; Double-Blind Method; Epilepsy; Europe; Female; Humans; Isoxazoles; Male; Middle Aged; Treatment Outcome; Zonisamide | 2004 |
Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Biotransformation; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Epilepsy; Female; Humans; In Vitro Techniques; Isoenzymes; Isoxazoles; Kinetics; Male; Microsomes, Liver; Middle Aged; Tissue Distribution; Zonisamide | 2004 |
Lack of clinically significant pharmacokinetic interactions between zonisamide and lamotrigine at steady state in patients with epilepsy.
Topics: Adult; Area Under Curve; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Lamotrigine; Liver; Male; Time Factors; Triazines; Zonisamide | 2005 |
Prospective study of zonisamide therapy for refractory idiopathic epilepsy in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Isoxazoles; Prospective Studies; Treatment Outcome; Zonisamide | 2007 |
Zonisamide and renal calculi in patients with epilepsy: how big an issue?
Topics: Adolescent; Adult; Anticonvulsants; Child; Double-Blind Method; Epilepsy; Female; Fructose; Humans; Isoxazoles; Kidney Calculi; Male; Middle Aged; Placebos; Product Surveillance, Postmarketing; Topiramate; Ultrasonography; Zonisamide | 2007 |
[Anticonvulsant treatment with zonisamide added to topiramate. A preliminary treatment analysis in 19 patients].
Topics: Adult; Aged; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Isoxazoles; Male; Middle Aged; Pilot Projects; Topiramate; Treatment Outcome; Zonisamide | 2007 |
Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients.
Topics: Adolescent; Adult; Affect; Anticonvulsants; Cognition; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Male; Neuropsychological Tests; Prospective Studies; Zonisamide | 2008 |
Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Female; Humans; Isoxazoles; Male; Pancreatitis; Seizures; Severity of Illness Index; Sweating; Time Factors; Treatment Outcome; Vertigo; Zonisamide | 2009 |
THIP: a single-blind controlled trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles | 1983 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electroencephalography; Epilepsy; Female; Half-Life; Humans; Infant; Isoxazoles; Male; Phenytoin; Prospective Studies; Valproic Acid; Zonisamide | 1993 |
Efficacy and safety of zonisamide: results of a multicenter study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Zonisamide | 1993 |
Long-term effects of zonisamide in the treatment of epilepsy in children with intellectual disability.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Intellectual Disability; Isoxazoles; Male; Time Factors; Zonisamide | 1998 |
Predictive value of acetylcholine stimulation testing for oligohidrosis caused by zonisamide.
Topics: Acetylcholine; Anticonvulsants; Child; Child, Preschool; Cholinergic Agents; Epilepsy; False Positive Reactions; Female; Fever; Humans; Hypohidrosis; Isoxazoles; Male; Predictive Value of Tests; Prognosis; Sensitivity and Specificity; Sweating; Treatment Outcome; Zonisamide | 2000 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; Drug Industry; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Half-Life; Humans; Infant; Intestinal Absorption; Isoxazoles; Lamotrigine; Prospective Studies; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2000 |
104 other study(ies) available for isoxazoles and Epilepsy
| Article | Year |
|---|---|
Chromatographic determination of zonisamide, topiramate and sulpiride in plasma by a fluorescent 'turn-on' chemosensor.
Topics: Adult; Anticonvulsants; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Epilepsy; Female; Fructose; Humans; Hydrogen-Ion Concentration; Isoxazoles; Limit of Detection; Linear Models; Male; Spectrometry, Fluorescence; Sulpiride; Time Factors; Topiramate; Water; Zonisamide | 2017 |
Suspected zonisamide-related anticonvulsant hypersensitivity syndrome in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Diagnosis, Differential; Drug Hypersensitivity; Epilepsy; Isoxazoles; Male; Seizures; Zonisamide | 2017 |
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammation; Isoxazoles; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Seizures; Zonisamide | 2018 |
[Progress in synaptic mechanism in epileptogenesis].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; N-Ethylmaleimide-Sensitive Proteins; Nerve Tissue Proteins; Qa-SNARE Proteins; Recurrence; Synapses; Synaptic Vesicles; Zonisamide | 2018 |
Risk factors for hyperammonemia in pediatric patients with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Infant; Isoxazoles; Male; Phenobarbital; Phenytoin; Retrospective Studies; Risk Factors; Sex Factors; Topiramate; Valproic Acid; Zonisamide | 2013 |
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isoxazoles; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Synapses; Synaptic Transmission | 2013 |
Safety and tolerability of zonisamide in elderly patients with epilepsy.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Databases, Bibliographic; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Isoxazoles; Male; Treatment Outcome; Zonisamide | 2013 |
Management and monitoring of patients treated with zonisamide: the OZONE study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Data Collection; Data Interpretation, Statistical; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Monitoring, Physiologic; Quality of Life; Seizures; Treatment Outcome; Young Adult; Zonisamide | 2013 |
Two nursing mothers treated with zonisamide: Should breast-feeding be avoided?
