Page last updated: 2024-08-21

isoxazoles and Carcinoma, Non-Small Cell Lung

isoxazoles has been researched along with Carcinoma, Non-Small Cell Lung in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.55)18.7374
1990's2 (9.09)18.2507
2000's1 (4.55)29.6817
2010's16 (72.73)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Bacon, NA; Larre, I; Lawag, AA; Merritt, C; Rosolen, M; Smith, M; Sollars, VE1
Abel, L; Baschnagel, AM; Clark, PA; Elnaggar, JH; Kaushik, S; Kimple, RJ; Kromke, AC; Leal, TA; Longhurst, CA; Nickel, KP; Skiba, JH; VanBeek, HJ; Zhao, SG1
de Vries, EGE; Giesen, D; Kol, A; Lub-de Hooge, MN; Pool, M; Terwisscha van Scheltinga, AGT1
Choi, J; Jeon, H; Kim, D; Kim, SW; Lee, CH; Lee, DH; Park, KS; Seo, S; Yang, H1
Jiang, L; Jiang, M; Li, W; Ling, C; Zhang, W1
Akimov, M; Avsar, E; Barlesi, F; Besse, B; Brunsvig, P; Carcereny, E; Chouaid, C; Chu, Q; Felip, E; Gandhi, L; Garon, EB; Groen, HJM; Kim, DW; Kim, SW; Park, K; Sequist, LV; Smit, EF; Szpakowski, S1
Balmaña, J; Cedrés, S; Cruz, C; Felip, E; Llop-Guevara, A; Mancuso, F; Martinez de Castro, A; Martinez-Marti, A; Miquel, JM; Navarro, A; Nuciforo, P; Pardo, N; Remon, J; Sansano, I; Serra, V; Vivancos, A; Zeron-Medina, J1
Pillai, RN; Ramalingam, SS2
Azzoli, CG; Costa, DB; Gainor, JF; Heist, RS; Huberman, M; Lennes, IT; Muzikansky, A; Oxnard, GR; Piotrowska, Z; Sequist, LV; Shaw, AT1
Avsar, E; Dering, J; Desai, AJ; Dubinett, SM; Finn, RS; Garon, EB; Hamidi, H; Hosmer, W; Ide, S; Jensen, MR; Kamranpour, N; Liu, M; Pitts, S; Quadt, C; Slamon, DJ1
Curwen, J; Elder, DJ; Hers, I; Kilgour, E; Tavaré, JM; Vincent, EE1
Asano, H; Furukawa, M; Hashida, S; Kanazawa, S; Maki, Y; Miyoshi, S; Ohtsuka, T; Shien, K; Soh, J; Suzawa, K; Toyooka, S; Tsukuda, K; Yamamoto, H1
Choi, J; Jin, HR; Kim, SW; Lee, DH; Lee, MH; Nam, KY; Oh, B; Park, KS; Yang, H1
Chen, DQ; Ding, J; Geng, MY; Liu, HC; Shen, AJ; Shen, JK; Sun, JY; Wang, X; Wang, YQ; Xiong, B; Zhang, MM; Zheng, M1
Berna, M; Del Soldato, P; Giaccone, G; Jensen, RT; Moody, TW; Ridnour, LA; Roberts, DD; Santana-Flores, W; Sparatore, A; Switzer, C; Thill, M; Wink, DA; Yeh, GC1
Cho, Y; Han, MS; Han, SH; Kim, C; Min, SS; Park, M; Park, MJ; Yee, J1
Ando, M; Asano, H; Furukawa, M; Kiura, K; Maki, Y; Miyoshi, S; Muraoka, T; Naomoto, Y; Shien, K; Soh, J; Takaoka, M; Tanaka, N; Toyooka, S; Tsukuda, K; Ueno, T; Yamatsuji, T1
Biehl, M; Djuzenova, CS; Flentje, M; Günther, N; Hartmann, S; Katzer, A; Krohne, G; Kuger, S; Sukhorukov, VL; Worschech, E; Zimmermann, H1
Bonomi, P; Chang, A; Finkelstein, D1
Eisenhauer, E; Evans, WK; Maroun, JA; Stewart, DJ; Verma, S1
Eisenhauer, E; Maksymiuk, A; Maroun, JA; Pater, J; Stewart, DJ; Young, V1

Reviews

1 review(s) available for isoxazoles and Carcinoma, Non-Small Cell Lung

ArticleYear
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
    Current opinion in oncology, 2014, Volume: 26, Issue:2

    Topics: Benzamides; Benzoquinones; Carcinoma, Non-Small-Cell Lung; HSP90 Heat-Shock Proteins; Humans; Isoindoles; Isoxazoles; Lactams, Macrocyclic; Lung Neoplasms; Molecular Targeted Therapy; Resorcinols; Treatment Outcome; Triazoles

