Compounds > isoxazoles
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isoxazoles and Acute Liver Injury, Drug-Induced

isoxazoles has been researched along with Acute Liver Injury, Drug-Induced in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.33)18.7374
1990's0 (0.00)18.2507
2000's15 (34.88)29.6817
2010's27 (62.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bae, GH; Bae, YS; Kim, HS; Lee, HY; Lee, M; Lee, SK1
Deng, WH; Guo, ZD; Hong, YP; Shi, Q; Wang, P; Wang, WX; Zhao, L; Zuo, T1
Couch, L; Guo, L; Qing, T; Ren, Z; Shi, L; Tolleson, WH; Xuan, J1
Catalá-López, F; de la Fuente Honrubia, C; Macías Saint-Gerons, D; Montero Corominas, D1
Andersson, LC; Bergare, J; Billger, M; Eakins, JA; Elebring, M; Elmore, CS; Foster, AJ; Kenna, JG; Stahl, SH; Thompson, RA1
Ali, EA; Bilasy, SE; Essawy, SS; Mandour, MF; Zaitone, SA1
Chen, CJ; Cheng, TT; Lin, JC; Lin, KM1
Chen, Z; Li, XM; Li, XP; Li, ZG; Su, Y; Xiang, N; Yang, M; Zhang, MJ; Zhao, DB; Zhu, P; Zuo, XX1
Fu, X; Huang, M; Huang, Z; Jin, J; Qiu, Y; Sun, X; Wang, W; Zhao, Z1
Alsleben, N; Donald, PR; Garcia-Prats, AJ; Hesseling, AC; Schaaf, HS; Willemse, M1
Cao, L; Cheng, X; Hao, H; Wang, G; Wang, H; Wu, M; Wu, Y; Xie, W; Xie, Y1
Cao, YY; Chen, C; Lin, YF; Luan, Y; Ma, LL; Ni, X; Pan, GY; Wang, J; Wang, L; Wu, ZT; Zhang, XF1
Goda, K; Kobayashi, A; Kuno, H; Shoda, T; Sugai, S; Takahashi, T1
Chan, EC; New, LS; Tan, SC1
Beukelman, T; Cassell, S; Curtis, JR; Greenberg, JD; Kavanaugh, A; Kremer, JM; Onofrei, A; Reed, G; Strand, V1
Aleksunes, LM; Cui, YJ; Goedken, MJ; Klaassen, CD; Tanaka, Y1
Golpon, H; Hoeper, MM; Olsson, KM; Schneider, A1
Hoeper, MM1
Gaine, SP; Kelleher, B; Lavelle, A; Lawler, G; Mulligan, N; Murphy, DM; Sugrue, R1
Andrade, RJ; Cotta, J; Lucena, MA; Robles, M; Toscano, E1
Hinton, DE; Howarth, DL; Kullman, SW; Law, JM; Law, SH; Mondon, JA1
Corris, PA; Langleben, D1
Gründer, G; Orfanos, S; Paulzen, M1
Galiè, N; Gibbs, JS; Hoeper, MM; Simonneau, G1
Fisher, AJ; Johnson, MK; Kirkham, N; Lee, WT; Lordan, JL; Peacock, AJ1
Galiè, N; Gibbs, R; Hoeper, MM; Simon, J; Simonneau, G1
Chen, B; Huang, WH; Lee, AR; Media, J; Shaw, J; Valeriote, FA1
Muñana, KR; Olby, NJ; Schwartz, M1
Bhatia, J; Gupta, R; Gupta, SK1
Izuta, S; Maekawa, N; Nishina, K; Shiozawa, S; Ueki, M; Ueno, M1
Gučev, F; Hočevar, A; Marolt, VF; Perdan-Pirkmajer, K; Rotar, Ž; Tomšič, M; Žibert, J1
Dulaurent, S; Gaulier, JM; Lachâtre, G; Moesch, C; Zouaoui, K1
Grove, ML1
Jin, Y; Li, CY; Li, J; Xu, SY; Yao, HW; Zhang, YF1
Agúndez, JA; Díaz-Rubio, M; Fernández-Gutiérrez, B; Ladero, JM; Ortega, L; Sevilla-Mantilla, C1
Brouwers, JR; Houtman, NM; Jansen, TL; Spoelstra, P; van Roon, EN1
Bitton, A; Ernst, P; Hudson, M; Kezouh, A; Suissa, S1
Gupta, R; Gupta, SK1
Choi, K; Khosla, C; Kosek, JC; Omary, MB; Siegel, M; Strnad, P; Toivola, DM1
Saito, E; Suwa, A; Suzuki, Y; Wakabayashi, T1
Hartmann, U; Reuss-Borst, M; Schmitt, S1
Breedveld, FC1
Tiegs, G; Wendel, A1

