isoxazoles has been researched along with Disease Models, Animal in 293 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (2.73) | 18.7374 |
1990's | 26 (8.87) | 18.2507 |
2000's | 79 (26.96) | 29.6817 |
2010's | 159 (54.27) | 24.3611 |
2020's | 21 (7.17) | 2.80 |
Authors | Studies |
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Chen, Q; Guo, Y; Min, S; Wu, B | 1 |
Baelde, HJ; Danser, AHJ; de Vries, R; Garrelds, IM; Mirabito Colafella, KM; Montezano, AC; Neves, KB; Touyz, RM; Uijl, E; van den Meiracker, AH; van Veghel, R; Versmissen, J | 1 |
Blaho, VA; Chun, J; Frantz, AJ; Kennedy, G; Kihara, Y; Lummis, NC; Sánchez-Pavón, P | 1 |
Takechi, K | 1 |
Allam, VSRR; Sukkar, MB | 1 |
Chu, X; Han, Y; Li, C; Mu, S; Qiu, D; Song, Z; Tong, C; Wang, J; Wei, W; Zhu, M | 1 |
Chen, YF; Cheng, M; Gao, YD; Huang, G; Wang, YM; Zhong, JN; Zhu, FF | 1 |
Nagaraju, B; Prasanna, B; Seelam, N; Shanmukhakumar, JV; Subbaiah, T | 1 |
Gzielo, K; Krawczyk, M; Nikiforuk, A; Popik, P; Potasiewicz, A | 1 |
Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB | 1 |
Akassoglou, K; Ang, KK; Arkin, MR; Baeten, KM; Bardehle, S; Bedard, C; Bruneau, BG; Green, AJ; Hanspers, K; Jiang, X; Machado, MR; Mendiola, AS; Merlini, M; Meyer-Franke, A; Meza-Acevedo, R; Petersen, MA; Pfaff, SJ; Pico, AR; Pleiss, MA; Rafalski, VA; Rios Coronado, PE; Ryu, JK; Thomas, R; Thomas, S; Tognatta, R; Wang, J; Williams, A; Wilson, C; Yan, Z; Zamvil, SS | 1 |
Bechmann, N; Bornstein, SR; Drechsel, A; Ehrlich, H; Helm, J; Pantovic, S | 1 |
Chai, X; Hu, S; Shu, S; Wang, D; Wei, X; Zhang, C; Zosky, GR | 1 |
Biancatelli, RMLC; Catravas, JD; Dimitropoulou, C; Marinova, M; Solopov, P | 1 |
Chen, W; Ge, K; Han, X; Huang, F; Huang, Y; Jia, W; Rajani, C; Wang, S; Yu, H; Zhao, A; Zheng, X; Zhu, J | 1 |
Azab, AN; Boyko, M; Ferorelli, S; Kaplanski, J; Perrone, MG; Rostevanov, IS; Scilimati, A; Zlotnik, A | 1 |
Buchholz, B; Grampp, S; Kraus, A; Safi, W; Schödel, J | 1 |
Basarab, GS; Doig, P; Eyermann, CJ; Galullo, V; Gowravaram, M; Hauck, S; Kern, G; Kimzey, A; Kutschke, A; Morningstar, M; Schuck, V; Vishwanathan, K; Zhou, F | 1 |
Lucena, F; McDougall, JJ | 1 |
Aricioglu, F; Sirvanci, S; Unal, G | 1 |
Demyanenko, SV; Uzdensky, A | 1 |
Chien, D; Dawson, PA; Dong, X; Fauler, G; Fickert, P; Gilmer, JF; Moustafa, T; Truong, JK; van de Graaf, SFJ; van de Wiel, SMW; Yin, L; Zaufel, A | 1 |
Cruz, JV; Maba, IK; Zampronio, AR | 1 |
Hewitt, T; Khokhar, JY; Lalonde, J; Perreault, ML; St-Denis, M; Thériault, RK | 1 |
Batteux, F; Cerles, O; Chéreau, C; Chouzenoux, S; Kavian, N; Morin, F; Nicco, C | 1 |
Jun, HS; Kim, D; Lee, SM; Park, E | 1 |
Gu, Y; Körbel, C; Laschke, MW; Menger, MD; Nenicu, A | 1 |
Barlow, EA; Bilger, A; Bristol, JA; Delecluse, HJ; Kenney, SC; Li, Z; Ma, S; Nawandar, D; Plowshay, J; Romero-Masters, JC; Tsai, MH | 1 |
Belguise, K; Chen, B; Chen, L; Gao, J; Liu, C; Lu, K; Wang, X; Yi, B; Yu, W | 1 |
Cui, H; Fu, G; Qiu, Y; Ren, A | 1 |
Eräranta, A; Lakkisto, P; Mustonen, J; Niemelä, O; Paavonen, T; Pörsti, I; Tikkanen, I; Törmänen, S | 1 |
Aikawa, Y; Ito, H; Kawaguchi, Y; Kimura, T; Makino, H; Motomura, H; Nogami, M; Sainoh, T; Seki, S; Shiozawa, S; Tsumaki, N; Watanabe, K; Yahara, Y; Yamazaki, M | 1 |
Deng, WH; Guo, ZD; Hong, YP; Shi, Q; Wang, P; Wang, WX; Zhao, L; Zuo, T | 1 |
Bakar, B; Budak Yildiran, FA; Dincel, GC; Kisa, U; Ogden, M; Yuksel, U | 1 |
Cheng, X; Dougherty, PM; Heijnen, CJ; Huo, X; Kavelaars, A; Li, Y; Mei, F; Singhmar, P | 1 |
Ali, A; Ashraf, M; Hu, H; Maienschein-Cline, M; Tang, Y; Wang, Y; Xuan, W | 1 |
Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B | 1 |
Bhatti, R; Gupta, M; Kumar, A; Sharma, A; Singh Ishar, MP; Singh, G | 1 |
Chen, X; Gao, E; Guo, Y; Li, C; Li, Y; Liu, Y; Tao, L; Wang, H; Wang, S; Wang, W; Xia, Y; Xiong, Z; Xu, X; Yan, W; Zhang, F; Zhang, J; Zhang, L; Zhang, X; Zhao, H; Zhao, S | 1 |
Bol, JGJM; Brevé, JJP; Chrobok, NL; Drukarch, B; El Alaoui, S; Jongenelen, CA; van Dam, AM; Wilhelmus, MMM | 1 |
Alzarea, S; Rahman, S | 2 |
Caton, E; Meyer, KJ; Shapiro, TA | 1 |
Byun, S; Guo, G; Kemper, B; Kemper, JK; Kim, DH; Kim, YC; Kong, B; Ryerson, D; Sun, H; Xu, HE; Yau, P | 1 |
Anil, SM; Balaji, KS; Jayarama, S; Kiran, KR; Lingaraju, GS; Sadashiva, MP | 1 |
Covel, J; Fierer, J; Kapoor, M; Okamoto, S; Shaw, KJ; Soltow, QA; Trzoss, M; Viriyakosol, S | 1 |
Batteux, F; Bordenave, J; Cumont, A; Dinh-Xuan, AT; Guignabert, C; Guilbert, T; Günther, S; Hua-Huy, T; Humbert, M; Jalce, G; Nicco, C; Quatremarre, T; Savale, L; Thuillet, R; Tu, L | 1 |
Gaberel, T; Gakuba, C; Lépine, M; Lo, EH; van Leyen, K; Zheng, Y | 1 |
Crawley, JN; Kazdoba, TM; Parrott, JM; Rhine, MA; Schultz, MN | 1 |
Chen, Z; Li, J; Shi, J; Wang, YB | 1 |
Chen, R; Liang, Y; Lin, Y; Liu, J; Ma, Y; Wang, H; Xu, B | 1 |
Conde, C; García, S; Gómez-Reino, JJ; González, A; Martínez, P; Orosa, B | 1 |
Ding, X; Greer, JJ; Lenal, F; Ren, J; Yang, M | 1 |
Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX | 1 |
Arikok, AT; Bavbek, M; Besalti, O; Caliskan, M; Demirci, AY; Seckin, H; Yigitkanli, K; Yigitkanli, T | 1 |
O'Doherty, C; Polasek, TM; Rowland, A; Sorich, MJ; Wiese, MD | 1 |
Castilla-Ortega, E; Chun, J; Estivill-Torrús, G; García-Fernández, M; Pedraza, C; Rodriguez de Fonseca, F; Rosell-Valle, C; Sánchez-López, J; Santín, LJ; Zambrana-Infantes, E | 1 |
Arung, W; Cheramy, JP; Defraigne, JO; Detry, O; Drion, P; Honoré, P; Jehaes, F; Meurisse, M | 1 |
Jin, K; Sun, F; Uteshev, VV | 1 |
Cui, H; Ding, HF; Xiang, Z; Yan, X; Zhu, S | 1 |
Alagarsamy, V; Dineshkumar, P; Saravanan, G | 1 |
Arslan, R; Bektas, N; Ozturk, Y | 1 |
Fadillioglu, E; Karaman, A; Ozturk, E; Samdancı, E; Surucu, M | 1 |
Andrzejak, V; Barczyk, A; Body-Malapel, M; Chavatte, P; Desreumaux, P; Djouina, M; Leleu-Chavain, N; Millet, R; Rigo, B; Tourteau, A | 1 |
Arawaka, S; Fukushima, S; Kato, T; Koga, K; Koyama, S; Sasaki, A; Sato, H | 1 |
Balasubramanian, A; Cao, Z; Feketa, VV; Flores, CM; Marrelli, SP; Player, MR; Zhang, Y | 1 |
Bayram, E; Karaoğlu, P; Kumral, A; Kurul, SH; Ozbal, S; Topçu, Y; Tuğyan, K; Yılmaz, O; Yiş, U | 1 |
Caeiro, JR; Conde, C; Gómez-Reino, JJ; González, A; Guede, D; Martínez, P; Orosa, B | 1 |
Gotoh, M; Morohoshi, T; Murakami-Murofushi, K; Murofushi, H; Nagano, A; Otsuka, K; Tsukahara, R | 1 |
Cheng, L; Dargham, RA; Kong, S; Liu, X; Ren, W; Wan, L; Wang, Y; Wu, Z | 1 |
Hara, H; Hashizume, T; Ishisaka, M; Shimazawa, M; Tsujii, S | 1 |
Bartsch, DK; Fendrich, V; L-Lopez, C; Lang, SA; Lauth, M; Rexin, P; Schlitt, HJ; Waldmann, J; Wichmann, S; Wiese, D | 1 |
Chen, M; Fu, BQ; Ma, X; Tao, LS; Xu, YP; Yao, J; Zhou, CS | 1 |
Caso, JR; García-Bueno, B; Leza, JC; MacDowell, KS; Madrigal, JL; Martín-Hernández, D | 1 |
Chang, JS; Chang, KC; Chen, LT; Chen, TY; Cheng, AL; Kuo, SH; Lin, HY; Lin, SF; Shih, NY; Tsai, HJ | 1 |
Cui, W; Yu, X; Zhang, H | 1 |
Duthie, KM; Hadoke, PW; Ivy, JR; Kirkby, NS; Lim, WG; McShane, JF; Miller, E; Webb, DJ | 1 |
Gatson, JW; Simpkins, JW; Uteshev, VV | 1 |
Cho, GH; Cho, YS; Jeong, KS; Keum, G; Kim, T; Koh, HY; Lee, J; Min, SJ; Pae, AN; Seo, SH; Son, WS | 1 |
Huang, H; Jacko, AM; Tsung, A; Weathington, N; Wei, J; Zhao, J; Zhao, Y | 1 |
Floyd, KL; Stevens, KE; Stitzel, JA; Zheng, L | 1 |
Brooks-Kayal, A; Carlsen, J; Cea-Del Rio, CA; Cruz Del Angel, Y; González, MI; Grabenstatter, HL; Huntsman, MM; Laoprasert, RP; White, AM | 1 |
Fischell, J; Kvarta, MD; LeGates, TA; Thompson, SM; Van Dyke, AM | 1 |
Angadi, V; Dissel, S; Donlea, J; English, D; Kirszenblat, L; Klose, M; Koch, Z; Shaw, PJ; Suzuki, Y; van Swinderen, B; Winsky-Sommerer, R | 1 |
Barros, GA; Calistro Neto, JP; Domingues, MA; Gonçalves, GM; Módolo, NS; Silva, LM; Torres, Rda C | 1 |
Ohashi, T; Yamamoto, T | 1 |
Arai, Y; Hiraoka, N; Kanai, Y; Miyagawa, S; Ojima, H; Rokutan, H; Shibata, T; Shimada, K; Shirota, T | 1 |
Alm, RA; Barvian, K; Basarab, GS; Doig, P; Galullo, V; Gardner, H; Gowravaram, M; Huband, M; Kern, GH; Kimzey, A; Kutschke, A; Lahiri, SD; Lawrence, K; McNulty, J; Morningstar, M; Mueller, JP; Newman, JV; Perros, M; Schuck, VJ; Singh, R; Tommasi, R; Vishwanathan, K; Walkup, G | 1 |
Balaji, KS; Jagadish, S; Jayarama, S; Mohan, CD; Rakesh, KS; Rangappa, KS; Swaroop, TR; Zameer, F | 1 |
Biederman, RW; Boyd, NH; DiCarlo, C; Finley, G; Jobe, BA; Kelly, LA; Kolano, EL; Komatsu, Y; Kosovec, JE; Landreneau, RJ; Matsui, D; Omstead, A; Rotoloni, CL; Silverman, JF; Vytlacil, C; Zaidi, AH | 1 |
Chen, Y; Feng, B; Gong, Y; Mu, J; Qin, Z; Shi, Z; Yuan, F; Zhang, J; Zhao, Y; Zhou, B | 1 |
Chen, X; Cuppen, E; DeRuiter, MC; Folkerts, G; Laghmani, EH; Sengers, RM; van Boxtel, R; Wagenaar, GT; Walther, FJ | 1 |
Huang, WQ; Ma, Y; Xu, KQ; Zhang, T | 1 |
