Page last updated: 2024-08-21

isoxazoles and Bile Duct Obstruction

isoxazoles has been researched along with Bile Duct Obstruction in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	3 (25.00)	29.6817
2010's	5 (41.67)	24.3611
2020's	3 (25.00)	2.80

Authors

Authors	Studies
Chen, PH; Chiu, TC; Huang, SC; Hung, TM; Kao, YH; Lee, HM; Lee, PH; Lin, YC; Sun, CK; Tsai, MS	1
Chien, D; Dawson, PA; Dong, X; Fauler, G; Fickert, P; Gilmer, JF; Moustafa, T; Truong, JK; van de Graaf, SFJ; van de Wiel, SMW; Yin, L; Zaufel, A	1
Anderson, AL; Balasubramaniyan, N; D'Alessandro, A; Devereaux, MW; El Kasmi, KC; Ghosh, S; Orlicky, DJ; Shearn, CT; Sokol, RJ; Suchy, FJ	1
Cao, L; Che, Y; Gonzalez, FJ; Hao, H; Jiang, C; Takahashi, S; Wang, G; Zhang, S	1
Alper, PB; Bao, D; Bursulaya, B; Chianelli, D; Groessl, T; Joseph, SB; Kim, Y; Laffitte, B; Liu, B; McNamara, P; Molteni, V; Mutnick, D; Phimister, A; Rucker, PV; Schmeits, J; Seidel, HM; Tully, DC; Vidal, A; Williams, J; Wu, X; Zoll, J	1
Cai, X; Chen, ZL; Jin, F; Li, G; Li, HR; Luo, L; Ma, Q; Wang, Y; Xue, J; Yang, F; Zhao, L; Zhou, X	1
Buist-Homan, M; Faber, KN; Groen, AK; Koehorst, M; Moshage, H; Verhaag, EM	1
Alawad, AS; Levy, C	1
Akwabi-Ameyaw, A; Bass, JY; Caldwell, RD; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Jones, SA; Kaldor, I; Liu, Y; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB	1
Accatino, L; Arrese, M; Koenig, CS; Pizarro, M; Solís, N	1
Binz, J; Dennis, S; Desai, B; Goodwin, B; Jones, SA; Kliewer, SA; Liu, Y; Luo, G; MacKenzie, KI; Mansfield, TA; Numerick, MJ	1
Barfuss, DW; Lash, LH; Zalups, RK	1

Reviews

1 review(s) available for isoxazoles and Bile Duct Obstruction

Article	Year
FXR Agonists: From Bench to Bedside, a Guide for Clinicians. Digestive diseases and sciences, 2016, Volume: 61, Issue:12 Topics: Animals; Azepines; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholestasis; Drug Evaluation, Preclinical; Gastrointestinal Agents; Hepatitis, Autoimmune; Humans; Hypertension, Portal; Indoles; Isoxazoles; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Liver Diseases; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Ursodeoxycholic Acid	2016

Article

Year

FXR Agonists: From Bench to Bedside, a Guide for Clinicians.

Digestive diseases and sciences, 2016, Volume: 61, Issue:12

Topics: Animals; Azepines; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholestasis; Drug Evaluation, Preclinical; Gastrointestinal Agents; Hepatitis, Autoimmune; Humans; Hypertension, Portal; Indoles; Isoxazoles; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Liver Diseases; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; Ursodeoxycholic Acid

