isotretinoin and Connective-Tissue-Diseases

Acne fulminans is a severe form of acne characterized by painful, inflammatory nodules that progress into ulcers and concurrent systemic symptoms. Treatment of acne with isotretinoin can precipitate a syndrome called isotretinoin-induced acne fulminans without systemic symptoms. An exuberant granulation tissue response, another known adverse event associated with isotretinoin, can occur concurrently, inhibiting wound repair and complicating treatment. We report a case of isotretinoin-induced acne fulminans without systemic symptoms with exuberant granulation tissue response that was treated successfully with topical clobetasol ointment.

Topics: Acne Vulgaris; Adolescent; Anti-Inflammatory Agents; Clobetasol; Connective Tissue Diseases; Dermatologic Agents; Humans; Isotretinoin; Male