Page last updated: 2024-08-21

isoxazoles and Aging

isoxazoles has been researched along with Aging in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.11)18.7374
1990's6 (22.22)18.2507
2000's10 (37.04)29.6817
2010's6 (22.22)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Chang, HC; Li, H; Li, Q; Li, Y; Ou, J; Peng, C; Tang, YC; Wu, P; Xu, N1
Cui, R; Ji, X; Kang, Y; Shi, G; Wang, Y; Yan, H; Zhang, G; Zhang, T; Zhao, H1
Lossius, MI; Markhus, R; Nakken, KO; Sætre, E1
Chondrogianni, N; Fotopoulou, T; Gonos, ES; Heropoulos, GA; Kapetanou, M; Koufaki, M1
Afroz, S; Shen, H; Smith, SS1
Angulo, MC; Audinat, E; Vélez-Fort, M1
Agüeros, C; Arias, M; Benito, A; Cosme, LS; Gimenez, T; Gómez-Alamillo, C; Merino, J; Merino, R; Ramos-Barrón, MA; Santiuste, I1
Calarge, CA; Miller, del D1
Chen, G; Gong, M; Wang, HM; Xu, LH; Yan, M; Zhang, XM1
Chen, C; Peng, M; Wang, CY; Wang, FF; Wang, YL1
Fukuoka, N; Kimura, M; Morita, S; Tsukamoto, T; Uno, J1
Aichhorn, W; Geretsegger, C; Kemmler, G; Marksteiner, J; Stelzig-Schoeler, R; Stuppaeck, C; Walch, T; Weiss, U; Zernig, G1
Furst, DE; Ranganath, VK1
Lauri, SE; Malkki, H; Sallert, M; Segerstråle, M; Taira, T1
Diaz, FJ; Leon, Jd; Orrego, ML; Pan, RM; Susce, MT; Wedlund, PJ1
Brust, P; Deuther-Conrad, W; Ebert, B; Friemel, A; Hutson, PH; Nieber, K1
Mueller, AL; Schwartzkroin, PA; Taube, JS1
Fitton, A; Grant, S1
Bartlett, RR; Brendel, S; Schorlemmer, HU1
Arneric, SP; Buccafusco, JJ; Decker, MW; Jackson, WJ; Marsh, KC; Prendergast, MA; Terry, AV1
Bartlett, RR; Schorlemmer, HU1
Andiné, P; Axelsson, R; Mårtensson, E; Nyberg, G; Olofsson, U; Sandberg, M; Widermark, N1
Huettner, JE; Wilding, TJ1
Kastango, KB; Kirshner, MA; Maxwell, RA; Mulsant, BH; Pollock, BG; Rosen, J; Sweet, RA1
Ebbesson, SO; Erdö, SL; Hofmann, MH; Malz, CR; Meyer, DL1
Gregus, Z; Klaassen, CD; Stein, AF1
Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y1

Reviews

3 review(s) available for isoxazoles and Aging

ArticleYear
[Epilepsy in the elderly].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2013, Mar-05, Volume: 133, Issue:5

    Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Piracetam; Quality of Life; Seizures; Triazines; Zonisamide

2013
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.
    Rheumatic diseases clinics of North America, 2007, Volume: 33, Issue:1

    Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Glomerular Filtration Rate; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine

2007
Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Absorption; Adult; Aged; Aging; Animals; Antipsychotic Agents; Central Nervous System; Cross-Over Studies; Disease Models, Animal; Drug Interactions; Hemodynamics; Humans; Isoxazoles; Neurosecretory Systems; Piperidines; Risperidone; Schizophrenia; Synaptic Transmission; Tissue Distribution

1994

Trials

2 trial(s) available for isoxazoles and Aging

ArticleYear
A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels.
    Pharmacopsychiatry, 2007, Volume: 40, Issue:3

    Topics: Adult; Aging; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Humans; Isoxazoles; Linear Models; Male; Middle Aged; Organic Anion Transporters; Paliperidone Palmitate; Pyrimidines; Risperidone; Sex Factors

