isospaglumic acid has been researched along with Disease Models, Animal in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Azuma, S; Fu, K; Iegaki, N; Ishikawa, Y; Miyamoto, Y; Muramatsu, SI; Nitta, A; Sumi, K; Uno, K | 1 |
| Alt, J; Hollinger, KR; Kaplin, AI; Rais, R; Slusher, BS | 1 |
| Fievisohn, EM; Hardy, WN; Sajja, VS; Vandevord, PJ | 1 |
| Dubovický, M; Kašparová, S; Kucharská, J; Liptaj, T; Lipták, B; Sumbalová, Z; Szomolányi, P; Trattnig, S; Tušková, R; Uličná, O; Vančová, O | 1 |
| Berneman, Z; Daans, J; Guglielmetti, C; Hens, N; Kara, F; Orije, J; Ponsaerts, P; Praet, J; Santermans, E; Van der Linden, A; Verhoye, M | 1 |
| Chen, H; Flora, MN; Guo, H; Liu, J; McCabe, JT; McDonough, JH; Myers, TM; Van Shura, K | 1 |
| Gröhn, H; Gröhn, OH; Immonen, RJ; Kharatishvili, I; Niskanen, JP; Pitkänen, A | 1 |
| de Mattos Dutra, A; Dutra-Filho, CS; Henn, NT; Pederzolli, CD; Rockenbach, FJ; Romagna, EC; Sgaravatti, AM; Wajner, M; Wannmacher, CM; Wyse, AT; Zanin, FR | 1 |
| Baslow, MH; Guilfoyle, DN | 1 |
| Canta, A; Carozzi, VA; Cavaletti, G; Chiorazzi, A; Lapidus, RG; Slusher, BS; Wozniak, KM | 1 |
| Bubeníková-Valešová, V; Franěk, M; Rokyta, R; Šťastný, F; Vaculín, S; Yamamotová, A | 1 |
| Adedoyin, MO; Neale, JH; Vicini, S | 1 |
| Rowland, LM | 1 |
| Aoki, I; Barkovich, AJ; Inoue, K; Ito, Y; Saito, S; Takanashi, J | 1 |
| Campbell, GA; Ezell, EL; Matalon, R; Michals-Matalon, K; Quast, MJ; Rady, PL; Rassin, DK; Surendran, S; Szucs, S; Tyring, SK; Wei, J | 1 |
| Carpenter, KJ; Dickenson, AH; Flatters, SL; Matthews, EA; Sen, S; Slusher, BS; Wozniak, KM | 1 |
| Cochran, SM; Morris, BJ; Pratt, JA; Reynolds, GP; Reynolds, LM | 1 |
| Minabe, Y; Ogino, T; Shirayama, Y; Takahashi, S | 1 |
| Ebinger, G; Hachimi-Idrissi, S; Michotte, Y; Sarre, S; Van Hemelrijck, A | 1 |
| Berman, RF; Bzdega, T; Jiang, J; Kozikowski, AP; Lyeth, BG; Neale, JH; O'Connor, WT; Smyth, A; Van, KC; Zhao, X; Zhong, C; Zhou, J | 1 |
| Garrido-Sanabria, ER; Moffett, JR; Pacheco Otalora, LF | 1 |
| Montero, JA; Pastor, S; Rodriguez, AE; Ruiz-Moreno, JM; Sanchis-Merino, ME | 1 |
| Comair, YG; Hong, SC; Lüders, HO; Najm, IM; Ng, TC; Wang, Y | 1 |
| Bhardwaj, A; Britton, P; Harukuni, I; Hurn, PD; Jackson, PF; Lu, XC; Potter, BM; Robinson, MB; Slusher, BS; Thomas, AG; Tortella, FC; Traystman, RJ; Vornov, JJ; Wozniak, KM; Yudkoff, M | 1 |
| Nozaki-Taguchi, N; Sakashita, Y; Yamamoto, T | 1 |
| Cai, Z; Lin, S; Rhodes, PG | 1 |
| Bixler, MA; Coyle, JT; Koller, KJ; Meyerhoff, JL; Robinson, MB | 1 |
28 other study(ies) available for isospaglumic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice.
