Page last updated: 2024-08-21

isoxazoles and Disease Models, Animal

isoxazoles has been researched along with Disease Models, Animal in 293 studies

Research

Studies (293)

TimeframeStudies, this research(%)All Research%
pre-19908 (2.73)18.7374
1990's26 (8.87)18.2507
2000's79 (26.96)29.6817
2010's159 (54.27)24.3611
2020's21 (7.17)2.80

Authors

AuthorsStudies
Chen, Q; Guo, Y; Min, S; Wu, B1
Baelde, HJ; Danser, AHJ; de Vries, R; Garrelds, IM; Mirabito Colafella, KM; Montezano, AC; Neves, KB; Touyz, RM; Uijl, E; van den Meiracker, AH; van Veghel, R; Versmissen, J1
Blaho, VA; Chun, J; Frantz, AJ; Kennedy, G; Kihara, Y; Lummis, NC; Sánchez-Pavón, P1
Takechi, K1
Allam, VSRR; Sukkar, MB1
Chu, X; Han, Y; Li, C; Mu, S; Qiu, D; Song, Z; Tong, C; Wang, J; Wei, W; Zhu, M1
Chen, YF; Cheng, M; Gao, YD; Huang, G; Wang, YM; Zhong, JN; Zhu, FF1
Nagaraju, B; Prasanna, B; Seelam, N; Shanmukhakumar, JV; Subbaiah, T1
Gzielo, K; Krawczyk, M; Nikiforuk, A; Popik, P; Potasiewicz, A1
Aricioglu, F; Bekci, H; Cumaoglu, A; Unal, G; Yerer, MB1
Akassoglou, K; Ang, KK; Arkin, MR; Baeten, KM; Bardehle, S; Bedard, C; Bruneau, BG; Green, AJ; Hanspers, K; Jiang, X; Machado, MR; Mendiola, AS; Merlini, M; Meyer-Franke, A; Meza-Acevedo, R; Petersen, MA; Pfaff, SJ; Pico, AR; Pleiss, MA; Rafalski, VA; Rios Coronado, PE; Ryu, JK; Thomas, R; Thomas, S; Tognatta, R; Wang, J; Williams, A; Wilson, C; Yan, Z; Zamvil, SS1
Bechmann, N; Bornstein, SR; Drechsel, A; Ehrlich, H; Helm, J; Pantovic, S1
Chai, X; Hu, S; Shu, S; Wang, D; Wei, X; Zhang, C; Zosky, GR1
Biancatelli, RMLC; Catravas, JD; Dimitropoulou, C; Marinova, M; Solopov, P1
Chen, W; Ge, K; Han, X; Huang, F; Huang, Y; Jia, W; Rajani, C; Wang, S; Yu, H; Zhao, A; Zheng, X; Zhu, J1
Azab, AN; Boyko, M; Ferorelli, S; Kaplanski, J; Perrone, MG; Rostevanov, IS; Scilimati, A; Zlotnik, A1
Buchholz, B; Grampp, S; Kraus, A; Safi, W; Schödel, J1
Basarab, GS; Doig, P; Eyermann, CJ; Galullo, V; Gowravaram, M; Hauck, S; Kern, G; Kimzey, A; Kutschke, A; Morningstar, M; Schuck, V; Vishwanathan, K; Zhou, F1
Lucena, F; McDougall, JJ1
Aricioglu, F; Sirvanci, S; Unal, G1
Demyanenko, SV; Uzdensky, A1
Chien, D; Dawson, PA; Dong, X; Fauler, G; Fickert, P; Gilmer, JF; Moustafa, T; Truong, JK; van de Graaf, SFJ; van de Wiel, SMW; Yin, L; Zaufel, A1
Cruz, JV; Maba, IK; Zampronio, AR1
Hewitt, T; Khokhar, JY; Lalonde, J; Perreault, ML; St-Denis, M; Thériault, RK1
Batteux, F; Cerles, O; Chéreau, C; Chouzenoux, S; Kavian, N; Morin, F; Nicco, C1
Jun, HS; Kim, D; Lee, SM; Park, E1
Gu, Y; Körbel, C; Laschke, MW; Menger, MD; Nenicu, A1
Barlow, EA; Bilger, A; Bristol, JA; Delecluse, HJ; Kenney, SC; Li, Z; Ma, S; Nawandar, D; Plowshay, J; Romero-Masters, JC; Tsai, MH1
Belguise, K; Chen, B; Chen, L; Gao, J; Liu, C; Lu, K; Wang, X; Yi, B; Yu, W1
Cui, H; Fu, G; Qiu, Y; Ren, A1
Eräranta, A; Lakkisto, P; Mustonen, J; Niemelä, O; Paavonen, T; Pörsti, I; Tikkanen, I; Törmänen, S1
Aikawa, Y; Ito, H; Kawaguchi, Y; Kimura, T; Makino, H; Motomura, H; Nogami, M; Sainoh, T; Seki, S; Shiozawa, S; Tsumaki, N; Watanabe, K; Yahara, Y; Yamazaki, M1
Deng, WH; Guo, ZD; Hong, YP; Shi, Q; Wang, P; Wang, WX; Zhao, L; Zuo, T1
Bakar, B; Budak Yildiran, FA; Dincel, GC; Kisa, U; Ogden, M; Yuksel, U1
Cheng, X; Dougherty, PM; Heijnen, CJ; Huo, X; Kavelaars, A; Li, Y; Mei, F; Singhmar, P1
Ali, A; Ashraf, M; Hu, H; Maienschein-Cline, M; Tang, Y; Wang, Y; Xuan, W1
Attri, SV; Kumar, B; Medhi, B; Modi, M; Patial, A; Saikia, B1
Bhatti, R; Gupta, M; Kumar, A; Sharma, A; Singh Ishar, MP; Singh, G1
Chen, X; Gao, E; Guo, Y; Li, C; Li, Y; Liu, Y; Tao, L; Wang, H; Wang, S; Wang, W; Xia, Y; Xiong, Z; Xu, X; Yan, W; Zhang, F; Zhang, J; Zhang, L; Zhang, X; Zhao, H; Zhao, S1
Bol, JGJM; Brevé, JJP; Chrobok, NL; Drukarch, B; El Alaoui, S; Jongenelen, CA; van Dam, AM; Wilhelmus, MMM1
Alzarea, S; Rahman, S2
Caton, E; Meyer, KJ; Shapiro, TA1
Byun, S; Guo, G; Kemper, B; Kemper, JK; Kim, DH; Kim, YC; Kong, B; Ryerson, D; Sun, H; Xu, HE; Yau, P1
Anil, SM; Balaji, KS; Jayarama, S; Kiran, KR; Lingaraju, GS; Sadashiva, MP1
Covel, J; Fierer, J; Kapoor, M; Okamoto, S; Shaw, KJ; Soltow, QA; Trzoss, M; Viriyakosol, S1
Batteux, F; Bordenave, J; Cumont, A; Dinh-Xuan, AT; Guignabert, C; Guilbert, T; Günther, S; Hua-Huy, T; Humbert, M; Jalce, G; Nicco, C; Quatremarre, T; Savale, L; Thuillet, R; Tu, L1
Gaberel, T; Gakuba, C; Lépine, M; Lo, EH; van Leyen, K; Zheng, Y1
Crawley, JN; Kazdoba, TM; Parrott, JM; Rhine, MA; Schultz, MN1
Chen, Z; Li, J; Shi, J; Wang, YB1
Chen, R; Liang, Y; Lin, Y; Liu, J; Ma, Y; Wang, H; Xu, B1
Conde, C; García, S; Gómez-Reino, JJ; González, A; Martínez, P; Orosa, B1
Ding, X; Greer, JJ; Lenal, F; Ren, J; Yang, M1
Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX1
Arikok, AT; Bavbek, M; Besalti, O; Caliskan, M; Demirci, AY; Seckin, H; Yigitkanli, K; Yigitkanli, T1
O'Doherty, C; Polasek, TM; Rowland, A; Sorich, MJ; Wiese, MD1
Castilla-Ortega, E; Chun, J; Estivill-Torrús, G; García-Fernández, M; Pedraza, C; Rodriguez de Fonseca, F; Rosell-Valle, C; Sánchez-López, J; Santín, LJ; Zambrana-Infantes, E1
Arung, W; Cheramy, JP; Defraigne, JO; Detry, O; Drion, P; Honoré, P; Jehaes, F; Meurisse, M1
Jin, K; Sun, F; Uteshev, VV1
Cui, H; Ding, HF; Xiang, Z; Yan, X; Zhu, S1
Alagarsamy, V; Dineshkumar, P; Saravanan, G1
Arslan, R; Bektas, N; Ozturk, Y1
Fadillioglu, E; Karaman, A; Ozturk, E; Samdancı, E; Surucu, M1
Andrzejak, V; Barczyk, A; Body-Malapel, M; Chavatte, P; Desreumaux, P; Djouina, M; Leleu-Chavain, N; Millet, R; Rigo, B; Tourteau, A1
Arawaka, S; Fukushima, S; Kato, T; Koga, K; Koyama, S; Sasaki, A; Sato, H1
Balasubramanian, A; Cao, Z; Feketa, VV; Flores, CM; Marrelli, SP; Player, MR; Zhang, Y1
Bayram, E; Karaoğlu, P; Kumral, A; Kurul, SH; Ozbal, S; Topçu, Y; Tuğyan, K; Yılmaz, O; Yiş, U1
Caeiro, JR; Conde, C; Gómez-Reino, JJ; González, A; Guede, D; Martínez, P; Orosa, B1
Gotoh, M; Morohoshi, T; Murakami-Murofushi, K; Murofushi, H; Nagano, A; Otsuka, K; Tsukahara, R1
Cheng, L; Dargham, RA; Kong, S; Liu, X; Ren, W; Wan, L; Wang, Y; Wu, Z1
Hara, H; Hashizume, T; Ishisaka, M; Shimazawa, M; Tsujii, S1
Bartsch, DK; Fendrich, V; L-Lopez, C; Lang, SA; Lauth, M; Rexin, P; Schlitt, HJ; Waldmann, J; Wichmann, S; Wiese, D1
Chen, M; Fu, BQ; Ma, X; Tao, LS; Xu, YP; Yao, J; Zhou, CS1
Caso, JR; García-Bueno, B; Leza, JC; MacDowell, KS; Madrigal, JL; Martín-Hernández, D1
Chang, JS; Chang, KC; Chen, LT; Chen, TY; Cheng, AL; Kuo, SH; Lin, HY; Lin, SF; Shih, NY; Tsai, HJ1
Cui, W; Yu, X; Zhang, H1
Duthie, KM; Hadoke, PW; Ivy, JR; Kirkby, NS; Lim, WG; McShane, JF; Miller, E; Webb, DJ1
Gatson, JW; Simpkins, JW; Uteshev, VV1
Cho, GH; Cho, YS; Jeong, KS; Keum, G; Kim, T; Koh, HY; Lee, J; Min, SJ; Pae, AN; Seo, SH; Son, WS1
Huang, H; Jacko, AM; Tsung, A; Weathington, N; Wei, J; Zhao, J; Zhao, Y1
Floyd, KL; Stevens, KE; Stitzel, JA; Zheng, L1
Brooks-Kayal, A; Carlsen, J; Cea-Del Rio, CA; Cruz Del Angel, Y; González, MI; Grabenstatter, HL; Huntsman, MM; Laoprasert, RP; White, AM1
Fischell, J; Kvarta, MD; LeGates, TA; Thompson, SM; Van Dyke, AM1
Angadi, V; Dissel, S; Donlea, J; English, D; Kirszenblat, L; Klose, M; Koch, Z; Shaw, PJ; Suzuki, Y; van Swinderen, B; Winsky-Sommerer, R1
Barros, GA; Calistro Neto, JP; Domingues, MA; Gonçalves, GM; Módolo, NS; Silva, LM; Torres, Rda C1
Ohashi, T; Yamamoto, T1
Arai, Y; Hiraoka, N; Kanai, Y; Miyagawa, S; Ojima, H; Rokutan, H; Shibata, T; Shimada, K; Shirota, T1
Alm, RA; Barvian, K; Basarab, GS; Doig, P; Galullo, V; Gardner, H; Gowravaram, M; Huband, M; Kern, GH; Kimzey, A; Kutschke, A; Lahiri, SD; Lawrence, K; McNulty, J; Morningstar, M; Mueller, JP; Newman, JV; Perros, M; Schuck, VJ; Singh, R; Tommasi, R; Vishwanathan, K; Walkup, G1
Balaji, KS; Jagadish, S; Jayarama, S; Mohan, CD; Rakesh, KS; Rangappa, KS; Swaroop, TR; Zameer, F1
Biederman, RW; Boyd, NH; DiCarlo, C; Finley, G; Jobe, BA; Kelly, LA; Kolano, EL; Komatsu, Y; Kosovec, JE; Landreneau, RJ; Matsui, D; Omstead, A; Rotoloni, CL; Silverman, JF; Vytlacil, C; Zaidi, AH1
Chen, Y; Feng, B; Gong, Y; Mu, J; Qin, Z; Shi, Z; Yuan, F; Zhang, J; Zhao, Y; Zhou, B1
Chen, X; Cuppen, E; DeRuiter, MC; Folkerts, G; Laghmani, EH; Sengers, RM; van Boxtel, R; Wagenaar, GT; Walther, FJ1
Huang, WQ; Ma, Y; Xu, KQ; Zhang, T1
Azay-Milhau, J; Balzarin, S; Chajistamatiou, AS; Chrysina, ED; Docsa, T; Duret, C; Gergely, P; Goyard, D; Kónya, B; Leroy, J; Maurel, P; Petit, P; Praly, JP; Somsák, L; Tournier, M; Tousch, D; Vidal, S1
Cao, L; Cheng, X; Hao, H; Wang, G; Wang, H; Wu, M; Wu, Y; Xie, W; Xie, Y1
Bruheim, S; Suo, Z; Wendel, T; Wiedlocha, A; Zhen, Y1
Adcock, IM; Barnes, PJ; Chung, KF; Clarke, CJ; Durham, AL; Footitt, J; Hall, SR; Hansbro, PM; Johnston, SL; Mallia, P; Russell, KE; Simpson, KD; Starkey, MR; Wiegman, CH1
Boychuk, JA; Butler, CR; Halmos, KC; Smith, BN1
Guo, ST; Jiang, CC; Jin, L; Liu, F; Wang, CY; Wang, JY; Yan, XG; Yari, H; Zhang, XD; Zhang, YY1
Liu, S; Parajuli, KR; You, Z; Zhang, Q1
Komori, T; Potschka, H; Rettenbeck, ML; Russmann, V; Salvamoser, JD1
Araki, H; Kiyoi, T; Suemaru, K; Takechi, K; Tanaka, A1
Chapin, S; Everett, WR; Mahabir, SP; Six, RH1
Araki, K; Kamide, D; Shiotani, A; Shiozawa, S; Tanaka, S; Tanaka, Y; Tomifuji, M; Yamashita, T1
Bieńkowski, P; Jastrzębska-Więsek, M; Kołaczkowski, M; Mierzejewski, P; Partyka, A; Wasik, A; Wesołowska, A1
Fernández-Ruiz, J; García-Arencibia, M; García-Toscano, L; Gómez-Cañas, M; Jagerovic, N; Morales, P; Muñoz, E; Navarrete, C; Pazos, MR1
Boychuk, JA; Butler, CR; Smith, BN1
Aisa, HA; Ge, M; Hu, J; Jiang, JD; Li, YH; Ma, LL; Sun, WF; Wang, HQ; Wu, P; Wu, S; Yin, JQ; Zhao, JY1
Cheung, L; Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Liu, S; Meehan, DT; Phillips, G; Song, W1
Deng, F; Feng, J; Wang, L; Zhang, P1
Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM1
Cosgrove, D; Delimont, D; Dufek, B; Gratton, MA; Meehan, DT; Phillips, G; Zallocchi, M1
Lin, W; Liu, BL; Pan, HL; Zhang, YQ1
Akbarali, HI; AlSharari, SD; Bagdas, D; Cabral, GA; Carroll, FI; Damaj, MI; Lichtman, PA; McGee, EA; Raborn, ES1
Ali, MS; Bishop-Bailey, D; Bye, AP; Dombrowicz, D; Dorchies, E; Flora, GD; Gibbins, JM; Kriek, N; Molendi-Coste, O; Moraes, LA; Sage, T; Sasikumar, P; Staels, B; Unsworth, AJ; Vaiyapuri, S1
Bot, I; Kritikou, E; Kröner, MJ; Kuiper, J; Schaftenaar, FH; Swart, M; van der Heijden, T; van Puijvelde, GH; van Santbrink, PJ1
Burnet, M; Deuschle, U; Garnys, L; Hambruch, E; Hayden, H; Kremoser, C; Mitteregger, D; Oberhuber, G; Peck-Radosavljevic, M; Podesser, BK; Reiberger, T; Riedl, F; Rohr-Udilova, N; Schubert, TL; Schwabl, P; Seeland, BA; Starlinger, P; Strobel, B; Trauner, M; Wagner, M1
Cui, N; Jiang, C; Johnson, CM; Wu, Y; Xing, H; Zhong, W1
Chaussenot, R; Vaillend, C1
Choi, JW; Jun, HS; Jung, JY; Li, HY; Oh, YS1
Begec, Z; Demirbilek, S; Ersoy, MO; Fadillioglu, E; Kirimlioglu, H; Ozturk, E; Surucu, M1
Rintala, JM; Rintala, SE; Savikko, J; von Willebrand, E1
Bian, F; Hao, N; Zhang, M1
Akwabi-Ameyaw, A; Bass, JY; Caldwell, RD; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Jones, SA; Kaldor, I; Liu, Y; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB1
Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG1
Chiba, Y; Misawa, M; Nakazawa, S; Sakai, H; Shinozaki, K; Todoroki, M1
Kondo, T; Kubo, T; Miwa, H; Suzuki, A1
Cao, GQ; Chakrabarti, PP; Henkle, B; Hsieh, F; Lee, MR; Middleton, S; Pettus, LH; Plant, MH; Powers, DA; Rzasa, RM; Saris, CJ; Sham, K; Sherman, L; Syed, R; Tasker, AS; Tudor, Y; Wong, LM; Wurz, RP; Xu, S; Yu, V; Zhang, D1
Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I1
Acencio, MM; Antonangelo, L; Costa, JD; Marchi, E; Novaes, NP; Teixeira, LR; Vargas, FS1
Melloni, RH; Morrison, RL; Ricci, LA; Schwartzer, JJ1
Cariou, B1
Cecen, S; Demir, EM; Ergin, K; Kose, H; Serter, M; Yildiz, Y1
Agarwal, G; B-Rao, C; Balachandran, S; Bhatt, P; Bose, J; Chetrapal-Kunwar, A; Dadarkar, SS; Dagia, NM; Fonseca, L; Gadekar, PK; Gupte, RD; Kamath, DV; Mandrekar, N; Pari, K; Parkale, SS; Rodge, AH; Sharma, S; Srinivasan, S; Vishwakarma, RA1
Bauer, M; Dietl, W; Hallström, S; Jürgens, G; Podesser, BK; Trescher, K; Ullrich, R; Wick, N; Wolfsberger, M; Wolner, E1
