isotretinoin and Porokeratosis

Porokeratosis, a well recognized disorder of keratinization, is known to have several clinical variants. This report describes a rare variant characterized by verrucous plaques.. An adult male presented with a slowly progressive verrucous plaque on the gluteal region that was resistant to conventional therapy. Careful inspection revealed a keratotic ridge at the plaque border leading to the diagnosis.. Histopathology showed the presence of multiple cornoid lamellae confirming the diagnosis of porokeratosis ptychotropica.. Porokeratosis ptychotropica is a rare variant of porokeratosis with fewer than 25 cases described in the literature. This report is to highlight the importance of considering this particular entity in the diagnosis of genitogluteal plaques, especially those not responding to conventional modalities.

Topics: Adult; Biopsy; Buttocks; Drug Therapy, Combination; Epidermis; Fluorouracil; Humans; Isotretinoin; Male; Porokeratosis

Porokeratosis is a disorder of epidermal keratinization characterized by annular plaques with an atrophic centre and hyperkeratotic edges, and includes a heterogeneous group of disorders that are mostly inherited in an autosomal dominant fashion. Facial porokeratosis is rare and is not well documented. We present six cases of facial porokeratosis seen over a period of 15 years in a hospital in Lima, Peru. In most of the cases, porokeratosis was found in younger women without any significant past medical history. Oral isotretinoin showed moderate improvement in two of our patients.

Topics: Adult; Dermatologic Agents; Face; Female; Humans; Isotretinoin; Male; Middle Aged; Peru; Porokeratosis; Salicylic Acid; Tretinoin; Young Adult

Disseminated actinic keratoses are a therapeutic problem.. Our purpose was to evaluate the efficacy of a combination of topical 5-fluorouracil twice a day and 20 mg of oral isotretinoin daily for disseminated actinic keratoses.. Twenty-seven patients who had disseminated actinic keratoses (3 women, 24 men) were treated with 5-fluorouracil (5%) twice a day applied to the photodamaged area bearing actinic keratoses along with oral isotretinoin, 20 mg daily. The median treatment time was 21 days.. Actinic keratoses disappeared and signs of photodamaged skin improved in all patients. Side effects were burning and itching as well as painful erosions during the final stage of treatment.. The combination of topical 5-fluorouracil and isotretinoin is highly effective in the treatment of disseminated actinic keratoses on photodamaged skin.

Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; Humans; Isotretinoin; Male; Middle Aged; Photosensitivity Disorders; Porokeratosis; Remission Induction; Treatment Outcome