Reviews

2 review(s) available for isoxazoles and Acute Liver Injury, Drug-Induced

ArticleYear
[Hepatotoxicity in patients treated with endothelin receptor antagonists: systematic review and meta-analysis of randomized clinical trials].
    Medicina clinica, 2014, Apr-22, Volume: 142, Issue:8

    Topics: Antihypertensive Agents; Biomarkers; Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals; Sulfonamides; Thiophenes; Transaminases

2014
[Adverse effects of conventional DMARDs and biologic DMARDs].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug Eruptions; Drug Hypersensitivity; Hematologic Diseases; Humans; Immune System Diseases; Infliximab; Isoxazoles; Kidney Diseases; Leflunomide; Lung Diseases; Methotrexate

2007

Trials

2 trial(s) available for isoxazoles and Acute Liver Injury, Drug-Induced

ArticleYear
Total glucosides of paeony can reduce the hepatotoxicity caused by Methotrexate and Leflunomide combination treatment of active rheumatoid arthritis.
    International immunopharmacology, 2015, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Paeonia; Treatment Outcome; Young Adult

2015
Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients.
    Arzneimittel-Forschung, 2011, Volume: 61, Issue:5

    Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Risk

2011

Other Studies

39 other study(ies) available for isoxazoles and Acute Liver Injury, Drug-Induced

ArticleYear
Lysophosphatidic acid protects against acetaminophen-induced acute liver injury.
    Experimental & molecular medicine, 2017, 12-08, Volume: 49, Issue:12

    Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hepatocytes; Humans; Interleukin-1beta; Isoxazoles; Liver; Lysophospholipids; Mice; Oxidative Stress; Propionates; Receptors, Lysophosphatidic Acid; Tumor Necrosis Factor-alpha

2017
Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy.
    The journal of obstetrics and gynaecology research, 2018, Volume: 44, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Isoxazoles; Macrophage Migration-Inhibitory Factors; Pancreatitis; Pregnancy; Pregnancy Complications; Prenatal Injuries; Rats; Rats, Sprague-Dawley

2018
Mitochondrial dysfunction induced by leflunomide and its active metabolite.
    Toxicology, 2018, 03-01, Volume: 396-397

    Topics: Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Bongkrekic Acid; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Galactose; Glucose; Hep G2 Cells; Humans; Isoxazoles; L-Lactate Dehydrogenase; Leflunomide; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Diseases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Phosphorylation

2018
Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 352, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bosentan; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Epithelial Cells; Hepatocytes; Humans; Isoxazoles; Mitochondria; Molecular Structure; Oxygen Consumption; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes

2015
Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Hindlimb; Isoxazoles; Leflunomide; Liver Cirrhosis; Male; Methotrexate; Rats; Rats, Wistar; Spleen

2015
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study.
    Clinical rheumatology, 2015, Volume: 34, Issue:6

    Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha

2015
Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, Sep-15, Volume: 22, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Gene Knockdown Techniques; Hep G2 Cells; Humans; Isoxazoles; Liver; Male; Mice, Inbred BALB C; Phenanthrenes; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering

2015
Successful Treatment of a Child With Extensively Drug-Resistant Tuberculous Meningitis.
    Journal of the Pediatric Infectious Diseases Society, 2015, Volume: 4, Issue:3

    Topics: Anti-Inflammatory Agents; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Female; Humans; Hypothyroidism; Isoxazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazolidinones; Prednisolone; Treatment Outcome; Tuberculosis, Meningeal

2015
Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming.
    Scientific reports, 2016, Jan-05, Volume: 6

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glycolysis; Hep G2 Cells; Humans; Isoxazoles; Liver Regeneration; Metabolome; Metabolomics; Mice; Mice, Knockout; Models, Biological; Protein Kinases; Receptors, Cytoplasmic and Nuclear