Abbate, A; Hoke, NN; Houser, JE; Ownby, ED; Salloum, FN; Seropian, IM; Van Tassell, BW; Varma, A1
Chae, YN; Choi, SH; Kim, HS; Kim, JG; Kim, JK; Kim, MK; Kim, SH; Lee, CH; Lim, JI; Moon, HS; Park, SK; Shin, CY; Shin, YA; Son, MH1
Perry, CM; Yang, LP1
Greer, JJ; Ren, J1
Kaptanoglu, B; Kutluana, U; Nart, D; Oruc, N; Ozutemiz, O; Yonetci, N1
Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y1
Anderson, DL; Armour, SL; Becherer, JD; Budzik, BW; Chen, L; Chen, ZB; Colilla, FJ; De Los Frailes, M; Evans, KA; Griffin, RJ; Jayawickreme, C; Jeune, MR; Jin, J; Moncol, DL; Rimele, TJ; Rivero, RA; Ross, SA; Shearer, TW; Szewczyk, GR; Tadepalli, SM; Vimal, M; Weaver, SP; Wisnoski, DD1
Buckley, B; Sonsalla, PK; Winnik, B; Wong, LY1
Schulze-Bonhage, A1
Guo, X; Liu, Y; Peng, Y; Shen, X; Wang, F; Xu, S; Yang, J1
Abrao, MS; Alves, LM; Berardo, PT; Fernandes, PD; Landgraf, RG; Machado, DE; Nasciutti, LE; Palmero, C1
Henningsen, K; Holm, MM; Jayatissa, MN; Jensen, K; Nieto-Gonzalez, JL; Vardya, I; Wiborg, O1
Kumar, A; Kumar, P; Kumari, B1
Howard, DJ; Iczkowski, KA; Jiang, L; Meyer-Siegler, KL; Vera, PL1
Demircan, M; Fadillioglu, E; Gülsul, C; Karadag, N; Karaman, A; Kirimlioglu, H; Tas, E1
Chen, LW; Chen, PH; Hsu, CM; Tseng, HT1
Asanuma, M; Diaz-Corrales, FJ; Kikkawa, Y; Kimoto, N; Miyazaki, I; Miyoshi, K; Murata, M; Takeshima, M1
Araki, T; Kasahara, J; Kato, H; Kuroiwa, H; Tsukada, T; Uchida, H; Yano, R; Yokoyama, H2
Bloudícková, S; Honsová, E; Lodererová, A; Rajnoch, J; Viklický, O1
Covey, DF; Handforth, A; Homanics, GE; Krishnan, K; Lee, JY; Martin, FC; Quesada, A; Sakimura, K1
Cox, GM; Gienapp, I; Kithcart, AP; Papenfuss, T; Pruitt, J; Satoskar, AR; Shawler, T; Short, A; Sielecki, T; Whitacre, CC1
Corbin, JG; Huntsman, MM; Kaufmann, WE; Martin, BS; Olmos-Serrano, JL; Paluszkiewicz, SM1
Li, Y; Meng, Q; Su, Z; Sui, C; Sun, F; Teng, L; Yuan, L; Zhang, C1
Brimioulle, S; Dewachter, C; Dewachter, L; Fesler, P; Franck, S; Hubloue, I; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B1
Barter, PJ; Beattie, DT; Bursill, CA; Castro, ML; Heather, AK; Nakhla, S; Rye, KA; van der Vorst, E1
Dartevelle, P; Eddahibi, S; Fadel, E; Humbert, M; Izziki, M; Mercier, O; Sage, E1
Mareš, P1
Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J1
Damgaard, T; Hansen, SL; Neill, JC; Plath, N1
He, C; Liu, S; Lu, X; Luo, P; Wu, M; Yan, Z; Yu, Y1
Choudhury, ME; Kubo, M; Kyaw, WT; Matsuda, S; Moritoyo, T; Nagai, M; Nishikawa, N; Nomoto, M; Yabe, H1
Bavbek, M; Bilginer, B; Çelik, Ö; Gürgör, PN; Korkmaz, A; Özgen, T; Ziyal, İ1
Burke, CJ; Cech, J; Chen, F; Datta, S; Granter, S; Kaufman, C; Kramer, M; Langdon, E; Lin, CY; Long, HK; Morrison, S; Mosher, J; Neuberg, D; Rahl, PB; Ratanasirintrawoot, S; Tomlinson, ML; Wheeler, GN; White, RM; Young, RA; Zon, LI1
Abernethy, L; Clarkson, T; Dempster, M; Easson, AM; Edwards, D; Everett, K; Feilden, H; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Nimz, O; Nisbet, LA; Palin, R; Ratcliffe, P; Tracey, H; Walker, G1
Ahlbrand, R; Bronson, SL; Horn, P; McNamara, RK; Richtand, NM; Stanford, K1
Dempster, J; Head, SI; Kueh, SL; Morley, JW1
Andrzejak, V; Body-Malapel, M; Chavatte, P; Desreumaux, P; Djouina, M; El Bakali, J; Lambert, DM; Millet, R; Muccioli, GG; Renault, N1
Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN1
Brandes, RP; Cornitescu, T; Dahal, BK; Davie, N; Ghofrani, HA; Grimminger, F; Janssen, W; Kojonazarov, B; Kosanovic, D; Luitel, H; Schermuly, RT; Seeger, W; Sydykov, A; Weissmann, N1
Ahlbrand, R; Bronson, SL; Gudelsky, G; Kern, JR; Richtand, NM; Roenker, NL; Waterman, H1
Abernethy, L; Ansari, N; Cameron, K; Clarkson, T; Dempster, M; Dunn, D; Easson, AM; Edwards, D; Everett, K; Feilden, H; Ho, KK; Kultgen, S; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Neagu, I; Nimz, O; Nisbet, LA; Ohlmeyer, M; Palin, R; Pham, Q; Ratcliffe, P; Rong, Y; Roughton, A; Sammons, M; Swanson, R; Tracey, H; Walker, G1
Calabresi, P; Cardaioli, G; Costa, C; Galletti, F; Pisani, F; Siliquini, S; Tantucci, M; Tozzi, A1
Burns, MP; Corbin, JG; Olmos-Serrano, JL1
Akhmetshina, A; Allanore, Y; Avouac, J; Beyer, C; Dees, C; Distler, JH; Distler, O; Horn, A; Maurer, B; Palumbo, K; Sadowski, A; Schett, G; Schneider, H; Shiozawa, S; Tomcik, M; Zerr, P1
Balabhadrapatruni, S; Darlington, CL; Masumura, C; Smith, PF; Zheng, Y1
Gendle, DF; Grayson, B; Idris, NF; Lesage, AS; Mackie, C; McLean, SL; Neill, JC; Pemberton, DJ1
Badn, W; Darabi, A; Eberstål, S; Esbjörnsson, M; Fritzell, S; Siesjö, P; Visse, E1
Duncan, GE; Koller, BH; Moy, SS1
He, XH; Li, H; Song, XM; Wang, YL; Zhan, J; Zhang, ZZ1
Bugaenko, SE; Elistratova, NA; Maliev, BM; Mozhokina, GN; Sokolova, GB; Solov'eva, IP1
Bétry, C; Christensen, T; Ebert, B; Etievant, A; Haddjeri, N; Mnie-Filali, O; Wiborg, O1
Choi, SH; Hwang, SH; Jang, CG; Kang, J; Kim, HC; Kim, HJ; Kwon, SH; Lee, BH; Lee, JH; Nah, SY; Shin, EJ; Shin, TJ1
Boettcher, A; Burnet, M; Deuschle, U; Hahn, U; Hambruch, E; Kinzel, O; Kremoser, C; Krol, HD; Levi, M; Matysik, S; Miyazaki, M; Miyazaki-Anzai, S; Perović-Ottstadt, S; Schlüter, T; Schmitz, G1
Izuta, S; Maekawa, N; Nishina, K; Shiozawa, S; Ueki, M; Ueno, M1
Guo, L; Guo, T; Liu, K; Yang, C1
Carroll, FI; Damaj, MI; Freitas, K; Negus, SS1
Freitas, K; Ghosh, S; Imad Damaj, M; Ivy Carroll, F; Lichtman, AH1
Kanemaru, A; Kojima, T; Tokashiki, S; Ueda, Y1
Banyard, D; Beazley, KE; Deasey, SC; Konoplyannikov, M; Lima, F; Nurminskaya, MV; Nurminsky, DI1
Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M1
Chun, J; Duffield, JS; Luster, AD; Sakai, N; Tager, AM; Wada, T1
Annadanam, A; Armour, E; Aziz, K; Cades, JA; Chettiar, ST; DeWeese, TL; Gajula, RP; Gandhi, N; Hales, RK; Herman, JM; Kato, Y; Schaeffer, EM; Song, D; Tran, PT; Wild, AT; Williams, RD; Zhang, Y1
Becker, A; Geisslinger, G; Grecksch, G; Höllt, V; Murín, R; Schröder, H; Zimmer, A1
Itoh, M; Kawamori, T; Kitamura, T; Matsuura, M; Noda, T; Sugimura, T; Uchiya, N; Wakabayashi, K1
Fürstenberger, G; Hirschner, W; Marks, F; Müller-Decker, K1
Adams, AD; Berger, JP; Doebber, TW; Hu, Z; Jones, AB; MacNaul, KL; Moller, DE; Santini, C; Yuen, W1
Flynn, DM; Hill, RJ; Knight, DR; Magee, WP; Oleynek, JJ; Smith, AH; Tracey, WR1
Doi, T; Tokumaru, J; Ueda, Y; Willmore, LJ1
Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H1
Accatino, L; Arrese, M; Koenig, CS; Pizarro, M; Solís, N1
Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L1
Gluck, MR; Granson, H; Santana, LA; Yahr, MD1
Jung, S; Korn, T; Magnus, T; Toyka, K1
Abe, F; Ichimura, E; Morohashi, H; Nishikawa, K; Saiga, K; Toyoda, E1
Li, Y; Qiang, CJ; Wei, YH1
Bloemendaal, AL; Borel Rinkes, IH; Kranenburg, O; Smakman, N; van Diest, P; Vogten, JM1
Kulkarni, SK; Padi, SS1
Bjerrum, OJ; Blackburn-Munro, G; Jensen, DG; Rode, F1
Bolte, H; Brossmann, J; Fändrich, F; Hedderich, J; Heller, M; Jahnke, T; Müller-Hülsbeck, S; Rector, L; Schäfer, FK; Schäfer, PJ1
Kitayama, J; Nagawa, H; Ohta, H; Sakai, T; Sako, A; Shida, D; Suzuki, R1
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M1
Böger, R; Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S; Schwedhelm, E1
Chen, FP; Davis, IC; Fortenberry, JA; Graves, LM; Hickman-Davis, JM; Lazarowski, ER; Matalon, S; Sorscher, E; Sullender, WM; Zhao, X1
Bros, M; Jarman, ER; Knop, J; Reske-Kunz, AB; Sudowe, S; Weigmann, B1
Detter, C; Deuse, T; Haddad, M; Koch-Nolte, F; Reichenspurner, H; Schäfer, H; Schrepfer, S1
Aytan, H; Batioglu, S; Uygur, D; Zergeroglu, S1
Barr, AM; Geyer, MA; Markou, A; Powell, SB1
Kuribayashi, Y; Onodera, K; Takahashi, A1
Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sobieszek, G1
Coelho, AM; da Cunha, JE; de Almeida, JL; Jukemura, J; Machado, MC; Patzina, RA1
Kumar, A; Naidu, PS; Padi, SV; Seghal, N1
Aytan, H; Batioglu, S; Caglar, P; Uygur, D; Zergeroglu, S1
Al-Ghawas, M; Alkhiary, YM; Cullinane, DM; Einhorn, TA; Fitch, JL; Gerstenfeld, LC; Krall, EA; Thiede, MA; Webb, EG1
Deuse, T; Haddad, M; Koch-Nolte, F; Krieger, T; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schäfer, H; Schrepfer, S1
Brimiouille, S; Fesler, P; Hubloue, I; Huez, S; Kerbaul, F; Naeije, R; Remmelink, M; Rondelet, B; Salmon, I; Vivian, GF1
Crain, EJ; Knabb, RM; Lam, PY; Quan, ML; Watson, CA; Wexler, RR; Wong, PC1
Deuse, T; Fischbein, MP; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schrepfer, S1
Al-Abed, Y; Kohn, N; Lin, X; Metz, CN; Miller, EJ; Ojamaa, K; Sakuragi, T1
Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M1
Birnbaum, F; Reinhard, T; Reis, A; Scholz, C; Schwartzkopff, J1
Deng, M; Heemann, U; Huang, H; Lutz, J; Roos, M; Schmaderer, C; Strobl, M; Wagner, B1
Abbate, A; Baldi, A; Biasucci, LM; Biondi-Zoccai, GG; Crea, F; Fowler, AA; Kukreja, RC; Lipinski, MJ; Ockaili, RA; Salloum, FN; Straino, S; Vetrovec, GW1
Kamerman, P; Koller, A; Loram, L1
Ono, H; Takeuchi, Y; Tanabe, M1
Dawson, PA; Gerard, RD; Inagaki, T; Jung, D; Kliewer, SA; Mangelsdorf, DJ; Moschetta, A1
Belen, D; Besalti, O; Bolay, H; Kösemehmetoğlu, K; Simşek, S; Yiğitkanli, K1
Isoe, T; Miura, T; Nakamura, K; Shibuya, M; Taguchi, E1
Clausen, RP; Frølund, B; Krogsgaard-Larsen, P; Larsson, OM; Saunders, GW; Schousboe, A; Smith, MD; White, HS; Wilcox, KS1
Aguirre, N; de la Torre, R; Goñi-Allo, B; Hervias, I; Lasheras, B; Mathúna, BO; Puerta, E1
Czugler, M; Erdélyi, P; Fischer, J; Fodor, T; Gere, A; Varga, AK1
Brueggen, J; Buckler, A; Chène, P; Cozens, R; Drysdale, MJ; Garcia-Echeverria, C; Guy, CT; Jensen, MR; Massey, A; Quadt, C; Radimerski, T; Schoepfer, J1
Chen, C; Gonzalez, FJ; Haase, VH; Ito, S; Morimura, K; Shah, YM; Yim, SH1
Liu, X; Lou, TQ; Peng, H; Tang, H; Tang, Y; Wang, C1
Frey, HH; Löscher, W; Reiche, R; Schultz, D1
Fariello, RG; Golden, GT1
Fitton, A; Grant, S1
Dan, T; Onoma, M; Onuma, E; Ozawa, K; Yoneya, T1
Anagnostopulos, H; Bartlett, RR; Mattar, T; Schleyerbach, R; Zielinski, T1
Bartlett, RR; Brendel, S; Schorlemmer, HU1
Bartlett, RR; Brendel, S; Schorlemmer, HU; Zielinski, T1
Howlett, W; Ijaz, S; Miyashita, H; Owen, AJ; Shuaib, A; Wishart, T1
Bozarth, J; Forsythe, M; Mousa, SA; Mu, DX; Wityak, J1
Bartlett, RR; Kurrle, R; Schorlemmer, HU1
Bartlett, RR; Schorlemmer, HU1
Ekberg, H; Hedlund, G; Ostraat, O; Qi, ZQ; Tufveson, G1
Eber, E; McMenamin, C; Sly, PD; Uhlig, T1
Cooper, D; Eber, E; McMenamin, C; Sly, PD; Uhlig, T; Wildhaber, JH1
Blinder, L; Chong, AS; Ma, LL; Sankary, H; Shen, J; Williams, JW; Yin, D1
Blinder, L; Chong, AS; Foster, P; Huang, W; Jensik, S; Liu, W; McChesney, L; Mital, D; Sankary, H; Shen, J; Williams, JW; Xiao, F1
Arthur, AS; Helm, GA; Kassell, NF; Lee, KS; Louis, HG; Wanebo, JE; West, K1
Bartlett, RR; Schleyerbach, R; Schorlemmer, HU1
Matsui, K; Shibata, T; Wakitani, K; Yonemori, F1
Amano, Y; Kitagawa, H; Mizushima, Y; Ogata, K1
Andiné, P; Axelsson, R; Mårtensson, E; Nyberg, G; Olofsson, U; Sandberg, M; Widermark, N1
Kapil, R; Mousa, SA; Mu, DX1
White, HS1
Leppik, IE1
Breedveld, FC1
Block, N; Brock, TA; Chen, SJ; Chen, YF; Dixon, RA; Munsch, CL; Sherwood, SJ; Tilton, RG; Wu, C1
Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M2
Allikmets, L; Matto, V; Pruus, K; Rudissaar, R; Skrebuhhova-Malmros, T1
Ji, LL; Leichtweis, S1
Almany, DK; Crawford, FA; Davis, JN; Fary, DJ; Goldberg, AT; Hendrick, JW; Joffs, C; Spinale, FG; Walker, CA1
Beckius, GE; Chambers, RJ; Chupak, LS; Duplantier, AJ; Jenkinson, TH; Klein, AS; Kraus, KG; Kudlacz, EM; McKechney, MW; Milici, AJ; Pettersson, MP; Whitney, CA1
Bennani, YL; Black, LA; Decker, MW; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Pan, JB1
Hamada, K; Ishida, S; Seino, M; Song, HK; Yagi, K1
Andresen, C; Beckius, G; Chupak, L; Duplantier, A; Klein, A; Kraus, K; Kudlacz, E; Milici, A; Whitney, C1
Bogden, AE; Houchens, DP; Johnson, RK; Neil, GL; Ovejera, AA; Sheridan, MA1
Ferrell, LD; Grendell, JH; Neuschwander-Tetri, BA; Sukhabote, RJ1
Snead, OC1
Bartlett, RR; Bremer, E; Dimitrijevic, M; Germann, T; Küchle, CC; Mattar, T; Rüde, E; Schorlemmer, HU; Thoenes, GH; Zielinski, T1
Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK1
Chapman, AG1
Allen, SD; Kinsolving, CR; Mullen, GB; Ordy, JM; Palmer, GC; Simmons, RD; St Georgiev, V; Strand, JC1
Bartlett, RR; Popovic, S1
Löscher, W1

