isotretinoin has been researched along with Purpura--Thrombotic-Thrombocytopenic* in 3 studies
3 other study(ies) available for isotretinoin and Purpura--Thrombotic-Thrombocytopenic
| Article | Year |
|---|---|
Control of thrombotic thrombocytopenic purpura by sirolimus in a child with juvenile myelomonocytic leukemia and somatic N-RAS mutation.
We describe an infant who developed juvenile myelomonocytic leukemia (JMML) at the age of 6 months. Myeloproliferation was effectively controlled by low-dose cytosine arabinoside and 13-cis retinoic acid therapy. Two years after therapy for JMML was stopped, at the age of 5 years, the patient developed autoimmune thrombotic thrombocytopenic purpura (TTP). TTP was transiently controlled by plasma exchange, prednisolone, rituximab, and cyclophosphamide, but relapsed within a short time. Long-term control of TTP was established by sirolimus. Somatic N-RAS G38A→Gly13Asp substitution was restricted to hematopoietic cells. The somatic N-RAS mutation may link myeloproliferation and autoimmunity. Topics: Age of Onset; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytarabine; Genes, ras; Humans; Infant; Isotretinoin; Leukemia, Myelomonocytic, Juvenile; Mutation; Purpura, Thrombotic Thrombocytopenic; Sirolimus | 2014 |
A case of severe refractory thrombotic thrombocytic purpura responding to treatment with 13-cis retinoic acid.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Isotretinoin; Purpura, Thrombotic Thrombocytopenic; Vincristine | 2002 |
Remission after 13-cis retinoic acid in thrombotic thrombocytopenic purpura.
Topics: Child; Combined Modality Therapy; Exchange Transfusion, Whole Blood; Humans; Isotretinoin; Male; Purpura, Thrombotic Thrombocytopenic; Remission Induction; Splenectomy; Treatment Outcome | 1998 |