Azay-Milhau, J; Balzarin, S; Chajistamatiou, AS; Chrysina, ED; Docsa, T; Duret, C; Gergely, P; Goyard, D; Kónya, B; Leroy, J; Maurel, P; Petit, P; Praly, JP; Somsák, L; Tournier, M; Tousch, D; Vidal, S | 1 |
Cao, L; Cheng, X; Hao, H; Wang, G; Wang, H; Wu, M; Wu, Y; Xie, W; Xie, Y | 1 |
Bruheim, S; Suo, Z; Wendel, T; Wiedlocha, A; Zhen, Y | 1 |
Adcock, IM; Barnes, PJ; Chung, KF; Clarke, CJ; Durham, AL; Footitt, J; Hall, SR; Hansbro, PM; Johnston, SL; Mallia, P; Russell, KE; Simpson, KD; Starkey, MR; Wiegman, CH | 1 |
Boychuk, JA; Butler, CR; Halmos, KC; Smith, BN | 1 |
Guo, ST; Jiang, CC; Jin, L; Liu, F; Wang, CY; Wang, JY; Yan, XG; Yari, H; Zhang, XD; Zhang, YY | 1 |
Liu, S; Parajuli, KR; You, Z; Zhang, Q | 1 |
Komori, T; Potschka, H; Rettenbeck, ML; Russmann, V; Salvamoser, JD | 1 |
Araki, H; Kiyoi, T; Suemaru, K; Takechi, K; Tanaka, A | 1 |
Chapin, S; Everett, WR; Mahabir, SP; Six, RH | 1 |
Araki, K; Kamide, D; Shiotani, A; Shiozawa, S; Tanaka, S; Tanaka, Y; Tomifuji, M; Yamashita, T | 1 |
Bieńkowski, P; Jastrzębska-Więsek, M; Kołaczkowski, M; Mierzejewski, P; Partyka, A; Wasik, A; Wesołowska, A | 1 |
Fernández-Ruiz, J; García-Arencibia, M; García-Toscano, L; Gómez-Cañas, M; Jagerovic, N; Morales, P; Muñoz, E; Navarrete, C; Pazos, MR | 1 |
Boychuk, JA; Butler, CR; Smith, BN | 1 |
Aisa, HA; Ge, M; Hu, J; Jiang, JD; Li, YH; Ma, LL; Sun, WF; Wang, HQ; Wu, P; Wu, S; Yin, JQ; Zhao, JY | 1 |
Cheung, L; Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Liu, S; Meehan, DT; Phillips, G; Song, W | 1 |
Deng, F; Feng, J; Wang, L; Zhang, P | 1 |
Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM | 1 |
Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Meehan, DT; Phillips, G; Zallocchi, M | 1 |
Lin, W; Liu, BL; Pan, HL; Zhang, YQ | 1 |
Akbarali, HI; AlSharari, SD; Bagdas, D; Cabral, GA; Carroll, FI; Damaj, MI; Lichtman, PA; McGee, EA; Raborn, ES | 1 |
Ali, MS; Bishop-Bailey, D; Bye, AP; Dombrowicz, D; Dorchies, E; Flora, GD; Gibbins, JM; Kriek, N; Molendi-Coste, O; Moraes, LA; Sage, T; Sasikumar, P; Staels, B; Unsworth, AJ; Vaiyapuri, S | 1 |
Bot, I; Kritikou, E; Kröner, MJ; Kuiper, J; Schaftenaar, FH; Swart, M; van der Heijden, T; van Puijvelde, GH; van Santbrink, PJ | 1 |
Burnet, M; Deuschle, U; Garnys, L; Hambruch, E; Hayden, H; Kremoser, C; Mitteregger, D; Oberhuber, G; Peck-Radosavljevic, M; Podesser, BK; Reiberger, T; Riedl, F; Rohr-Udilova, N; Schubert, TL; Schwabl, P; Seeland, BA; Starlinger, P; Strobel, B; Trauner, M; Wagner, M | 1 |
Cui, N; Jiang, C; Johnson, CM; Wu, Y; Xing, H; Zhong, W | 1 |
Chaussenot, R; Vaillend, C | 1 |
Choi, JW; Jun, HS; Jung, JY; Li, HY; Oh, YS | 1 |
Begec, Z; Demirbilek, S; Ersoy, MO; Fadillioglu, E; Kirimlioglu, H; Ozturk, E; Surucu, M | 1 |
Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E | 1 |
Bian, F; Hao, N; Zhang, M | 1 |
Akwabi-Ameyaw, A; Bass, JY; Caldwell, RD; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Jones, SA; Kaldor, I; Liu, Y; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB | 1 |
Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG | 1 |
Chiba, Y; Misawa, M; Nakazawa, S; Sakai, H; Shinozaki, K; Todoroki, M | 1 |
Kondo, T; Kubo, T; Miwa, H; Suzuki, A | 1 |
Cao, GQ; Chakrabarti, PP; Henkle, B; Hsieh, F; Lee, MR; Middleton, S; Pettus, LH; Plant, MH; Powers, DA; Rzasa, RM; Saris, CJ; Sham, K; Sherman, L; Syed, R; Tasker, AS; Tudor, Y; Wong, LM; Wurz, RP; Xu, S; Yu, V; Zhang, D | 1 |
Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I | 1 |
Acencio, MM; Antonangelo, L; Costa, JD; Marchi, E; Novaes, NP; Teixeira, LR; Vargas, FS | 1 |
Melloni, RH; Morrison, RL; Ricci, LA; Schwartzer, JJ | 1 |
Cariou, B | 1 |
Cecen, S; Demir, EM; Ergin, K; Kose, H; Serter, M; Yildiz, Y | 1 |
Agarwal, G; B-Rao, C; Balachandran, S; Bhatt, P; Bose, J; Chetrapal-Kunwar, A; Dadarkar, SS; Dagia, NM; Fonseca, L; Gadekar, PK; Gupte, RD; Kamath, DV; Mandrekar, N; Pari, K; Parkale, SS; Rodge, AH; Sharma, S; Srinivasan, S; Vishwakarma, RA | 1 |
Bauer, M; Dietl, W; Hallström, S; Jürgens, G; Podesser, BK; Trescher, K; Ullrich, R; Wick, N; Wolfsberger, M; Wolner, E | 1 |
Abbate, A; Hoke, NN; Houser, JE; Ownby, ED; Salloum, FN; Seropian, IM; Van Tassell, BW; Varma, A | 1 |
Chae, YN; Choi, SH; Kim, HS; Kim, JG; Kim, JK; Kim, MK; Kim, SH; Lee, CH; Lim, JI; Moon, HS; Park, SK; Shin, CY; Shin, YA; Son, MH | 1 |
Perry, CM; Yang, LP | 1 |
Greer, JJ; Ren, J | 1 |
Kaptanoglu, B; Kutluana, U; Nart, D; Oruc, N; Ozutemiz, O; Yonetci, N | 1 |
Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y | 1 |
Anderson, DL; Armour, SL; Becherer, JD; Budzik, BW; Chen, L; Chen, ZB; Colilla, FJ; De Los Frailes, M; Evans, KA; Griffin, RJ; Jayawickreme, C; Jeune, MR; Jin, J; Moncol, DL; Rimele, TJ; Rivero, RA; Ross, SA; Shearer, TW; Szewczyk, GR; Tadepalli, SM; Vimal, M; Weaver, SP; Wisnoski, DD | 1 |
Buckley, B; Sonsalla, PK; Winnik, B; Wong, LY | 1 |
Schulze-Bonhage, A | 1 |
Guo, X; Liu, Y; Peng, Y; Shen, X; Wang, F; Xu, S; Yang, J | 1 |
Abrao, MS; Alves, LM; Berardo, PT; Fernandes, PD; Landgraf, RG; Machado, DE; Nasciutti, LE; Palmero, C | 1 |
Henningsen, K; Holm, MM; Jayatissa, MN; Jensen, K; Nieto-Gonzalez, JL; Vardya, I; Wiborg, O | 1 |
Kumar, A; Kumar, P; Kumari, B | 1 |
Howard, DJ; Iczkowski, KA; Jiang, L; Meyer-Siegler, KL; Vera, PL | 1 |
Demircan, M; Fadillioglu, E; Gülsul, C; Karadag, N; Karaman, A; Kirimlioglu, H; Tas, E | 1 |
Chen, LW; Chen, PH; Hsu, CM; Tseng, HT | 1 |
Asanuma, M; Diaz-Corrales, FJ; Kikkawa, Y; Kimoto, N; Miyazaki, I; Miyoshi, K; Murata, M; Takeshima, M | 1 |
Araki, T; Kasahara, J; Kato, H; Kuroiwa, H; Tsukada, T; Uchida, H; Yano, R; Yokoyama, H | 2 |
Bloudícková, S; Honsová, E; Lodererová, A; Rajnoch, J; Viklický, O | 1 |
Covey, DF; Handforth, A; Homanics, GE; Krishnan, K; Lee, JY; Martin, FC; Quesada, A; Sakimura, K | 1 |
Cox, GM; Gienapp, I; Kithcart, AP; Papenfuss, T; Pruitt, J; Satoskar, AR; Shawler, T; Short, A; Sielecki, T; Whitacre, CC | 1 |
Corbin, JG; Huntsman, MM; Kaufmann, WE; Martin, BS; Olmos-Serrano, JL; Paluszkiewicz, SM | 1 |
Li, Y; Meng, Q; Su, Z; Sui, C; Sun, F; Teng, L; Yuan, L; Zhang, C | 1 |
Brimioulle, S; Dewachter, C; Dewachter, L; Fesler, P; Franck, S; Hubloue, I; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B | 1 |
Barter, PJ; Beattie, DT; Bursill, CA; Castro, ML; Heather, AK; Nakhla, S; Rye, KA; van der Vorst, E | 1 |
Dartevelle, P; Eddahibi, S; Fadel, E; Humbert, M; Izziki, M; Mercier, O; Sage, E | 1 |
Mareš, P | 1 |
Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J | 1 |
Damgaard, T; Hansen, SL; Neill, JC; Plath, N | 1 |
He, C; Liu, S; Lu, X; Luo, P; Wu, M; Yan, Z; Yu, Y | 1 |
Choudhury, ME; Kubo, M; Kyaw, WT; Matsuda, S; Moritoyo, T; Nagai, M; Nishikawa, N; Nomoto, M; Yabe, H | 1 |
Bavbek, M; Bilginer, B; Çelik, Ö; Gürgör, PN; Korkmaz, A; Özgen, T; Ziyal, İ | 1 |
Burke, CJ; Cech, J; Chen, F; Datta, S; Granter, S; Kaufman, C; Kramer, M; Langdon, E; Lin, CY; Long, HK; Morrison, S; Mosher, J; Neuberg, D; Rahl, PB; Ratanasirintrawoot, S; Tomlinson, ML; Wheeler, GN; White, RM; Young, RA; Zon, LI | 1 |
Abernethy, L; Clarkson, T; Dempster, M; Easson, AM; Edwards, D; Everett, K; Feilden, H; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Nimz, O; Nisbet, LA; Palin, R; Ratcliffe, P; Tracey, H; Walker, G | 1 |
Ahlbrand, R; Bronson, SL; Horn, P; McNamara, RK; Richtand, NM; Stanford, K | 1 |
Dempster, J; Head, SI; Kueh, SL; Morley, JW | 1 |
Andrzejak, V; Body-Malapel, M; Chavatte, P; Desreumaux, P; Djouina, M; El Bakali, J; Lambert, DM; Millet, R; Muccioli, GG; Renault, N | 1 |
Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN | 1 |
Brandes, RP; Cornitescu, T; Dahal, BK; Davie, N; Ghofrani, HA; Grimminger, F; Janssen, W; Kojonazarov, B; Kosanovic, D; Luitel, H; Schermuly, RT; Seeger, W; Sydykov, A; Weissmann, N | 1 |
Ahlbrand, R; Bronson, SL; Gudelsky, G; Kern, JR; Richtand, NM; Roenker, NL; Waterman, H | 1 |
Abernethy, L; Ansari, N; Cameron, K; Clarkson, T; Dempster, M; Dunn, D; Easson, AM; Edwards, D; Everett, K; Feilden, H; Ho, KK; Kultgen, S; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Neagu, I; Nimz, O; Nisbet, LA; Ohlmeyer, M; Palin, R; Pham, Q; Ratcliffe, P; Rong, Y; Roughton, A; Sammons, M; Swanson, R; Tracey, H; Walker, G | 1 |
Calabresi, P; Cardaioli, G; Costa, C; Galletti, F; Pisani, F; Siliquini, S; Tantucci, M; Tozzi, A | 1 |
Burns, MP; Corbin, JG; Olmos-Serrano, JL | 1 |
Akhmetshina, A; Allanore, Y; Avouac, J; Beyer, C; Dees, C; Distler, JH; Distler, O; Horn, A; Maurer, B; Palumbo, K; Sadowski, A; Schett, G; Schneider, H; Shiozawa, S; Tomcik, M; Zerr, P | 1 |
Balabhadrapatruni, S; Darlington, CL; Masumura, C; Smith, PF; Zheng, Y | 1 |
Gendle, DF; Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ | 1 |