Reviews

13 review(s) available for isoxazoles and Disease Models, Animal

ArticleYear
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:11

    Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxazoles; Kindling, Neurologic; Membrane Proteins; Mental Disorders; Mice; Nerve Tissue Proteins; Pentylenetetrazole; Piriform Cortex; Psychomotor Performance; Pyrrolidines; Quality of Life; Receptors, Nicotinic; Seizures; Social Behavior

2019
Pharmacokinetic evaluation of teriflunomide for the treatment of multiple sclerosis.
    Expert opinion on drug metabolism & toxicology, 2013, Volume: 9, Issue:8

    Topics: Administration, Oral; Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Crotonates; Disease Models, Animal; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Multiple Sclerosis; Nitriles; Randomized Controlled Trials as Topic; Toluidines

2013
Zonisamide in the treatment of epilepsy.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:1

    Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Compassionate Use Trials; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Europe; Humans; Isoxazoles; Randomized Controlled Trials as Topic; Syndrome; Treatment Outcome; Zonisamide

2010
Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Absorption; Adult; Aged; Aging; Animals; Antipsychotic Agents; Central Nervous System; Cross-Over Studies; Disease Models, Animal; Drug Interactions; Hemodynamics; Humans; Isoxazoles; Neurosecretory Systems; Piperidines; Risperidone; Schizophrenia; Synaptic Transmission; Tissue Distribution

1994
Effects of leflunomide on immune responses and models of inflammation.
    Springer seminars in immunopathology, 1993, Volume: 14, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Autoimmune Diseases; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Graft Rejection; Humans; Immunity, Cellular; Immunosuppressive Agents; Inflammation; Isoxazoles; Leflunomide; Mice; Protein-Tyrosine Kinases; Rats

1993
Leflunomide, an immunorestoring drug for the therapy of autoimmune disorders, especially rheumatoid arthritis.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Clinical Trials as Topic; Disease Models, Animal; Humans; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Mammals

1996
Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage: dose study and review of endothelin-based therapies in the literature on cerebral vasospasm.
    Neurosurgery, 1998, Volume: 43, Issue:6

    Topics: Animals; Basilar Artery; Calcium Signaling; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Endothelin-1; Infusions, Intravenous; Ischemic Attack, Transient; Isoxazoles; Male; Rabbits; Receptor, Endothelin A; Subarachnoid Hemorrhage; Thiophenes

1998
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fructose; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Receptors, GABA; Sodium Channels; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide

1999
Zonisamide.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Adult; Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy; Humans; Isoxazoles; Treatment Outcome; Zonisamide

1999
Investigational treatments in rheumatoid arthritis.
    Bailliere's best practice & research. Clinical rheumatology, 1999, Volume: 13, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drugs, Investigational; Genetic Therapy; Humans; Immunotherapy; Isoxazoles; Leflunomide; Tumor Necrosis Factor-alpha

1999
Pharmacological models of generalized absence seizures in rodents.
    Journal of neural transmission. Supplementum, 1992, Volume: 35

    Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rodentia; Sodium Oxybate; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1992
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.
    Agents and actions, 1991, Volume: 32, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Disease Models, Animal; Graft Rejection; Graft vs Host Disease; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Molecular Sequence Data

1991
Valproate and myoclonus.
    Advances in neurology, 1986, Volume: 43

    Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid

1986

Trials

3 trial(s) available for isoxazoles and Disease Models, Animal

ArticleYear
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
    Scientific reports, 2015, Jul-14, Volume: 5

    Topics: Adult; Animals; Anti-Bacterial Agents; Barbiturates; Disease Models, Animal; DNA Topoisomerases, Type II; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Female; Fluoroquinolones; Gonorrhea; Haplorhini; Humans; Isoxazoles; Male; Mice; Microbial Sensitivity Tests; Middle Aged; Models, Molecular; Molecular Conformation; Morpholines; Mutation; Neisseria gonorrhoeae; Oxazolidinones; Rats; Spiro Compounds; Staphylococcal Infections; Staphylococcus aureus; Topoisomerase II Inhibitors; Young Adult

2015
Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Absorption; Adult; Aged; Aging; Animals; Antipsychotic Agents; Central Nervous System; Cross-Over Studies; Disease Models, Animal; Drug Interactions; Hemodynamics; Humans; Isoxazoles; Neurosecretory Systems; Piperidines; Risperidone; Schizophrenia; Synaptic Transmission; Tissue Distribution

1994
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass.
    The Journal of thoracic and cardiovascular surgery, 2001, Volume: 122, Issue:2

    Topics: Analysis of Variance; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Isoxazoles; Pulmonary Circulation; Receptors, Endothelin; Swine; Thiophenes; Vascular Resistance; Ventricular Function, Left

2001

Other Studies

278 other study(ies) available for isoxazoles and Disease Models, Animal

ArticleYear
Parecoxib ameliorates renal toxicity and injury in sepsis-induced mouse model and LPS-induced HK-2 cells.
    Drug development research, 2022, Volume: 83, Issue:3

    Topics: Acute Kidney Injury; Animals; Apoptosis; Cyclooxygenase 2; Disease Models, Animal; I-kappa B Kinase; Inflammation; Isoxazoles; Lipopolysaccharides; Mice; NF-kappa B; Sepsis

2022
Selective ETA vs. dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats.
    Cardiovascular research, 2020, 08-01, Volume: 116, Issue:10

    Topics: Albuminuria; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Epoprostenol; Hypertension; Isoxazoles; Kidney; Male; Oxidative Stress; Pyrimidines; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Sulfonamides; Sunitinib; Thiophenes

2020
LPA
    Science advances, 2019, Volume: 5, Issue:10

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Calcium-Binding Proteins; Disease Models, Animal; Ependyma; Ependymoglial Cells; Infant, Premature, Diseases; Isoxazoles; Lysophospholipids; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microfilament Proteins; Phagocytosis; Propionates; Receptors, Lysophosphatidic Acid

2019
Investigating MIF in Mouse Models of Severe Corticosteroid-Resistant Neutrophilic Asthma.
    Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2080

    Topics: Adrenal Cortex Hormones; Animals; Antigens, Dermatophagoides; Asthma; Dexamethasone; Disease Models, Animal; Drug Resistance; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Neutrophils; Severity of Illness Index

2020
The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
    International immunopharmacology, 2020, Volume: 81

    Topics: Animals; B-Lymphocytes; Benzophenones; Disease Models, Animal; Humans; Isoxazoles; Lipopolysaccharides; Mice; Mice, Knockout; Proto-Oncogene Proteins c-fos; Receptors, G-Protein-Coupled; RNA-Seq; Sepsis; Signal Transduction; Spleen; Up-Regulation

2020
Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.
    Respiratory research, 2019, Dec-18, Volume: 20, Issue:1

    Topics: Airway Remodeling; Animals; Apoptosis; Asthma; Calcium Signaling; Cell Proliferation; Cells, Cultured; Cyclic AMP; Disease Models, Animal; Female; Guanine Nucleotide Exchange Factors; Hydrazones; Inflammation Mediators; Isoxazoles; Lung; Mice, Inbred BALB C; Myocytes, Smooth Muscle; Ovalbumin; Pneumonia; Respiratory Hypersensitivity

2019
A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles
    Current organic synthesis, 2019, Volume: 16, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Coordination Complexes; Cyclization; Diclofenac; Disease Models, Animal; Drug Design; Inflammation; Isoxazoles; Ketones; Molecular Structure; Oxidation-Reduction; Rats; Structure-Activity Relationship; Tin Compounds

2019
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats.
    Behavioural brain research, 2020, 05-15, Volume: 385

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Galantamine; Isoxazoles; Memantine; Nootropic Agents; Phenylurea Compounds; Rats; Recognition, Psychology; Scopolamine

2020
Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 193

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Clozapine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dizocilpine Maleate; Glycogen Synthase Kinase 3 beta; Isoxazoles; Male; Phenylurea Compounds; Prefrontal Cortex; Proto-Oncogene Proteins c-akt; Pyridazines; Pyrroles; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Social Interaction; Treatment Outcome

2020
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
    Nature immunology, 2020, Volume: 21, Issue:5

    Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Profiling; Gene Regulatory Networks; High-Throughput Screening Assays; Humans; Immunity, Innate; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microglia; Multiple Sclerosis; Neurogenic Inflammation; Oxidative Stress; Sequence Analysis, RNA; Single-Cell Analysis

2020
Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro.
    Marine drugs, 2020, May-01, Volume: 18, Issue:5

    Topics: Animals; Antineoplastic Agents; BALB 3T3 Cells; Cell Line, Tumor; Disease Models, Animal; Isoxazoles; Mice; Porifera; Spiro Compounds; Tyrosine

2020
Paracoxib Alleviates Ventilator-Induced Lung Injury Through Functional Modulation of Lung-Recruited CD11bloLy6Chi Monocytes.
    Shock (Augusta, Ga.), 2021, 02-01, Volume: 55, Issue:2

    Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Lung; Male; Mice; Mice, Inbred C57BL; Monocytes; Ventilator-Induced Lung Injury

2021
The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice.
    International journal of molecular sciences, 2020, Jul-03, Volume: 21, Issue:13

    Topics: Animals; Biomarkers; Disease Models, Animal; Extracellular Matrix Proteins; HSP90 Heat-Shock Proteins; Isoxazoles; Lung; Lung Injury; Male; MAP Kinase Signaling System; Mechlorethamine; Mice; Mice, Inbred C57BL; Pulmonary Alveoli; Pulmonary Fibrosis; Resorcinols

2020
Increased levels of conjugated bile acids are associated with human bile reflux gastritis.
    Scientific reports, 2020, 07-14, Volume: 10, Issue:1

    Topics: Animals; Bile Acids and Salts; Bile Reflux; Digestion; Disease Models, Animal; Gastric Juice; Gastritis; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lipids; Liver; Mice