2016
Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:3

    Topics: Animals; Antirheumatic Agents; Cells, Cultured; Chemical and Drug Induced Liver Injury; Crotonates; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; HEK293 Cells; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Liver; Male; Mice, Inbred C57BL; Nitriles; Organic Anion Transporters, Sodium-Dependent; Rats, Sprague-Dawley; Symporters; Toluidines

2016
Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:5

    Topics: Acetaminophen; Apoptosis; Biological Assay; Biomarkers; Caspase 3; Caspase 7; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Diclofenac; Dose-Response Relationship, Drug; Ethanol; Hepatocytes; Humans; Isoxazoles; Leflunomide; Liver; Mitochondria, Liver; Oxygen Consumption; Primary Cell Culture; Ranitidine; Risk Assessment; Thiazolidinediones; Time Factors; Toxicity Tests; Troglitazone

2016
Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.
    Toxicology letters, 2008, Aug-28, Volume: 180, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Glutathione; Humans; Imines; Isoxazoles; Leflunomide; Mass Spectrometry; Mice; Microsomes, Liver; Phenacetin; Recombinant Proteins

2008
Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide.
    Annals of the rheumatic diseases, 2010, Volume: 69, Issue:1

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Cohort Studies; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Young Adult

2010
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 110, Issue:1

    Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Branched DNA Signal Amplification Assay; Carrier Proteins; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fluorescent Antibody Technique; Isoxazoles; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA

2009
Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy.
    The European respiratory journal, 2009, Volume: 33, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Eisenmenger Complex; Endothelin Receptor Antagonists; Female; Glucocorticoids; Humans; Isoxazoles; Liver Function Tests; Thiophenes; Young Adult

2009
Liver toxicity: the Achilles' heel of endothelin receptor antagonist therapy?
    The European respiratory journal, 2009, Volume: 34, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Isoxazoles; Thiophenes

2009
Sitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension.
    The European respiratory journal, 2009, Volume: 34, Issue:3

    Topics: Aged; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes

2009
[Hepatotoxicity induced by new immunosuppressants].
    Gastroenterologia y hepatologia, 2010, Volume: 33, Issue:1

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha

2010
Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes).
    Toxicology and applied pharmacology, 2010, Feb-15, Volume: 243, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental; Isoxazoles; Liver; Male; Oryzias; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Yolk Sac

2010
The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension.
    The European respiratory journal, 2010, Volume: 35, Issue:2

    Topics: Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Phenotype; Receptors, Endothelin; Sulfonamides; Thiophenes

2010
Remission of drug-induced hepatitis after switching from risperidone to paliperidone.
    The American journal of psychiatry, 2010, Volume: 167, Issue:3

    Topics: Adult; Antipsychotic Agents; Biotransformation; Chemical and Drug Induced Liver Injury; Clozapine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Liver Function Tests; Paliperidone Palmitate; Pyrimidines; Reference Values; Risperidone; Schizophrenia

2010
Liver toxicity of sitaxentan in pulmonary arterial hypertension.
    The European respiratory journal, 2011, Volume: 37, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Failure; Practice Guidelines as Topic; Thiophenes

2011
Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension.
    The European respiratory journal, 2011, Volume: 37, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Fatal Outcome; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Jaundice; Liver Failure, Acute; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Vasodilator Agents; Young Adult

2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension.
    European heart journal, 2011, Volume: 32, Issue:4

    Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Early Termination of Clinical Trials; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Safety-Based Drug Withdrawals; Thiophenes

2011
The small-molecule TNF-alpha modulator, UTL-5g, reduces side effects induced by cisplatin and enhances the therapeutic effect of cisplatin in vivo.
    Journal of experimental therapeutics & oncology, 2011, Volume: 9, Issue:2

    Topics: Animals; Antineoplastic Agents; Blood Urea Nitrogen; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cisplatin; Colonic Neoplasms; Female; Hematologic Diseases; Humans; Isoxazoles; Kidney Diseases; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Mice, SCID; Platelet Count; Toxicity Tests, Acute; Tumor Necrosis Factor-alpha

2011
Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy.
    The Journal of veterinary medical science, 2011, Volume: 73, Issue:11

    Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Epilepsy; Female; Isoxazoles; Zonisamide