Badn, W; Darabi, A; Eberstål, S; Esbjörnsson, M; Fritzell, S; Siesjö, P; Visse, E | 1 |
Duncan, GE; Koller, BH; Moy, SS | 1 |
He, XH; Li, H; Song, XM; Wang, YL; Zhan, J; Zhang, ZZ | 1 |
Bugaenko, SE; Elistratova, NA; Maliev, BM; Mozhokina, GN; Sokolova, GB; Solov'eva, IP | 1 |
Bétry, C; Christensen, T; Ebert, B; Etievant, A; Haddjeri, N; Mnie-Filali, O; Wiborg, O | 1 |
Choi, SH; Hwang, SH; Jang, CG; Kang, J; Kim, HC; Kim, HJ; Kwon, SH; Lee, BH; Lee, JH; Nah, SY; Shin, EJ; Shin, TJ | 1 |
Boettcher, A; Burnet, M; Deuschle, U; Hahn, U; Hambruch, E; Kinzel, O; Kremoser, C; Krol, HD; Levi, M; Matysik, S; Miyazaki, M; Miyazaki-Anzai, S; Perović-Ottstadt, S; Schlüter, T; Schmitz, G | 1 |
Izuta, S; Maekawa, N; Nishina, K; Shiozawa, S; Ueki, M; Ueno, M | 1 |
Guo, L; Guo, T; Liu, K; Yang, C | 1 |
Carroll, FI; Damaj, MI; Freitas, K; Negus, SS | 1 |
Freitas, K; Ghosh, S; Imad Damaj, M; Ivy Carroll, F; Lichtman, AH | 1 |
Kanemaru, A; Kojima, T; Tokashiki, S; Ueda, Y | 1 |
Banyard, D; Beazley, KE; Deasey, SC; Konoplyannikov, M; Lima, F; Nurminskaya, MV; Nurminsky, DI | 1 |
Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M | 1 |
Chun, J; Duffield, JS; Luster, AD; Sakai, N; Tager, AM; Wada, T | 1 |
Annadanam, A; Armour, E; Aziz, K; Cades, JA; Chettiar, ST; DeWeese, TL; Gajula, RP; Gandhi, N; Hales, RK; Herman, JM; Kato, Y; Schaeffer, EM; Song, D; Tran, PT; Wild, AT; Williams, RD; Zhang, Y | 1 |
Becker, A; Geisslinger, G; Grecksch, G; Höllt, V; Murín, R; Schröder, H; Zimmer, A | 1 |
Itoh, M; Kawamori, T; Kitamura, T; Matsuura, M; Noda, T; Sugimura, T; Uchiya, N; Wakabayashi, K | 1 |
Fürstenberger, G; Hirschner, W; Marks, F; Müller-Decker, K | 1 |
Adams, AD; Berger, JP; Doebber, TW; Hu, Z; Jones, AB; MacNaul, KL; Moller, DE; Santini, C; Yuen, W | 1 |
Flynn, DM; Hill, RJ; Knight, DR; Magee, WP; Oleynek, JJ; Smith, AH; Tracey, WR | 1 |
Doi, T; Tokumaru, J; Ueda, Y; Willmore, LJ | 1 |
Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H | 1 |
Accatino, L; Arrese, M; Koenig, CS; Pizarro, M; Solís, N | 1 |
Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L | 1 |
Gluck, MR; Granson, H; Santana, LA; Yahr, MD | 1 |
Jung, S; Korn, T; Magnus, T; Toyka, K | 1 |
Abe, F; Ichimura, E; Morohashi, H; Nishikawa, K; Saiga, K; Toyoda, E | 1 |
Li, Y; Qiang, CJ; Wei, YH | 1 |
Bloemendaal, AL; Borel Rinkes, IH; Kranenburg, O; Smakman, N; van Diest, P; Vogten, JM | 1 |
Kulkarni, SK; Padi, SS | 1 |
Bjerrum, OJ; Blackburn-Munro, G; Jensen, DG; Rode, F | 1 |
Bolte, H; Brossmann, J; Fändrich, F; Hedderich, J; Heller, M; Jahnke, T; Müller-Hülsbeck, S; Rector, L; Schäfer, FK; Schäfer, PJ | 1 |
Kitayama, J; Nagawa, H; Ohta, H; Sakai, T; Sako, A; Shida, D; Suzuki, R | 1 |
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M | 1 |
Böger, R; Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S; Schwedhelm, E | 1 |
Chen, FP; Davis, IC; Fortenberry, JA; Graves, LM; Hickman-Davis, JM; Lazarowski, ER; Matalon, S; Sorscher, E; Sullender, WM; Zhao, X | 1 |
Bros, M; Jarman, ER; Knop, J; Reske-Kunz, AB; Sudowe, S; Weigmann, B | 1 |
Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S | 1 |
Aytan, H; Batioglu, S; Uygur, D; Zergeroglu, S | 1 |
Barr, AM; Geyer, MA; Markou, A; Powell, SB | 1 |
Kuribayashi, Y; Onodera, K; Takahashi, A | 1 |
Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sobieszek, G | 1 |
Coelho, AM; da Cunha, JE; de Almeida, JL; Jukemura, J; Machado, MC; Patzina, RA | 1 |
Kumar, A; Naidu, PS; Padi, SV; Seghal, N | 1 |
Aytan, H; Batioglu, S; Caglar, P; Uygur, D; Zergeroglu, S | 1 |
Al-Ghawas, M; Alkhiary, YM; Cullinane, DM; Einhorn, TA; Fitch, JL; Gerstenfeld, LC; Krall, EA; Thiede, MA; Webb, EG | 1 |
Deuse, T; Haddad, M; Koch-Nolte, F; Krieger, T; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schäfer, H; Schrepfer, S | 1 |
Brimiouille, S; Fesler, P; Hubloue, I; Huez, S; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B; Salmon, I; Vivian, GF | 1 |
Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC | 1 |
Deuse, T; Fischbein, MP; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schrepfer, S | 1 |
Al-Abed, Y; Kohn, N; Lin, X; Metz, CN; Miller, EJ; Ojamaa, K; Sakuragi, T | 1 |
Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M | 1 |
Birnbaum, F; Reinhard, T; Reis, A; Scholz, C; Schwartzkopff, J | 1 |
Deng, M; Heemann, U; Huang, H; Lutz, J; Roos, M; Schmaderer, C; Strobl, M; Wagner, B | 1 |
Abbate, A; Baldi, A; Biasucci, LM; Biondi-Zoccai, GG; Crea, F; Fowler, AA; Kukreja, RC; Lipinski, MJ; Ockaili, RA; Salloum, FN; Straino, S; Vetrovec, GW | 1 |
Kamerman, P; Koller, A; Loram, L | 1 |
Ono, H; Takeuchi, Y; Tanabe, M | 1 |
Dawson, PA; Gerard, RD; Inagaki, T; Jung, D; Kliewer, SA; Mangelsdorf, DJ; Moschetta, A | 1 |
Belen, D; Besalti, O; Bolay, H; Kösemehmetoğlu, K; Simşek, S; Yiğitkanli, K | 1 |
Isoe, T; Miura, T; Nakamura, K; Shibuya, M; Taguchi, E | 1 |
Clausen, RP; Frølund, B; Krogsgaard-Larsen, P; Larsson, OM; Saunders, GW; Schousboe, A; Smith, MD; White, HS; Wilcox, KS | 1 |
Aguirre, N; de la Torre, R; Goñi-Allo, B; Hervias, I; Lasheras, B; Mathúna, BO; Puerta, E | 1 |
Czugler, M; Erdélyi, P; Fischer, J; Fodor, T; Gere, A; Varga, AK | 1 |
Brueggen, J; Buckler, A; Chène, P; Cozens, R; Drysdale, MJ; Garcia-Echeverria, C; Guy, CT; Jensen, MR; Massey, A; Quadt, C; Radimerski, T; Schoepfer, J | 1 |
Chen, C; Gonzalez, FJ; Haase, VH; Ito, S; Morimura, K; Shah, YM; Yim, SH | 1 |
Liu, X; Lou, TQ; Peng, H; Tang, H; Tang, Y; Wang, C | 1 |
Frey, HH; Löscher, W; Reiche, R; Schultz, D | 1 |
Fariello, RG; Golden, GT | 1 |
Fitton, A; Grant, S | 1 |
Dan, T; Onoma, M; Onuma, E; Ozawa, K; Yoneya, T | 1 |
Anagnostopulos, H; Bartlett, RR; Mattar, T; Schleyerbach, R; Zielinski, T | 1 |
Bartlett, RR; Brendel, S; Schorlemmer, HU | 1 |
Bartlett, RR; Brendel, S; Schorlemmer, HU; Zielinski, T | 1 |
Howlett, W; Ijaz, S; Miyashita, H; Owen, AJ; Shuaib, A; Wishart, T | 1 |
Bozarth, J; Forsythe, M; Mousa, SA; Mu, DX; Wityak, J | 1 |
Bartlett, RR; Kurrle, R; Schorlemmer, HU | 1 |
Bartlett, RR; Schorlemmer, HU | 1 |
Ekberg, H; Hedlund, G; Ostraat, O; Qi, ZQ; Tufveson, G | 1 |
Eber, E; McMenamin, C; Sly, PD; Uhlig, T | 1 |
Cooper, D; Eber, E; McMenamin, C; Sly, PD; Uhlig, T; Wildhaber, JH | 1 |
Blinder, L; Chong, AS; Ma, LL; Sankary, H; Shen, J; Williams, JW; Yin, D | 1 |
Blinder, L; Chong, AS; Foster, P; Huang, W; Jensik, S; Liu, W; McChesney, L; Mital, D; Sankary, H; Shen, J; Williams, JW; Xiao, F | 1 |
Arthur, AS; Helm, GA; Kassell, NF; Lee, KS; Louis, HG; Wanebo, JE; West, K | 1 |
Bartlett, RR; Schleyerbach, R; Schorlemmer, HU | 1 |
Matsui, K; Shibata, T; Wakitani, K; Yonemori, F | 1 |
Amano, Y; Kitagawa, H; Mizushima, Y; Ogata, K | 1 |
Andiné, P; Axelsson, R; Mårtensson, E; Nyberg, G; Olofsson, U; Sandberg, M; Widermark, N | 1 |
Kapil, R; Mousa, SA; Mu, DX | 1 |
White, HS | 1 |
Leppik, IE | 1 |
Breedveld, FC | 1 |
Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C | 1 |
Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M | 2 |
Allikmets, L; Matto, V; Pruus, K; Rudissaar, R; Skrebuhhova-Malmros, T | 1 |
Ji, LL; Leichtweis, S | 1 |
Almany, DK; Crawford, FA; Davis, JN; Fary, DJ; Goldberg, AT; Hendrick, JW; Joffs, C; Spinale, FG; Walker, CA | 1 |
Beckius, GE; Chambers, RJ; Chupak, LS; Duplantier, AJ; Jenkinson, TH; Klein, AS; Kraus, KG; Kudlacz, EM; McKechney, MW; Milici, AJ; Pettersson, MP; Whitney, CA | 1 |
Bennani, YL; Black, LA; Decker, MW; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Pan, JB | 1 |
Hamada, K; Ishida, S; Seino, M; Song, HK; Yagi, K | 1 |
Andresen, C; Beckius, G; Chupak, L; Duplantier, A; Klein, A; Kraus, K; Kudlacz, E; Milici, A; Whitney, C | 1 |
Bogden, AE; Houchens, DP; Johnson, RK; Neil, GL; Ovejera, AA; Sheridan, MA | 1 |
Ferrell, LD; Grendell, JH; Neuschwander-Tetri, BA; Sukhabote, RJ | 1 |
Snead, OC | 1 |
Bartlett, RR; Bremer, E; Dimitrijevic, M; Germann, T; Küchle, CC; Mattar, T; Rüde, E; Schorlemmer, HU; Thoenes, GH; Zielinski, T | 1 |
Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK | 1 |
Chapman, AG | 1 |
Allen, SD; Kinsolving, CR; Mullen, GB; Ordy, JM; Palmer, GC; Simmons, RD; St Georgiev, V; Strand, JC | 1 |
Bartlett, RR; Popovic, S | 1 |
Löscher, W | 1 |
13 review(s) available for isoxazoles and Disease Models, Animal
Article | Year |
---|---|
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxazoles; Kindling, Neurologic; Membrane Proteins; Mental Disorders; Mice; Nerve Tissue Proteins; Pentylenetetrazole; Piriform Cortex; Psychomotor Performance; Pyrrolidines; Quality of Life; Receptors, Nicotinic; Seizures; Social Behavior | 2019 |
Pharmacokinetic evaluation of teriflunomide for the treatment of multiple sclerosis.