2020
Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats.
    Neuroscience letters, 2020, 10-15, Volume: 737

    Topics: Animals; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Ischemic Stroke; Isoxazoles; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2020
Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner.
    Journal of molecular medicine (Berlin, Germany), 2020, Volume: 98, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter 1; Biomarkers; Cell Line; Cell Proliferation; Cyclic AMP; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intramolecular Oxidoreductases; Isoxazoles; Kidney Diseases, Cystic; Macrophage Migration-Inhibitory Factors; Macrophages; Mice; Mice, Knockout

2020
Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
    Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20

    Topics: Animals; Anti-Bacterial Agents; Azoles; Disease Models, Animal; DNA Gyrase; Dose-Response Relationship, Drug; Isoxazoles; Mice; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Rats; Rats, Wistar; Spiro Compounds; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors

2020
Pain responses to protease-activated receptor-2 stimulation in the spinal cord of naïve and arthritic rats.
    Neuroscience letters, 2020, 11-20, Volume: 739

    Topics: Animals; Arthritis; Dipeptides; Disease Models, Animal; Hyperalgesia; Isoxazoles; Male; Nociception; Pain Threshold; Rats, Wistar; Receptor, PAR-2; Spinal Cord

2020
α7 nicotinic receptor agonist and positive allosteric modulators differently improved schizophrenia-like cognitive deficits in male rats.
    Behavioural brain research, 2021, 01-15, Volume: 397

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoxazoles; Male; Nicotinic Agonists; Phenylurea Compounds; Pyridazines; Pyrroles; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia

2021
LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke.
    Brain injury, 2021, 03-21, Volume: 35, Issue:4

    Topics: Animals; Benzamides; Brain; Brain Ischemia; Disease Models, Animal; Isoxazoles; Lim Kinases; Mice; Stroke

2021
Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
    Biochimica et biophysica acta. Molecular basis of disease, 2021, 08-01, Volume: 1867, Issue:8

    Topics: Animals; Bile Acids and Salts; Caco-2 Cells; Cell Line; Cell Line, Tumor; Cholestasis; Disease Models, Animal; Fibroblast Growth Factors; HEK293 Cells; Hep G2 Cells; Humans; Ileum; Isoxazoles; Ligands; Liver; Male; Mice; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Transcription Factors

2021
Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.
    Behavioural brain research, 2021, 07-23, Volume: 410

    Topics: Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Disease Models, Animal; Estrous Cycle; Female; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Illness Behavior; Isoquinolines; Isoxazoles; Lipopolysaccharides; Ovariectomy; Rats; Rats, Wistar; Signal Transduction; Sulfonamides

2021
Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia.
    International journal of molecular sciences, 2021, May-24, Volume: 22, Issue:11

    Topics: Animals; Animals, Newborn; Antipsychotic Agents; Cannabidiol; Cell Culture Techniques; Cerebral Cortex; Disease Models, Animal; Female; Isoxazoles; Male; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics

2021
Leflunomide prevents ROS-induced systemic fibrosis in mice.
    Free radical biology & medicine, 2017, Volume: 108

    Topics: Animals; Antirheumatic Agents; Autoantibodies; Bleomycin; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Humans; Hypochlorous Acid; Immunosuppression Therapy; Isoxazoles; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Leflunomide; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; Reactive Oxygen Species; Signal Transduction; Skin; STAT6 Transcription Factor

2017
Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice.
    Oncotarget, 2017, Apr-18, Volume: 8, Issue:16

    Topics: Animals; Autoantibodies; Cytokines; Disease Models, Animal; Female; Gene Expression; Immunotherapy, Adoptive; Inflammation Mediators; Interleukin-17; Isoxazoles; Lacrimal Apparatus; Male; Mice; Mice, Inbred NOD; p38 Mitogen-Activated Protein Kinases; Phosphoric Diester Hydrolases; Propionates; Receptors, Lysophosphatidic Acid; rho-Associated Kinases; Saliva; Signal Transduction; Sjogren's Syndrome

2017
Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions.
    British journal of pharmacology, 2017, Volume: 174, Issue:16

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Caspase 3; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Endometriosis; Female; Isoxazoles; Matrix Metalloproteinase 9; Mice, Inbred C57BL; PPAR gamma; Proto-Oncogene Proteins c-akt; Telmisartan; Ultrasonography

2017
Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.
    Oncotarget, 2017, Jul-04, Volume: 8, Issue:27

    Topics: Animals; Apoptosis; B-Lymphocytes; Cell Line, Transformed; Cell Proliferation; Crotonates; Cyclin E; Disease Models, Animal; Epstein-Barr Virus Infections; Gene Expression Regulation; Gene Expression Regulation, Viral; Genes, myc; Herpesvirus 4, Human; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; NF-kappa B; Nitriles; Toluidines; Virus Activation; Virus Latency; Virus Replication; Xenograft Model Antitumor Assays

2017
Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome.
    Biochemical pharmacology, 2017, 08-15, Volume: 138

    Topics: Animals; Bone Morphogenetic Protein 2; Carrier Proteins; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endothelium, Vascular; Hepatopulmonary Syndrome; Injections, Intraperitoneal; Injections, Intravenous; Isoxazoles; Lung; Macrophage Activation; Macrophages, Alveolar; Microvessels; Neovascularization, Pathologic; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction

2017
Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma.
    Molecular medicine reports, 2017, Volume: 16, Issue:6

    Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Isoxazoles; Leflunomide; Mice; Mouth Neoplasms; Xenograft Model Antitumor Assays

2017
Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency.
    BMC nephrology, 2017, Oct-27, Volume: 18, Issue:1

    Topics: Adenine; Animals; Calcimimetic Agents; Cinacalcet; Disease Models, Animal; Endothelin A Receptor Antagonists; Isoxazoles; Male; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thiophenes

2017
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.
    Scientific reports, 2017, 12-05, Volume: 7, Issue:1

    Topics: Animals; Benzophenones; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Intervertebral Disc Degeneration; Isoxazoles; Mice, Inbred C57BL; Molecular Targeted Therapy; Nucleus Pulposus; Pain; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Transcription Factor AP-1

2017
Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy.
    The journal of obstetrics and gynaecology research, 2018, Volume: 44, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Isoxazoles; Macrophage Migration-Inhibitory Factors; Pancreatitis; Pregnancy; Pregnancy Complications; Prenatal Injuries; Rats; Rats, Sprague-Dawley

2018
The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2019, Volume: 32, Issue:5

    Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Humans; Injections, Intraperitoneal; Isoxazoles; Laminectomy; Male; Methylprednisolone; Rats; Spinal Cord; Spinal Cord Injuries; Treatment Outcome

2019
Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.
    Pain, 2018, Volume: 159, Issue:5

    Topics: Animals; Antineoplastic Agents; Astrocytes; Disease Models, Animal; Female; Ganglia, Spinal; Guanine Nucleotide Exchange Factors; Hydrazones; Hyperalgesia; Isoxazoles; Male; Mice; Mice, Knockout; Nerve Fibers; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Spinal Cord

2018
Cardiac Progenitors Induced from Human Induced Pluripotent Stem Cells with Cardiogenic Small Molecule Effectively Regenerate Infarcted Hearts and Attenuate Fibrosis.
    Shock (Augusta, Ga.), 2018, Volume: 50, Issue:6

    Topics: Animals; Cell Differentiation; Disease Models, Animal; Fibrosis; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Mice; Myocardial Infarction; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stem Cell Transplantation; Thiophenes

2018
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures.
    Inflammopharmacology, 2018, Volume: 26, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Free Radicals; Inflammation; Isoxazoles; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Seizures; Zonisamide

2018
Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead.
    European journal of medicinal chemistry, 2018, Jun-10, Volume: 153

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation; Interleukin-6; Isoxazoles; Lipopolysaccharides; Mice; Sepsis; Tumor Necrosis Factor-alpha

2018
Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction.
    Cardiovascular research, 2018, 08-01, Volume: 114, Issue:10

    Topics: 3T3-L1 Cells; Adiponectin; Animals; Apoptosis; Disease Models, Animal; Heart Ventricles; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Infarction; Myocytes, Cardiac; Organelle Biogenesis; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Stroke Volume; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2018
Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis.
    PloS one, 2018, Volume: 13, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Fibronectins; GTP-Binding Proteins; Humans; Isoxazoles; Mice; Mice, Inbred C57BL; Monocytes; Multiple Sclerosis; Naphthalenes; Piperidines; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Pyrrolidines; Quinolines; Spinal Cord; Transglutaminases

2018
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2018, 08-30, Volume: 86

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cholinergic Agents; Depressive Disorder; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Motor Activity; Phenylurea Compounds; Prefrontal Cortex

2018
Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:8

    Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Area Under Curve; Benzodioxoles; Benzoquinones; Biological Assay; Disease Models, Animal; Drug Repositioning; Female; Gene Expression; HSP90 Heat-Shock Proteins; Imidazoles; Isoxazoles; Lactams, Macrocyclic; Malaria, Falciparum; Mice; Models, Biological; Plasmodium falciparum; Protozoan Proteins; Resorcinols; Trypanosoma brucei brucei; Trypanosomiasis, African

2018
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.
    Nature communications, 2018, 07-03, Volume: 9, Issue:1

    Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Biomarkers; Cell Nucleus; Disease Models, Animal; Fibroblast Growth Factors; Healthy Volunteers; Hepatocytes; Humans; Intestinal Mucosa; Isoxazoles; Liver; Liver Cirrhosis, Biliary; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phosphorylation; Postprandial Period; Primary Cell Culture; Receptors, Cytoplasmic and Nuclear; Signal Transduction; src-Family Kinases; Tyrosine

2018
Synthesis of new coumarin tethered isoxazolines as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2018, 12-15, Volume: 28, Issue:23-24

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coumarins; Disease Models, Animal; Humans; Isoxazoles; Microvessels; Structure-Activity Relationship; Survival Rate

2018
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:2

    Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles

2019
Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis.
    International journal of molecular sciences, 2018, Dec-18, Volume: 19, Issue:12

    Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Bleomycin; Disease Models, Animal; Female; Histocompatibility Antigens Class II; Humans; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Inflammation; Intramolecular Oxidoreductases; Isoxazoles; Lung; Macrophage Migration-Inhibitory Factors; Male; Mice; Receptors, CXCR4; Vascular Remodeling

2018
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
    Stroke, 2019, Volume: 50, Issue:2

    Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Brain Injuries; Disease Models, Animal; Isoxazoles; Lipoxygenase Inhibitors; Macrophages; Mice; Mice, Knockout; Naphthalenes; Oxidative Stress; Subarachnoid Hemorrhage

2019
Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism.
    Autism research : official journal of the International Society for Autism Research, 2019, Volume: 12, Issue:3

    Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Grooming; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Receptor, trkB

2019
Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice.
    Behavioural brain research, 2019, 07-02, Volume: 366

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Astrocytes; Cognition; Cognition Disorders; Cognitive Dysfunction; Cytokines; Depression; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Phenylurea Compounds; Prefrontal Cortex

2019
Parecoxib improves the cognitive function of POCD rats via attenuating COX-2.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:11

    Topics: Animals; Apoptosis; Cognition; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hippocampus; Humans; Isoxazoles; Male; Neurons; Postoperative Cognitive Complications; Rats; Up-Regulation

2019
An Isoxazole Derivative SHU00238 Suppresses Colorectal Cancer Growth through miRNAs Regulation.
    Molecules (Basel, Switzerland), 2019, Jun-25, Volume: 24, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Computational Biology; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Mice; MicroRNAs; Molecular Structure; RNA Interference; Xenograft Model Antitumor Assays

2019
Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:1

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Osteoblasts; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid; Synovitis

2014
Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas.
    Anesthesiology, 2013, Volume: 118, Issue:6

    Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apnea; Disease Models, Animal; Drug Therapy, Combination; Isoxazoles; Male; Mice; Plethysmography; Propofol; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency

2013
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Animals; Autoimmune Diseases; Chemokines; Disease Models, Animal; Eye; Female; Gene Expression Regulation; Interferon-gamma; Interleukin-17; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Peptide Fragments; Rats; Retina; Retinol-Binding Proteins; RNA, Messenger; Th17 Cells; Uveitis

2013
Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model.
    Acta neurochirurgica, 2013, Volume: 155, Issue:8

    Topics: Animals; Basilar Artery; Disease Models, Animal; Hippocampus; Isoxazoles; Male; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial; Zonisamide

2013
Fear extinction and acute stress reactivity reveal a role of LPA(1) receptor in regulating emotional-like behaviors.
    Brain structure & function, 2014, Volume: 219, Issue:5

    Topics: Amygdala; Animals; Conditioning, Classical; Corticosterone; Cues; Disease Models, Animal; Emotions; Extinction, Psychological; Fear; Gene Expression Regulation; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Knockout; Neurons; Phosphopyruvate Hydratase; Propionates; Receptors, Lysophosphatidic Acid; Stress, Psychological; Time Factors

2014
Effects of parecoxib on the prevention of postoperative peritoneal adhesions in rats.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2013, Volume: 26, Issue:6

    Topics: Anastomosis, Surgical; Animals; Burns, Electric; Cecum; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Injections, Intramuscular; Isoxazoles; Male; Peritoneal Diseases; Plasminogen Activator Inhibitor 1; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tissue Adhesions; Tissue Plasminogen Activator; Wound Healing

2013
A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Isoxazoles; Male; Motor Activity; Neuroprotective Agents; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Stroke

2013
Leflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivo.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dihydroorotate Dehydrogenase; Disease Models, Animal; Down-Regulation; Humans; Isoxazoles; Leflunomide; Mice; Mice, SCID; Neuroblastoma; Oxidoreductases Acting on CH-CH Group Donors; S Phase; Xenograft Model Antitumor Assays

2013
Synthesis, analgesic, anti-inflammatory and in vitro antimicrobial activities of some novel isoxazole coupled quinazolin-4(3H)-one derivatives.
    Archives of pharmacal research, 2021, Volume: 44, Issue:8

    Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Disease Models, Animal; Female; Isoxazoles; Male; Mice; Quinazolinones; Rats; Rats, Wistar; Structure-Activity Relationship; Toxicity Tests

2021
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
    Life sciences, 2014, Jan-24, Volume: 95, Issue:1

    Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Isoxazoles; Ketanserin; Male; Morphine; Ondansetron; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Streptozocin; Zonisamide

2014
Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis.
    The Journal of surgical research, 2014, Volume: 187, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Catalase; Cecum; Disease Models, Animal; Intestinal Mucosa; Intestines; Isoxazoles; Leflunomide; Male; Malondialdehyde; Multiple Organ Failure; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Sepsis; Superoxide Dismutase

2014
Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.
    Bioorganic & medicinal chemistry letters, 2014, Mar-01, Volume: 24, Issue:5

    Topics: Adamantane; Amidohydrolases; Animals; Anti-Inflammatory Agents; Body Weight; Cannabinoids; Colitis; Disease Models, Animal; Enzyme Inhibitors; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Protein Binding; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

2014
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: alpha-Synuclein; Animals; Cell Count; Dependovirus; Disease Models, Animal; Dopaminergic Neurons; Isoxazoles; Male; Mice; Neuroprotective Agents; Parkinson Disease; Protein Aggregation, Pathological; Rats; Substantia Nigra; Time Factors; Zonisamide

2014
Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.
    Critical care medicine, 2014, Volume: 42, Issue:5

    Topics: Age Factors; Analysis of Variance; Animals; Benzimidazoles; Body Temperature Regulation; Capsaicin; Disease Models, Animal; Hypothermia, Induced; Isoxazoles; Male; Mice; Mice, Inbred C57BL; TRPM Cation Channels; TRPV Cation Channels

