isoxazoles has been researched along with Autoimmune Disease in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.71) | 18.7374 |
| 1990's | 14 (40.00) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 10 (28.57) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; He, C; Li, M; Liu, S; Wang, L; Wu, D; Yang, Y; Zeng, X; Zhang, F; Zheng, K | 1 |
| Gao, D; Huang, F; Jin, J; Li, K; Luo, G; Wang, X; Wang, Y; Yang, C; Zhang, J; Zhao, Y; Zhao, Z; Zhu, J | 1 |
| Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX | 1 |
| Brooks, JB; Fragoso, YD | 1 |
| Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D | 1 |
| Baker, TA; Colopy, SA; Muir, P | 1 |
| Leban, J; Vitt, D | 1 |
| Mishra, OP; Mittal, R; Prasad, R; Singh, UK | 1 |
| Kiss, CG; Kiss, E; Poór, G | 1 |
| Duan, K; Jin, D; Peng, J; Zhang, L; Zhao, Y | 1 |
| Palazzo, E; Yahia, SA | 1 |
| Frieling, U; Luger, TA | 1 |
| Kushwaha, SS; Mayer, DF | 1 |
| Kiely, PD | 1 |
| Apostolski, S; Bartlett, RR; Damjanovic, M; Isakovic, K; Kosec, D; Vidic-Dankovic, B | 1 |
| Lang, LS; Robertson, SM | 1 |
| Anagnostopulos, H; Bartlett, RR; Mattar, T; Schleyerbach, R; Zielinski, T | 1 |
| Brazelton, TR; Morris, RE | 1 |
| Bartlett, RR; Brendel, S; Schorlemmer, HU; Zielinski, T | 1 |
| Morris, RE; Silva Júnior, HT | 1 |
| Blinder, L; Chong, AS; Finnegan, A; Gong, H; Shen, J; Williams, JW; Xu, X | 1 |
| Bartlett, RR; Schorlemmer, HU | 2 |
| Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X | 1 |
| Chong, AS; Foster, P; Guo, Z; Jensik, SC; McChesney, L; Mital, D; Sankary, H; Shen, J; Tian, Y; Williams, JW | 1 |
| Colic, M; Dimitrijevic, M; Milenkovic, M; Milosavljevic, P | 1 |
| Bartlett, R; Dimitrijevic, M; Stosic-Grujicic, S | 1 |
| Herrmann, ML; Kirschbaum, BJ; Schleyerbach, R | 1 |
| Schorlemmer, HU | 1 |
| Fehr, T; Ochsenbein, AF; Pinschewer, DD; Zinkernagel, RM | 1 |
| Harisdangkul, V; Sanders, S | 1 |
| Pfeiffer, C; Wozel, G | 1 |
| Bartlett, RR; Bremer, E; Dimitrijevic, M; Germann, T; Küchle, CC; Mattar, T; Rüde, E; Schorlemmer, HU; Thoenes, GH; Zielinski, T | 1 |
| Bartlett, RR; Langer, KH; Schleyerbach, R; Sitter, T; Thoenes, GH | 1 |
| Bartlett, RR; Popovic, S | 1 |
19 review(s) available for isoxazoles and Autoimmune Disease
| Article | Year |
|---|---|
Leflunomide: Traditional immunosuppressant with concurrent antiviral effects.
Topics: Antiviral Agents; Autoimmune Diseases; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide | 2023 |
Combination therapy of leflunomide and glucocorticoids for the maintenance of remission in patients with IgG4-related disease: a retrospective study and literature review.
Topics: Autoimmune Diseases; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Remission Induction; Retrospective Studies; Treatment Outcome | 2017 |
Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases.
Topics: Animals; Autoimmune Diseases; Crotonates; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Pyrimidines; T-Lymphocytes; Toluidines | 2015 |
Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Autoimmune Diseases; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Humans; Inflammation; Isoxazoles; Leflunomide; Oxidoreductases Acting on CH-CH Group Donors; Randomized Controlled Trials as Topic; Structure-Activity Relationship | 2011 |
Immunosuppressive therapy in children.
