isotretinoin and Pulmonary-Edema

Isotretinoin is considered to be a safe and effective therapy in otherwise therapy-resistant acne. Elevated serum creatine phosphokinase values with or without muscle-related symptoms in isotretinoin-treated patients have been reported and interpreted as benign phenomena, lethal cases have not been described yet. We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.

Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Substitution; Fatal Outcome; Humans; Isotretinoin; Long-Term Care; Lung; Male; Muscle, Skeletal; Necrosis; Phagocytosis; Pulmonary Edema; Rhabdomyolysis; Ventricular Fibrillation; Young Adult