2014
Zonisamide attenuates hyperoxia-induced apoptosis in the developing rat brain.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35, Issue:11

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Disease Models, Animal; Hyperoxia; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Zonisamide

2014
Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.
    Journal of bone and mineral metabolism, 2015, Volume: 33, Issue:4

    Topics: Animals; Bone and Bones; Bone Remodeling; Bone Resorption; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal; Female; Femur; Humans; Immunoenzyme Techniques; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Propionates; Receptors, Lysophosphatidic Acid; Signal Transduction; X-Ray Microtomography

2015
Cyclic phosphatidic acid relieves osteoarthritis symptoms.
    Molecular pain, 2014, Aug-14, Volume: 10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Disease Models, Animal; Edema; Female; Follow-Up Studies; Humans; Isoxazoles; Joint Capsule; Male; Middle Aged; Osteoarthritis; Pain Measurement; Phosphatidic Acids; Propionates; Rabbits; RNA, Messenger; Synovial Membrane; Time Factors

2014
Activation of extrasynaptic GABA(A) receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons.
    Neuroscience bulletin, 2014, Volume: 30, Issue:5

    Topics: Animals; Benzothiadiazines; CA1 Region, Hippocampal; Convulsants; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Membrane Potentials; Neurons; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures

2014
Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo.
    European journal of pharmacology, 2015, Jan-05, Volume: 746

    Topics: Animals; Anticonvulsants; Antiparkinson Agents; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum Stress; Half-Life; Humans; Isoxazoles; Male; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Neuroprotective Agents; Parkinson Disease; Substantia Nigra; Thapsigargin; Tunicamycin; Zonisamide

2015
Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms.
    Neuroendocrinology, 2014, Volume: 100, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; HSP90 Heat-Shock Proteins; Humans; Insulin; Islets of Langerhans; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Resorcinols; RNA, Messenger

2014
FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation.
    World journal of gastroenterology, 2014, Oct-21, Volume: 20, Issue:39

    Topics: Adult; Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Apoptosis; Cell Line; Disease Models, Animal; Down-Regulation; Female; Humans; Inflammation Mediators; Isoxazoles; Lipopolysaccharides; Liver; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Middle Aged; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear

2014
Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress.
    The international journal of neuropsychopharmacology, 2014, Oct-31, Volume: 18, Issue:3

    Topics: Animals; Antipsychotic Agents; Brain; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gene Expression Regulation; Isoxazoles; Lipopolysaccharides; Male; Nitric Oxide Synthase Type II; Nitrites; Paliperidone Palmitate; Pyrimidines; Rats; Rats, Wistar; Restraint, Physical; Signal Transduction; Stress, Physiological; Toll-Like Receptor 4

2014
AUY922 effectively targets against activated B cell subtype of diffuse large B-cell lymphoma and low-grade lymphoma cells harboring genetic alteration-associated nuclear factor-κB activation.
    Leukemia & lymphoma, 2015, Volume: 56, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromosome Aberrations; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; Disease Models, Animal; Down-Regulation; Enzyme Activation; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mitochondria; Neoplasm Grading; NF-kappa B; Resorcinols; Signal Transduction; Translocation, Genetic; Tumor Burden; Xenograft Model Antitumor Assays

2015
The Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain.
    Cell biochemistry and biophysics, 2015, Volume: 72, Issue:1

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Administration Schedule; Hot Temperature; Inflammation; Injections, Intraperitoneal; Injections, Spinal; Isoxazoles; Male; Neuralgia; Pain Management; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Nerves

2015
Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury.
    British journal of pharmacology, 2015, Volume: 172, Issue:11

    Topics: Animals; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Femoral Artery; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Neointima; Pyrrolidines; Thiophenes

2015
High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept.
    Brain research bulletin, 2015, Volume: 112

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Astrocytes; Brain Injuries; Cholinergic Agents; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Isoxazoles; Male; Neurons; Neuroprotective Agents; Phenylurea Compounds; Rats, Sprague-Dawley

2015
Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
    Bioorganic & medicinal chemistry letters, 2015, Mar-15, Volume: 25, Issue:6

    Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Isoxazoles; Neuralgia; Protein Binding; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship

2015
Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis.
    Translational research : the journal of laboratory and clinical medicine, 2015, Volume: 166, Issue:1

    Topics: Alanine Transaminase; Animals; Apoptosis; Cell Line; Cytokines; Disease Models, Animal; HEK293 Cells; Hep G2 Cells; Humans; Isoxazoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Peritonitis; Peroxidase; Propionates; Receptors, Lysophosphatidic Acid; Sepsis; Signal Transduction; Translational Research, Biomedical

2015
Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.
    Brain research, 2015, Jun-22, Volume: 1611

    Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perception; Choline; Disease Models, Animal; Female; Heterozygote; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Transgenic; Phenylurea Compounds; Schizophrenia; Sensory Gating

2015
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
    Neurobiology of disease, 2015, Volume: 77

    Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Muscarinic Agonists; Neurons; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Valine

2015
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:11

    Topics: Animals; Antidepressive Agents; CA1 Region, Hippocampal; Chronic Disease; Dietary Sucrose; Disease Models, Animal; Exploratory Behavior; Feeding Behavior; GABA Modulators; Imidazoles; Isoxazoles; Male; Random Allocation; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Restraint, Physical; Social Behavior; Stress, Psychological; Synapses; Synaptic Transmission; Tissue Culture Techniques; Triazines

2015
Sleep restores behavioral plasticity to Drosophila mutants.
    Current biology : CB, 2015, May-18, Volume: 25, Issue:10

    Topics: Adenylyl Cyclases; Alzheimer Disease; Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Fatty Acid-Binding Proteins; Female; Isoxazoles; Male; Memory, Long-Term; Memory, Short-Term; Mutation; Organophosphorus Compounds; Receptors, GABA; Reserpine; Sleep

2015
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:4

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Blood Pressure; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Isoxazoles; Kidney; Lipocalin-2; Lipocalins; Male; Prospective Studies; Proto-Oncogene Proteins; Random Allocation; Rats, Wistar; Reperfusion Injury; Reproducibility of Results; Severity of Illness Index; Time Factors; Treatment Outcome

2015
Antifibrotic effect of lysophosphatidic acid receptors LPA1 and LPA3 antagonist on experimental murine scleroderma induced by bleomycin.
    Experimental dermatology, 2015, Volume: 24, Issue:9

    Topics: Animals; Bleomycin; Cell Count; Chemokine CCL3; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Interferon-gamma; Isoxazoles; Lung; Mast Cells; Mice; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1

2015
Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Line, Tumor; Cholangiocarcinoma; Disease Models, Animal; Female; Follow-Up Studies; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Isoxazoles; Male; Mice; Middle Aged; Molecular Targeted Therapy; Neoplasm Staging; Prognosis; Resorcinols; Treatment Outcome; Xenograft Model Antitumor Assays

2015
3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer.
    Inflammation, 2016, Volume: 39, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Binding Sites; Carcinoma, Ehrlich Tumor; Catalytic Domain; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; HeLa Cells; Humans; Inflammation; Isoxazoles; Lipoxygenase; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Thiophenes

2016
Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.
    Annals of surgery, 2016, Volume: 264, Issue:2

    Topics: Adenocarcinoma; Animals; Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Esophageal Neoplasms; HSP90 Heat-Shock Proteins; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Resorcinols

2016
Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy.
    Molecular and cellular endocrinology, 2016, Jan-05, Volume: 419

    Topics: Animals; Cell Line; Cell Proliferation; Cytokines; Diabetic Nephropathies; Disease Models, Animal; Gene Expression Regulation; Humans; Isoxazoles; Male; Mesangial Cells; Mice; Nicotinamide Phosphoribosyltransferase; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Transcription, Genetic

2016
Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats.
    Acta physiologica (Oxford, England), 2016, Volume: 216, Issue:3

    Topics: Animals; Animals, Newborn; Blotting, Western; Bronchopulmonary Dysplasia; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hyperoxia; Isoxazoles; Propionates; Rats; Rats, Mutant Strains; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Lysophosphatidic Acid

2016
Pretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats.
    BMC anesthesiology, 2015, Nov-17, Volume: 15

    Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2015
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glycogen Phosphorylase; Hypoglycemic Agents; Isoxazoles; Molecular Structure; Rats; Rats, Zucker; Spiro Compounds; Structure-Activity Relationship

2016
Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming.
    Scientific reports, 2016, Jan-05, Volume: 6

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glycolysis; Hep G2 Cells; Humans; Isoxazoles; Liver Regeneration; Metabolome; Metabolomics; Mice; Mice, Knockout; Models, Biological; Protein Kinases; Receptors, Cytoplasmic and Nuclear

2016
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo.
    Experimental cell research, 2016, Jan-15, Volume: 340, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytarabine; Disease Models, Animal; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Leukemia; Male; Neoplasm Proteins; Resorcinols; Signal Transduction

2016
The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Aged; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Dexamethasone; Disease Models, Animal; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoxazoles; Lung; Macrophage Migration-Inhibitory Factors; Macrophages; Male; Middle Aged; Ozone; Pneumonia; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Respiratory Hypersensitivity; RNA, Messenger; Smoking; Sputum

2016
Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
    Experimental neurology, 2016, Volume: 277

    Topics: Anesthetics; Animals; Brain Injuries; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Electric Stimulation; Functional Laterality; GABA Agonists; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Neurons; Receptors, GABA-A; RNA, Messenger; Signal Transduction

2016
Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression; Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Membrane Proteins; Mitochondrial Proteins; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Resorcinols; Tumor Burden; X-Box Binding Protein 1; Xenograft Model Antitumor Assays

2016
Aminomethylphosphonic acid inhibits growth and metastasis of human prostate cancer in an orthotopic xenograft mouse model.
    Oncotarget, 2016, Mar-01, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cyclin D1; Disease Models, Animal; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; Isoxazoles; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphonates; Prostatic Neoplasms; Tetrazoles; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2016
Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy.
    Epilepsia, 2016, Volume: 57, Issue:4

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Isoxazoles; Kindling, Neurologic; Nitriles; Pyridones; Rats; Rats, Sprague-Dawley; Zonisamide

2016
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
    European journal of pharmacology, 2016, Mar-15, Volume: 775

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Models, Animal; Isoxazoles; Kindling, Neurologic; Male; Mice, Inbred ICR; Motor Activity; Nicotinic Agonists; Pentylenetetrazole; Psychomotor Performance; Pyrrolidines; Receptors, Nicotinic; Rotarod Performance Test; Seizures; Social Behavior

2016
Comparative speed of kill of sarolaner (Simparica) and afoxolaner (NexGard) against induced infestations of Amblyomma americanum on dogs.
    Parasites & vectors, 2016, Feb-19, Volume: 9

    Topics: Acaricides; Administration, Oral; Animals; Disease Models, Animal; Dogs; Isoxazoles; Ixodidae; Parasite Load; Placebos; Tick Infestations; Time Factors; Treatment Outcome

2016
Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model.
    Cancer science, 2016, Volume: 107, Issue:5

    Topics: Animals; Benzophenones; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Isoxazoles; Lymphatic Metastasis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mouth Neoplasms; Neoplasm Invasiveness; Transcription Factor AP-1; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2016
ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.
    Naunyn-Schmiedeberg's archives of pharmacology, 2016, Volume: 389, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Aripiprazole; Behavior, Animal; Benzodiazepines; Conditioning, Psychological; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Isoxazoles; Male; Maze Learning; Mice; Motor Activity; Olanzapine; Punishment; Rats, Wistar; Reaction Time; Receptors, Serotonin; Risperidone; Serotonin Antagonists; Sulfonamides

2016
Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.
    Pharmacological research, 2016, Volume: 110

    Topics: Animals; Binding Sites; Blood-Brain Barrier; Brain; Brain Injuries; Cannabinoid Receptor Agonists; Cell Line; Disease Models, Animal; Humans; Isoxazoles; Male; Malonates; Mice; Models, Biological; Nerve Degeneration; Neurons; Neuroprotective Agents; Permeability; Protein Binding; Rats, Wistar; Receptor, Cannabinoid, CB2; Transfection

2016
Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice.
    Experimental neurology, 2016, Volume: 280

    Topics: Anesthetics; Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Functional Laterality; GABA Agents; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Immunosuppressive Agents; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Ribosomal Protein S6 Kinases; Sirolimus; Time Factors

2016
Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response.
    Free radical biology & medicine, 2016, Volume: 96

    Topics: Animals; Antiviral Agents; Azulenes; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Host-Pathogen Interactions; Humans; Indans; Influenza A virus; Influenza, Human; Interferons; Isoxazoles; Lung; MAP Kinase Signaling System; Membrane Proteins; Mice; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Sesquiterpenes; Viral Load; Virus Replication

2016
Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease.
    Kidney international, 2016, Volume: 90, Issue:2

    Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Endothelial Cells; Endothelin Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glomerular Basement Membrane; Hypertension; Isoxazoles; Laminin; Mesangial Cells; Mice; Mice, Inbred C57BL; Nephritis, Hereditary; Podocytes; Proteinuria; Pseudopodia; Receptor, Endothelin A; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiophenes; Up-Regulation

2016
[Effect of Leflunomideon Inflammatory Factors and Immune Function in Rats with Chronic Glomerulonephritis].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2016, Volume: 47, Issue:2

    Topics: Animals; Chronic Disease; Disease Models, Animal; Glomerulonephritis; Inflammation; Interleukin-6; Isoxazoles; Leflunomide; Rats; RNA, Messenger; Serum Albumin, Bovine; Tumor Necrosis Factor-alpha

2016
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
    Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraperitoneal; Isoxazoles; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship

2016
Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.
    Hearing research, 2016, Volume: 341

    Topics: Animals; Basement Membrane; Body Temperature; Capillaries; Cell Line; Collagen Type IV; Disease Models, Animal; Endothelin-1; Extracellular Matrix; Gene Expression Regulation; Hypoxia; Isoxazoles; Laminin; Mice; Nephritis, Hereditary; Oxidative Stress; Phenotype; Stria Vascularis; Thiophenes

2016
Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain.
    Neuroscience bulletin, 2016, Volume: 32, Issue:5

    Topics: Animals; Biophysics; Bone Neoplasms; Cancer Pain; Carcinoma; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia, Spinal; Gene Expression Regulation, Neoplastic; Hyperalgesia; Isoxazoles; Lysophospholipids; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain Measurement; Patch-Clamp Techniques; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid

2016
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2017, Apr-01, Volume: 19, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds, Heterocyclic; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Isoxazoles; Male; Mice; Mice, Knockout; Phenylurea Compounds; Quinuclidines

2017
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:12

    Topics: Animals; Blood Platelets; Calcium Signaling; Chenodeoxycholic Acid; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinogen; Genotype; Hemostasis; Humans; Isoxazoles; Ligands; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cytoplasmic and Nuclear; Thrombosis; Time Factors

2016
Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice.
    Scientific reports, 2016, 11-24, Volume: 6

    Topics: Animals; Atherosclerosis; Cholesterol, LDL; Disease Models, Animal; Endocytosis; Humans; Isoxazoles; Lysophospholipids; Mice; Propionates; Receptors, LDL; Receptors, Lysophosphatidic Acid; Signal Transduction

2016
The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.
    Journal of hepatology, 2017, Volume: 66, Issue:4

    Topics: Animals; Benzoates; Bile Acids and Salts; Bilirubin; Capillaries; Cholesterol; Disease Models, Animal; Hypertension, Portal; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Vascular Remodeling; Vascular Resistance

2017
Effects of chronic exposure to low dose THIP on brainstem neuronal excitability in mouse models of Rett syndrome: Evidence from symptomatic females.
    Neuropharmacology, 2017, Volume: 116

    Topics: Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Isoxazoles; Membrane Potentials; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Random Allocation; Rett Syndrome; Tissue Culture Techniques

