isotretinoin and Facial-Neoplasms

A 23-year-old man with a typical trichilemmal cyst nevus is reported. This recently described disorder is sufficiently characteristic to differentiate it from sebaceous nevus, nevus comedonicus, porokeratotic eccrine nevus, nevus corniculatus, follicular basaloid hamartoma, Munro's nevus and Gardner's syndrome.

Topics: Dermatologic Agents; Epidermal Cyst; Facial Neoplasms; Humans; Isotretinoin; Male; Nevus; Skin Neoplasms; Sweat Gland Neoplasms; Treatment Outcome; Young Adult

We report on a 63-year-old female patient with Muir-Torre syndrome (MTS). In the course of this disease two carcinomas of the colon, a kerato-acanthoma and multiple sebaceous gland tumours, including four sebaceous carcinomas, appeared. This case is thought to be a hereditary form as one of daughters was also found to have a sebaceous epithelioma. MTS is a mostly autosomal-dominant disease with the association of sebaceous gland tumours and internal carcinomas. As the malignant tumours only show slight aggressiveness the prognosis is quite favourable. Oral isotretinoin therapy was successfully used for the inhibition of sebaceous gland proliferation. A narrower definition is presented and an updated survey of the published cases is given. Furthermore, the histopathologic peculiarities of sebaceous gland tumours, especially of sebaceous gland carcinomas, are discussed and compared to sebaceous gland tumours not connected with MTS. A total number of 100 of the 135 published cases of MTS were included and analysed regarding sebaceous gland tumours and other skin tumours. The data on internal carcinomas were taken from the work of Cohen et al. (1991) and 11 current cases were added.

Topics: Adenocarcinoma; Adenoma, Sweat Gland; Adenomatous Polyposis Coli; Administration, Oral; Carcinoma; Carcinoma, Squamous Cell; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Facial Neoplasms; Female; Genes, Dominant; Humans; Isotretinoin; Keratoacanthoma; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Neoplastic Syndromes, Hereditary; Sebaceous Gland Neoplasms; Sweat Glands; Syndrome

Topics: Adolescent; Dermatologic Agents; Facial Neoplasms; Hemangioma; Humans; Isotretinoin; Male

Topics: Aged; Carcinoma, Squamous Cell; Drug Therapy, Combination; Facial Neoplasms; Humans; Interferon-alpha; Isotretinoin; Male; Remission Induction; Skin Neoplasms; Treatment Outcome

Topics: Facial Neoplasms; Female; Hamartoma; Humans; Isotretinoin; Middle Aged; Neoplasms, Multiple Primary; Tretinoin

A florid case of osteoma cutis was observed following isotretinoin treatment of severe cystic acne in which a few scattered osteomata of the skin were observed prior to the treatment with isotretinoin.

Topics: Acne Vulgaris; Adult; Facial Neoplasms; Female; Humans; Isomerism; Isotretinoin; Osteoma; Skin Neoplasms; Time Factors; Tretinoin