2014

Trials

3 trial(s) available for isoxazoles and Carcinoma, Non-Small Cell Lung

ArticleYear
Phase 2 Study of the HSP-90 Inhibitor AUY922 in Previously Treated and Molecularly Defined Patients with Advanced Non-Small Cell Lung Cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018, Volume: 13, Issue:4

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Resorcinols

2018
Activity of the Hsp90 inhibitor luminespib among non-small-cell lung cancers harboring EGFR exon 20 insertions.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 10-01, Volume: 29, Issue:10

    Topics: Adenocarcinoma; Adult; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cohort Studies; ErbB Receptors; Exons; Female; Follow-Up Studies; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Mutagenesis, Insertional; Prognosis; Resorcinols; Survival Rate

2018
Phase II trial of acivicin versus etoposide-cisplatin in non-small cell lung cancer. An Eastern Cooperative Oncology Group study.
    American journal of clinical oncology, 1994, Volume: 17, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Administration Schedule; Etoposide; Female; Humans; Isoxazoles; Lung Neoplasms; Male; Remission Induction; Survival Analysis

1994

Other Studies

18 other study(ies) available for isoxazoles and Carcinoma, Non-Small Cell Lung

ArticleYear
Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-β and paclitaxel in A549 cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 129

    Topics: A549 Cells; Antigens, CD; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Plasticity; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Paclitaxel; Resorcinols; Signal Transduction; Transforming Growth Factor beta

2020
ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts.
    Molecular cancer therapeutics, 2021, Volume: 20, Issue:11

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Female; Heterografts; Humans; Isoxazoles; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Pyrazines; Treatment Outcome

2021
    European journal of nuclear medicine and molecular imaging, 2017, Volume: 44, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Feasibility Studies; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Male; Mice; Positron-Emission Tomography; Proto-Oncogene Proteins c-met; Radioisotopes; Resorcinols; Up-Regulation; Zirconium

2017
The HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer.
    Cancer letters, 2017, 10-10, Volume: 406

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mutation; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Resorcinols; Signal Transduction

2017
Anti-inflammatory drug, leflunomide and its metabolite teriflunomide inhibit NSCLC proliferation in vivo and in vitro.
    Toxicology letters, 2018, Jan-05, Volume: 282

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Crotonates; Female; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Mice, Nude; Nitriles; Toluidines; Xenograft Model Antitumor Assays

2018
Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.
    Journal of the National Cancer Institute, 2018, 08-01, Volume: 110, Issue:8

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Female; Gemcitabine; Germ-Line Mutation; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Maintenance Chemotherapy; Resorcinols; Treatment Outcome

2018
Throwing More Cold Water on Heat Shock Protein 90 Inhibitors in NSCLC.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018, Volume: 13, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Resorcinols

2018
The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:6

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; ErbB Receptors; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Molecular Chaperones; Resorcinols; Xenograft Model Antitumor Assays

2013
Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Isoxazoles; Lung Neoplasms; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyrimidines; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction

2013
Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.
    Oncology reports, 2015, Volume: 33, Issue:3

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA End-Joining Repair; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; M Phase Cell Cycle Checkpoints; Protein Kinase Inhibitors; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Resorcinols

2015
The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib.
    Cancer letters, 2016, Mar-01, Volume: 372, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Resorcinols; Signal Transduction; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

2016
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:12

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Heterografts; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Transplantation; Oxazoles; Quinazolines; Resorcinols

2016
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.
    Lung cancer (Amsterdam, Netherlands), 2010, Volume: 68, Issue:2

    Topics: Anethole Trithione; Animals; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Pyrazoles; Sulfones; Valproic Acid

2010
Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells.
    Respirology (Carlton, Vic.), 2009, Volume: 14, Issue:6

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Humans; Isoxazoles; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sulfones

2009
Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2012, Volume: 76, Issue:1

    Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Immunoprecipitation; Isoxazoles; Lung Neoplasms; Mice; Resorcinols; Tumor Cells, Cultured

2012
Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines.
    Cancer letters, 2013, May-01, Volume: 331, Issue:2

    Topics: Blotting, Western; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Flow Cytometry; Glioblastoma; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Microscopy, Electron, Scanning; Neoplasm Invasiveness; Pyrimidines; Resorcinols; Wound Healing

2013
Phase I study of acivicin and cisplatin in non-small-cell lung cancer. A National Cancer Institute of Canada study.
    American journal of clinical oncology, 1990, Volume: 13, Issue:5

    Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Canada; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Administration Schedule; Drug Evaluation; Female; Government Agencies; Humans; Isoxazoles; Kidney; Lung Neoplasms; Male; Middle Aged; Remission Induction; Thrombocytopenia

1990
Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:11

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Carcinoma, Non-Small-Cell Lung; Cognition Disorders; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Oxazoles

1986
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