2017
Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice.
    Human molecular genetics, 2017, 03-15, Volume: 26, Issue:6

    Topics: Animals; Brain; Cognition; Disease Models, Animal; Dystrophin; Fear; GABAergic Neurons; Humans; Isoxazoles; Mice; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Receptors, GABA-A; Stress, Psychological

2017
Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice.
    Kidney international, 2017, Volume: 91, Issue:6

    Topics: Animals; Cell Line; Diabetes Mellitus; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Glycogen Synthase Kinase 3 beta; Isoxazoles; Kidney Cortex; Lysophospholipids; Male; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction; Smad2 Protein; Smad3 Protein; Sterol Regulatory Element Binding Protein 1; Time Factors; Transfection; Transforming Growth Factor beta

2017
Does leflunomide attenuate the sepsis-induced acute lung injury?
    Pediatric surgery international, 2008, Volume: 24, Issue:8

    Topics: Acute Lung Injury; Adjuvants, Immunologic; Animals; Disease Models, Animal; Glutathione; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Sepsis; Spectrophotometry; Superoxide Dismutase; Treatment Outcome

2008
FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:11

    Topics: Alkynes; Animals; Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Male; Nitriles; Platelet-Derived Growth Factor; Rats; Rats, Inbred WF; Risk Factors; Tacrolimus; Transforming Growth Factor beta; Transplantation, Homologous

2008
The active metabolite of leflunomide A771726 inhibits corneal neovascularization.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:3

    Topics: Aniline Compounds; Animals; Cell Nucleus; Cell Proliferation; Corneal Neovascularization; Crotonates; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines; Umbilical Veins

2008
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
    Bioorganic & medicinal chemistry letters, 2008, 08-01, Volume: 18, Issue:15

    Topics: Administration, Oral; Animals; Carboxylic Acids; Cholestasis; Crystallography, X-Ray; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gastric Mucosa; Haplorhini; Isoxazoles; Mice; Molecular Conformation; Molecular Structure; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Stomach; Structure-Activity Relationship; Transcription Factors

2008
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
    The Journal of surgical research, 2009, Volume: 151, Issue:1

    Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles

2009
Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein.
    American journal of respiratory cell and molecular biology, 2009, Volume: 40, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage; Cell Line; Disease Models, Animal; Humans; Interleukin-13; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Signal Transduction; STAT6 Transcription Factor; Up-Regulation

2009
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect.
    Parkinsonism & related disorders, 2009, Volume: 15, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Isoxazoles; Jaw; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tacrine; Tremor; Zonisamide

2009
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Administration, Oral; Amines; Animals; Arthritis; Benzene; Crystallography, X-Ray; Disease Models, Animal; Humans; Isoxazoles; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Structure; Phthalazines; Protein Kinase Inhibitors; Rats; Structure-Activity Relationship

2008
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
    Prostaglandins, leukotrienes, and essential fatty acids, 2008, Volume: 79, Issue:6

    Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Gene Expression Regulation, Enzymologic; Hindlimb; Hyperalgesia; Inflammation; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Zymosan

2008
Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis.
    Respiratory medicine, 2009, Volume: 103, Issue:4

    Topics: Animals; Biomarkers; Brazil; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Isoxazoles; Lung; Pleura; Pleural Diseases; Pleurodesis; Rabbits; Random Allocation; Silver Nitrate; Talc

2009
Paliperidone suppresses the development of the aggressive phenotype in a developmentally sensitive animal model of escalated aggression.
    Psychopharmacology, 2009, Volume: 203, Issue:4

    Topics: Age Factors; Aggression; Animals; Antipsychotic Agents; Behavior, Animal; Cocaine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Isoxazoles; Male; Mesocricetus; Paliperidone Palmitate; Phenotype; Pyrimidines; Reaction Time

2009
The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis.
    Diabetes & metabolism, 2008, Volume: 34, Issue:6 Pt 2

    Topics: Animals; Bile Acids and Salts; Chromosome Mapping; Chromosomes, Human, Pair 12; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Humans; Insulin; Isoxazoles; Liver Regeneration; Mice; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2008
Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion.
    Digestive diseases and sciences, 2010, Volume: 55, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Intestinal Diseases; Intestinal Mucosa; Isoxazoles; Leflunomide; Malondialdehyde; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Treatment Outcome

2010
A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Colitis; Dextran Sulfate; Disease Models, Animal; Drug Delivery Systems; Humans; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Mice, Inbred C57BL; Monocytes; Quinolines

2009
Improved myocardial protection in the failing heart by selective endothelin-A receptor blockade.
    The Journal of thoracic and cardiovascular surgery, 2009, Volume: 137, Issue:4

    Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Endothelin A Receptor Antagonists; Heart; Heart Failure; Isoxazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sulfonamides

2009
Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion.
    Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:6

    Topics: Acute Disease; Animals; Apoptosis; Coronary Stenosis; Coronary Vessels; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Echocardiography; Injections, Intraperitoneal; Isoxazoles; Ligation; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Ventricular Remodeling

2009
PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.
    Archives of pharmacal research, 2009, Volume: 32, Issue:5

    Topics: Adipogenesis; Administration, Oral; Animals; Blood Glucose; Blood Volume; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Genes, Reporter; Humans; Hypoglycemic Agents; Isoxazoles; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; PPAR gamma; Propionates; Rosiglitazone; Thiazolidinediones; Thiophenes; Transfection; Water-Electrolyte Balance

2009
Zonisamide: in Parkinson's disease.
    CNS drugs, 2009, Volume: 23, Issue:8

    Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Epilepsy; Humans; Isoxazoles; Parkinson Disease; Zonisamide

2009
Ampakine therapy to counter fentanyl-induced respiratory depression.
    Respiratory physiology & neurobiology, 2009, Aug-31, Volume: 168, Issue:1-2

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Fentanyl; Heart Rate; Hyperalgesia; Isoxazoles; Male; Pain Measurement; Phrenic Nerve; Plethysmography; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Respiratory Insufficiency; Time Factors

2009
Leflunomide: is a new oral agent in treatment of acute pancreatitis?
    Pancreas, 2010, Volume: 39, Issue:2

    Topics: Administration, Oral; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Isoxazoles; Leflunomide; Male; Malondialdehyde; Neutrophil Infiltration; Nitric Oxide; Pancreas; Pancreatitis, Acute Necrotizing; Peroxidase; Pulmonary Edema; Rats; Rats, Wistar; Severity of Illness Index; Taurocholic Acid

2010
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Generalized; Frontal Lobe; Hippocampus; Isoxazoles; Kindling, Neurologic; Male; Olfactory Bulb; Rats; Rats, Wistar; Seizures; Valproic Acid; Zonisamide

2010
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
    Journal of medicinal chemistry, 2009, Dec-24, Volume: 52, Issue:24

    Topics: Amides; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Dogs; Glucagon-Like Peptide 1; Glucose; Humans; Isoxazoles; Rats; Receptors, G-Protein-Coupled

2009
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance.
    Experimental neurology, 2010, Volume: 221, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glutathione; Isoxazoles; Male; Mass Spectrometry; Mice; Monoamine Oxidase; MPTP Poisoning; Regression, Psychology; Tyrosine 3-Monooxygenase; Zonisamide

2010
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.
    Pain, 2010, Volume: 148, Issue:2

    Topics: Analysis of Variance; Animals; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Functional Laterality; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Injections, Spinal; Intramolecular Oxidoreductases; Isoxazoles; Lectins; Macrophage Migration-Inhibitory Factors; Male; Microglia; Mitogen-Activated Protein Kinase Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; tau Proteins; Up-Regulation

2010
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model.
    Fertility and sterility, 2010, May-15, Volume: 93, Issue:8

    Topics: Angiogenesis Inhibitors; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Endometriosis; Female; Isoxazoles; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2010
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
    Hippocampus, 2011, Volume: 21, Issue:4

    Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Male; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors

2011
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
    Neuroscience bulletin, 2010, Volume: 26, Issue:1

    Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Isoxazoles; Lactones; Lipid Peroxidation; Male; Meloxicam; Memory; Mice; Motor Activity; Naproxen; Nitrites; Random Allocation; Stress, Psychological; Sulfonamides; Sulfones; Thiazines; Thiazoles

2010
Antagonism of macrophage migration inhibitory factor decreases cyclophosphamide cystitis in mice.
    Neurourology and urodynamics, 2010, Volume: 29, Issue:8

    Topics: Animals; Cyclophosphamide; Cystitis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalgesia; Inflammation Mediators; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Sensory Thresholds; Urinary Bladder; Urination

2010
Effect of leflunomide on liver regeneration after partial hepatectomy in rats.
    Pediatric surgery international, 2010, Volume: 26, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Catalase; Disease Models, Animal; Hepatectomy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Liver Diseases; Liver Regeneration; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxidase; Protein Carbonylation; Rats; Rats, Wistar; Treatment Outcome

2010
Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.
    Critical care medicine, 2010, Volume: 38, Issue:4

    Topics: Animals; Anthracenes; Blotting, Western; Dimethyl Sulfoxide; Disease Models, Animal; Hematopoiesis; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Leflunomide; Lung Injury; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Nitric Oxide Synthase; Peritonitis; Peroxynitrous Acid; Rhodamines; Signal Transduction; Transcription Factor AP-1

2010
Neuroprotective effects of zonisamide target astrocyte.
    Annals of neurology, 2010, Volume: 67, Issue:2

    Topics: Animals; Antiparkinson Agents; Astrocytes; Basal Ganglia; Carbidopa; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Glial Fibrillary Acidic Protein; Glutathione; Isoxazoles; Male; Mice; Mice, Inbred ICR; Nerve Growth Factors; Neuroprotective Agents; Oxidopamine; Parkinson Disease; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Tyrosine 3-Monooxygenase; Zonisamide

2010
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice.
    Metabolic brain disease, 2010, Volume: 25, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopamine; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Substantia Nigra; Treatment Outcome; Zonisamide

2010
Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
    Folia biologica, 2010, Volume: 56, Issue:2

    Topics: Alkynes; Animals; Blood Pressure; Disease Models, Animal; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Diseases; Leflunomide; Male; Nitriles; Placebos; Rats; Rats, Transgenic; Reperfusion Injury

2010
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
    Neuropharmacology, 2010, Volume: 59, Issue:6

    Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels, T-Type; Cyclopropanes; Disease Models, Animal; Essential Tremor; Estranes; Ethosuximide; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Naphthalenes; Nitriles; Receptors, GABA-A; Zonisamide

2010
A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Flow Cytometry; Gene Deletion; Gene Expression Regulation; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Spinal Cord; Vascular Cell Adhesion Molecule-1

2010
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jul-21, Volume: 30, Issue:29

    Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Interneurons; Isoxazoles; Male; Mice; Mice, Knockout; Neural Inhibition; Neurons; Patch-Clamp Techniques; Synaptic Transmission

2010
Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives--comparison to paliperidone and risperidone in mice and rats.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:2

    Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Electrocardiography; Excitatory Amino Acid Antagonists; Female; Heart; Heart Rate; Hyperkinesis; Isoxazoles; Lethal Dose 50; Male; Maximum Tolerated Dose; Mice; Mice, Inbred Strains; Paliperidone Palmitate; Pyrimidines; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Toxicity Tests, Acute

2010
Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:4

    Topics: Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Phosphodiesterase 5 Inhibitors; Piperazines; Pulmonary Artery; Pulmonary Circulation; Purines; Sildenafil Citrate; Subclavian Artery; Sulfones; Thiophenes; Treatment Outcome

2010
High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:9

    Topics: Animals; Apolipoprotein A-I; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokine CX3CL1; Chemokines; Chemotaxis, Leukocyte; Disease Models, Animal; Down-Regulation; Endothelial Cells; Humans; I-kappa B Proteins; Injections, Intravenous; Isoxazoles; Lipoproteins, HDL; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-KappaB Inhibitor alpha; Phosphorylation; PPAR gamma; Receptors, CCR2; Receptors, Chemokine; Receptors, Interleukin-8A; RNA, Messenger; Sulfones; Transcription Factor RelA

2010
Endothelin A receptor blockade improves regression of flow-induced pulmonary vasculopathy in piglets.
    The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:3

    Topics: Angiopoietin-1; Animals; Animals, Newborn; Antihypertensive Agents; Aorta; Apoptosis; Cell Proliferation; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy; Isoxazoles; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Circulation; Pulmonary Embolism; Receptor, Endothelin A; Receptor, TIE-2; RNA, Messenger; Sulfones; Swine; Time Factors

2010
Zonisamide suppresses the tonic phase but not the clonic phase of generalized seizures in developing rats.
    Epilepsy research, 2010, Volume: 92, Issue:2-3

    Topics: Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Incidence; Isoxazoles; Male; Rats; Rats, Wistar; Reaction Time; Seizures; Zonisamide

2010
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
    Neuropharmacology, 2011, Volume: 60, Issue:7-8

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Animal; Electrodes; Epilepsy; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Mice; Mice, Inbred C57BL; Microarray Analysis; Motion Pictures; Piperazines; Potassium Channel Blockers; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Software; Somatosensory Cortex

2011
Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.
    Psychopharmacology, 2011, Volume: 214, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Exploratory Behavior; Female; GABA-A Receptor Agonists; Isoxazoles; Motor Activity; Phencyclidine; Rats; Receptors, GABA-A; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Time Factors

2011
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice.
    Metabolic brain disease, 2010, Volume: 25, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Antiparkinson Agents; Disease Models, Animal; Dopamine; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Substantia Nigra; Treatment Outcome; Zonisamide

2010
Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice.
    Rheumatology international, 2012, Volume: 32, Issue:3

    Topics: Animals; Antigen-Antibody Complex; Ascites; Cell Proliferation; Disease Models, Animal; Female; Graft vs Host Disease; Immunity, Innate; Immunosuppressive Agents; Isoxazoles; Kidney; Leflunomide; Longevity; Lupus Nephritis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Signal Transduction; Spleen; Toll-Like Receptor 9

2012
Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity.
    Brain research, 2011, Apr-12, Volume: 1384

    Topics: Analysis of Variance; Animals; Antioxidants; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Glial Fibrillary Acidic Protein; Isoxazoles; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Growth Factors; Neurons; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Time Factors; Zonisamide

2011
Effects of intramuscular parecoxib administration on vasospasm in an experimental subarachnoid hemorrhage model.
    The International journal of neuroscience, 2011, Volume: 121, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Injections, Intramuscular; Isoxazoles; Male; Rabbits; Random Allocation; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2011
DHODH modulates transcriptional elongation in the neural crest and melanoma.
    Nature, 2011, Mar-24, Volume: 471, Issue:7339

    Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Dihydroorotate Dehydrogenase; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Isoxazoles; Leflunomide; Melanoma; Mice; Neural Crest; Oxidoreductases Acting on CH-CH Group Donors; Proto-Oncogene Proteins B-raf; Rats; Stem Cells; Transcription, Genetic; Xenograft Model Antitumor Assays; Zebrafish

2011
Identification of potent, soluble, and orally active TRPV1 antagonists.
    Bioorganic & medicinal chemistry letters, 2011, Apr-15, Volume: 21, Issue:8

    Topics: Administration, Oral; Amides; Animals; Disease Models, Animal; Humans; Isoxazoles; Pain; Rats; TRPV Cation Channels

2011
Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation.
    Journal of psychiatric research, 2011, Volume: 45, Issue:9

    Topics: Amphetamine; Animals; Animals, Newborn; Antipsychotic Agents; Central Nervous System Stimulants; Disease Models, Animal; Drug Interactions; Female; Isoxazoles; Motor Activity; Paliperidone Palmitate; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrimidines; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Time Factors

2011
Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse.
    Neurobiology of disease, 2011, Volume: 43, Issue:3

