isotretinoin and Myopia

To investigate the effect of oral isotretinoin use on refractive error, axial length, and anteroposterior segment parameters.. In this prospective study, 50 eyes of 50 patients using isotretinoin with a diagnosis of acne vulgaris and 50 eyes of 50 healthy control subjects were included. After detailed biomicroscopy, measurements were taken of axial length, lens thickness, central corneal thickness, anterior chamber depth, central retinal thickness, and subfoveal choroidal thickness. The pupils of both eyes were dilated with one drop of cycloplegic drops after refraction measurement. Visual acuity examination was performed with a Snellen chart the next day. The same procedure was repeated at the end of the third and sixth month of drug treatment.. Forty-seven patients with acne vulgaris and 45 healthy controls met the inclusion criteria and were included in the analysis. The mean ages of the patients and the controls were 21.7 ± 2.5 years (range, 18-28 years) and 22.6 ± 2.7 years (range, 19-27 years), respectively. No significant changes were observed in any parameters in the third and sixth month in the control group (. Isotretinoin is one of the important molecules in the aetiology of myopia. Oral isotretinoin treatment may increase myopia and axial length, although not to a clinically significant degree. However, as this was a pilot study, there is a need for further studies with more patients and longer follow-up periods.

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Dermatologic Agents; Eye; Female; Humans; Isotretinoin; Male; Myopia; Pilot Projects; Visual Acuity; Young Adult

To report and describe the management a rare case of transient bilateral angle closure with increased intraocular pressure (IOP) and myopic shift while on isotretinoin therapy for acne.. A 28-year-old woman presented with bilateral myopic shift, angle closure with IOP increase, and supraciliary effusion 1 week after acne therapy with isotretinoin. Two weeks after stopping isotretinoin, and treatment with topical prednisolone acetate, atropine, and fixed combination of timolol and dorzolamide, refraction, IOP returned to normal and supraciliary effusions was decreased on ultrasound biomicroscopy.. Oral isotretinoin for acne treatment may be associated with an adverse reaction, resulting in bilateral transient myopia and angle closure with IOP elevation.

Topics: Acne Vulgaris; Adult; Antihypertensive Agents; Dermatologic Agents; Female; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Isotretinoin; Microscopy, Acoustic; Myopia; Sulfonamides; Thiophenes; Timolol

Topics: Acne Vulgaris; Acute Disease; Administration, Oral; Adult; Female; Humans; Isotretinoin; Myopia

A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne. This idiosynactic adverse reaction has not been previously described. There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.

Topics: Acne Vulgaris; Acute Disease; Adult; Female; Humans; Isotretinoin; Myopia; Tretinoin