Topics: Administration, Oral; Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Crotonates; Disease Models, Animal; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Multiple Sclerosis; Nitriles; Randomized Controlled Trials as Topic; Toluidines | 2013 |
Zonisamide in the treatment of epilepsy.
Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Compassionate Use Trials; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Europe; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Syndrome; Treatment Outcome; Zonisamide | 2010 |
Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.
Topics: Absorption; Adult; Aged; Aging; Animals; Antipsychotic Agents; Central Nervous System; Cross-Over Studies; Disease Models, Animal; Drug Interactions; Hemodynamics; Humans; Isoxazoles; Neurosecretory Systems; Piperidines; Risperidone; Schizophrenia; Synaptic Transmission; Tissue Distribution | 1994 |
Effects of leflunomide on immune responses and models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Autoimmune Diseases; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Graft Rejection; Humans; Immunity, Cellular; Immunosuppressive Agents; Inflammation; Isoxazoles; Leflunomide; Mice; Protein-Tyrosine Kinases; Rats | 1993 |
Leflunomide, an immunorestoring drug for the therapy of autoimmune disorders, especially rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Clinical Trials as Topic; Disease Models, Animal; Humans; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Mammals | 1996 |
Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: dose study and review of endothelin-based therapies in the literature on cerebral vasospasm.
Topics: Animals; Basilar Artery; Calcium Signaling; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Ischemic Attack, Transient; Isoxazoles; Male; Rabbits; Receptor, Endothelin A; Subarachnoid Hemorrhage; Thiophenes | 1998 |
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fructose; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Receptors, GABA; Sodium Channels; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1999 |
Zonisamide.
Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy; Humans; Isoxazoles; Treatment Outcome; Zonisamide | 1999 |
Investigational treatments in rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drugs, Investigational; Genetic Therapy; Humans; Immunotherapy; Isoxazoles; Leflunomide; Tumor Necrosis Factor-alpha | 1999 |
Pharmacological models of generalized absence seizures in rodents.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rodentia; Sodium Oxybate; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1992 |
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Disease Models, Animal; Graft Rejection; Graft vs Host Disease; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Molecular Sequence Data | 1991 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid | 1986 |
3 trial(s) available for isoxazoles and Disease Models, Animal
Article | Year |
---|---|
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Topics: Adult; Animals; Anti-Bacterial Agents; Barbiturates; Disease Models, Animal; DNA Topoisomerases, Type II; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Female; Fluoroquinolones; Gonorrhea; Haplorhini; Humans; Isoxazoles; Male; Mice; Microbial Sensitivity Tests; Middle Aged; Models, Molecular; Molecular Conformation; Morpholines; Mutation; Neisseria gonorrhoeae; Oxazolidinones; Rats; Spiro Compounds; Staphylococcal Infections; Staphylococcus aureus; Topoisomerase II Inhibitors; Young Adult | 2015 |
Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.
Topics: Absorption; Adult; Aged; Aging; Animals; Antipsychotic Agents; Central Nervous System; Cross-Over Studies; Disease Models, Animal; Drug Interactions; Hemodynamics; Humans; Isoxazoles; Neurosecretory Systems; Piperidines; Risperidone; Schizophrenia; Synaptic Transmission; Tissue Distribution | 1994 |
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass.
Topics: Analysis of Variance; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Isoxazoles; Pulmonary Circulation; Receptors, Endothelin; Swine; Thiophenes; Vascular Resistance; Ventricular Function, Left | 2001 |
278 other study(ies) available for isoxazoles and Disease Models, Animal
Article | Year |
---|---|
Parecoxib ameliorates renal toxicity and injury in sepsis-induced mouse model and LPS-induced HK-2 cells.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cyclooxygenase 2; Disease Models, Animal; I-kappa B Kinase; Inflammation; Isoxazoles; Lipopolysaccharides; Mice; NF-kappa B; Sepsis | 2022 |
Selective ETA vs. dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats.
Topics: Albuminuria; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Epoprostenol; Hypertension; Isoxazoles; Kidney; Male; Oxidative Stress; Pyrimidines; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Sulfonamides; Sunitinib; Thiophenes | 2020 |
LPA
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Calcium-Binding Proteins; Disease Models, Animal; Ependyma; Ependymoglial Cells; Infant, Premature, Diseases; Isoxazoles; Lysophospholipids; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microfilament Proteins; Phagocytosis; Propionates; Receptors, Lysophosphatidic Acid | 2019 |
Investigating MIF in Mouse Models of Severe Corticosteroid-Resistant Neutrophilic Asthma.
Topics: Adrenal Cortex Hormones; Animals; Antigens, Dermatophagoides; Asthma; Dexamethasone; Disease Models, Animal; Drug Resistance; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Neutrophils; Severity of Illness Index | 2020 |
The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
Topics: Animals; B-Lymphocytes; Benzophenones; Disease Models, Animal; Humans; Isoxazoles; Lipopolysaccharides; Mice; Mice, Knockout; Proto-Oncogene Proteins c-fos; Receptors, G-Protein-Coupled; RNA-Seq; Sepsis; Signal Transduction; Spleen; Up-Regulation | 2020 |
Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.
Topics: Airway Remodeling; Animals; Apoptosis; Asthma; Calcium Signaling; Cell Proliferation; Cells, Cultured; Cyclic AMP; Disease Models, Animal; Female; Guanine Nucleotide Exchange Factors; Hydrazones; Inflammation Mediators; Isoxazoles; Lung; Mice, Inbred BALB C; Myocytes, Smooth Muscle; Ovalbumin; Pneumonia; Respiratory Hypersensitivity | 2019 |
A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coordination Complexes; Cyclization; Diclofenac; Disease Models, Animal; Drug Design; Inflammation; Isoxazoles; Ketones; Molecular Structure; Oxidation-Reduction; Rats; Structure-Activity Relationship; Tin Compounds | 2019 |
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Galantamine; Isoxazoles; Memantine; Nootropic Agents; Phenylurea Compounds; Rats; Recognition, Psychology; Scopolamine | 2020 |
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome | 2020 |
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Profiling; Gene Regulatory Networks; High-Throughput Screening Assays; Humans; Immunity, Innate; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microglia; Multiple Sclerosis; Neurogenic Inflammation; Oxidative Stress; Sequence Analysis, RNA; Single-Cell Analysis | 2020 |
Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro.
Topics: Animals; Antineoplastic Agents; BALB 3T3 Cells; Cell Line, Tumor; Disease Models, Animal; Isoxazoles; Mice; Porifera; Spiro Compounds; Tyrosine | 2020 |
Paracoxib Alleviates Ventilator-Induced Lung Injury Through Functional Modulation of Lung-Recruited CD11bloLy6Chi Monocytes.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocytes; Ventilator-Induced Lung Injury | 2021 |
The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice.
Topics: Animals; Biomarkers; Disease Models, Animal; Extracellular Matrix Proteins; HSP90 Heat-Shock Proteins; Isoxazoles; Lung; Lung Injury; Male; MAP Kinase Signaling System; Mechlorethamine; Mice; Mice, Inbred C57BL; Pulmonary Alveoli; Pulmonary Fibrosis; Resorcinols | 2020 |
Increased levels of conjugated bile acids are associated with human bile reflux gastritis.
Topics: Animals; Bile Acids and Salts; Bile Reflux; Digestion; Disease Models, Animal; Gastric Juice; Gastritis; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lipids; Liver; Mice | 2020 |
Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats.
Topics: Animals; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Ischemic Stroke; Isoxazoles; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2020 |
Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner.
Topics: Animals; ATP Binding Cassette Transporter 1; Biomarkers; Cell Line; Cell Proliferation; Cyclic AMP; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intramolecular Oxidoreductases; Isoxazoles; Kidney Diseases, Cystic; Macrophage Migration-Inhibitory Factors; Macrophages; Mice; Mice, Knockout | 2020 |
Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
Topics: Animals; Anti-Bacterial Agents; Azoles; Disease Models, Animal; DNA Gyrase; Dose-Response Relationship, Drug; Isoxazoles; Mice; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Rats; Rats, Wistar; Spiro Compounds; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2020 |
Pain responses to protease-activated receptor-2 stimulation in the spinal cord of naïve and arthritic rats.
Topics: Animals; Arthritis; Dipeptides; Disease Models, Animal; Hyperalgesia; Isoxazoles; Male; Nociception; Pain Threshold; Rats, Wistar; Receptor, PAR-2; Spinal Cord | 2020 |
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia | 2021 |
LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke.
Topics: Animals; Benzamides; Brain; Brain Ischemia; Disease Models, Animal; Isoxazoles; Lim Kinases; Mice; Stroke | 2021 |
Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
Topics: Animals; Bile Acids and Salts; Caco-2 Cells; Cell Line; Cell Line, Tumor; Cholestasis; Disease Models, Animal; Fibroblast Growth Factors; HEK293 Cells; Hep G2 Cells; Humans; Ileum; Isoxazoles; Ligands; Liver; Male; Mice; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Transcription Factors | 2021 |
Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.
Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Disease Models, Animal; Estrous Cycle; Female; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Illness Behavior; Isoquinolines; Isoxazoles; Lipopolysaccharides; Ovariectomy; Rats; Rats, Wistar; Signal Transduction; Sulfonamides | 2021 |
Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Cannabidiol; Cell Culture Techniques; Cerebral Cortex; Disease Models, Animal; Female; Isoxazoles; Male; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics | 2021 |
Leflunomide prevents ROS-induced systemic fibrosis in mice.
Topics: Animals; Antirheumatic Agents; Autoantibodies; Bleomycin; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Humans; Hypochlorous Acid; Immunosuppression Therapy; Isoxazoles; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Leflunomide; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; Reactive Oxygen Species; Signal Transduction; Skin; STAT6 Transcription Factor | 2017 |
Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice.
Topics: Animals; Autoantibodies; Cytokines; Disease Models, Animal; Female; Gene Expression; Immunotherapy, Adoptive; Inflammation Mediators; Interleukin-17; Isoxazoles; Lacrimal Apparatus; Male; Mice; Mice, Inbred NOD; p38 Mitogen-Activated Protein Kinases; Phosphoric Diester Hydrolases; Propionates; Receptors, Lysophosphatidic Acid; rho-Associated Kinases; Saliva; Signal Transduction; Sjogren's Syndrome | 2017 |
Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Caspase 3; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Endometriosis; Female; Isoxazoles; Matrix Metalloproteinase 9; Mice, Inbred C57BL; PPAR gamma; Proto-Oncogene Proteins c-akt; Telmisartan; Ultrasonography | 2017 |
Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Line, Transformed; Cell Proliferation; Crotonates; Cyclin E; Disease Models, Animal; Epstein-Barr Virus Infections; Gene Expression Regulation; Gene Expression Regulation, Viral; Genes, myc; Herpesvirus 4, Human; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; NF-kappa B; Nitriles; Toluidines; Virus Activation; Virus Latency; Virus Replication; Xenograft Model Antitumor Assays | 2017 |
Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome.
Topics: Animals; Bone Morphogenetic Protein 2; Carrier Proteins; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endothelium, Vascular; Hepatopulmonary Syndrome; Injections, Intraperitoneal; Injections, Intravenous; Isoxazoles; Lung; Macrophage Activation; Macrophages, Alveolar; Microvessels; Neovascularization, Pathologic; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction | 2017 |
Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Isoxazoles; Leflunomide; Mice; Mouth Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency.
Topics: Adenine; Animals; Calcimimetic Agents; Cinacalcet; Disease Models, Animal; Endothelin A Receptor Antagonists; Isoxazoles; Male; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thiophenes | 2017 |
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.
Topics: Animals; Benzophenones; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Intervertebral Disc Degeneration; Isoxazoles; Mice, Inbred C57BL; Molecular Targeted Therapy; Nucleus Pulposus; Pain; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Transcription Factor AP-1 | 2017 |
Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Isoxazoles; Macrophage Migration-Inhibitory Factors; Pancreatitis; Pregnancy; Pregnancy Complications; Prenatal Injuries; Rats; Rats, Sprague-Dawley | 2018 |
The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Humans; Injections, Intraperitoneal; Isoxazoles; Laminectomy; Male; Methylprednisolone; Rats; Spinal Cord; Spinal Cord Injuries; Treatment Outcome | 2019 |
Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Astrocytes; Disease Models, Animal; Female; Ganglia, Spinal; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Isoxazoles; Male; Mice; Mice, Knockout; Nerve Fibers; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Spinal Cord | 2018 |
Cardiac Progenitors Induced from Human Induced Pluripotent Stem Cells with Cardiogenic Small Molecule Effectively Regenerate Infarcted Hearts and Attenuate Fibrosis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Fibrosis; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Mice; Myocardial Infarction; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stem Cell Transplantation; Thiophenes | 2018 |
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammation; Isoxazoles; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Seizures; Zonisamide | 2018 |
Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation; Interleukin-6; Isoxazoles; Lipopolysaccharides; Mice; Sepsis; Tumor Necrosis Factor-alpha | 2018 |
Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction.