2011
T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice.
    Biotechnology letters, 2012, Volume: 34, Issue:12

    Topics: Animals; Benzophenones; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Enzymes; Gastrointestinal Agents; Hepatitis, Animal; Isoxazoles; Lipopolysaccharides; Liver; Mice; Survival Analysis

2012
Tumour necrosis factor-alpha inhibitor-induced hepatic injury in patients with rheumatoid arthritis: two case reports and an analysis of the laboratory data from the Slovenian national biologicals registry.
    Rheumatology international, 2013, Volume: 33, Issue:11

    Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Registries; Slovenia; Sulfasalazine; Tumor Necrosis Factor-alpha

2013
Determination of glyphosate and AMPA in blood and urine from humans: about 13 cases of acute intoxication.
    Forensic science international, 2013, Mar-10, Volume: 226, Issue:1-3

    Topics: Accidents; Acidosis; Adult; Aged; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Consciousness Disorders; Deglutition Disorders; Disseminated Intravascular Coagulation; Female; Forensic Toxicology; Glycine; Glyphosate; Heart Arrest; Hemodynamics; Herbicides; Humans; Hyperkalemia; Isoxazoles; Lactic Acid; Male; Mass Spectrometry; Middle Aged; Multiple Organ Failure; Nausea; Organophosphonates; Oropharynx; Pharyngeal Diseases; Pharyngitis; Renal Insufficiency; Respiratory Distress Syndrome; Shock; Suicide; Tetrazoles; Ulcer; Vomiting

2013
US Food and Drug Administration gets it right.
    BMJ (Clinical research ed.), 2002, Oct-05, Volume: 325, Issue:7367

    Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Drug Approval; Humans; Isoenzymes; Isoxazoles; Leflunomide; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Records; United Kingdom; United States; United States Food and Drug Administration

2002
[Effects of leflunomide on immunological liver injury].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2001, Volume: 36, Issue:10

    Topics: Adjuvants, Immunologic; Animals; Cell Division; Chemical and Drug Induced Liver Injury; Interleukin-1; Isoxazoles; Leflunomide; Lipopolysaccharides; Lymphocytes; Male; Mice; Nitric Oxide; Tumor Necrosis Factor-alpha

2001
Leflunomide-induced acute hepatitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2004, Volume: 36, Issue:1

    Topics: Adjuvants, Immunologic; Aged; Anion Exchange Resins; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestyramine Resin; Female; Humans; Isoxazoles; Leflunomide; Liver

2004
Leflunomide for the treatment of rheumatoid arthritis in clinical practice: incidence and severity of hepatotoxicity.
    Drug safety, 2004, Volume: 27, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Isoxazoles; Jaundice; Leflunomide; Male; Middle Aged

2004
Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis.
    The American journal of medicine, 2004, Jul-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Liver; Liver Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Severity of Illness Index; Treatment Outcome; United States

2004
Severe hepatotoxicity in a rheumatoid arthritis patient switched from leflunomide to methotrexate.
    MedGenMed : Medscape general medicine, 2005, Sep-06, Volume: 7, Issue:3

    Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Severity of Illness Index

2005
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
    FEBS letters, 2006, Apr-17, Volume: 580, Issue:9

    Topics: Animals; Cell Size; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Enzyme Inhibitors; GTP-Binding Proteins; Hepatomegaly; Humans; Inclusion Bodies; Isoxazoles; Keratins; Liver Diseases; Mice; Mice, Inbred C3H; Protein Glutamine gamma Glutamyltransferase 2; Proteins; Transglutaminases

2006
[Elevated liver enzymes in rheumatoid arthritis : differential diagnostic considerations based on a case report].
    Zeitschrift fur Rheumatologie, 2008, Volume: 67, Issue:5

    Topics: Adalimumab; Adolescent; Alanine Transaminase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Aspartate Aminotransferases; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Cortisone; Diagnosis, Differential; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Isoxazoles; Leflunomide; Liver; Liver Function Tests; Methotrexate; Prednisolone

2008
Is there a place for leflunomide in the treatment of rheumatoid arthritis?
    Lancet (London, England), 2001, Oct-13, Volume: 358, Issue:9289

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic

2001
Leukotriene-mediated liver injury.
    Biochemical pharmacology, 1988, Jul-01, Volume: 37, Issue:13

    Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Glutathione; Isoxazoles; Leukotriene E4; Liver; Male; Mice; SRS-A

1988