2007
Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.
    Drugs, 1994, Volume: 48, Issue:2

    Topics: Absorption; Adult; Aged; Aging; Animals; Antipsychotic Agents; Central Nervous System; Cross-Over Studies; Disease Models, Animal; Drug Interactions; Hemodynamics; Humans; Isoxazoles; Neurosecretory Systems; Piperidines; Risperidone; Schizophrenia; Synaptic Transmission; Tissue Distribution

1994

Other Studies

23 other study(ies) available for isoxazoles and Aging

ArticleYear
ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude.
    Communications biology, 2022, 07-28, Volume: 5, Issue:1

    Topics: Aging; Animals; ARNTL Transcription Factors; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Circadian Rhythm; Homeostasis; Isoxazoles; Mice; Sleep; Thiophenes

2022
Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition.
    Neuropharmacology, 2021, 08-15, Volume: 194

    Topics: Aging; Animals; Calcium-Binding Proteins; Cyclooxygenase 2; Cytokines; Dinoprostone; Dopamine Plasma Membrane Transport Proteins; Isoxazoles; Male; Microfilament Proteins; Microglia; Mitochondria; Mitochondrial Proteins; Motor Activity; Organelle Biogenesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Substantia Nigra; Superoxide Dismutase; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases

2021
Microwave-assisted synthesis of 3,5-disubstituted isoxazoles and evaluation of their anti-ageing activity.
    European journal of medicinal chemistry, 2014, Aug-18, Volume: 83

    Topics: Aging; Alkynes; Animals; Caenorhabditis elegans; Cell Line; Chemistry Techniques, Synthetic; Humans; Isoxazoles; Longevity; Microwaves; Oxidative Stress; Oxides; Stereoisomerism; Substrate Specificity

2014
α4βδ GABA
    Neuroscience, 2017, 04-07, Volume: 347

    Topics: Aging; Animals; CA1 Region, Hippocampal; Dendritic Spines; Female; GABA-A Receptor Agonists; Isoxazoles; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Pregnanolone; Receptors, GABA-A; Spatial Learning

2017
Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus.
    Glia, 2009, Aug-01, Volume: 57, Issue:10

    Topics: Age Factors; Aging; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Antigens; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Hippocampus; Ion Channel Gating; Isoxazoles; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Oligodendroglia; Organ Culture Techniques; Patch-Clamp Techniques; Phenylurea Compounds; Proteoglycans; Receptors, Nicotinic; Stem Cells

2009
Leflunomide derivative FK778 inhibits production of antibodies in an experimental model of alloreactive T-B cell interaction.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2009, Volume: 7, Issue:4

    Topics: Age Factors; Aging; Alkynes; Animals; Antibody Formation; Autoantibodies; B-Lymphocytes; Dose-Response Relationship, Drug; Genes, bcl-2; Humans; Immunosuppressive Agents; Isoxazoles; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; T-Lymphocytes; Transplantation Tolerance

2009
Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents.
    Journal of child and adolescent psychopharmacology, 2011, Volume: 21, Issue:2

    Topics: Adolescent; Aging; Antipsychotic Agents; Body Mass Index; Child; Child Development Disorders, Pervasive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Therapy, Combination; Female; Humans; Isoxazoles; Male; Mental Disorders; Paliperidone Palmitate; Polypharmacy; Psychotic Disorders; Pyrimidines; Risperidone; Sex Factors; Sexual Development

2011
Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:5

    Topics: Aging; Anesthetics, Intravenous; Animals; Blotting, Western; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Hippocampus; Isoxazoles; Male; Maze Learning; Memory; Memory Disorders; Methyl Ethers; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Sevoflurane; Synapses

2012
The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats.
    The Journal of surgical research, 2012, Volume: 178, Issue:1