Topics: Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Child; Cyclophosphamide; Cyclosporine; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mercaptopurine; Methotrexate; Mycophenolic Acid; Nitriles; Sirolimus; Tacrolimus | 2011 |
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Administration Schedule; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Remission Induction; Sjogren's Syndrome; Sulfasalazine; Teratogens; Tumor Necrosis Factor-alpha | 2011 |
Progressive multifocal leukoencephalopathy in autoimmune diseases.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Comorbidity; Drug Therapy, Combination; Glucocorticoids; Humans; Infliximab; Isoxazoles; JC Virus; Leflunomide; Leukoencephalopathy, Progressive Multifocal; Lupus Erythematosus, Systemic; Rituximab; Virus Activation | 2012 |
Mycophenolate mofetil and leflunomide: promising compounds for the treatment of skin diseases.
Topics: Administration, Oral; Autoimmune Diseases; Female; Fertility; Fetal Death; Humans; Immunosuppressive Agents; Infertility, Male; Isoxazoles; Leflunomide; Male; Mycophenolic Acid; Pregnancy; Skin Diseases | 2002 |
Transplant immunosuppressant agents and their role in autoimmune rheumatic diseases.
Topics: Autoimmune Diseases; Azathioprine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mycophenolic Acid; Rheumatic Diseases; Severity of Illness Index; Sirolimus; Tacrolimus; Transplants; Treatment Outcome | 2003 |
The broadening use of leflunomide in clinical practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide | 2004 |
Effects of leflunomide on immune responses and models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Autoimmune Diseases; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Graft Rejection; Humans; Immunity, Cellular; Immunosuppressive Agents; Inflammation; Isoxazoles; Leflunomide; Mice; Protein-Tyrosine Kinases; Rats | 1993 |
Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide.
Topics: Animals; Autoimmune Diseases; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Polyenes; Pyrimidine Nucleotides; Sirolimus; Tacrolimus; Xenobiotics | 1996 |
Leflunomide, an immunorestoring drug for the therapy of autoimmune disorders, especially rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Clinical Trials as Topic; Disease Models, Animal; Humans; Immune Tolerance; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Mammals | 1996 |
Leflunomide and malononitrilamides.
Topics: Aniline Compounds; Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Clinical Trials as Topic; Crotonates; Graft Rejection; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Molecular Structure; Nitriles; Organ Transplantation; Toluidines; Transplantation Immunology | 1997 |
Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Autoimmune Diseases; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; T-Lymphocytes | 2000 |
Development of a novel drug for transplantation: current results and future perspectives.
Topics: Alkynes; Aniline Compounds; Animals; Autoimmune Diseases; Biological Availability; Crotonates; Drug Design; Graft Rejection; Graft Survival; Graft vs Host Disease; Graft vs Host Reaction; Heart Transplantation; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Nitriles; Skin Transplantation; Toluidines; Transplantation, Homologous | 2001 |
Leflunomide for the treatment of rheumatoid arthritis and autoimmunity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Autoimmune Diseases; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide | 2002 |
[Leflunomide--a new drug for pharmacological immunomodulation].
Topics: Animals; Autoimmune Diseases; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Psoriasis; Skin Diseases | 2002 |
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Disease Models, Animal; Graft Rejection; Graft vs Host Disease; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Molecular Sequence Data | 1991 |
16 other study(ies) available for isoxazoles and Autoimmune Disease
| Article | Year |
|---|---|
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.
Topics: Animals; Autoimmune Diseases; Chemokines; Disease Models, Animal; Eye; Female; Gene Expression Regulation; Interferon-gamma; Interleukin-17; Isoxazoles; Leflunomide; Lymphocyte Activation; Lymphocytes; Peptide Fragments; Rats; Retina; Retinol-Binding Proteins; RNA, Messenger; Th17 Cells; Uveitis | 2013 |
[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats].
