isotretinoin and Hand-Injuries

Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype-phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the disease may be present in the same patient or relatives. Histopathology reveals dyskeratosis and suprabasal acantholysis with hemorrhagic lacunae. We report 3 new cases of this type of Darier disease triggered by injuries. Response to retinoid therapy was good.

Topics: Acitretin; Adult; Darier Disease; Dermatologic Agents; Female; Hand Injuries; Humans; Isotretinoin; Male; Middle Aged; Nails, Malformed; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Seasons; Tretinoin