Topics: 3T3-L1 Cells; Adiponectin; Animals; Apoptosis; Disease Models, Animal; Heart Ventricles; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Infarction; Myocytes, Cardiac; Organelle Biogenesis; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Stroke Volume; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Fibronectins; GTP-Binding Proteins; Humans; Isoxazoles; Mice; Mice, Inbred C57BL; Monocytes; Multiple Sclerosis; Naphthalenes; Piperidines; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Pyrrolidines; Quinolines; Spinal Cord; Transglutaminases | 2018 |
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cholinergic Agents; Depressive Disorder; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Motor Activity; Phenylurea Compounds; Prefrontal Cortex | 2018 |
Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Area Under Curve; Benzodioxoles; Benzoquinones; Biological Assay; Disease Models, Animal; Drug Repositioning; Female; Gene Expression; HSP90 Heat-Shock Proteins; Imidazoles; Isoxazoles; Lactams, Macrocyclic; Malaria, Falciparum; Mice; Models, Biological; Plasmodium falciparum; Protozoan Proteins; Resorcinols; Trypanosoma brucei brucei; Trypanosomiasis, African | 2018 |
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Cell Nucleus; Disease Models, Animal; Fibroblast Growth Factors; Healthy Volunteers; Hepatocytes; Humans; Intestinal Mucosa; Isoxazoles; Liver; Liver Cirrhosis, Biliary; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phosphorylation; Postprandial Period; Primary Cell Culture; Receptors, Cytoplasmic and Nuclear; Signal Transduction; src-Family Kinases; Tyrosine | 2018 |
Synthesis of new coumarin tethered isoxazolines as potential anticancer agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coumarins; Disease Models, Animal; Humans; Isoxazoles; Microvessels; Structure-Activity Relationship; Survival Rate | 2018 |
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles | 2019 |
Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Bleomycin; Disease Models, Animal; Female; Histocompatibility Antigens Class II; Humans; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Inflammation; Intramolecular Oxidoreductases; Isoxazoles; Lung; Macrophage Migration-Inhibitory Factors; Male; Mice; Receptors, CXCR4; Vascular Remodeling | 2018 |
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Brain Injuries; Disease Models, Animal; Isoxazoles; Lipoxygenase Inhibitors; Macrophages; Mice; Mice, Knockout; Naphthalenes; Oxidative Stress; Subarachnoid Hemorrhage | 2019 |
Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Grooming; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Receptor, trkB | 2019 |
Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Astrocytes; Cognition; Cognition Disorders; Cognitive Dysfunction; Cytokines; Depression; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Phenylurea Compounds; Prefrontal Cortex | 2019 |
Parecoxib improves the cognitive function of POCD rats via attenuating COX-2.
Topics: Animals; Apoptosis; Cognition; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hippocampus; Humans; Isoxazoles; Male; Neurons; Postoperative Cognitive Complications; Rats; Up-Regulation | 2019 |
An Isoxazole Derivative SHU00238 Suppresses Colorectal Cancer Growth through miRNAs Regulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Computational Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Mice; MicroRNAs; Molecular Structure; RNA Interference; Xenograft Model Antitumor Assays | 2019 |
Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Osteoblasts; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid; Synovitis | 2014 |
Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apnea; Disease Models, Animal; Drug Therapy, Combination; Isoxazoles; Male; Mice; Plethysmography; Propofol; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency | 2013 |
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.
Topics: Animals; Autoimmune Diseases; Chemokines; Disease Models, Animal; Eye; Female; Gene Expression Regulation; Interferon-gamma; Interleukin-17; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Peptide Fragments; Rats; Retina; Retinol-Binding Proteins; RNA, Messenger; Th17 Cells; Uveitis | 2013 |
Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model.
Topics: Animals; Basilar Artery; Disease Models, Animal; Hippocampus; Isoxazoles; Male; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial; Zonisamide | 2013 |
Fear extinction and acute stress reactivity reveal a role of LPA(1) receptor in regulating emotional-like behaviors.
Topics: Amygdala; Animals; Conditioning, Classical; Corticosterone; Cues; Disease Models, Animal; Emotions; Extinction, Psychological; Fear; Gene Expression Regulation; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Knockout; Neurons; Phosphopyruvate Hydratase; Propionates; Receptors, Lysophosphatidic Acid; Stress, Psychological; Time Factors | 2014 |
Effects of parecoxib on the prevention of postoperative peritoneal adhesions in rats.
Topics: Anastomosis, Surgical; Animals; Burns, Electric; Cecum; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Injections, Intramuscular; Isoxazoles; Male; Peritoneal Diseases; Plasminogen Activator Inhibitor 1; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tissue Adhesions; Tissue Plasminogen Activator; Wound Healing | 2013 |
A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Isoxazoles; Male; Motor Activity; Neuroprotective Agents; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Stroke | 2013 |
Leflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dihydroorotate Dehydrogenase; Disease Models, Animal; Down-Regulation; Humans; Isoxazoles; Leflunomide; Mice; Mice, SCID; Neuroblastoma; Oxidoreductases Acting on CH-CH Group Donors; S Phase; Xenograft Model Antitumor Assays | 2013 |
Synthesis, analgesic, anti-inflammatory and in vitro antimicrobial activities of some novel isoxazole coupled quinazolin-4(3H)-one derivatives.
Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Disease Models, Animal; Female; Isoxazoles; Male; Mice; Quinazolinones; Rats; Rats, Wistar; Structure-Activity Relationship; Toxicity Tests | 2021 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Isoxazoles; Ketanserin; Male; Morphine; Ondansetron; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Streptozocin; Zonisamide | 2014 |
Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Catalase; Cecum; Disease Models, Animal; Intestinal Mucosa; Intestines; Isoxazoles; Leflunomide; Male; Malondialdehyde; Multiple Organ Failure; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Sepsis; Superoxide Dismutase | 2014 |
Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.
Topics: Adamantane; Amidohydrolases; Animals; Anti-Inflammatory Agents; Body Weight; Cannabinoids; Colitis; Disease Models, Animal; Enzyme Inhibitors; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Protein Binding; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2014 |
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cell Count; Dependovirus; Disease Models, Animal; Dopaminergic Neurons; Isoxazoles; Male; Mice; Neuroprotective Agents; Parkinson Disease; Protein Aggregation, Pathological; Rats; Substantia Nigra; Time Factors; Zonisamide | 2014 |
Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.
Topics: Age Factors; Analysis of Variance; Animals; Benzimidazoles; Body Temperature Regulation; Capsaicin; Disease Models, Animal; Hypothermia, Induced; Isoxazoles; Male; Mice; Mice, Inbred C57BL; TRPM Cation Channels; TRPV Cation Channels | 2014 |
Zonisamide attenuates hyperoxia-induced apoptosis in the developing rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Disease Models, Animal; Hyperoxia; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Zonisamide | 2014 |
Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.
Topics: Animals; Bone and Bones; Bone Remodeling; Bone Resorption; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal; Female; Femur; Humans; Immunoenzyme Techniques; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Propionates; Receptors, Lysophosphatidic Acid; Signal Transduction; X-Ray Microtomography | 2015 |
Cyclic phosphatidic acid relieves osteoarthritis symptoms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Disease Models, Animal; Edema; Female; Follow-Up Studies; Humans; Isoxazoles; Joint Capsule; Male; Middle Aged; Osteoarthritis; Pain Measurement; Phosphatidic Acids; Propionates; Rabbits; RNA, Messenger; Synovial Membrane; Time Factors | 2014 |
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Membrane Potentials; Neurons; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2014 |
Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum Stress; Half-Life; Humans; Isoxazoles; Male; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease; Substantia Nigra; Thapsigargin; Tunicamycin; Zonisamide | 2015 |
Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Insulin; Islets of Langerhans; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Resorcinols; RNA, Messenger | 2014 |
FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Apoptosis; Cell Line; Disease Models, Animal; Down-Regulation; Female; Humans; Inflammation Mediators; Isoxazoles; Lipopolysaccharides; Liver; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Middle Aged; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear | 2014 |
Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress.
Topics: Animals; Antipsychotic Agents; Brain; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gene Expression Regulation; Isoxazoles; Lipopolysaccharides; Male; Nitric Oxide Synthase Type II; Nitrites; Paliperidone Palmitate; Pyrimidines; Rats; Rats, Wistar; Restraint, Physical; Signal Transduction; Stress, Physiological; Toll-Like Receptor 4 | 2014 |
AUY922 effectively targets against activated B cell subtype of diffuse large B-cell lymphoma and low-grade lymphoma cells harboring genetic alteration-associated nuclear factor-κB activation.
Topics: Animals; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromosome Aberrations; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; Disease Models, Animal; Down-Regulation; Enzyme Activation; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mitochondria; Neoplasm Grading; NF-kappa B; Resorcinols; Signal Transduction; Translocation, Genetic; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
The Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Administration Schedule; Hot Temperature; Inflammation; Injections, Intraperitoneal; Injections, Spinal; Isoxazoles; Male; Neuralgia; Pain Management; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2015 |
Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury.
Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Femoral Artery; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Neointima; Pyrrolidines; Thiophenes | 2015 |
High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Astrocytes; Brain Injuries; Cholinergic Agents; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Male; Neurons; Neuroprotective Agents; Phenylurea Compounds; Rats, Sprague-Dawley | 2015 |
Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Isoxazoles; Neuralgia; Protein Binding; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2015 |
Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis.
Topics: Alanine Transaminase; Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; HEK293 Cells; Hep G2 Cells; Humans; Isoxazoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Peritonitis; Peroxidase; Propionates; Receptors, Lysophosphatidic Acid; Sepsis; Signal Transduction; Translational Research, Biomedical | 2015 |
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline; Disease Models, Animal; Female; Heterozygote; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Transgenic; Phenylurea Compounds; Schizophrenia; Sensory Gating | 2015 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Muscarinic Agonists; Neurons; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Valine | 2015 |
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
Topics: Animals; Antidepressive Agents; CA1 Region, Hippocampal; Chronic Disease; Dietary Sucrose; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; GABA Modulators; Imidazoles; Isoxazoles; Male; Random Allocation; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Restraint, Physical; Social Behavior; Stress, Psychological; Synapses; Synaptic Transmission; Tissue Culture Techniques; Triazines | 2015 |
Sleep restores behavioral plasticity to Drosophila mutants.
Topics: Adenylyl Cyclases; Alzheimer Disease; Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Fatty Acid-Binding Proteins; Female; Isoxazoles; Male; Memory, Long-Term; Memory, Short-Term; Mutation; Organophosphorus Compounds; Receptors, GABA; Reserpine; Sleep | 2015 |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Blood Pressure; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Isoxazoles; Kidney; Lipocalin-2; Lipocalins; Male; Prospective Studies; Proto-Oncogene Proteins; Random Allocation; Rats, Wistar; Reperfusion Injury; Reproducibility of Results; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
Antifibrotic effect of lysophosphatidic acid receptors LPA1 and LPA3 antagonist on experimental murine scleroderma induced by bleomycin.
Topics: Animals; Bleomycin; Cell Count; Chemokine CCL3; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Interferon-gamma; Isoxazoles; Lung; Mast Cells; Mice; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2015 |
Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Line, Tumor; Cholangiocarcinoma; Disease Models, Animal; Female; Follow-Up Studies; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Isoxazoles; Male; Mice; Middle Aged; Molecular Targeted Therapy; Neoplasm Staging; Prognosis; Resorcinols; Treatment Outcome; Xenograft Model Antitumor Assays | 2015 |
3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Binding Sites; Carcinoma, Ehrlich Tumor; Catalytic Domain; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; HeLa Cells; Humans; Inflammation; Isoxazoles; Lipoxygenase; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Thiophenes | 2016 |
Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Esophageal Neoplasms; HSP90 Heat-Shock Proteins; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Resorcinols | 2016 |
Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy.
Topics: Animals; Cell Line; Cell Proliferation; Cytokines; Diabetic Nephropathies; Disease Models, Animal; Gene Expression Regulation; Humans; Isoxazoles; Male; Mesangial Cells; Mice; Nicotinamide Phosphoribosyltransferase; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Transcription, Genetic | 2016 |
Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Bronchopulmonary Dysplasia; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hyperoxia; Isoxazoles; Propionates; Rats; Rats, Mutant Strains; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Lysophosphatidic Acid | 2016 |
Pretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2015 |
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glycogen Phosphorylase; Hypoglycemic Agents; Isoxazoles; Molecular Structure; Rats; Rats, Zucker; Spiro Compounds; Structure-Activity Relationship | 2016 |
Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glycolysis; Hep G2 Cells; Humans; Isoxazoles; Liver Regeneration; Metabolome; Metabolomics; Mice; Mice, Knockout; Models, Biological; Protein Kinases; Receptors, Cytoplasmic and Nuclear | 2016 |
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Disease Models, Animal; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Leukemia; Male; Neoplasm Proteins; Resorcinols; Signal Transduction | 2016 |
The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.
