isotretinoin and Genital-Diseases--Male

The aim of our study was to evaluate the efficacy and safety of oral isotretinoin in the treatment of condylomata acuminata.. A total of 56 male patients with a history of condylomata acuminata refractory to at least 1 standard therapeutic regimen was treated orally with isotretinoin (1 mg./kg. daily) during a 3-month period.. At the end of treatment 21 of the 53 evaluated patients (39.6%) had complete response, 7 (13.2%) had partial response and 25 (47.1%) had no response. A statistically significant inverse relationship was found between age and area of treated lesions and response to medication. Two complete responders (9.5%) revealed recurrence during the 1-year followup.. Oral isotretinoin may be regarded as an effective, fairly well tolerated and noninvasive alternative form of therapy for immature and small condylomata acuminata.

Topics: Administration, Oral; Adult; Condylomata Acuminata; Genital Diseases, Male; Humans; Isotretinoin; Male; Middle Aged

Purpose of the present study was to evaluate the effectiveness of isotretinoin versus interferon alfa-2a plus isotretinoin in the treatment of recurrent condyloma acuminatum in 86 men.. Men were randomly assigned to group A (n = 42) who received isotretinoin 1 mg/kg orally daily until remission was achieved, but not more than 3 months, or to group B (n = 44) who received interferon alfa-2a 3 x 10(5) IU subcutaneously three times weekly until remission was achieved, but not more than 8 weeks, plus isotretinoin in the same dosage as in group A.. The reduced duration of treatment to achieve remission was statistically significant in group B (2.18 versus 2.5 months; P < 0.01) and the recurrence rate was less in group B (4 of 44 versus 16 of 42; P < 0.01).. The results of this study are encouraging and demonstrated that the combination of isotretinoin plus interferon alfa-2a achieves higher remission rates and a shorter duration of treatment than isotretinoin alone.

Topics: Adolescent; Adult; Combined Modality Therapy; Condylomata Acuminata; Follow-Up Studies; Genital Diseases, Male; Humans; Interferon alpha-2; Interferon-alpha; Isotretinoin; Male; Recombinant Proteins; Recurrence; Remission Induction; Time Factors

Scrotal calcinosis is a rare disorder characterized by multiple papules or nodules of calcification in the scrotal skin. The pathogenesis of this disease is poorly understood. The condition presents as several brown to yellowish asymptomatic nodules on the scrotum. Excision followed by scrotal reconstruction is the treatment of choice. It leaves a good cosmetic result with low chances of recurrence. Newer treatments, such as ablative lasers, have been proposed with very good results. We describe the case of a 28-year-old patient with a history of severe acne treated with oral isotretinoin that presented for scrotal nodules. On laboratory examination, hypercalcemia was found with normal phosphorus, parathyroid hormone, and vitamin D hormone levels. Hypercalcemia was linked to his isotretinoin therapy. Serum calcium concentrations normalized after cessation of isotretinoin and hydration. Because the patient refused surgery, a biopsy of the lesion confirmed the diagnosis of scrotal calcinosis. Then the patient was referred to a cosmetic laser center to treat his condition.

Topics: Adult; Calcinosis; Calcium; Genital Diseases, Male; Humans; Hypercalcemia; Isotretinoin; Male; Parathyroid Hormone; Phosphorus; Scrotum; Vitamin D

Topics: Adolescent; Adult; Anus Diseases; Drug Eruptions; Dyspareunia; Female; Genital Diseases, Female; Genital Diseases, Male; Hemorrhage; Humans; Isotretinoin; Male; Middle Aged; Mucositis; Sebaceous Glands; Young Adult