    Topics: Animals; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Patch-Clamp Techniques; Purkinje Cells; Receptor Aggregation; Receptors, GABA-A; Synaptic Potentials

2011
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.
    Bioorganic & medicinal chemistry, 2011, Jun-15, Volume: 19, Issue:12

    Topics: Amidohydrolases; Animals; Colitis; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoxazoles; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure

2011
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
    PloS one, 2011, Volume: 6, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Thrombosis

2011
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
    Respiratory research, 2011, Jun-23, Volume: 12

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling

2011
Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801.
    Neuroscience letters, 2011, Aug-18, Volume: 500, Issue:3

    Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Extracellular Space; Female; Glutamic Acid; Isoxazoles; Male; Maternal Exposure; Paliperidone Palmitate; Poly I-C; Prefrontal Cortex; Pregnancy; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenia

2011
Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles.
    Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

    Topics: Administration, Oral; Amides; Animals; Capsaicin; Cyclohexanols; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Isoxazoles; Microsomes, Liver; Rats; Structure-Activity Relationship; TRPV Cation Channels

2011
A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide.
    Neurobiology of disease, 2011, Volume: 44, Issue:2

    Topics: Animals; Anticonvulsants; Brain Ischemia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Hippocampus; Isoxazoles; Long-Term Potentiation; Male; Neuroprotective Agents; Nitric Oxide; Organ Culture Techniques; Rats; Rats, Wistar; Signal Transduction; Zonisamide

2011
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
    Developmental neuroscience, 2011, Volume: 33, Issue:5

    Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Mice; Mice, Knockout; Motor Activity; Neuropsychological Tests; Receptors, GABA-A

2011
Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.
    Arthritis and rheumatism, 2012, Volume: 64, Issue:5

    Topics: Animals; Benzophenones; Bleomycin; Cells, Cultured; Collagen; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Proto-Oncogene Proteins c-fos; RNA, Small Interfering; Scleroderma, Systemic; Signal Transduction; Transcription Factor AP-1; Transfection; Transforming Growth Factor beta; Up-Regulation

2012
Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory.
    Current Alzheimer research, 2011, Volume: 8, Issue:8

    Topics: Animals; Attention; Cognition; Cognition Disorders; Disease Models, Animal; Isoxazoles; Male; Memory; Memory Disorders; Neural Inhibition; Nootropic Agents; Rats; Rats, Wistar; Reaction Time; Recognition, Psychology; Time Factors; Treatment Outcome; Vestibular Diseases

2011
PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:9

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Brain; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Drug Interactions; Female; Half-Life; Hallucinogens; Isoxazoles; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Phencyclidine; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tissue Distribution

2012
Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors.
    Cancer immunology, immunotherapy : CII, 2012, Volume: 61, Issue:8

    Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Flow Cytometry; Glioblastoma; Immunohistochemistry; Immunotherapy, Adoptive; Interferon-gamma; Isoxazoles; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344

2012
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.
    Brain research, 2012, Mar-14, Volume: 1443

    Topics: Alanine; Animals; Antipsychotic Agents; Carrier Proteins; Disease Models, Animal; Gene Knockdown Techniques; Isoxazoles; Mice; Nerve Tissue Proteins; Propionates; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Uracil

2012
Protective effect of PNU-120596, a selective alpha7 nicotinic acetylcholine receptor-positive allosteric modulator, on myocardial ischemia-reperfusion injury in rats.
    Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cytokines; Disease Models, Animal; Inflammation; Isoxazoles; Lipid Peroxidation; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NF-kappa B; Nicotinic Agonists; Phenylurea Compounds; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2012
[Efficacy and tolerance of rezonizate in complex with fluoroquinolones or mycobutin on a model of experimental murine tuberculosis].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2011, Volume: 56, Issue:7-8

    Topics: Animals; Antibiotics, Antitubercular; Disease Models, Animal; Drug Therapy, Combination; Drug Tolerance; Fluoroquinolones; Gatifloxacin; Isoxazoles; Levofloxacin; Mice; Mycobacterium tuberculosis; Ofloxacin; Oxazolidinones; Rifabutin; Tuberculosis

2011
Synergistic antidepressant-like action of gaboxadol and escitalopram.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:10

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dentate Gyrus; Depression; Disease Models, Animal; Drug Resistance; Drug Synergism; Drug Therapy, Combination; GABA-A Receptor Agonists; Isoxazoles; Male; Neurogenesis; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Up-Regulation

2012
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
    Journal of Alzheimer's disease : JAD, 2012, Volume: 31, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Calcium; Calcium-Binding Proteins; Cell Survival; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Glycoproteins; Humans; Indans; Isoxazoles; Ligands; Maze Learning; Memory Disorders; Metalloproteases; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Neuroblastoma; Nootropic Agents; Panax; Peptide Fragments; Phytotherapy; Piperidines; Plant Proteins; Presenilin-1; Propionates; Protein Binding; Receptors, Lysophosphatidic Acid; Signal Transduction; Time Factors; Transfection

2012
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:3

    Topics: Animals; Anticholesteremic Agents; Aorta; Atherosclerosis; Benzoates; Biological Transport; Cholesterol; Cholesterol Ester Transfer Proteins; Diet, High-Fat; Disease Models, Animal; Feces; Female; Humans; Isoxazoles; Lipoproteins, HDL; Liver; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Species Specificity; Structure-Activity Relationship

2012
T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice.
    Biotechnology letters, 2012, Volume: 34, Issue:12

    Topics: Animals; Benzophenones; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Enzymes; Gastrointestinal Agents; Hepatitis, Animal; Isoxazoles; Lipopolysaccharides; Liver; Mice; Survival Analysis

2012
A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD.
    Neuroscience letters, 2012, Oct-18, Volume: 528, Issue:1

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease Models, Animal; Immunohistochemistry; Isoxazoles; Male; Maze Learning; Memory; Methylphenidate; Nicotinic Agonists; Pyrrolidines; Rats; Rats, Inbred SHR; Receptors, Nicotinic

2012
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.
    British journal of pharmacology, 2013, Volume: 169, Issue:3

    Topics: Acute Pain; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Body Temperature Regulation; Bridged Bicyclo Compounds, Heterocyclic; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nociceptive Pain; Pain Measurement; Phenylurea Compounds; Quinuclidines

2013
Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.
    Neuropharmacology, 2013, Volume: 65

    Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Disease Models, Animal; Inflammation; Isoxazoles; Male; Mice; Mice, Inbred ICR; Neuralgia; Nicotinic Agonists; Phenylurea Compounds; Receptors, Nicotinic; Treatment Outcome

2013
Effect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with Parkinson's disease.
    Biochemical and biophysical research communications, 2012, Nov-23, Volume: 428, Issue:3

    Topics: Animals; Anticonvulsants; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Drug Therapy, Combination; Gene Expression; Gene Expression Profiling; Isoxazoles; Levodopa; Male; Oligonucleotide Array Sequence Analysis; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rats, Wistar; Zonisamide

2012
Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:1

    Topics: Animals; Aorta; Aortic Diseases; beta Catenin; Blood Pressure; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GTP-Binding Proteins; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Osteogenesis; Phosphorylation; Protein Glutamine gamma Glutamyltransferase 2; Quercetin; Rats; Rats, Wistar; Signal Transduction; Transglutaminases; Vascular Calcification; Warfarin

2013
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
    Science translational medicine, 2012, Dec-05, Volume: 4, Issue:163

    Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Isoxazoles; Mice; Purkinje Cells; Ubiquitin-Protein Ligases

2012
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:5

    Topics: Anilides; Animals; Benzamides; Biphenyl Compounds; Cell Proliferation; Chlorhexidine; Connective Tissue Growth Factor; Cytoskeleton; Disease Models, Animal; Epithelial Cells; Epithelium; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Peritoneal Fibrosis; Receptors, Lysophosphatidic Acid; Trans-Activators; Transcription Factors

2013
Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.
    Cancer biology & therapy, 2013, Volume: 14, Issue:4

    Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Division; Cell Growth Processes; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Down-Regulation; G2 Phase; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Male; Mice; Mice, Transgenic; Prostatic Neoplasms; Radiation-Sensitizing Agents; Random Allocation; Resorcinols; Signal Transduction; Xenograft Model Antitumor Assays

2013
Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:5

    Topics: Animals; Cannabinoids; Chronic Disease; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cannabinoid, CB1; Sciatic Neuropathy; Species Specificity; Treatment Outcome

2013
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
    Carcinogenesis, 2002, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Genes, APC; Intestinal Neoplasms; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides

2002
The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin.
    The Journal of investigative dermatology, 2002, Volume: 119, Issue:5

    Topics: Acute Disease; Animals; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Isoenzymes; Isoxazoles; Mice; Mice, Inbred Strains; Neovascularization, Physiologic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Skin; Sulfonamides; Tensile Strength; Wound Healing

2002
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
    Bioorganic & medicinal chemistry letters, 2003, Mar-10, Volume: 13, Issue:5

    Topics: Administration, Oral; Animals; Biological Availability; COS Cells; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Isoxazoles; Mice; Mice, Mutant Strains; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors

2003
Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:6

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Humans; Iodine Radioisotopes; Isoxazoles; Myocardial Infarction; Myocardial Reperfusion Injury; Purines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Sertraline; Transfection

2003
Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures.
    Brain research. Molecular brain research, 2003, Aug-19, Volume: 116, Issue:1-2

    Topics: Amino Acid Transport System X-AG; Amygdala; Animals; Anticonvulsants; Blotting, Western; Carrier Proteins; Chlorides; Chronic Disease; Disease Models, Animal; Epilepsy; Ferric Compounds; Frontal Lobe; GABA Plasma Membrane Transport Proteins; Hippocampus; Isoxazoles; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Rats; Rats, Wistar; Zonisamide

2003
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:10

    Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, Volume: 9, Issue:11

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cysteine; Disease Models, Animal; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Isoxazoles; Liver; Male; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ribosomal Proteins; Saccharomyces cerevisiae Proteins

2003
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
    Pain, 2004, Volume: 107, Issue:1-2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Isoenzymes; Isoxazoles; Organic Chemicals; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Radiology; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Tumor Cells, Cultured

2004
Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity.
    Journal of neural transmission (Vienna, Austria : 1996), 2004, Volume: 111, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Carbidopa; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Isoxazoles; Levodopa; Microdialysis; Oxidopamine; Parkinson Disease; Rats; Zonisamide

2004
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion.
    Journal of leukocyte biology, 2004, Volume: 76, Issue:5

    Topics: Adoptive Transfer; Animals; Animals, Newborn; Antigens, CD; B7-2 Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-2; Isoxazoles; Leflunomide; Membrane Glycoproteins; Microglia; Multiple Sclerosis; Myelin Basic Protein; Pyrimidines; Rats; Rats, Inbred Lew; STAT6 Transcription Factor; T-Lymphocytes, Helper-Inducer; Trans-Activators; Uridine

2004
NK95806, a newly synthesized microtubule-disrupting agent that suppresses collagen-induced arthritis in mice.
    International immunopharmacology, 2004, Volume: 4, Issue:12

    Topics: Administration, Oral; Animals; Antibody Formation; Antirheumatic Agents; Arthritis, Experimental; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Isoxazoles; Joints; Lower Extremity; Male; Mice; Mice, Inbred Strains; Microtubules; Sulfonamides

2004
Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats.
    International immunopharmacology, 2004, Dec-15, Volume: 4, Issue:13

    Topics: Animals; Arthritis, Experimental; Body Weight; Cell Proliferation; China; Disease Models, Animal; Down-Regulation; Freund's Adjuvant; Injections, Subcutaneous; Interleukin-1; Interleukin-10; Isoxazoles; Knee Joint; Leflunomide; Male; Organ Size; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spleen; Synovial Fluid; Thymus Gland; Tumor Necrosis Factor-alpha

2004
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jan-01, Volume: 11, Issue:1

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Genes, ras; Image Processing, Computer-Assisted; Immunohistochemistry; Isoxazoles; Ki-67 Antigen; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microcirculation; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); RNA Interference; Time Factors

2005
Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:1

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Female; Hyperalgesia; Isoenzymes; Isoxazoles; Ketorolac; Lipopolysaccharides; Male; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Salmonella typhimurium

2005
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
    European journal of pharmacology, 2005, Jun-01, Volume: 516, Issue:2

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Isonicotinic Acids; Isoxazoles; Male; Muscimol; Neuralgia; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Mechanical; Time Factors; Trauma, Nervous System; Zolpidem

2005
2005 Dr. Gary J. Becker Young Investigator Award: periprocedural oral administration of the leflunomide analogue FK778 inhibits neointima formation in a double-injury rat model of restenosis.
    Journal of vascular and interventional radiology : JVIR, 2005, Volume: 16, Issue:7

    Topics: Actins; Administration, Oral; Alkynes; Angioplasty, Balloon; Animals; Disease Models, Animal; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Isoxazoles; Male; Muscle, Smooth, Vascular; Nitriles; Rats; Rats, Inbred Lew; Tunica Intima

2005
Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.
    The Journal of surgical research, 2006, Volume: 130, Issue:1

    Topics: Animals; Ascites; Cell Line, Tumor; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Epithelium; Female; Humans; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Pertussis Toxin; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Stomach Neoplasms; Vascular Endothelial Growth Factor A

2006
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:2

    Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide

2005
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2005, Volume: 24, Issue:11

    Topics: Actins; Alkynes; Animals; Bronchiolitis Obliterans; Disease Models, Animal; Granulation Tissue; Immunosuppressive Agents; Isoxazoles; Lymphocyte Activation; Nitriles; Postoperative Complications; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tacrolimus; Trachea

2005
Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus.
    American journal of respiratory and critical care medicine, 2006, Mar-15, Volume: 173, Issue:6

    Topics: Animals; Antiviral Agents; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Disease Progression; Female; Isoxazoles; Leflunomide; Lung; Male; Mice; Mice, Inbred BALB C; Nucleotidases; Pneumonia, Viral; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Severity of Illness Index

2006
Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity.
    The Journal of investigative dermatology, 2006, Volume: 126, Issue:7

    Topics: Allergens; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Female; Immunosuppressive Agents; Interleukin-10; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Oxazolone; RNA, Messenger

2006
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
    Transplant international : official journal of the European Society for Organ Transplantation, 2006, Volume: 19, Issue:4

    Topics: Alkynes; Animals; Disease Models, Animal; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Lung Diseases, Obstructive; Lung Transplantation; Male; Myocytes, Smooth Muscle; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Homologous; Transplantation, Isogeneic

2006
Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis.
    Journal of the Society for Gynecologic Investigation, 2006, Volume: 13, Issue:5

    Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Immunologic Factors; Isoxazoles; Leflunomide; Rats; Rats, Wistar

2006
Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats.
    Neuropharmacology, 2006, Volume: 51, Issue:3

    Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Gait Disorders, Neurologic; Imidazoles; Isoxazoles; Male; Neural Inhibition; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Reflex, Startle

2006
[An animal model of antiepileptic-induced osteoporosis in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2006, Volume: 127, Issue:5

    Topics: Animals; Anticonvulsants; Bone Density; Disease Models, Animal; Isoxazoles; Osteoporosis; Phenytoin; Rats; Zonisamide

2006
Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2007, Volume: 17, Issue:4

    Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Epilepsy; Fluorescent Antibody Technique; Isoxazoles; Male; Mice; Zonisamide

2007
Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.
    Clinics (Sao Paulo, Brazil), 2006, Volume: 61, Issue:4

    Topics: Acute Disease; Amylases; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Interleukin-10; Interleukin-6; Isoxazoles; Male; Pancreatitis; Rats; Rats, Wistar; Survival Rate; Taurocholic Acid