Topics: Adrenal Cortex Hormones; Adult; Aged; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Dexamethasone; Disease Models, Animal; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoxazoles; Lung; Macrophage Migration-Inhibitory Factors; Macrophages; Male; Middle Aged; Ozone; Pneumonia; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Respiratory Hypersensitivity; RNA, Messenger; Smoking; Sputum | 2016 |
Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Electric Stimulation; Functional Laterality; GABA Agonists; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Neurons; Receptors, GABA-A; RNA, Messenger; Signal Transduction | 2016 |
Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression; Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Membrane Proteins; Mitochondrial Proteins; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Resorcinols; Tumor Burden; X-Box Binding Protein 1; Xenograft Model Antitumor Assays | 2016 |
Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cyclin D1; Disease Models, Animal; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; Isoxazoles; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphonates; Prostatic Neoplasms; Tetrazoles; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays | 2016 |
Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Isoxazoles; Kindling, Neurologic; Nitriles; Pyridones; Rats; Rats, Sprague-Dawley; Zonisamide | 2016 |
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Models, Animal; Isoxazoles; Kindling, Neurologic; Male; Mice, Inbred ICR; Motor Activity; Nicotinic Agonists; Pentylenetetrazole; Psychomotor Performance; Pyrrolidines; Receptors, Nicotinic; Rotarod Performance Test; Seizures; Social Behavior | 2016 |
Comparative speed of kill of sarolaner (Simparica) and afoxolaner (NexGard) against induced infestations of Amblyomma americanum on dogs.
Topics: Acaricides; Administration, Oral; Animals; Disease Models, Animal; Dogs; Isoxazoles; Ixodidae; Parasite Load; Placebos; Tick Infestations; Time Factors; Treatment Outcome | 2016 |
Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model.
Topics: Animals; Benzophenones; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Isoxazoles; Lymphatic Metastasis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mouth Neoplasms; Neoplasm Invasiveness; Transcription Factor AP-1; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2016 |
ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Aripiprazole; Behavior, Animal; Benzodiazepines; Conditioning, Psychological; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Isoxazoles; Male; Maze Learning; Mice; Motor Activity; Olanzapine; Punishment; Rats, Wistar; Reaction Time; Receptors, Serotonin; Risperidone; Serotonin Antagonists; Sulfonamides | 2016 |
Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Brain; Brain Injuries; Cannabinoid Receptor Agonists; Cell Line; Disease Models, Animal; Humans; Isoxazoles; Male; Malonates; Mice; Models, Biological; Nerve Degeneration; Neurons; Neuroprotective Agents; Permeability; Protein Binding; Rats, Wistar; Receptor, Cannabinoid, CB2; Transfection | 2016 |
Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Functional Laterality; GABA Agents; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Immunosuppressive Agents; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors | 2016 |
Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response.
Topics: Animals; Antiviral Agents; Azulenes; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Host-Pathogen Interactions; Humans; Indans; Influenza A virus; Influenza, Human; Interferons; Isoxazoles; Lung; MAP Kinase Signaling System; Membrane Proteins; Mice; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Sesquiterpenes; Viral Load; Virus Replication | 2016 |
Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease.
Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Endothelial Cells; Endothelin Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glomerular Basement Membrane; Hypertension; Isoxazoles; Laminin; Mesangial Cells; Mice; Mice, Inbred C57BL; Nephritis, Hereditary; Podocytes; Proteinuria; Pseudopodia; Receptor, Endothelin A; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiophenes; Up-Regulation | 2016 |
[Effect of Leflunomideon Inflammatory Factors and Immune Function in Rats with Chronic Glomerulonephritis].
Topics: Animals; Chronic Disease; Disease Models, Animal; Glomerulonephritis; Inflammation; Interleukin-6; Isoxazoles; Leflunomide; Rats; RNA, Messenger; Serum Albumin, Bovine; Tumor Necrosis Factor-alpha | 2016 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraperitoneal; Isoxazoles; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship | 2016 |
Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.
Topics: Animals; Basement Membrane; Body Temperature; Capillaries; Cell Line; Collagen Type IV; Disease Models, Animal; Endothelin-1; Extracellular Matrix; Gene Expression Regulation; Hypoxia; Isoxazoles; Laminin; Mice; Nephritis, Hereditary; Oxidative Stress; Phenotype; Stria Vascularis; Thiophenes | 2016 |
Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain.
Topics: Animals; Biophysics; Bone Neoplasms; Cancer Pain; Carcinoma; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia, Spinal; Gene Expression Regulation, Neoplastic; Hyperalgesia; Isoxazoles; Lysophospholipids; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain Measurement; Patch-Clamp Techniques; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid | 2016 |
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds, Heterocyclic; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Isoxazoles; Male; Mice; Mice, Knockout; Phenylurea Compounds; Quinuclidines | 2017 |
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.
Topics: Animals; Blood Platelets; Calcium Signaling; Chenodeoxycholic Acid; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinogen; Genotype; Hemostasis; Humans; Isoxazoles; Ligands; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cytoplasmic and Nuclear; Thrombosis; Time Factors | 2016 |
Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice.
Topics: Animals; Atherosclerosis; Cholesterol, LDL; Disease Models, Animal; Endocytosis; Humans; Isoxazoles; Lysophospholipids; Mice; Propionates; Receptors, LDL; Receptors, Lysophosphatidic Acid; Signal Transduction | 2016 |
The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.
Topics: Animals; Benzoates; Bile Acids and Salts; Bilirubin; Capillaries; Cholesterol; Disease Models, Animal; Hypertension, Portal; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Vascular Remodeling; Vascular Resistance | 2017 |
Effects of chronic exposure to low dose THIP on brainstem neuronal excitability in mouse models of Rett syndrome: Evidence from symptomatic females.
Topics: Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Isoxazoles; Membrane Potentials; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Random Allocation; Rett Syndrome; Tissue Culture Techniques | 2017 |
Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice.
Topics: Animals; Brain; Cognition; Disease Models, Animal; Dystrophin; Fear; GABAergic Neurons; Humans; Isoxazoles; Mice; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Receptors, GABA-A; Stress, Psychological | 2017 |
Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice.
Topics: Animals; Cell Line; Diabetes Mellitus; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Glycogen Synthase Kinase 3 beta; Isoxazoles; Kidney Cortex; Lysophospholipids; Male; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction; Smad2 Protein; Smad3 Protein; Sterol Regulatory Element Binding Protein 1; Time Factors; Transfection; Transforming Growth Factor beta | 2017 |
Does leflunomide attenuate the sepsis-induced acute lung injury?
Topics: Acute Lung Injury; Adjuvants, Immunologic; Animals; Disease Models, Animal; Glutathione; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Sepsis; Spectrophotometry; Superoxide Dismutase; Treatment Outcome | 2008 |
FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.
Topics: Alkynes; Animals; Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Male; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred WF; Risk Factors; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous | 2008 |
The active metabolite of leflunomide A771726 inhibits corneal neovascularization.
Topics: Aniline Compounds; Animals; Cell Nucleus; Cell Proliferation; Corneal Neovascularization; Crotonates; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines; Umbilical Veins | 2008 |
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Topics: Administration, Oral; Animals; Carboxylic Acids; Cholestasis; Crystallography, X-Ray; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gastric Mucosa; Haplorhini; Isoxazoles; Mice; Molecular Conformation; Molecular Structure; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Stomach; Structure-Activity Relationship; Transcription Factors | 2008 |
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles | 2009 |
Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage; Cell Line; Disease Models, Animal; Humans; Interleukin-13; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Signal Transduction; STAT6 Transcription Factor; Up-Regulation | 2009 |
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Isoxazoles; Jaw; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tacrine; Tremor; Zonisamide | 2009 |
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Topics: Administration, Oral; Amines; Animals; Arthritis; Benzene; Crystallography, X-Ray; Disease Models, Animal; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Structure; Phthalazines; Protein Kinase Inhibitors; Rats; Structure-Activity Relationship | 2008 |
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Gene Expression Regulation, Enzymologic; Hindlimb; Hyperalgesia; Inflammation; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Zymosan | 2008 |
Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis.
Topics: Animals; Biomarkers; Brazil; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Lung; Pleura; Pleural Diseases; Pleurodesis; Rabbits; Random Allocation; Silver Nitrate; Talc | 2009 |
Paliperidone suppresses the development of the aggressive phenotype in a developmentally sensitive animal model of escalated aggression.
Topics: Age Factors; Aggression; Animals; Antipsychotic Agents; Behavior, Animal; Cocaine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Isoxazoles; Male; Mesocricetus; Paliperidone Palmitate; Phenotype; Pyrimidines; Reaction Time | 2009 |
The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis.
Topics: Animals; Bile Acids and Salts; Chromosome Mapping; Chromosomes, Human, Pair 12; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Humans; Insulin; Isoxazoles; Liver Regeneration; Mice; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2008 |
Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Intestinal Diseases; Intestinal Mucosa; Isoxazoles; Leflunomide; Malondialdehyde; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Treatment Outcome | 2010 |
A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Colitis; Dextran Sulfate; Disease Models, Animal; Drug Delivery Systems; Humans; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred C57BL; Monocytes; Quinolines | 2009 |
Improved myocardial protection in the failing heart by selective endothelin-A receptor blockade.
Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Endothelin A Receptor Antagonists; Heart; Heart Failure; Isoxazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sulfonamides | 2009 |
Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion.
Topics: Acute Disease; Animals; Apoptosis; Coronary Stenosis; Coronary Vessels; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Echocardiography; Injections, Intraperitoneal; Isoxazoles; Ligation; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Ventricular Remodeling | 2009 |
PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.
Topics: Adipogenesis; Administration, Oral; Animals; Blood Glucose; Blood Volume; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Genes, Reporter; Humans; Hypoglycemic Agents; Isoxazoles; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; PPAR gamma; Propionates; Rosiglitazone; Thiazolidinediones; Thiophenes; Transfection; Water-Electrolyte Balance | 2009 |
Zonisamide: in Parkinson's disease.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Epilepsy; Humans; Isoxazoles; Parkinson Disease; Zonisamide | 2009 |
Ampakine therapy to counter fentanyl-induced respiratory depression.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Fentanyl; Heart Rate; Hyperalgesia; Isoxazoles; Male; Pain Measurement; Phrenic Nerve; Plethysmography; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Respiratory Insufficiency; Time Factors | 2009 |
Leflunomide: is a new oral agent in treatment of acute pancreatitis?
Topics: Administration, Oral; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Isoxazoles; Leflunomide; Male; Malondialdehyde; Neutrophil Infiltration; Nitric Oxide; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Pulmonary Edema; Rats; Rats, Wistar; Severity of Illness Index; Taurocholic Acid | 2010 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Generalized; Frontal Lobe; Hippocampus; Isoxazoles; Kindling, Neurologic; Male; Olfactory Bulb; Rats; Rats, Wistar; Seizures; Valproic Acid; Zonisamide | 2010 |
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
Topics: Amides; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Dogs; Glucagon-Like Peptide 1; Glucose; Humans; Isoxazoles; Rats; Receptors, G-Protein-Coupled | 2009 |
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glutathione; Isoxazoles; Male; Mass Spectrometry; Mice; Monoamine Oxidase; MPTP Poisoning; Regression, Psychology; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.
Topics: Analysis of Variance; Animals; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Functional Laterality; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Injections, Spinal; Intramolecular Oxidoreductases; Isoxazoles; Lectins; Macrophage Migration-Inhibitory Factors; Male; Microglia; Mitogen-Activated Protein Kinase Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; tau Proteins; Up-Regulation | 2010 |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model.
Topics: Angiogenesis Inhibitors; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endometriosis; Female; Isoxazoles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Male; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors | 2011 |
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Isoxazoles; Lactones; Lipid Peroxidation; Male; Meloxicam; Memory; Mice; Motor Activity; Naproxen; Nitrites; Random Allocation; Stress, Psychological; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2010 |
Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice.
Topics: Animals; Cyclophosphamide; Cystitis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalgesia; Inflammation Mediators; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Sensory Thresholds; Urinary Bladder; Urination | 2010 |
Effect of leflunomide on liver regeneration after partial hepatectomy in rats.
Topics: Adjuvants, Immunologic; Animals; Catalase; Disease Models, Animal; Hepatectomy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Liver Diseases; Liver Regeneration; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxidase; Protein Carbonylation; Rats; Rats, Wistar; Treatment Outcome | 2010 |
Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.
Topics: Animals; Anthracenes; Blotting, Western; Dimethyl Sulfoxide; Disease Models, Animal; Hematopoiesis; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Leflunomide; Lung Injury; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Nitric Oxide Synthase; Peritonitis; Peroxynitrous Acid; Rhodamines; Signal Transduction; Transcription Factor AP-1 | 2010 |
Neuroprotective effects of zonisamide target astrocyte.
Topics: Animals; Antiparkinson Agents; Astrocytes; Basal Ganglia; Carbidopa; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Glutathione; Isoxazoles; Male; Mice; Mice, Inbred ICR; Nerve Growth Factors; Neuroprotective Agents; Oxidopamine; Parkinson Disease; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine 3-Monooxygenase; Zonisamide | 2010 |
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopamine; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Substantia Nigra; Treatment Outcome; Zonisamide | 2010 |
Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
Topics: Alkynes; Animals; Blood Pressure; Disease Models, Animal; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Diseases; Leflunomide; Male; Nitriles; Placebos; Rats; Rats, Transgenic; Reperfusion Injury | 2010 |
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclopropanes; Disease Models, Animal; Essential Tremor; Estranes; Ethosuximide; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Naphthalenes; Nitriles; Receptors, GABA-A; Zonisamide | 2010 |
A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Gene Deletion; Gene Expression Regulation; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Spinal Cord; Vascular Cell Adhesion Molecule-1 | 2010 |
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Interneurons; Isoxazoles; Male; Mice; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Synaptic Transmission | 2010 |
Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Electrocardiography; Excitatory Amino Acid Antagonists; Female; Heart; Heart Rate; Hyperkinesis; Isoxazoles; Lethal Dose 50; Male; Maximum Tolerated Dose; Mice; Mice, Inbred Strains; Paliperidone Palmitate; Pyrimidines; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Toxicity Tests, Acute | 2010 |
Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.
