isotretinoin and Papillomavirus-Infections

Retinoids (RA) and interferon (IFN) have been reported to be active against a variety of tumors and human papillomavirus (HPV)-related lesions. Because chronic and recurrent HPV-linked vulvar intraepithelial neoplasia 3 (VIN 3) have a high risk of invasion, we evaluated combined therapy of IFN-alpha with 13-cis-retinoic acid (13 cRA) in the treatment of two VIN 3 cases of this type.. Two patients with chronic and recurrent VIN 3 were treated with combined therapy of IFN-alpha (4.5 x 10(6) five times a week) and 13 cRA (1 mg/kg/d) for six months. Clinical regression was observed at the end of treatment in both cases, but histologic features of VIN 3 were still present.. These data demonstrate the ineffectiveness of the combined regimen of IFN-alpha and 13 cRA with this schedule for a period of six months in recurrent and chronic VIN 3.

Topics: Adult; Drug Therapy, Combination; Female; Humans; Interferon-alpha; Isotretinoin; Keratolytic Agents; Middle Aged; Papillomaviridae; Papillomavirus Infections; Treatment Failure; Treatment Outcome; Uterine Cervical Dysplasia; Vulva; Vulvar Neoplasms

In contrast to squamous cell carcinoma of the penis, scrotal carcinoma has historically been associated with exposure to environmental or industrial carcinogens and has only rarely been correlated with human papillomavirus. We report on a patient with squamous cell carcinoma of the scrotum in which human papillomavirus type 16 was integrated into the tumor cell genome, suggesting a causal role of human papillomavirus in the development of squamous cell carcinoma of the scrotum. Other unique features of our case include the presence of Darier's disease, an uncommon genodermatosis, and treatment with oral retinoids, which have prophylactic value in the prevention of cutaneous malignancies.

Topics: Amino Acid Sequence; Carcinoma, Squamous Cell; Darier Disease; DNA, Viral; Genital Neoplasms, Male; Humans; Isotretinoin; Male; Middle Aged; Molecular Sequence Data; Papillomaviridae; Papillomavirus Infections; Scrotum; Tumor Virus Infections

Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Interferon-alpha; Isotretinoin; Male; Neoplasms; Papillomaviridae; Papillomavirus Infections; Skin Neoplasms; Tumor Virus Infections; Uterine Cervical Neoplasms

Local treatment was administrated to 130 women, in whom colposcopy, cytology and (if the latter was abnormal) histology pointed to HPV infection in uterine cervix. The best results were obtained with 13-cis-retinoic acid (provitamin A) in conjunction with interferon beta (94.2% cured patients), followed by interferon beta in combination with TFX (90% cured patients) and interferon beta administered alone (88% cured patients).

Topics: Administration, Topical; Adult; Aged; Drug Combinations; Female; Follow-Up Studies; Humans; Interferon-beta; Isotretinoin; Middle Aged; Papillomaviridae; Papillomavirus Infections; Remission Induction; Thymus Extracts; Tumor Virus Infections; Uterine Cervical Diseases