2016

Other Studies

11 other study(ies) available for isoxazoles and Bile Duct Obstruction

Article	Year
Nerve growth factor induced farnesoid X receptor upregulation modulates autophagy flux and protects hepatocytes in cholestatic livers. Archives of biochemistry and biophysics, 2020, 03-30, Volume: 682 Topics: Animals; Autophagy; Cell Line, Tumor; Cholestasis; Cytoprotection; Hepatocytes; Humans; Isoxazoles; Liver; Male; Mice; Mice, Inbred ICR; Nerve Growth Factor; Protective Agents; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Signal Transduction; Transcriptional Activation	2020
Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions. Biochimica et biophysica acta. Molecular basis of disease, 2021, 08-01, Volume: 1867, Issue:8 Topics: Animals; Bile Acids and Salts; Caco-2 Cells; Cell Line; Cell Line, Tumor; Cholestasis; Disease Models, Animal; Fibroblast Growth Factors; HEK293 Cells; Hep G2 Cells; Humans; Ileum; Isoxazoles; Ligands; Liver; Male; Mice; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Transcription Factors	2021
Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice. Hepatology (Baltimore, Md.), 2022, Volume: 75, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; Bile Acids and Salts; Cholestasis; Gene Expression; Gene Expression Regulation; Hepatocytes; Interleukin-1beta; Intestinal Diseases; Isoxazoles; Lipoproteins; Liver Diseases; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Parenteral Nutrition; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction	2022
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis. Cell metabolism, 2017, Apr-04, Volume: 25, Issue:4 Topics: Animals; Bile Acids and Salts; Calcium; Caspase 1; Cholestasis; Humans; Inflammasomes; Isoxazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Models, Biological; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Binding; RAW 264.7 Cells; Receptors, Cytoplasmic and Nuclear; Sepsis	2017
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). Journal of medicinal chemistry, 2017, 12-28, Volume: 60, Issue:24 Topics: Administration, Oral; Animals; Benzothiazoles; Biological Availability; Cholestasis; Dogs; Drug Evaluation, Preclinical; Fibroblast Growth Factors; Gene Expression Regulation; Humans; Isoxazoles; Male; Microsomes, Liver; Non-alcoholic Fatty Liver Disease; Piperidines; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Triglycerides	2017
Effects of corilagin on alleviating cholestasis via farnesoid X receptor-associated pathways in vitro and in vivo. British journal of pharmacology, 2018, Volume: 175, Issue:5 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Cell Survival; Cells, Cultured; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cytochrome P450 Family 7; Dexamethasone; Down-Regulation; Glucosides; Glucuronosyltransferase; Humans; Hydrolyzable Tannins; Isoxazoles; Liver; Male; Organic Anion Transporters, Sodium-Dependent; Pregnenediones; Primary Cell Culture; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Steroid Hydroxylases; Sulfotransferases; Symporters; Up-Regulation; Ursodeoxycholic Acid	2018
Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity. PloS one, 2016, Volume: 11, Issue:3 Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis; Cytokines; Cytoprotection; Hep G2 Cells; Hepatocytes; Hormesis; Humans; Isoxazoles; Liver Diseases; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Time Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha; Vitamin K 3	2016
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorganic & medicinal chemistry letters, 2008, 08-01, Volume: 18, Issue:15 Topics: Administration, Oral; Animals; Carboxylic Acids; Cholestasis; Crystallography, X-Ray; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gastric Mucosa; Haplorhini; Isoxazoles; Mice; Molecular Conformation; Molecular Structure; Naphthalenes; Rats; Receptors, Cytoplasmic and Nuclear; Stomach; Structure-Activity Relationship; Transcription Factors	2008
Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, Volume: 9, Issue:11 Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Cysteine; Disease Models, Animal; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Isoxazoles; Liver; Male; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ribosomal Proteins; Saccharomyces cerevisiae Proteins	2003
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. The Journal of clinical investigation, 2003, Volume: 112, Issue:11 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Carrier Proteins; Cholestasis; Cytoprotection; DNA-Binding Proteins; Isocyanates; Isoxazoles; Male; Membrane Transport Proteins; Naphthalenes; Organic Anion Transporters, Sodium-Dependent; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Steroid 12-alpha-Hydroxylase; Symporters; Taurine; Transcription Factors; Ursodeoxycholic Acid	2003
Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride. Toxicology and applied pharmacology, 1999, Jan-15, Volume: 154, Issue:2 Topics: Animals; Cholestasis; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Injections, Intravenous; Intestine, Small; Isoxazoles; Kidney; Liver; Male; Mercuric Chloride; Organ Size; Rats; Rats, Sprague-Dawley; Tissue Distribution	1999