Topics: Adult; Anticonvulsants; Biological Availability; Breast Feeding; Child Development; Epilepsy; Female; Fetal Blood; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Isoxazoles; Lactation; Male; Milk, Human; Zonisamide | 2014 |
Psychiatric adverse effects of zonisamide in patients with epilepsy and mental disorder comorbidities.
Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Electroencephalography; Epilepsy; Female; Humans; Isoxazoles; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Disorders; Middle Aged; Psychotic Disorders; Zonisamide | 2013 |
Impact of pregnancy on zonisamide pharmacokinetics in rabbits.
Topics: Administration, Oral; Animals; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Pregnancy; Rabbits; Tandem Mass Spectrometry; Zonisamide | 2013 |
Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.
Topics: Amygdala; Animals; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Isoxazoles; Mice; Mice, Knockout; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures | 2014 |
Safety and tolerability of zonisamide in paediatric patients with epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Female; Humans; Isoxazoles; Male; Pediatrics; Treatment Outcome; Zonisamide | 2014 |
Zonisamide: pharmacokinetics, efficacy, and adverse events in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Male; Metabolic Clearance Rate; Retrospective Studies; Sex Factors; Treatment Outcome; Zonisamide | 2014 |
Retention rate of zonisamide in intractable epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Denmark; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Male; Middle Aged; Norway; Patient Dropouts; Piracetam; Quality of Life; Sweden; Treatment Outcome; Triazines; Young Adult; Zonisamide | 2015 |
Erythema multiforme associated with zonisamide in a dog.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Erythema Multiforme; Isoxazoles; Male; Skin; Zonisamide | 2015 |
Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy.
Topics: Anticonvulsants; Drug Interactions; Epilepsy; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Zonisamide | 2015 |
Safety and tolerability of an oral zonisamide loading dose.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Drug Administration Schedule; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Young Adult; Zonisamide | 2015 |
Zonisamide-induced Acute-on-Chronic Liver Failure: First Report.
Topics: Acute-On-Chronic Liver Failure; Adult; Alcoholism; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Zonisamide | 2016 |
Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Seizures; Treatment Outcome; Young Adult; Zonisamide | 2016 |
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Japan; Lamotrigine; Levetiracetam; Male; Phenobarbital; Phenytoin; Piracetam; Triazines; Valproic Acid; Young Adult; Zonisamide | 2016 |
Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.
Topics: Animals; Anticonvulsants; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Epilepsy; Hippocampus; Humans; Isoxazoles; Mammals; Protein Isoforms; Structure-Activity Relationship; Substrate Specificity; Zonisamide | 2008 |
The impact of zonisamide on weight. A clinical study in 103 patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Body Mass Index; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Time Factors; Young Adult; Zonisamide | 2009 |
[New antiepileptic drugs].
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Epilepsy; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Oxcarbazepine; Piracetam; Pregabalin; Triazines; Zonisamide | 2009 |
Reversible erectile dysfunction in a patient with brain tumor-related epilepsy in therapy with zonisamide in add-on.
Topics: Adult; Anticonvulsants; Astrocytoma; Brain Neoplasms; Epilepsy; Erectile Dysfunction; Humans; Isoxazoles; Male; Seizures; Zonisamide | 2011 |
Zonisamide: in Parkinson's disease.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Epilepsy; Humans; Isoxazoles; Parkinson Disease; Zonisamide | 2009 |
Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Neurologic Examination; Zonisamide | 2009 |
Effectiveness and tolerability of zonisamide in children with epilepsy: a retrospective review.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Evaluation; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Young Adult; Zonisamide | 2010 |
Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Triazines; Triazoles; Ultraviolet Rays; Zonisamide | 2010 |
Zonisamide-related erectile dysfunction.