Topics: Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Pulmonary Circulation; Purines; Sildenafil Citrate; Subclavian Artery; Sulfones; Thiophenes; Treatment Outcome | 2010 |
High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokine CX3CL1; Chemokines; Chemotaxis, Leukocyte; Disease Models, Animal; Down-Regulation; Endothelial Cells; Humans; I-kappa B Proteins; Injections, Intravenous; Isoxazoles; Lipoproteins, HDL; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-KappaB Inhibitor alpha; Phosphorylation; PPAR gamma; Receptors, CCR2; Receptors, Chemokine; Receptors, Interleukin-8A; RNA, Messenger; Sulfones; Transcription Factor RelA | 2010 |
Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets.
Topics: Angiopoietin-1; Animals; Animals, Newborn; Antihypertensive Agents; Aorta; Apoptosis; Cell Proliferation; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Isoxazoles; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Circulation; Pulmonary Embolism; Receptor, Endothelin A; Receptor, TIE-2; RNA, Messenger; Sulfones; Swine; Time Factors | 2010 |
Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Incidence; Isoxazoles; Male; Rats; Rats, Wistar; Reaction Time; Seizures; Zonisamide | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex | 2011 |
Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Exploratory Behavior; Female; GABA-A Receptor Agonists; Isoxazoles; Motor Activity; Phencyclidine; Rats; Receptors, GABA-A; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Time Factors | 2011 |
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopamine; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Substantia Nigra; Treatment Outcome; Zonisamide | 2010 |
Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice.
Topics: Animals; Antigen-Antibody Complex; Ascites; Cell Proliferation; Disease Models, Animal; Female; Graft vs Host Disease; Immunity, Innate; Immunosuppressive Agents; Isoxazoles; Kidney; Leflunomide; Longevity; Lupus Nephritis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Signal Transduction; Spleen; Toll-Like Receptor 9 | 2012 |
Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity.
Topics: Analysis of Variance; Animals; Antioxidants; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Glial Fibrillary Acidic Protein; Isoxazoles; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Growth Factors; Neurons; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Zonisamide | 2011 |
Effects of intramuscular parecoxib administration on vasospasm in an experimental subarachnoid hemorrhage model.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Injections, Intramuscular; Isoxazoles; Male; Rabbits; Random Allocation; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2011 |
DHODH modulates transcriptional elongation in the neural crest and melanoma.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Dihydroorotate Dehydrogenase; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Isoxazoles; Leflunomide; Melanoma; Mice; Neural Crest; Oxidoreductases Acting on CH-CH Group Donors; Proto-Oncogene Proteins B-raf; Rats; Stem Cells; Transcription, Genetic; Xenograft Model Antitumor Assays; Zebrafish | 2011 |
Identification of potent, soluble, and orally active TRPV1 antagonists.
Topics: Administration, Oral; Amides; Animals; Disease Models, Animal; Humans; Isoxazoles; Pain; Rats; TRPV Cation Channels | 2011 |
Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation.
Topics: Amphetamine; Animals; Animals, Newborn; Antipsychotic Agents; Central Nervous System Stimulants; Disease Models, Animal; Drug Interactions; Female; Isoxazoles; Motor Activity; Paliperidone Palmitate; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrimidines; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Time Factors | 2011 |
Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.
Topics: Animals; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Patch-Clamp Techniques; Purkinje Cells; Receptor Aggregation; Receptors, GABA-A; Synaptic Potentials | 2011 |
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.
Topics: Amidohydrolases; Animals; Colitis; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoxazoles; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure | 2011 |
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Thrombosis | 2011 |
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling | 2011 |
Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Extracellular Space; Female; Glutamic Acid; Isoxazoles; Male; Maternal Exposure; Paliperidone Palmitate; Poly I-C; Prefrontal Cortex; Pregnancy; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenia | 2011 |
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
Topics: Administration, Oral; Amides; Animals; Capsaicin; Cyclohexanols; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Isoxazoles; Microsomes, Liver; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2011 |
A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Hippocampus; Isoxazoles; Long-Term Potentiation; Male; Neuroprotective Agents; Nitric Oxide; Organ Culture Techniques; Rats; Rats, Wistar; Signal Transduction; Zonisamide | 2011 |
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Neuropsychological Tests; Receptors, GABA-A | 2011 |
Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.
Topics: Animals; Benzophenones; Bleomycin; Cells, Cultured; Collagen; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Proto-Oncogene Proteins c-fos; RNA, Small Interfering; Scleroderma, Systemic; Signal Transduction; Transcription Factor AP-1; Transfection; Transforming Growth Factor beta; Up-Regulation | 2012 |
Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory.
Topics: Animals; Attention; Cognition; Cognition Disorders; Disease Models, Animal; Isoxazoles; Male; Memory; Memory Disorders; Neural Inhibition; Nootropic Agents; Rats; Rats, Wistar; Reaction Time; Recognition, Psychology; Time Factors; Treatment Outcome; Vestibular Diseases | 2011 |
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Brain; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Drug Interactions; Female; Half-Life; Hallucinogens; Isoxazoles; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Phencyclidine; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tissue Distribution | 2012 |
Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Flow Cytometry; Glioblastoma; Immunohistochemistry; Immunotherapy, Adoptive; Interferon-gamma; Isoxazoles; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 2012 |
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.
Topics: Alanine; Animals; Antipsychotic Agents; Carrier Proteins; Disease Models, Animal; Gene Knockdown Techniques; Isoxazoles; Mice; Nerve Tissue Proteins; Propionates; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Uracil | 2012 |
Protective effect of PNU-120596, a selective alpha7 nicotinic acetylcholine receptor-positive allosteric modulator, on myocardial ischemia-reperfusion injury in rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cytokines; Disease Models, Animal; Inflammation; Isoxazoles; Lipid Peroxidation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NF-kappa B; Nicotinic Agonists; Phenylurea Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2012 |
[Efficacy and tolerance of rezonizate in complex with fluoroquinolones or mycobutin on a model of experimental murine tuberculosis].
Topics: Animals; Antibiotics, Antitubercular; Disease Models, Animal; Drug Therapy, Combination; Drug Tolerance; Fluoroquinolones; Gatifloxacin; Isoxazoles; Levofloxacin; Mice; Mycobacterium tuberculosis; Ofloxacin; Oxazolidinones; Rifabutin; Tuberculosis | 2011 |
Synergistic antidepressant-like action of gaboxadol and escitalopram.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; Drug Resistance; Drug Synergism; Drug Therapy, Combination; GABA-A Receptor Agonists; Isoxazoles; Male; Neurogenesis; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Up-Regulation | 2012 |
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Calcium; Calcium-Binding Proteins; Cell Survival; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Glycoproteins; Humans; Indans; Isoxazoles; Ligands; Maze Learning; Memory Disorders; Metalloproteases; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Neuroblastoma; Nootropic Agents; Panax; Peptide Fragments; Phytotherapy; Piperidines; Plant Proteins; Presenilin-1; Propionates; Protein Binding; Receptors, Lysophosphatidic Acid; Signal Transduction; Time Factors; Transfection | 2012 |
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice.
Topics: Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Benzoates; Biological Transport; Cholesterol; Cholesterol Ester Transfer Proteins; Diet, High-Fat; Disease Models, Animal; Feces; Female; Humans; Isoxazoles; Lipoproteins, HDL; Liver; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Species Specificity; Structure-Activity Relationship | 2012 |
T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice.
Topics: Animals; Benzophenones; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Enzymes; Gastrointestinal Agents; Hepatitis, Animal; Isoxazoles; Lipopolysaccharides; Liver; Mice; Survival Analysis | 2012 |
A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease Models, Animal; Immunohistochemistry; Isoxazoles; Male; Maze Learning; Memory; Methylphenidate; Nicotinic Agonists; Pyrrolidines; Rats; Rats, Inbred SHR; Receptors, Nicotinic | 2012 |
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines | 2013 |
Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Disease Models, Animal; Inflammation; Isoxazoles; Male; Mice; Mice, Inbred ICR; Neuralgia; Nicotinic Agonists; Phenylurea Compounds; Receptors, Nicotinic; Treatment Outcome | 2013 |
Effect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with Parkinson's disease.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Drug Therapy, Combination; Gene Expression; Gene Expression Profiling; Isoxazoles; Levodopa; Male; Oligonucleotide Array Sequence Analysis; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Zonisamide | 2012 |
Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
Topics: Animals; Aorta; Aortic Diseases; beta Catenin; Blood Pressure; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GTP-Binding Proteins; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Osteogenesis; Phosphorylation; Protein Glutamine gamma Glutamyltransferase 2; Quercetin; Rats; Rats, Wistar; Signal Transduction; Transglutaminases; Vascular Calcification; Warfarin | 2013 |
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Mice; Purkinje Cells; Ubiquitin-Protein Ligases | 2012 |
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.
Topics: Anilides; Animals; Benzamides; Biphenyl Compounds; Cell Proliferation; Chlorhexidine; Connective Tissue Growth Factor; Cytoskeleton; Disease Models, Animal; Epithelial Cells; Epithelium; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Peritoneal Fibrosis; Receptors, Lysophosphatidic Acid; Trans-Activators; Transcription Factors | 2013 |
Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Growth Processes; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Down-Regulation; G2 Phase; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Mice; Mice, Transgenic; Prostatic Neoplasms; Radiation-Sensitizing Agents; Random Allocation; Resorcinols; Signal Transduction; Xenograft Model Antitumor Assays | 2013 |
Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain.
Topics: Animals; Cannabinoids; Chronic Disease; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Sciatic Neuropathy; Species Specificity; Treatment Outcome | 2013 |
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Genes, APC; Intestinal Neoplasms; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides | 2002 |
The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin.
Topics: Acute Disease; Animals; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Isoenzymes; Isoxazoles; Mice; Mice, Inbred Strains; Neovascularization, Physiologic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin; Sulfonamides; Tensile Strength; Wound Healing | 2002 |
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
Topics: Administration, Oral; Animals; Biological Availability; COS Cells; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Isoxazoles; Mice; Mice, Mutant Strains; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Humans; Iodine Radioisotopes; Isoxazoles; Myocardial Infarction; Myocardial Reperfusion Injury; Purines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Sertraline; Transfection | 2003 |
Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures.
Topics: Amino Acid Transport System X-AG; Amygdala; Animals; Anticonvulsants; Blotting, Western; Carrier Proteins; Chlorides; Chronic Disease; Disease Models, Animal; Epilepsy; Ferric Compounds; Frontal Lobe; GABA Plasma Membrane Transport Proteins; Hippocampus; Isoxazoles; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Rats; Rats, Wistar; Zonisamide | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cysteine; Disease Models, Animal; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Isoxazoles; Liver; Male; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ribosomal Proteins; Saccharomyces cerevisiae Proteins | 2003 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Isoenzymes; Isoxazoles; Organic Chemicals; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Radiology; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Tumor Cells, Cultured | 2004 |
Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Isoxazoles; Levodopa; Microdialysis; Oxidopamine; Parkinson Disease; Rats; Zonisamide | 2004 |
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion.
Topics: Adoptive Transfer; Animals; Animals, Newborn; Antigens, CD; B7-2 Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-2; Isoxazoles; Leflunomide; Membrane Glycoproteins; Microglia; Multiple Sclerosis; Myelin Basic Protein; Pyrimidines; Rats; Rats, Inbred Lew; STAT6 Transcription Factor; T-Lymphocytes, Helper-Inducer; Trans-Activators; Uridine | 2004 |
NK95806, a newly synthesized microtubule-disrupting agent that suppresses collagen-induced arthritis in mice.
Topics: Administration, Oral; Animals; Antibody Formation; Antirheumatic Agents; Arthritis, Experimental; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Isoxazoles; Joints; Lower Extremity; Male; Mice; Mice, Inbred Strains; Microtubules; Sulfonamides | 2004 |
Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats.
Topics: Animals; Arthritis, Experimental; Body Weight; Cell Proliferation; China; Disease Models, Animal; Down-Regulation; Freund's Adjuvant; Injections, Subcutaneous; Interleukin-1; Interleukin-10; Isoxazoles; Knee Joint; Leflunomide; Male; Organ Size; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spleen; Synovial Fluid; Thymus Gland; Tumor Necrosis Factor-alpha | 2004 |
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Genes, ras; Image Processing, Computer-Assisted; Immunohistochemistry; Isoxazoles; Ki-67 Antigen; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microcirculation; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA Interference; Time Factors | 2005 |
Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Ketorolac; Lipopolysaccharides; Male; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium | 2005 |
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neuralgia; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Mechanical; Time Factors; Trauma, Nervous System; Zolpidem | 2005 |
2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis.
Topics: Actins; Administration, Oral; Alkynes; Angioplasty, Balloon; Animals; Disease Models, Animal; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Isoxazoles; Male; Muscle, Smooth, Vascular; Nitriles; Rats; Rats, Inbred Lew; Tunica Intima | 2005 |
Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.
