isoxazoles has been researched along with Alloxan Diabetes in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (37.14) | 18.2507 |
| 2000's | 11 (31.43) | 29.6817 |
| 2010's | 9 (25.71) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Bao, Y; Chen, T; Dong, B; Hu, C; Jia, W; Jiang, C; Jiang, R; Kuang, J; Lan, K; Li, D; Li, H; Li, M; Lu, A; Rajani, C; Ren, Z; Sun, D; Wang, S; Wang, X; Wu, J; Wu, Q; Xia, J; Xie, G; Zhao, A; Zhao, M; Zheng, X | 1 |
| Cha, DR; Cha, JJ; Han, JY; Han, SY; Kang, YS; Song, HK | 1 |
| Battiprolu, PK; De Marchi, U; Dioum, EHM; Hajibeigi, A; Heikkila, E; Öz, OK; Pujol, JB; Savoia, C | 1 |
| Aboul-Fotouh, S; Elgayar, N | 1 |
| Cui, ZH; Jiang, YJ; Jin, H; Jin, HF; Jin, JZ; Jin, YS; Li, C; Li, JJ; Piao, SG; Yang, CW; Zheng, HL | 1 |
| Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M | 1 |
| Boychuk, CR; Halmos, KC; Smith, BN | 1 |
| He, T; Ji, Y; Lv, W; Wang, J; Zhang, Q | 1 |
| Azay-Milhau, J; Balzarin, S; Chajistamatiou, AS; Chrysina, ED; Docsa, T; Duret, C; Gergely, P; Goyard, D; Kónya, B; Leroy, J; Maurel, P; Petit, P; Praly, JP; Somsák, L; Tournier, M; Tousch, D; Vidal, S | 1 |
| Murakami, T; Ono, H; Tanabe, M | 1 |
| Ahmad, P; Kumar, A; Maurya, RA; Sharma, S; Singh, AB; Srivastava, AK; Tamrakar, AK | 1 |
| Bass, JY; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Mills, WY; Navas, F; Parks, DJ; Smalley, TL; Spearing, PK; Todd, D; Williams, SP; Wisely, GB | 1 |
| Liu, JP; Ren, XJ; Wang, H; Wang, JY; Yu, WM | 1 |
| Ekberg, H; Qi, Z; Shan, S; Wu, D; Zhang, L | 1 |
| Al-Abed, Y; Bacher, M; Cvetkovic, I; Lan, HY; Maksimovic-Ivanic, D; Miljkovic, D; Nicoletti, F; Roth, J; Stosic-Grujicic, S | 1 |
| Barrera, G; Edwards, PA; Gonzalez, FJ; Lee, FY; Lee, H; Vales, C; Willson, TM; Zhang, Y | 1 |
| Kim, J; Lim, S; Park, HS; Park, KS; Ryu, SH; Suh, PG; Yea, K | 1 |
| Kearns, H; McDonald, AS; Wright, JR | 1 |
| See, DM; Tilles, JG | 1 |
| Koshal, A; Lakey, JR; Rajotte, RV; Yatscoff, RW | 1 |
| Bartlett, RR; Dimitrijević, M; Stosić-Grujicić, S | 2 |
| Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Stone, L; Sun, WM; Wu, H | 1 |
| Chong, AS; Foster, P; Guo, Z; Jensik, S; McChesney, L; Mital, D; Sankary, H; Shen, J; Tian, Y; Williams, JW; Yin, D | 1 |
| Chong, AS; Foster, PF; Fu, Z; Guo, Z; Jensik, S; McChesney, LP; Mital, D; Sankary, HN; Shen, J; Tian, Y; Williams, JW | 1 |
| Chong, AS; Foster, P; Guo, Z; Jensik, SC; McChesney, L; Mital, D; Sankary, H; Shen, J; Tian, Y; Williams, JW | 1 |
| Matsui, K; Nagao, K; Shibata, T; Shinkai, H; Wakitani, K; Yonemori, F | 1 |
| Kadowaki, T | 1 |
| Asnis, N; Barros, HM; Gomez, R; Tannhauser, SL | 1 |
| Chan, O; Giacca, A; Kawamori, R; Mathoo, JM; Niwa, M; Rashid, S; Shum, K; Tchipashvili, V; Vranic, M | 1 |
| Blinder, L; Chong, A; Foster, P; Ma, LL; Sankary, HN; Shen, J; Williams, JW; Yin, DP | 1 |
| Bari, S; Bennet, W; Groth, CG; Korsgren, O; Nava, S; Song, Z; Sundberg, B; Wennberg, L; Zhang, J | 2 |
| Hasegawa, M; Makino, H; Nishimiya, T; Ochi, M; Onuma, H; Osawa, H; Tang, Y | 1 |
| Hall, IH; Izydore, RA; Simlot, R; Wong, OT | 1 |
1 review(s) available for isoxazoles and Alloxan Diabetes
| Article | Year |
|---|---|
[Insulin-sensitizing agents].