Topics: Anticonvulsants; Brain Neoplasms; Epilepsy; Humans; Impotence, Vasculogenic; Isoxazoles; Male; Nitric Oxide Synthase; Zonisamide | 2011 |
Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Anticonvulsants; Drug Hypersensitivity; Epilepsy; Exanthema; Humans; Isoxazoles; Male; Patch Tests; Treatment Outcome; Zonisamide | 2010 |
A prospective audit of adjunctive zonisamide in an everyday clinical setting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Chemotherapy, Adjuvant; Electroencephalography; Epilepsy; Female; Humans; Isoxazoles; Male; Medical Audit; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult; Zonisamide | 2010 |
Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy.
Topics: Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Epilepsy; Female; Fructose; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Risk Factors; Topiramate; Urolithiasis; Zonisamide | 2010 |
Zonisamide discontinuation due to psychiatric and cognitive adverse events: a case-control study.
Topics: Adult; Anticonvulsants; Case-Control Studies; Cognition Disorders; Epilepsy; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Retrospective Studies; Risk Factors; Young Adult; Zonisamide | 2010 |
[Different expression of GluR5 and GluR6 in rat astrocyte induced with coriaria lactone and ATPA].
Topics: Animals; Animals, Newborn; Astrocytes; Epilepsy; GluK2 Kainate Receptor; Isoxazoles; Lactones; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA, Messenger | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.
Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Aged; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Epilepsy; Female; Fructose; Genome-Wide Association Study; Humans; Isoxazoles; Male; Middle Aged; Polymorphism, Single Nucleotide; Prevalence; Severity of Illness Index; Topiramate; Young Adult; Zonisamide | 2011 |
The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Referral and Consultation; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult; Zonisamide | 2011 |
Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Epilepsy; Female; Isoxazoles; Zonisamide | 2011 |
Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Leptin; Linear Models; Middle Aged; Obesity; Prospective Studies; Weight Loss; Young Adult; Zonisamide | 2012 |
[Clinical application of newer anti-epileptic drugs].
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Pregnancy; Pregnancy Complications; Topiramate; Triazines; Zonisamide | 2012 |
[Urolithiasis induced by combined ACTH and zonisamide treatment in a patient with startle induced epilepsy].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Kidney Calculi; Kidney Pelvis; Male; Reflex, Startle; Zonisamide | 2002 |
[Clinical features and treatment of refractory epilepsy in children].
Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Clonazepam; Epilepsy; Female; Humans; Infant; Infant, Newborn; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Valproic Acid; Zonisamide | 2001 |
Zonisamide-induced restless legs syndrome.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Fatigue; Female; Humans; Isoxazoles; Restless Legs Syndrome; Treatment Outcome; Zonisamide | 2003 |
[A five-year-old girl with epilepsy showing forced normalization due to zonisamide].
Topics: Anticonvulsants; Child Behavior Disorders; Child, Preschool; Communication Disorders; Electroencephalography; Epilepsy; Female; Fluvoxamine; Humans; Isoxazoles; Psychoses, Substance-Induced; Zonisamide | 2003 |
Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures.
Topics: Amino Acid Transport System X-AG; Amygdala; Animals; Anticonvulsants; Blotting, Western; Carrier Proteins; Chlorides; Chronic Disease; Disease Models, Animal; Epilepsy; Ferric Compounds; Frontal Lobe; GABA Plasma Membrane Transport Proteins; Hippocampus; Isoxazoles; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Rats; Rats, Wistar; Zonisamide | 2003 |
Effect of antiepileptic drug monotherapy on crystalluria in children and young adults.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Retrospective Studies; Risk Factors; Sex Factors; Thiazines; Urinalysis; Urinary Calculi; Zonisamide | 2003 |
Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.
Topics: Administration, Oral; Adolescent; Adult; Aging; Anticonvulsants; Biological Availability; Body Surface Area; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Patient Selection; Phenytoin; Powders; Regression Analysis; Sex; Tablets; Zonisamide | 2003 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-Response Relationship, Drug; Epilepsy; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Isoxazoles; Kindling, Neurologic; Ligands; Mice; Pentylenetetrazole; Pregnanediones; Receptors, GABA-A | 2004 |
Zonisamide-induced depression and mania in patients with epilepsy.
Topics: Adult; Bipolar Disorder; Depression; Epilepsy; Humans; Isoxazoles; Male; Polypharmacy; Treatment Outcome; Zonisamide | 2004 |
Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Chronic Disease; Epilepsy; Humans; Isoxazoles; Male; Middle Aged; Pain; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
Overview of Japanese experience-controlled and uncontrolled trials.