Topics: Animals; Ascites; Cell Line, Tumor; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Epithelium; Female; Humans; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Pertussis Toxin; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Stomach Neoplasms; Vascular Endothelial Growth Factor A | 2006 |
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide | 2005 |
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
Topics: Actins; Alkynes; Animals; Bronchiolitis Obliterans; Disease Models, Animal; Granulation Tissue; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Nitriles; Postoperative Complications; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Trachea | 2005 |
Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus.
Topics: Animals; Antiviral Agents; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Disease Progression; Female; Isoxazoles; Leflunomide; Lung; Male; Mice; Mice, Inbred BALB C; Nucleotidases; Pneumonia, Viral; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Severity of Illness Index | 2006 |
Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity.
Topics: Allergens; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Female; Immunosuppressive Agents; Interleukin-10; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Oxazolone; RNA, Messenger | 2006 |
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
Topics: Alkynes; Animals; Disease Models, Animal; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Lung Diseases, Obstructive; Lung Transplantation; Male; Myocytes, Smooth Muscle; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Homologous; Transplantation, Isogeneic | 2006 |
Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis.
Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Immunologic Factors; Isoxazoles; Leflunomide; Rats; Rats, Wistar | 2006 |
Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats.
Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Gait Disorders, Neurologic; Imidazoles; Isoxazoles; Male; Neural Inhibition; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Reflex, Startle | 2006 |
[An animal model of antiepileptic-induced osteoporosis in rats].
Topics: Animals; Anticonvulsants; Bone Density; Disease Models, Animal; Isoxazoles; Osteoporosis; Phenytoin; Rats; Zonisamide | 2006 |
Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Epilepsy; Fluorescent Antibody Technique; Isoxazoles; Male; Mice; Zonisamide | 2007 |
Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Interleukin-10; Interleukin-6; Isoxazoles; Male; Pancreatitis; Rats; Rats, Wistar; Survival Rate; Taurocholic Acid | 2006 |
Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cognition Disorders; Colchicine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Isoxazoles; Lipid Peroxidation; Male; Maze Learning; Memory; Naproxen; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Space Perception; Spatial Behavior; Sulfonamides; Time Factors | 2006 |
Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model.
Topics: Animals; Disease Models, Animal; Endometriosis; Female; Immunologic Factors; Isoxazoles; Leflunomide; Rats; Uterus | 2007 |
Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.
Topics: Animals; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Fracture Fixation, Intramedullary; Fracture Healing; Fractures, Bone; Fractures, Ununited; Isoxazoles; Ketorolac; Male; Rats; Rats, Sprague-Dawley; Sulfonamides | 2007 |
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
Topics: Alkynes; Animals; Antibodies, Anti-Idiotypic; Aorta, Abdominal; Cricetinae; Disease Models, Animal; Endothelium, Vascular; Flow Cytometry; Graft Rejection; Humans; Immunoglobulin G; Immunoglobulin M; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Heterologous; Treatment Outcome | 2007 |
Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension.
Topics: Anastomosis, Surgical; Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors; Brachiocephalic Trunk; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; RNA, Messenger; Swine; Thiophenes | 2007 |
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor Xa; Fibrinolytic Agents; Hemorrhage; Hemostasis; Isoxazoles; Male; Platelet Aggregation; Pyrazoles; Rabbits; Thrombosis; Ticlopidine | 2007 |
Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tacrolimus; Trachea; Transplantation, Homologous | 2007 |
Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression.
Topics: Animals; Cardiac Volume; Disease Models, Animal; Echocardiography; Immunologic Factors; Isoxazoles; Lung; Macrophage Migration-Inhibitory Factors; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Shock; Stroke Volume | 2007 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Isoxazoles; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Pharmacogenetics; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Reproducibility of Results; Species Specificity | 2007 |
The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model.
Topics: Alkynes; Animals; Cornea; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Mycophenolic Acid; Nitriles; Postoperative Care; Postoperative Period; Rats; Rats, Inbred F344; Rats, Inbred Lew; Survival Analysis; Treatment Outcome | 2007 |
The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.
Topics: Alkynes; Animals; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Nitriles; Proteinuria; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Transforming Growth Factor beta; Transplantation, Homologous | 2007 |
Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Echocardiography; Heart Failure; Heart Function Tests; Isoxazoles; Male; Myocardial Ischemia; Myocardium; Rats; Rats, Wistar | 2007 |
Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hyperalgesia; Isoxazoles; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Tramadol | 2007 |
The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system.
Topics: Analgesics; Animals; Biogenic Monoamines; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Ligation; Male; Mice; Neuralgia; Pain Measurement; Physical Stimulation; Sciatic Nerve; Sciatic Neuropathy; Zonisamide | 2007 |
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; DNA-Binding Proteins; Fibroblast Growth Factors; Isoxazoles; Liver; Malabsorption Syndromes; Mice; Mice, Inbred Strains; Models, Animal; Organic Anion Transporters, Sodium-Dependent; Receptors, Cytoplasmic and Nuclear; Symporters; Transcription Factors | 2007 |
Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basilar Artery; Disease Models, Animal; Fibromuscular Dysplasia; Isoxazoles; Leflunomide; Leukocyte Count; Muscle, Smooth, Vascular; Rabbits; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2007 |
Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model.
Topics: Animals; Antineoplastic Agents; Ascites; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Humans; Isoxazoles; Neovascularization, Pathologic; Peritoneal Neoplasms; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Inbred F344; Receptors, Vascular Endothelial Growth Factor | 2008 |
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
Topics: Animals; Carrier Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Entorhinal Cortex; Evoked Potentials; GABA Agonists; GABA Plasma Membrane Transport Proteins; In Vitro Techniques; Isoxazoles; Kainic Acid; Male; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Status Epilepticus; Tiagabine | 2008 |
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.
Topics: Analysis of Variance; Animals; Antimetabolites; Area Under Curve; Body Temperature; Brain; Catechols; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Isoxazoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Nitriles; Protein Binding; Rats; Rats, Wistar; Serotonin; Time Factors; Tyrosine | 2008 |
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Rabbits; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Sulfonamides; Time Factors | 2008 |
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Immunoprecipitation; Isoxazoles; Mice; Mice, Nude; Molecular Chaperones; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Resorcinols; Transplantation, Heterologous; Up-Regulation | 2008 |
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Integrases; Intestinal Mucosa; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Mice, Transgenic; Recombination, Genetic; Signal Transduction; Time Factors; Von Hippel-Lindau Tumor Suppressor Protein | 2008 |
[Study on protective effects and its mechanism of leflunomide on renal tissue in rat IgA nephropathy model].
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Fibrosis; Glomerulonephritis, IGA; Isoxazoles; Kidney; Leflunomide; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1 | 2008 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid | 1983 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Penicillins; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Taurine; Time Factors | 1984 |
Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Isoxazoles; Kidney; Liver; Male; Oxonic Acid; Rats; Rats, Wistar; Time Factors; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase | 1994 |
Malononitrilamides prevent the development of murine systemic lupus erythematosus-like diseases in BDF1 hybrid mice and MRL/lpr autoimmune mice.
Topics: Aging; Alkynes; Animals; Antibody Formation; Crosses, Genetic; Disease Models, Animal; Female; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles | 1996 |
Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Isoxazoles; Male; Maze Learning; Microdialysis; Neuroprotective Agents; Prosencephalon; Silver Staining; Zonisamide | 1997 |
Intravenous and oral antiplatelet/antithrombotic efficacy and specificity of XR300, a novel nonpeptide platelet GPIIb/IIIa antagonist.
Topics: Administration, Oral; Amino Acids; Animals; Antithrombins; Carotid Arteries; Disease Models, Animal; Dogs; Female; Humans; Hydrolysis; Infusions, Intravenous; Isoxazoles; Kinetics; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis | 1998 |
The new immunosuppressants, the malononitrilamides MNA 279 and MNA 715, inhibit various graft-vs.-host diseases (GvHD) in rodents.
Topics: Alkynes; Animals; Disease Models, Animal; Graft vs Host Disease; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1997 |
Therapeutic activity of malononitrilamides (MNA 279 and MNA 715) on acute and chronic, relapsing, experimental, allergic encephalomyelitis (EAE).
Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred Strains; Nitriles; Rabbits; Rats; Rats, Inbred Lew | 1997 |
The effects of leflunomide and cyclosporin A on rejection of cardiac allografts in the rat.
Topics: Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Wistar | 1998 |
Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cell Degranulation; Dimercaprol; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Histamine Release; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mast Cells; Ovalbumin; Rats; Rats, Inbred BN; Respiratory Function Tests | 1998 |
Effects of long-term oral treatment with leflunomide on allergic sensitization, lymphocyte activation, and airway inflammation in a rat model of asthma.
Topics: Administration, Inhalation; Administration, Oral; Age Factors; Animals; Anti-Inflammatory Agents; Antibody Specificity; Asthma; Bronchoalveolar Lavage Fluid; Cell Division; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Ovalbumin; Rats; Rats, Inbred BN; T-Lymphocytes; Time Factors | 1998 |
Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model.
Topics: Acute Disease; Animals; Cricetinae; Cyclosporine; Disease Models, Animal; Drug Combinations; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Inbred Lew; Species Specificity; Time Factors; Transplantation, Heterologous | 1998 |
Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation.
Topics: Animals; Chronic Disease; Cricetinae; Cyclosporine; Disease Models, Animal; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Myocardium; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Heterologous | 1998 |
Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis.
Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibodies, Antinuclear; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Disease Models, Animal; Female; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Mutant Strains; Nitriles; Rats; Rats, Inbred Lew | 1998 |
JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models.
Topics: Animals; Blood Glucose; Disease Models, Animal; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulin Resistance; Isoxazoles; Leptin; Lipids; Male; Obesity; Oxidation-Reduction; Phosphorylation; Proteins; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor, Insulin; Triglycerides | 1998 |
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model.
Topics: Administration, Oral; Aniline Compounds; Animals; Antibody Specificity; Crotonates; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxybutyrates; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Nitriles; Ovalbumin; Rats; Rats, Inbred BN; Toluidines; Uridine | 1999 |
Characterization of MK-801-induced behavior as a putative rat model of psychosis.
Topics: Aging; Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Isoxazoles; Male; Motor Activity; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Receptors, GABA; Sex Characteristics; Stereotyped Behavior; Stereotypic Movement Disorder | 1999 |
Intravenous and oral antithrombotic efficacy of the novel platelet GPIIb/IIIa antagonist roxifiban (DMP754) and its free acid form, XV459.
Topics: Administration, Oral; Amidines; Amino Acids; Animals; Bleeding Time; Disease Models, Animal; Dogs; Electroshock; Female; Femoral Artery; Humans; Injections, Intravenous; Isoxazoles; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis | 1999 |
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain | 2000 |
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Mutant Strains; Nitric Oxide; Phenytoin; Valproic Acid; Zonisamide | 2000 |
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Neurotransmitter Agents; Psychotic Disorders; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission | 2000 |
Glutathione deficiency intensifies ischaemia-reperfusion induced cardiac dysfunction and oxidative stress.
Topics: Animals; Buthionine Sulfoximine; Disease Models, Animal; Drug Therapy, Combination; Female; Glutathione; Heart; Isoxazoles; Liver; Mitochondria, Heart; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Ventricular Function | 2001 |
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Phenobarbital; Receptors, N-Methyl-D-Aspartate; Zonisamide | 2001 |
Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
Topics: Animals; Disease Models, Animal; Humans; Hypersensitivity; Integrin alpha4beta1; Integrins; Isoxazoles; Jurkat Cells; Mice; Propionates; Receptors, Lymphocyte Homing; Structure-Activity Relationship | 2001 |
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Topics: Animals; Anti-Anxiety Agents; Arousal; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Histamine Antagonists; Imidazoles; Impulsive Behavior; Isoxazoles; Ligands; Male; Methylphenidate; Motor Activity; Nicotinic Agonists; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Histamine H3 | 2002 |
Contrasting effects of zonisamide and acetazolamide on amygdaloid kindling in rats.
Topics: Acetazolamide; Amygdala; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsies, Partial; Isoxazoles; Kindling, Neurologic; Male; Rats; Rats, Wistar; Zonisamide | 2001 |
Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists.
Topics: Animals; Anti-Allergic Agents; Disease Models, Animal; Humans; Hypersensitivity; Inflammation; Integrin alpha4beta1; Integrins; Isoxazoles; Jurkat Cells; Mice; Phenylurea Compounds; Pulmonary Eosinophilia; Receptors, Lymphocyte Homing; Vascular Cell Adhesion Molecule-1 | 2002 |
Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.
Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Oxazoles; Transplantation, Heterologous | 1979 |
Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse.
Topics: Amylases; Animals; Ceruletide; Cholecystokinin; Disease Models, Animal; Female; Free Radicals; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Mice; Pancreas; Pancreatitis; Radiation-Protective Agents | 1992 |
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
Topics: Animals; Antiviral Agents; Brain; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Microbial; Enterovirus Infections; Immunosuppression Therapy; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Oxazoles; Poliomyelitis; Poliovirus | 1989 |
Comparisons of ketoconazole, PR 969-566, PR 967-234, and PR 967-248 as antifungals in vitro and in the rat model of candidal vaginitis based on efficacy/safety profiles.
Topics: Animals; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Fungi; Isoxazoles; Ketoconazole; Microbial Sensitivity Tests; Oxazoles; Rats | 1988 |
The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery.
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft vs Host Disease; Indomethacin; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Mice; Prednisolone | 1987 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity | 1985 |