isotretinoin and Tibial-Fractures

Using etretinate as a model compound, the bone changes characteristic of hypervitaminosis A were evaluated in the rat in terms of tibial bone-breaking strain. Dose-related effects were observed in the dose range of 5-30 mg/kg p.o. for 15 days. The model proved a simple and precise means of assessing hypervitaminosis A in this species. Isotretinoin also showed a small but significant reduction in tibial breaking strain, but with a shallow dose-response curve in the range of 50-150 mg/kg.

Topics: Animals; Body Weight; Bone and Bones; Dose-Response Relationship, Drug; Etretinate; Female; Isotretinoin; Rats; Tensile Strength; Tibial Fractures; Tretinoin; Vitamin A