Topics: Adolescent; Age Distribution; Anticonvulsants; Child; Child, Preschool; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Japan; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
Safety of zonisamide therapy: prospective follow-up survey.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Incidence; Infant; Isoxazoles; Male; Mental Disorders; Middle Aged; Product Surveillance, Postmarketing; Zonisamide | 2004 |
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Combinations; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Middle Aged; Phenobarbital; Phenytoin; Sex Factors; Valproic Acid; Zonisamide | 2004 |
Zonisamide monotherapy for epilepsy in children and young adults.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Isoxazoles; Retrospective Studies; Treatment Outcome; United States; Zonisamide | 2005 |
Clinical experience with zonisamide monotherapy and adjunctive therapy in children with epilepsy at a tertiary care referral center.
Topics: Adolescent; Anticonvulsants; Chemotherapy, Adjuvant; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electric Stimulation Therapy; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2005 |
Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Valproic Acid; Zonisamide | 2005 |
[Effective and 15 years experience. New add-on option in epilepsy therapy]].
Topics: Anticonvulsants; Body Weight; Child; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Approval; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Isoxazoles; Patient Acceptance of Health Care; Zonisamide | 2005 |
[Control of side effects. Add on therapy demonstrates good tolerance].
Topics: Anticonvulsants; Body Weight; Controlled Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Patient Acceptance of Health Care; Treatment Outcome; Zonisamide | 2005 |
Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Zonisamide | 2006 |
Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Infant; Isoxazoles; Zonisamide | 2006 |
Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Epilepsy; Fluorescent Antibody Technique; Isoxazoles; Male; Mice; Zonisamide | 2007 |
A long-term follow-up of zonisamide monotherapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Longitudinal Studies; Male; Medical Records; Statistics, Nonparametric; Treatment Outcome; Zonisamide | 2006 |
A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Isoxazoles; Mobius Syndrome; Pregnancy; Pregnancy Complications; Vocal Cord Paralysis; Zonisamide | 2007 |
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Isoxazoles; Lung Diseases, Interstitial; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Spasms, Infantile; Valproic Acid; Zonisamide | 2007 |
Erratum to "Safety of zonisamide therapy: prospective follow-up survey.".
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Incidence; Infant; Isoxazoles; Male; Mental Disorders; Middle Aged; Product Surveillance, Postmarketing; Zonisamide | 2007 |
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Monitoring; Epilepsy; Female; Gene Frequency; Genetics, Population; Heterozygote; Homozygote; Humans; Immunoassay; Isoxazoles; Japan; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Polymorphism, Genetic; Regression Analysis; Valproic Acid; Zonisamide | 2007 |
Psychosis following initiation of zonisamide.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Middle Aged; Psychoses, Substance-Induced; Zonisamide | 2007 |
Zonisamide as treatment for seizures.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Humans; Isoxazoles; Seizures; Zonisamide | 2007 |
Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoxazoles; Neural Inhibition; Neurons; Serotonin; Theophylline; Zonisamide | 2007 |
Neuroleptic malignant syndrome-like state in an epileptic patient with organic brain comorbidity treated with zonisamide and carbamazepine.
Topics: Adult; Anticonvulsants; Brain Diseases; Carbamazepine; Comorbidity; Epilepsy; Humans; Isoxazoles; Male; Neuroleptic Malignant Syndrome; Zonisamide | 2007 |
Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Isoxazoles; Korea; Male; Retrospective Studies; Treatment Outcome; Zonisamide | 2008 |
Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Data Interpretation, Statistical; Electrophysiology; Epilepsy; Female; Guinea Pigs; Hippocampus; Hydrogen-Ion Concentration; In Vitro Techniques; Isoxazoles; Membrane Potentials; Microelectrodes; Neurons; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Theophylline; Zonisamide | 2008 |
Nonlinear pharmacokinetics of CI-912 in adult epileptic patients.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Pilot Projects; Zonisamide | 1984 |
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide | 1982 |
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Electroencephalographic profile.
Topics: Animals; Anticonvulsants; Arousal; Cats; Electroencephalography; Epilepsy; Female; Freezing; Hippocampus; Isoxazoles; Male; Oxazoles; Thalamus; Time Factors; Tungsten; Zonisamide | 1980 |
Population analysis of the dose-dependent pharmacokinetics of zonisamide in epileptic patients.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Biological Availability; Carbamazepine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studies; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Software; Zonisamide | 1994 |
Concentrations of zonisamide in serum, free fraction, mixed saliva and cerebrospinal fluid in epileptic children treated with monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Protein Binding; Saliva; Zonisamide | 1993 |
Mechanisms of T-type calcium channel blockade by zonisamide.