Topics: Animals; Autoimmune Diseases; Cyclosporine; Down-Regulation; Eye Proteins; Immunosuppressive Agents; Interferon-gamma; Interleukin-17; Isoxazoles; Leflunomide; Random Allocation; Rats; Rats, Inbred Lew; Retinitis; Retinol-Binding Proteins; RNA, Messenger; Th17 Cells; Uveitis | 2015 |
Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006-2008).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Autoimmune Diseases; Dog Diseases; Dogs; Female; Isoxazoles; Leflunomide; Male; Retrospective Studies | 2010 |
The effects of leflunomide on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation.
Topics: Animals; Antibodies, Monoclonal; Autoimmune Diseases; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; Female; Forkhead Transcription Factors; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes, Regulatory | 2012 |
Leflunomide prevents the development of experimentally induced myasthenia gravis.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Female; Flow Cytometry; Immunization; Immunosuppressive Agents; Isoxazoles; Leflunomide; Myasthenia Gravis; Rats; Rats, Inbred Strains; Receptors, Cholinergic; T-Lymphocyte Subsets; Thymus Gland; Time Factors; Torpedo | 1995 |
Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats.
Topics: Administration, Oral; Administration, Topical; Animals; Antibodies; Antigens; Arrestin; Autoimmune Diseases; Cyclosporine; Dexamethasone; Dose-Response Relationship, Drug; Eye Proteins; Freund's Adjuvant; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Rats; Retina; Uveitis | 1994 |
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.
Topics: Aniline Compounds; Animals; Autoimmune Diseases; Crotonates; Dihydroorotate Dehydrogenase; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymph Nodes; Lymphoproliferative Disorders; Mice; Mice, Mutant Strains; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidine Nucleotides; Toluidines; Uridine | 1997 |
Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715.
Topics: Aging; Alkynes; Animals; Autoimmune Diseases; Female; Immunosuppressive Agents; Isoxazoles; Kinetics; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred DBA; Nitriles; Spleen; Splenomegaly | 1997 |
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Biphenyl Compounds; Cytidine Triphosphate; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Phosphorylation; Tyrosine; Uridine; Uridine Triphosphate | 1997 |
Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice.
Topics: Animals; Autoimmune Diseases; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred NOD; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Recurrence; Transplantation, Heterologous | 1998 |
Effects of leflunomide on experimental autoimmune myocarditis with special reference to the dendritic cells.
Topics: Animals; Autoimmune Diseases; Dendritic Cells; Freund's Adjuvant; Heart; Immunosuppressive Agents; Isoxazoles; Leflunomide; Myocarditis; Myocardium; Myosins; Rats; Rats, Inbred Strains; Swine | 1998 |
Modulation of immunoglobulin dysregulation in graft versus host-and systemic lupus erythematosus-like diseases by malononitrilamides.
Topics: Acrylamide; Acrylamides; Alkynes; Animals; Antibody Formation; Autoantibodies; Autoimmune Diseases; Caproates; Crosses, Genetic; Female; Glomerulonephritis; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Lymphocyte Transfusion; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles; Spleen; Transplantation, Homologous | 1998 |
Leflunomide protects mice from multiple low dose streptozotocin (MLD-SZ)-induced insulitis and diabetes.
Topics: Animals; Autoimmune Diseases; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Immunosuppressive Agents; Interferon-gamma; Islets of Langerhans; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred CBA; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatitis; Streptozocin; T-Lymphocytes, Cytotoxic | 1999 |
Leflunomide-mediated suppression of antiviral antibody and Tcell responses: differential restoration by uridine.
Topics: Animals; Antibodies, Viral; Antibody Formation; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Diabetes Mellitus; Dose-Response Relationship, Drug; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Transgenic; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Uridine; Vesicular stomatitis Indiana virus | 2001 |
Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoimmune Diseases; Basement Membrane; Cyclosporins; Isoxazoles; Kidney Tubules; Leflunomide; Nephritis, Interstitial; Oxazoles; Rats; Rats, Inbred BN | 1989 |
Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Mice; Mice, Inbred Strains; Oxazoles | 1986 |