isotretinoin and Hair-Diseases

Topics: Acne Vulgaris; COVID-19; COVID-19 Vaccines; Dermatologic Agents; Hair Diseases; Humans; Isotretinoin; Vaccines

Topics: Abnormalities, Multiple; Adolescent; Hair Diseases; Humans; Isotretinoin; Male; Skin Diseases; Syndrome; Treatment Outcome

An 18-month-old cross-breed dog developed multiple skin nodules, which over 8 months had increased in size and number. Biopsy samples were submitted for histopathological examination and revealed multiple benign pilomatrixomas. The dog was treated with 1 mg kg(-1) isotretinoin daily, which led to a stabilization of the size and number of the lesions. Attempts to lower the dosage to an every other day regimen led to an increase in the nodules' size and number. Monthly complete blood count and chemistry tests and Schirmer tear tests were performed to monitor any adverse effects of the retinoid treatment. No adverse effects were noted. To the authors' knowledge, this is the first report of multiple pilomatrixomas arising in a young dog and successfully controlled with oral retinoids.

Topics: Animals; Dermatologic Agents; Diagnosis, Differential; Dog Diseases; Dogs; Drug Administration Schedule; Hair Diseases; Isotretinoin; Male; Pilomatrixoma; Skin Neoplasms

A mother and daughter with epidermolytic hyperkeratosis were treated with two different synthetic retinoids at different times. Both patients exhibited the previously unreported side effect of increased curliness of scalp hair. Light microscopic examination revealed pili torti during the administration of isotretinoin. Both patients also experienced a better therapeutic response to and more hair loss with etretinate than with isotretinoin.

Topics: Adolescent; Adult; Female; Hair; Hair Diseases; Humans; Isotretinoin; Keratosis; Tretinoin