isotretinoin and Acne-Conglobata

Topics: Acne Conglobata; Acne Vulgaris; Administration, Oral; Dermatologic Agents; Humans; Isotretinoin; Lasers; Treatment Outcome

Topics: Acne Conglobata; Acne Vulgaris; Animals; Cysts; Dermatologic Agents; History, 20th Century; Humans; Isotretinoin; Mice; Models, Animal; Papilloma; Placebo Effect; Skin Neoplasms; Vitamin A

Topics: Acne Conglobata; Dermatologic Agents; Humans; Isotretinoin; Tumor Necrosis Factor-alpha

Topics: Acne Conglobata; Dermatologic Agents; Humans; Isotretinoin; Male; Scleritis; Treatment Outcome; Vision Disorders; Young Adult

Acne fulminans is an uncommon and debilitating disease that presents as an acute eruption of nodular and ulcerative acne lesions in association with systemic symptoms. It occurs commonly during treatment of severe acne (eg, acne conglobata) with isotretinoin in young adolescent male patients. Isotretinoin and doxycycline also can potentially induce development of neutrophilic dermatoses in patients with severe acne lesions, which are characterized by the acute appearance of painful ulcerative papulonodules accompanied by systemic symptoms including fever and leukocytosis. We report a challenging case of a 13-year-old adolescent boy who acutely developed hundreds of ulcerative plaques as well as systemic symptoms after being treated with doxycycline and isotretinoin for acne conglobata. He was treated with prednisone, dapsone, and colchicine and had to switch to cyclosporine to achieve relief from his condition.

Topics: Acne Conglobata; Adolescent; Colchicine; Cyclosporine; Dapsone; Dermatologic Agents; Doxycycline; Humans; Isotretinoin; Male; Neutrophils; Prednisone; Skin Ulcer

Topics: Acne Conglobata; Acquired Hyperostosis Syndrome; Adult; Arthralgia; Chest Pain; Drug Therapy, Combination; Etanercept; Humans; Isotretinoin; Male; Taiwan; Tumor Necrosis Factor-alpha