isotretinoin and Eosinophilia

Topics: Eosinophilia; Folliculitis; Humans; Isotretinoin; Skin Diseases, Vesiculobullous

Topics: Clobetasol; Dermatologic Agents; Diagnosis, Differential; Eosinophilia; Humans; Hydroxyzine; Isotretinoin; Male; Middle Aged; Pityriasis Rubra Pilaris; Psoriasis; Severity of Illness Index; Skin; Treatment Outcome; Urea

Eosinophilic pustular folliculitis is a secondary symptom associated with HIV infection appears as levels of CD4 lymphocyte cells and T4 lymphocyte cell. Isotretinoin, an analog of vitamin A (retinoid) alters the DNA transcription mechanism and interferes in the process of DNA formation. It also inhibits the eosinophilic chemotactic factors present in sebaceous lipids and in the stratum corneum of patients suffering from this ailment.. The present research was aimed to formulate isotretenoin-loaded invasomal gel to deliver and target the drug to pilosebaceous follicular unit.. Nine invasomal formulations (F1-F9) were prepared applying 3. Formulation F9 was selected as optimized formulation due to optimum results and highest %CDP of 85.94 ± 1.86% in 8 h. Transmission electron microscopy (TEM) suggested uniformity in vesicles shape and size in F9 and developed as invasomal gel (IG).. Clinical phase-I, phase-II, and phase-III studies will be required before using on human patients.. Confocal laser scanning microscopy (CLSM) validates that IG successfully reaches the pilosebaceous follicular unit and further studied on cell line (SZ-95) exhibited IC50 of ≤8 (25 μM of isotretenoin). Cell cycle analysis confirmed IG arrested the cell growth up to 82% with insignificant difference to pure isotretenion.

Topics: CD4 Lymphocyte Count; Cell Cycle; Eosinophilia; Folliculitis; HIV Infections; Humans; Isotretinoin; Microscopy, Confocal; Skin Diseases, Vesiculobullous

Topics: Adult; Aged; Dermatologic Agents; Eosinophilia; Fasciitis; Glucocorticoids; Humans; Isotretinoin; Male; Prednisone; Ultraviolet Therapy

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign but potentially disfiguring vascular lesion. It is usually characterized by dermal and subcutaneous nodules, primarily in the head and neck region. Spontaneous regression is common, but persistent or recurrent lesions may require treatment. Several treatments have been reported but surgery is the most efficient one.. We report a 32-year-old man presenting with multiple nodules on the cheeks, preauricular region and the scalp and who received treatment with isotretinoin (0.5 mg/kg/day) for 1 year with complete resolution of one of his scalp nodules. The rest of the lesions remained stable and were treated with surgical excision without recurrence.. Isotretinoin may play a role in the treatment of ALHE due to its antiangiogenic properties via a reduction of vascular endothelial growth factor (VEGF) production by keratinocytes.

Topics: Adult; Castleman Disease; Dermatologic Agents; Dose-Response Relationship, Drug; Eosinophilia; Follow-Up Studies; Humans; Isotretinoin; Male; Skin Diseases

Topics: Antineoplastic Agents; Bone Marrow Transplantation; Child, Preschool; Eosinophilia; Humans; Infant; Isotretinoin; Male; Neuroblastoma

Eosinophilic folliculitis (EF) is a chronic, intensely pruritic condition of unknown pathogenesis that causes marked morbidity in those HIV patients whom it affects. There is a wide differential diagnosis of itchy skin conditions in HIV which are amenable to different treatments. It is therefore essential to take a biopsy of each suspected case and examine multiple sections of the biopsy to confirm or refute a diagnosis of EF. Treatment of EF can be difficult but we hope that by suggesting a rational approach to this and considering possible therapeutic options more patients may be helped with this troublesome dermatosis.

Topics: Administration, Topical; Anti-Infective Agents; Anti-Inflammatory Agents; Antifungal Agents; Eosinophilia; Folliculitis; Glucocorticoids; Histamine H1 Antagonists; HIV Infections; Humans; Insecticides; Isotretinoin; Itraconazole; Keratolytic Agents; Metronidazole; Permethrin; Pyrethrins; Skin Diseases; Ultraviolet Therapy

Topics: Acquired Immunodeficiency Syndrome; Adult; Eosinophilia; Folliculitis; Humans; Isotretinoin; Keratolytic Agents; Male; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Eosinophilia; Humans; Isotretinoin; Keratolytic Agents; Pleural Effusion

The case of a 30-year-old man with a 6-year history of eosinophilic pustular folliculitis (EPF) is reported. Isotretinoin (1 mg/kg/day) led to a dramatic improvement of all the lesions within 2 weeks. The withdrawal of the drug was followed by a recurrence after 10 days of the papulopustular, follicular and pruritic lesions. Reintroduction of isotretinoin was successful. The benefits of isotretinoin in the treatment of EPF have, to the best of our knowledge, never been reported previously. The mechanisms underlying this efficacy may involve the inhibition of the eosinophilic chemotactic factors thought to be present in sebaceous lipids and in the stratum corneum of patients suffering from EPF.

Topics: Adult; Eosinophilia; Folliculitis; Humans; Isotretinoin; Male

Topics: Adult; Dapsone; Eosinophilia; Female; Folliculitis; Humans; Isotretinoin; Skin Diseases, Vesiculobullous