isotretinoin and Corneal-Diseases

We reviewed the most recent systemic drugs used in Belgium causing toxic corneal side effects. These adverse reactions are rarely specific and often ignored or unknown. This description can help the physician's evaluation for a better interdisciplinary approach.

Topics: Belgium; Chloroquine; Cornea; Corneal Diseases; Cytarabine; Drug-Related Side Effects and Adverse Reactions; Humans; Isotretinoin; Keratitis; Pharmaceutical Preparations; Rifabutin; Tamoxifen

Topics: Acne Vulgaris; Adult; Corneal Diseases; Dermatologic Agents; Eye Pain; Female; Humans; Isotretinoin

Whereas there are numerous reported ocular side-effects from isotretinoin medication, we present the first case report of corneal steepening after systemic treatment with isotretinoin for seven and a half weeks. The case was associated with a significant drop in visual acuity which could not be explained from the refractive error change. All signs and symptoms were absent seven and a half weeks after the medication was withdrawn. The case indicates that eye care professionals need to be vigilant about the possibility of adverse ocular manifestations associated with the use of systemic medications.

Topics: Acne Vulgaris; Adult; Adverse Drug Reaction Reporting Systems; Corneal Diseases; Corneal Topography; Dermatologic Agents; Female; Humans; Isotretinoin; Treatment Outcome; Visual Acuity