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Isoxazoles; Pioglitazone; Rosiglitazone; Thiazoles; Thiazolidinediones | 1999 |
34 other study(ies) available for isoxazoles and Alloxan Diabetes
| Article | Year |
|---|---|
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.
Topics: Animals; Blood Glucose; Cell Line; Cholic Acids; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Signal Transduction; Swine | 2021 |
Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model.
Topics: Adipose Tissue; Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Insulin Resistance; Isoxazoles; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear | 2021 |
Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function.
Topics: Animals; Calbindins; Cell Line, Tumor; Cell Survival; Diabetes Mellitus, Experimental; Gene Expression Regulation, Neoplastic; Humans; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Mice, Inbred NOD; Mice, SCID; NFATC Transcription Factors; Rats; Thiophenes | 2018 |
Atypical antipsychotics such as risperidone, but not paliperidone, worsen vascular endothelial function via upregulation of adhesion molecules VCAM-1, ICAM-1, and E-selectin in diabetic rats.
Topics: Animals; Antipsychotic Agents; Aorta; Blood Pressure; Cell Adhesion Molecules; Chemokine CCL2; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; E-Selectin; Endothelium, Vascular; Glucose; Insulin Resistance; Isoxazoles; Lipids; Male; Paliperidone Palmitate; Pyrimidines; Rats; Rats, Wistar; Risperidone; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2013 |
Synergistic effects of leflunomide and benazepril in streptozotocin-induced diabetic nephropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Benzazepines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Synergism; Isoxazoles; Leflunomide; Male; Rats; Rats, Wistar; Treatment Outcome | 2014 |
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles | 2014 |
Diabetes induces GABA receptor plasticity in murine vagal motor neurons.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Immunohistochemistry; Isoxazoles; Male; Membrane Potentials; Mice; Motor Neurons; Muscimol; Neuronal Plasticity; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Synapses; Vagus Nerve | 2015 |
Protective effects of leflunomide on renal lesions in a rat model if diabetic nephropathy.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Urea Nitrogen; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Evaluation, Preclinical; Immunosuppressive Agents; Isoxazoles; Kidney; Leflunomide; Male; Organ Size; Osteopontin; Rats, Wistar; Transforming Growth Factor beta1 | 2016 |
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Glycogen Phosphorylase; Hypoglycemic Agents; Isoxazoles; Molecular Structure; Rats; Rats, Zucker; Spiro Compounds; Structure-Activity Relationship | 2016 |
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Inflammation; Isoxazoles; Male; Mice; Pain; Streptozocin; Zonisamide | 2008 |
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Hypoglycemic Agents; Hypolipidemic Agents; Isoxazoles; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Rats, Sprague-Dawley; Rats, Wistar; Streptozocin; Sucrose; Triglycerides | 2009 |
Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.
Topics: Animals; Binding Sites; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Dogs; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Mice; Molecular Conformation; Naphthalenes; Protein Structure, Tertiary; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Weight Gain | 2011 |
Experimental study of leflunomide on renal protective effect and on inflammatory response of streptozotocin induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Chemokine CCL2; Creatinine; Cytoprotection; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Regulation; Immunohistochemistry; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Isoxazoles; Kidney; Leflunomide; Male; Nephrectomy; NF-kappa B; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2012 |
Additive effects of leflunomide and tacrolimus in prevention of islet xenograft rejection.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Synergism; Graft Rejection; Histocytochemistry; Immunosuppressive Agents; Interleukin-2; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Lymphocyte Subsets; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; T-Lymphocytes; Tacrolimus; Transplantation, Heterologous | 2004 |
Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes.
