isotretinoin and Leukemia--Radiation-Induced

The aim of the study was to analyze the incidence of X-ray induced lymphomas in C57B1/10W mice kept on diet with varying retinoid content. The mice whose diet was supplemented with 13-cis retinoic acid (300 mg per kg of chow) developed less lymphomas than those kept on Vitamin A deficient diet as well as on a standard diet (15 mg per kg of chow). Mice subjected to Vitamin A deficient diet displayed a shortening of the latency period.

Topics: Administration, Oral; Animals; Female; Isotretinoin; Leukemia, Radiation-Induced; Lymphoma; Mice; Mice, Inbred Strains; Thymus Neoplasms; Tretinoin