    Topics: Aging; Animals; Cognition Disorders; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Encephalitis; Gene Expression; Hippocampus; Interleukin-1beta; Isoxazoles; Male; Postoperative Complications; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2012
Influence of coadministered antiepileptic drugs on serum zonisamide concentrations in epileptic patients: quantitative analysis based on suitable transforming factor.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Aging; Anticonvulsants; Biological Availability; Body Surface Area; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Isoxazoles; Male; Patient Selection; Phenytoin; Powders; Regression Analysis; Sex; Tablets; Zonisamide

2003
Influence of age and gender on risperidone plasma concentrations.
    Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Female; Humans; Isoxazoles; Male; Middle Aged; Paliperidone Palmitate; Pyrimidines; Risperidone; Sex Characteristics

2005
Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development.
    Neuropharmacology, 2007, Volume: 52, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Electrophysiology; Excitatory Amino Acid Agonists; Glutamates; Hippocampus; In Vitro Techniques; Isoxazoles; Neuronal Plasticity; Propionates; Rats; Rats, Wistar; Receptors, Kainic Acid; Signal Transduction; Synapses; Synaptic Transmission

2007
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
    Brain research, 2007, Sep-19, Volume: 1170

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Subcellular Fractions

2007
Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neurons; Rabbits; Synapses

1984
Malononitrilamides prevent the development of murine systemic lupus erythematosus-like diseases in BDF1 hybrid mice and MRL/lpr autoimmune mice.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Aging; Alkynes; Animals; Antibody Formation; Crosses, Genetic; Disease Models, Animal; Female; Graft vs Host Disease; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Lupus Erythematosus, Systemic; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Nitriles

1996
Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418.
    Psychopharmacology, 1997, Volume: 130, Issue:3

    Topics: Administration, Cutaneous; Aging; Anti-Anxiety Agents; Female; Humans; Injections, Intramuscular; Isoxazoles; Male; Mental Recall; Pyrrolidines; Time Factors

1997
Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 2

    Topics: Aging; Alkynes; Animals; Autoimmune Diseases; Female; Immunosuppressive Agents; Isoxazoles; Kinetics; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred DBA; Nitriles; Spleen; Splenomegaly

1997
Characterization of MK-801-induced behavior as a putative rat model of psychosis.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Aging; Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Isoxazoles; Male; Motor Activity; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Receptors, GABA; Sex Characteristics; Stereotyped Behavior; Stereotypic Movement Disorder

1999
Functional diversity and developmental changes in rat neuronal kainate receptors.
    The Journal of physiology, 2001, Apr-15, Volume: 532, Issue:Pt 2

    Topics: Aging; Animals; Animals, Newborn; Cells, Cultured; Electric Conductivity; Embryo, Mammalian; Excitatory Amino Acid Agonists; Ganglia, Spinal; Hippocampus; Isoxazoles; Kainic Acid; Neurons; Propionates; Rats; Rats, Long-Evans; Receptors, Kainic Acid; Spinal Cord

2001
Risperidone and 9-hydroxyrisperidone concentrations are not dependent on age or creatinine clearance among elderly subjects.
    Journal of geriatric psychiatry and neurology, 2002,Summer, Volume: 15, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Creatinine; Female; Humans; Isoxazoles; Male; Middle Aged; Paliperidone Palmitate; Pyrimidines; Radioimmunoassay; Risperidone

2002
Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
    Journal fur Hirnforschung, 1992, Volume: 33, Issue:4-5

    Topics: Aging; Aminobutyrates; Analgesics; Animals; Baclofen; Bicuculline; Binding, Competitive; Brain; Female; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Ligands; Male; Muscimol; Receptors, GABA-A; Salmon; Sexual Behavior, Animal

1992
Age-dependent biliary excretion of glutathione-related thiols in rats: role of gamma-glutamyltransferase.
    The American journal of physiology, 1987, Volume: 253, Issue:1 Pt 1

    Topics: Aging; Animals; Bile; Disulfides; gamma-Glutamyltransferase; Glutathione; Hydrolysis; Isoxazoles; Liver; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfur

1987
Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice.
    Life sciences, 1987, Sep-14, Volume: 41, Issue:11

    Topics: Aging; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Zonisamide

1987