Topics: Animals; Antibodies; CD11b Antigen; Cell Adhesion; Cell Proliferation; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Isoxazoles; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Monocytes; Nitric Oxide; Receptors, Interleukin-2; Spleen | 2005 |
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Topics: 3-Hydroxybutyric Acid; Adenoviridae; Animals; Blood Glucose; Blotting, Northern; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; DNA-Binding Proteins; Etoposide; Gluconeogenesis; Glucose; Glycogen; Hepatocytes; Hyperglycemia; Hyperlipidemias; Insulin; Insulin Resistance; Isoxazoles; Lipids; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Statistical; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Triglycerides | 2006 |
Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Blood Glucose; Cell Membrane; Chromones; Diabetes Mellitus, Experimental; Down-Regulation; Glucose; Glucose Transporter Type 4; GTP-Binding Protein alpha Subunits, Gi-Go; Insulin; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Morpholines; Muscle Fibers, Skeletal; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propionates; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid | 2008 |
Leflunomide and cyclosporin-A prolong fish-to-mouse islet xenograft survival in BALB/C mice.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred BALB C; Tilapia; Transplantation, Heterologous | 1994 |
WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirus.
Topics: Animals; Antiviral Agents; Autoantibodies; Base Sequence; Coxsackievirus Infections; Diabetes Mellitus, Experimental; Enterovirus B, Human; Glucose Tolerance Test; Insulin; Islets of Langerhans; Isoxazoles; Male; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Molecular Sequence Data; Pancreas; RNA, Viral; Time Factors | 1993 |
Prolongation of concordant islet xenografts with leflunomide.
Topics: Animals; Antilymphocyte Serum; Cryopreservation; Diabetes Mellitus, Experimental; Graft Survival; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred WF; Time Factors; Transplantation, Heterologous | 1996 |
A novel immunomodulating agent--leflunomide inhibits experimental autoimmune diabetes in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hyperglycemia; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred CBA; Time Factors | 1996 |
Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats.
Topics: Animals; Bile; Diabetes Mellitus, Experimental; Disease Progression; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Liver; Male; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1997 |
Effect of leflunomide and cyclosporine on concordant xenogeneic islet transplantation in streptozotocin-induced and autoimmune diabetic mice.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Rats; Rats, Sprague-Dawley; Species Specificity; Transplantation, Heterologous | 1997 |
Successful xenotransplantation of adult porcine islets in NOD and BALB/c mice with leflunomide and cyclosporine.
Topics: Animals; Cyclosporine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Graft Survival; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Swine; Transplantation, Heterologous | 1997 |
Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice.
Topics: Animals; Autoimmune Diseases; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mice; Mice, Inbred NOD; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Recurrence; Transplantation, Heterologous | 1998 |
Prevention of experimental autoimmune diabetes in mice by treatment with leflunomide.
Topics: Aniline Compounds; Animals; Crotonates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fibrosis; Hydroxybutyrates; Immunosuppressive Agents; Islets of Langerhans; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred CBA; Nitriles; Toluidines | 1998 |
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative.
Topics: 3T3 Cells; Administration, Oral; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxidation-Reduction; Pioglitazone; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 1999 |
GABA agonists differentially modify blood glucose levels of diabetic rats.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Benzodiazepines; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Female; GABA Agonists; Insulin; Isoxazoles; Rats; Rats, Wistar | 1999 |
Effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glucose; Hypoglycemic Agents; Insulin; Isoxazoles; Liver; Male | 2000 |
Efficacy of FK506, leflunomide, anti-CD4, and CTLA4IG treatments in rat to mouse pancreas xenograft transplantation.
Topics: Abatacept; Animals; Antibodies, Heterophile; Antigens, CD; Antigens, Differentiation; CD4 Antigens; CTLA-4 Antigen; Diabetes Mellitus, Experimental; Immunoconjugates; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred C57BL; Pancreas Transplantation; Rats; Rats, Inbred Lew; Tacrolimus; Transplantation, Heterologous | 2000 |
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2000 |
Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days.
Topics: Animals; Antibodies, Heterophile; Blood Glucose; C-Peptide; Cell Culture Techniques; Cell Separation; Cyclosporine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Female; Graft Survival; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Macrophages; Mice; Mice, Nude; Mycophenolic Acid; Rats; Rats, Inbred Lew; Swine; Transplantation, Heterologous | 2001 |
Adipocyte-specific reduction of phosphodiesterase 3B gene expression and its restoration by JTT-501 in the obese, diabetic KKAy mouse.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Adipose Tissue; Animals; Blood Glucose; Blotting, Western; Cyclic Nucleotide Phosphodiesterases, Type 3; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epididymis; Fatty Acids; Female; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Insulin; Insulin Resistance; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; RNA, Messenger; Triglycerides | 2001 |
Potential aldose reductase inhibitors: 1,2,4-triazolidine-3,5-diones and 2-(3,4,5-trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione .
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Isoxazoles; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Triazoles | 1992 |