2006
Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats.
    European journal of pharmacology, 2006, Dec-03, Volume: 551, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cognition Disorders; Colchicine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Isoxazoles; Lipid Peroxidation; Male; Maze Learning; Memory; Naproxen; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Space Perception; Spatial Behavior; Sulfonamides; Time Factors

2006
Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model.
    Fertility and sterility, 2007, Volume: 87, Issue:3

    Topics: Animals; Disease Models, Animal; Endometriosis; Female; Immunologic Factors; Isoxazoles; Leflunomide; Rats; Uterus

2007
Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment.
    The Journal of bone and joint surgery. American volume, 2007, Volume: 89, Issue:1

    Topics: Animals; Biomechanical Phenomena; Bony Callus; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Fracture Fixation, Intramedullary; Fracture Healing; Fractures, Bone; Fractures, Ununited; Isoxazoles; Ketorolac; Male; Rats; Rats, Sprague-Dawley; Sulfonamides

2007
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007, Volume: 26, Issue:1

    Topics: Alkynes; Animals; Antibodies, Anti-Idiotypic; Aorta, Abdominal; Cricetinae; Disease Models, Animal; Endothelium, Vascular; Flow Cytometry; Graft Rejection; Humans; Immunoglobulin G; Immunoglobulin M; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Male; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Heterologous; Treatment Outcome

2007
Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension.
    Pediatric research, 2007, Volume: 61, Issue:3

    Topics: Anastomosis, Surgical; Angiopoietin-1; Animals; Bone Morphogenetic Protein Receptors; Brachiocephalic Trunk; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Isoxazoles; Pulmonary Artery; RNA, Messenger; Swine; Thiophenes

2007
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
    Journal of thrombosis and thrombolysis, 2007, Volume: 24, Issue:1

    Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor Xa; Fibrinolytic Agents; Hemorrhage; Hemostasis; Isoxazoles; Male; Platelet Aggregation; Pyrazoles; Rabbits; Thrombosis; Ticlopidine

2007
Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
    Transplantation proceedings, 2007, Volume: 39, Issue:2

    Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tacrolimus; Trachea; Transplantation, Homologous

2007
Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression.
    Surgical infections, 2007, Volume: 8, Issue:1

    Topics: Animals; Cardiac Volume; Disease Models, Animal; Echocardiography; Immunologic Factors; Isoxazoles; Lung; Macrophage Migration-Inhibitory Factors; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Shock; Stroke Volume

2007
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
    European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3

    Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Isoxazoles; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Peripheral Nerve Injuries; Pharmacogenetics; Rats; Rats, Inbred BN; Rats, Inbred F344; Rats, Inbred Lew; Rats, Sprague-Dawley; Reproducibility of Results; Species Specificity

2007
The new malononitrilamide immunosuppressant FK778 prolongs corneal allograft survival in the rat keratoplasty model.
    Eye (London, England), 2007, Volume: 21, Issue:12

    Topics: Alkynes; Animals; Cornea; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft Rejection; Graft Survival; Immunosuppressive Agents; Isoxazoles; Keratoplasty, Penetrating; Mycophenolic Acid; Nitriles; Postoperative Care; Postoperative Period; Rats; Rats, Inbred F344; Rats, Inbred Lew; Survival Analysis; Treatment Outcome

2007
The effect of FK778 on the progression of chronic allograft nephropathy in a rat model.
    Transplantation, 2007, Mar-27, Volume: 83, Issue:6

    Topics: Alkynes; Animals; Creatinine; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Graft Rejection; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantation; Male; Nitriles; Proteinuria; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Transforming Growth Factor beta; Transplantation, Homologous

2007
Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure.
    Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:6

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Echocardiography; Heart Failure; Heart Function Tests; Isoxazoles; Male; Myocardial Ischemia; Myocardium; Rats; Rats, Wistar

2007
Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats.
    Pharmacology, 2007, Volume: 80, Issue:4

    Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hyperalgesia; Isoxazoles; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Tramadol

2007
The supraspinally mediated analgesic effects of zonisamide in mice after peripheral nerve injury are independent of the descending monoaminergic system.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:4

    Topics: Analgesics; Animals; Biogenic Monoamines; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intraperitoneal; Injections, Intraventricular; Isoxazoles; Ligation; Male; Mice; Neuralgia; Pain Measurement; Physical Stimulation; Sciatic Nerve; Sciatic Neuropathy; Zonisamide

2007
FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.
    Journal of lipid research, 2007, Volume: 48, Issue:12

    Topics: Animals; Bile Acids and Salts; Disease Models, Animal; DNA-Binding Proteins; Fibroblast Growth Factors; Isoxazoles; Liver; Malabsorption Syndromes; Mice; Mice, Inbred Strains; Models, Animal; Organic Anion Transporters, Sodium-Dependent; Receptors, Cytoplasmic and Nuclear; Symporters; Transcription Factors

2007
Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage.
    Acta neurochirurgica, 2007, Volume: 149, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basilar Artery; Disease Models, Animal; Fibromuscular Dysplasia; Isoxazoles; Leflunomide; Leukocyte Count; Muscle, Smooth, Vascular; Rabbits; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial

2007
Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model.
    Cancer science, 2008, Volume: 99, Issue:3

    Topics: Animals; Antineoplastic Agents; Ascites; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Humans; Isoxazoles; Neovascularization, Pathologic; Peritoneal Neoplasms; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Inbred F344; Receptors, Vascular Endothelial Growth Factor

2008
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
    Epilepsy research, 2008, Volume: 79, Issue:1

    Topics: Animals; Carrier Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Entorhinal Cortex; Evoked Potentials; GABA Agonists; GABA Plasma Membrane Transport Proteins; In Vitro Techniques; Isoxazoles; Kainic Acid; Male; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Status Epilepticus; Tiagabine

2008
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.
    Neuropharmacology, 2008, Volume: 54, Issue:5

    Topics: Analysis of Variance; Animals; Antimetabolites; Area Under Curve; Body Temperature; Brain; Catechols; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Isoxazoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Nitriles; Protein Binding; Rats; Rats, Wistar; Serotonin; Time Factors; Tyrosine

2008
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
    Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Rabbits; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Sulfonamides; Time Factors

2008
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.
    Breast cancer research : BCR, 2008, Volume: 10, Issue:2

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Immunoprecipitation; Isoxazoles; Mice; Mice, Nude; Molecular Chaperones; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Resorcinols; Transplantation, Heterologous; Up-Regulation

2008
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
    Gastroenterology, 2008, Volume: 134, Issue:7

    Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Integrases; Intestinal Mucosa; Intramolecular Oxidoreductases; Isoxazoles; Macrophage Migration-Inhibitory Factors; Mice; Mice, Transgenic; Recombination, Genetic; Signal Transduction; Time Factors; Von Hippel-Lindau Tumor Suppressor Protein

2008
[Study on protective effects and its mechanism of leflunomide on renal tissue in rat IgA nephropathy model].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2008, Volume: 20, Issue:5

    Topics: Animals; Chemokine CCL2; Disease Models, Animal; Fibrosis; Glomerulonephritis, IGA; Isoxazoles; Kidney; Leflunomide; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1

2008
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Mice; Seizures; Valproic Acid

1983
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
    Neuropharmacology, 1984, Volume: 23, Issue:9

    Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Isoxazoles; Male; Penicillins; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Taurine; Time Factors

1984
Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:1

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Isoxazoles; Kidney; Liver; Male; Oxonic Acid; Rats; Rats, Wistar; Time Factors; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase

1994
Malononitrilamides prevent the development of murine systemic lupus erythematosus-like diseases in BDF1 hybrid mice and MRL/lpr autoimmune mice.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Aging; Alkynes; Animals; Antibody Formation; Crosses, Genetic; Disease Models, Animal; Female; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles

1996
Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral study.
    Brain research, 1997, Oct-03, Volume: 770, Issue:1-2

    Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Isoxazoles; Male; Maze Learning; Microdialysis; Neuroprotective Agents; Prosencephalon; Silver Staining; Zonisamide

1997
Intravenous and oral antiplatelet/antithrombotic efficacy and specificity of XR300, a novel nonpeptide platelet GPIIb/IIIa antagonist.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:3

    Topics: Administration, Oral; Amino Acids; Animals; Antithrombins; Carotid Arteries; Disease Models, Animal; Dogs; Female; Humans; Hydrolysis; Infusions, Intravenous; Isoxazoles; Kinetics; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis

1998
The new immunosuppressants, the malononitrilamides MNA 279 and MNA 715, inhibit various graft-vs.-host diseases (GvHD) in rodents.
    Drugs under experimental and clinical research, 1997, Volume: 23, Issue:5-6

    Topics: Alkynes; Animals; Disease Models, Animal; Graft vs Host Disease; Graft vs Host Reaction; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nitriles; Rats; Rats, Inbred BN; Rats, Inbred Lew

1997
Therapeutic activity of malononitrilamides (MNA 279 and MNA 715) on acute and chronic, relapsing, experimental, allergic encephalomyelitis (EAE).
    Drugs under experimental and clinical research, 1997, Volume: 23, Issue:5-6

    Topics: Acute Disease; Alkynes; Animals; Chronic Disease; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred Strains; Nitriles; Rabbits; Rats; Rats, Inbred Lew

1997
The effects of leflunomide and cyclosporin A on rejection of cardiac allografts in the rat.
    Scandinavian journal of immunology, 1998, Volume: 47, Issue:3

    Topics: Animals; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Rats, Wistar

1998
Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28, Issue:3

    Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cell Degranulation; Dimercaprol; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Histamine Release; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mast Cells; Ovalbumin; Rats; Rats, Inbred BN; Respiratory Function Tests

1998
Effects of long-term oral treatment with leflunomide on allergic sensitization, lymphocyte activation, and airway inflammation in a rat model of asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28, Issue:6

    Topics: Administration, Inhalation; Administration, Oral; Age Factors; Animals; Anti-Inflammatory Agents; Antibody Specificity; Asthma; Bronchoalveolar Lavage Fluid; Cell Division; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Ovalbumin; Rats; Rats, Inbred BN; T-Lymphocytes; Time Factors

1998
Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Aug-15, Volume: 161, Issue:4

    Topics: Acute Disease; Animals; Cricetinae; Cyclosporine; Disease Models, Animal; Drug Combinations; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Inbred Lew; Species Specificity; Time Factors; Transplantation, Heterologous

1998
Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation.
    Transplantation, 1998, Sep-27, Volume: 66, Issue:6

    Topics: Animals; Chronic Disease; Cricetinae; Cyclosporine; Disease Models, Animal; Graft Rejection; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mesocricetus; Myocardium; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Heterologous

1998
Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibodies, Antinuclear; Arthritis, Experimental; Arthritis, Rheumatoid; Caproates; Disease Models, Animal; Female; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Mutant Strains; Nitriles; Rats; Rats, Inbred Lew

1998
JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models.
    British journal of pharmacology, 1998, Volume: 125, Issue:8

    Topics: Animals; Blood Glucose; Disease Models, Animal; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulin Resistance; Isoxazoles; Leptin; Lipids; Male; Obesity; Oxidation-Reduction; Phosphorylation; Proteins; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor, Insulin; Triglycerides

1998
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Administration, Oral; Aniline Compounds; Animals; Antibody Specificity; Crotonates; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxybutyrates; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Nitriles; Ovalbumin; Rats; Rats, Inbred BN; Toluidines; Uridine

1999
Characterization of MK-801-induced behavior as a putative rat model of psychosis.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Aging; Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Isoxazoles; Male; Motor Activity; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Receptors, GABA; Sex Characteristics; Stereotyped Behavior; Stereotypic Movement Disorder

1999
Intravenous and oral antithrombotic efficacy of the novel platelet GPIIb/IIIa antagonist roxifiban (DMP754) and its free acid form, XV459.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:10

    Topics: Administration, Oral; Amidines; Amino Acids; Animals; Bleeding Time; Disease Models, Animal; Dogs; Electroshock; Female; Femoral Artery; Humans; Injections, Intravenous; Isoxazoles; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis

1999
Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.
    Pulmonary pharmacology & therapeutics, 2000, Volume: 13, Issue:2

    Topics: Animals; Cardiomegaly; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertension, Pulmonary; Hypertrophy; Hypoxia; Isoxazoles; Male; Monocrotaline; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Thiophenes; Vasoconstriction; Weight Gain

2000
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
    Brain research bulletin, 2000, Sep-15, Volume: 53, Issue:2

    Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Mutant Strains; Nitric Oxide; Phenytoin; Valproic Acid; Zonisamide

2000
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:8

    Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists; Isoxazoles; Male; Neurotransmitter Agents; Psychotic Disorders; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission

2000
Glutathione deficiency intensifies ischaemia-reperfusion induced cardiac dysfunction and oxidative stress.
    Acta physiologica Scandinavica, 2001, Volume: 172, Issue:1

    Topics: Animals; Buthionine Sulfoximine; Disease Models, Animal; Drug Therapy, Combination; Female; Glutathione; Heart; Isoxazoles; Liver; Mitochondria, Heart; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Ventricular Function

2001
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
    Psychiatry and clinical neurosciences, 2001, Volume: 55, Issue:4

    Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Phenobarbital; Receptors, N-Methyl-D-Aspartate; Zonisamide

2001
Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
    Bioorganic & medicinal chemistry letters, 2001, Oct-08, Volume: 11, Issue:19

    Topics: Animals; Disease Models, Animal; Humans; Hypersensitivity; Integrin alpha4beta1; Integrins; Isoxazoles; Jurkat Cells; Mice; Propionates; Receptors, Lymphocyte Homing; Structure-Activity Relationship

2001
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
    Behavioural brain research, 2002, Apr-01, Volume: 131, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Arousal; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Histamine Antagonists; Imidazoles; Impulsive Behavior; Isoxazoles; Ligands; Male; Methylphenidate; Motor Activity; Nicotinic Agonists; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Histamine H3

2002
Contrasting effects of zonisamide and acetazolamide on amygdaloid kindling in rats.
    Epilepsia, 2001, Volume: 42, Issue:11

    Topics: Acetazolamide; Amygdala; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsies, Partial; Isoxazoles; Kindling, Neurologic; Male; Rats; Rats, Wistar; Zonisamide

2001
Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Animals; Anti-Allergic Agents; Disease Models, Animal; Humans; Hypersensitivity; Inflammation; Integrin alpha4beta1; Integrins; Isoxazoles; Jurkat Cells; Mice; Phenylurea Compounds; Pulmonary Eosinophilia; Receptors, Lymphocyte Homing; Vascular Cell Adhesion Molecule-1

2002
Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Oxazoles; Transplantation, Heterologous

1979
Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse.
    The Journal of clinical investigation, 1992, Volume: 89, Issue:1

    Topics: Amylases; Animals; Ceruletide; Cholecystokinin; Disease Models, Animal; Female; Free Radicals; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Mice; Pancreas; Pancreatitis; Radiation-Protective Agents

1992
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
    The Journal of infectious diseases, 1989, Volume: 159, Issue:5

    Topics: Animals; Antiviral Agents; Brain; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Microbial; Enterovirus Infections; Immunosuppression Therapy; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Oxazoles; Poliomyelitis; Poliovirus

1989
Comparisons of ketoconazole, PR 969-566, PR 967-234, and PR 967-248 as antifungals in vitro and in the rat model of candidal vaginitis based on efficacy/safety profiles.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Animals; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Fungi; Isoxazoles; Ketoconazole; Microbial Sensitivity Tests; Oxazoles; Rats

1988
The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery.
    Agents and actions, 1987, Volume: 21, Issue:3-4

    Topics: Animals; Cyclophosphamide; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft vs Host Disease; Indomethacin; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Mice; Prednisolone

1987
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 276, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Gerbillinae; In Vitro Techniques; Isoxazoles; Mice; Pentylenetetrazole; Seizures; Species Specificity

1985