isotretinoin has been researched along with Hyperhomocysteinemia* in 4 studies
1 review(s) available for isotretinoin and Hyperhomocysteinemia
| Article | Year |
|---|---|
Depression, isotretinoin, and folic acid: A practical review.
Isotretinoin (ISO) is a first-generation retinoid discovered in 1952 and approved by the FDA for the treatment of nodulocystic acne in 1982. The anti-inflammatory properties of ISO have found its use in disorders other than acne. ISO can create psychiatric problems, including depression and suicidal ideation. These neuropsychiatric problems are very similar to disorders secondary to hyperhomocysteinemia (HHcy), vitamin B12, and folic acid (vitamin B9) deficiencies. Given that previous literature suggested folate supplementation improved the efficacy of traditional antidepressant medications, clinicians may wish to consider folate supplementation for patients with depression or possible depressive symptoms, such as acne patients with genetic susceptibility. Brain-derived neurotrophic factor may be a cytokine-specific screening biomarker in immune-based antidepressive therapy. Topics: Acne Vulgaris; Brain-Derived Neurotrophic Factor; Depression; Fatty Acids; Folic Acid; Humans; Hyperhomocysteinemia; Isotretinoin | 2019 |
3 other study(ies) available for isotretinoin and Hyperhomocysteinemia
| Article | Year |
|---|---|
Comment on 'The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne': may retinoids be useful to treat hyperhomocysteinemia found in patients affected by hidradenitis suppurativa?
Topics: Acne Vulgaris; Folic Acid; Hidradenitis Suppurativa; Homocysteine; Humans; Hyperhomocysteinemia; Isotretinoin; Retinoids; Vitamin B 12 | 2020 |
A novel explanation for isotretinoin-induced psychiatric problems and its practical implication.
Topics: Dermatologic Agents; Humans; Hyperhomocysteinemia; Isotretinoin; Mental Disorders | 2011 |
The effect of isotretinoin treatment on plasma homocysteine levels in acne vulgaris.
Isotretinoin has revolutionized the treatment of acne by improving the cosmetic outcome and decreasing the psychological damage. However, use of isotretinoin is associated with significant side-effects such as mucocutaneous involvement, dyslipidaemia and liver dysfunction, as indicated by increases in liver enzymes. The responsible enzyme for homocysteine metabolism, cystathionine-beta-synthase, might also be affected by isotretinoin-induced liver dysfunction, which leads to hyperhomocysteinaemia, an independent risk factor for thrombovascular diseases. The aim of this study was to evaluate homocysteine levels and the responsible vitamins for its metabolism in patients with moderate to severe acne vulgaris on isotretinoin treatment, before and after treatment. We found increased level of homocysteine in patients after 2 months of taking isotretinoin. Our findings suggest that isotretinoin may increase the risk of cardiovascular disorders by causing hyperhomocysteinaemia. Topics: Acne Vulgaris; Adolescent; Dermatologic Agents; Female; Homocysteine; Humans; Hyperhomocysteinemia; Isotretinoin; Liver Function Tests; Male; Risk Factors; Treatment Outcome; Young Adult | 2010 |