isotretinoin and Lymphoma--T-Cell

To report a rare case of T-cell malignant lymphoma involving the conjunctiva.. A 63-year-old woman had rapid onset of bilateral perilimbal congestion and chemosis. Perilimbal thickening with corneal infiltration developed 20 days later. Computed tomography incidentally disclosed a right maxillary sinus mass. Biopsy specimens from the maxillary sinus mass and the left limbus were subjected to histopathologic examination and immunohistochemical study.. T-cell malignant lymphoma of diffuse large cell type, stage IV, was diagnosed. The patient was treated with combination chemotherapy plus 13-cis-retinoic acid and remained in remission 1 1/2 years after diagnosis.. Conjunctival involvement with T-cell lymphoma may present as episcleritis and chemosis.

Topics: Antineoplastic Combined Chemotherapy Protocols; Conjunctival Neoplasms; Female; Humans; Immunohistochemistry; Immunophenotyping; Isotretinoin; Leukocyte Common Antigens; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell; Maxillary Sinus Neoplasms; Middle Aged; Neoplasm Staging; Tomography, X-Ray Computed