Topics: Anticonvulsants; Calcium Channel Blockers; Cell Culture Techniques; Epilepsy; Humans; Isoxazoles; Neuroblastoma; Zonisamide | 1996 |
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Valproic Acid; Zonisamide | 1996 |
Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anencephaly; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Isoxazoles; Polypharmacy; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Risk Factors; Zonisamide | 1996 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Isoxazoles; Male; Phenobarbital; Time Factors; Valproic Acid; Zonisamide | 1997 |
IgA and IgG2 deficiency associated with zonisamide therapy: a case report.
Topics: Anticonvulsants; Epilepsy; Humans; IgA Deficiency; IgG Deficiency; Immunoglobulin A; Immunoglobulin G; Infant; Isoxazoles; Male; Zonisamide | 1997 |
Heat stroke-like episode in a child caused by zonisamide.
Topics: Anticonvulsants; Biopsy; Child, Preschool; Epilepsy; Fever; Heat Stroke; Humans; Hypohidrosis; Isoxazoles; Male; Skin; Zonisamide | 1997 |
Psychotic episodes during zonisamide treatment.
Topics: Adult; Age Factors; Anticonvulsants; Case-Control Studies; Child; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Obsessive-Compulsive Disorder; Psychoses, Substance-Induced; Remission Induction; Retrospective Studies; Treatment Outcome; Zonisamide | 2000 |
Two new drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Isoxazoles; Levetiracetam; Nootropic Agents; Oxcarbazepine; Piracetam; Sodium Channel Blockers; Zonisamide | 2000 |
Zonisamide reduces the increase in 8-hydroxy-2'-deoxyguanosine levels formed during iron-induced epileptogenesis in the brains of rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Chlorides; Deoxyguanosine; DNA Damage; Epilepsy; Ferric Compounds; Isoxazoles; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Zonisamide | 2000 |
Zonisamide (Zonegran) for epilepsy.
Topics: Adult; Anticonvulsants; Ataxia; Biological Availability; Calcium Channel Blockers; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Half-Life; Humans; Isoxazoles; Zonisamide | 2000 |
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Mutant Strains; Nitric Oxide; Phenytoin; Valproic Acid; Zonisamide | 2000 |
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Phenobarbital; Receptors, N-Methyl-D-Aspartate; Zonisamide | 2001 |
Influences of caffeine to nitric oxide production and zonisamide concentration in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Brain; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Zonisamide | 2001 |
[A case of epilepsy after therapy with interferon-alpha-treated chronic hepatitis C].
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hepatitis C, Chronic; Humans; Interferon-alpha; Isoxazoles; Male; Middle Aged; Zonisamide | 2002 |
Pharmacokinetics of zonisamide in perinatal period.
Topics: Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Isoxazoles; Milk, Human; Pregnancy; Pregnancy Complications; Zonisamide | 2002 |
Clobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Circadian Rhythm; Clobazam; Clonazepam; Epilepsy; Epilepsy, Tonic-Clonic; Isoxazoles; Male; Rats; Rats, Mutant Strains; Zonisamide | 2002 |
Methodological requirements for clinical trials in refractory epilepsies--our experience with zonisamide.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Infant; Isoxazoles; Research Design; Zonisamide | 1992 |
Factors influencing serum concentration of zonisamide in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Zonisamide | 1992 |
Monotherapy for childhood epilepsies with zonisamide.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Female; Humans; Infant; Isoxazoles; Male; Neurologic Examination; Zonisamide | 1991 |
Effect of zonisamide on serum immunoglobulins.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Isoxazoles; Male; Middle Aged; Zonisamide | 1990 |
Effect of a novel anticonvulsant, zonisamide (AD-810, CI-912), in an experimental model of photosensitive epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Male; Photic Stimulation; Zonisamide | 1990 |
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.
Topics: Animals; Anticonvulsants; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Kindling, Neurologic; Male; Oxazoles; Phenytoin; Visual Cortex; Zonisamide | 1990 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid | 1986 |
The antiepileptic effect of zonisamide on patients with refractory seizures and its side effect.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Evoked Potentials; Female; Humans; Isoxazoles; Male; Oxazoles; Zonisamide | 1988 |
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Humans; Isoxazoles; Kinetics; Male; Oxazoles; Phenytoin; Zonisamide | 1986 |