Topics: Acetyltransferases; Animals; Aspartic Acid; Corpus Striatum; Depression; Dipeptides; Disease Models, Animal; Gene Expression Regulation; Green Fluorescent Proteins; HEK293 Cells; Hindlimb Suspension; Humans; Interpersonal Relations; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microdialysis; Microinjections; Receptors, Metabotropic Glutamate; Serotonin; Swimming; Transduction, Genetic | 2017 |
The NAAG'ing Concerns of Modeling Human Alzheimer's Disease in Mice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antigens, Surface; Brain; Brain Chemistry; Dipeptides; Disease Models, Animal; Female; Gas Chromatography-Mass Spectrometry; Glutamate Carboxypeptidase II; Humans; Male; Mice; Mice, Inbred C57BL | 2019 |
Evaluation of impact-induced traumatic brain injury in the Göttingen Minipig using two input modes.
Topics: Animals; Aspartic Acid; Brain Injuries; Dipeptides; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Swine; Swine, Miniature | 2014 |
Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Dementia; Dipeptides; Disease Models, Animal; Galactose; Inositol; Magnetic Resonance Spectroscopy; Male; Nootropic Agents; Organ Size; Phosphorus Isotopes; Protons; Rats, Wistar; Simvastatin; Spatial Learning; Spatial Memory; Thiobarbituric Acid Reactive Substances; Treatment Outcome; Ubiquinone | 2015 |
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Cuprizone; Demyelinating Diseases; Dipeptides; Disease Models, Animal; Female; Gliosis; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neuroimaging; Oligodendroglia; Phosphocreatine; Proton Magnetic Resonance Spectroscopy | 2015 |
N-acetyl-aspartyl-glutamate and inhibition of glutamate carboxypeptidases protects against soman-induced neuropathology.
Topics: Animals; Brain; Carboxypeptidases; Cell Death; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Male; Neurons; Neuroprotective Agents; Organophosphate Poisoning; Organophosphorus Compounds; Rats, Sprague-Dawley; Signal Transduction; Soman; Time Factors | 2015 |
Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat--11 months follow-up.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffusion Magnetic Resonance Imaging; Dipeptides; Disease Models, Animal; Follow-Up Studies; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Statistics, Nonparametric; Time Factors | 2009 |
Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.
Topics: Animals; Antioxidants; Aspartic Acid; Brain Damage, Chronic; Canavan Disease; Catalase; Cerebral Cortex; Dipeptides; Disease Models, Animal; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Injections, Intraventricular; Lipid Peroxidation; Male; Neuropeptides; Neurotoxins; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar | 2009 |
Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?
Topics: Amidohydrolases; Animals; Aspartic Acid; Astrocytes; Brain; Canavan Disease; Dipeptides; Disease Models, Animal; Extracellular Fluid; Humans; Myelin Sheath | 2009 |
Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat.
Topics: Animals; Antineoplastic Agents; Body Weight; Carboxypeptidases; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Enzyme Inhibitors; Female; Ganglia, Spinal; Glutamic Acid; Neuroprotective Agents; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Statistics, Nonparametric | 2010 |
Pain perception in neurodevelopmental animal models of schizophrenia.
Topics: Age Factors; Animals; Animals, Newborn; Dipeptides; Disease Models, Animal; Female; Hot Temperature; Humans; Injections, Intraventricular; Male; Neuralgia; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2010 |
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Topics: Amygdala; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Excitatory Postsynaptic Potentials; Formaldehyde; Glutamate Carboxypeptidase II; Hyperalgesia; In Vitro Techniques; Inflammation; Mice; Models, Biological; Neuronal Plasticity; Nociceptors; Pain; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Urea | 2010 |
Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues.
Topics: Animals; Depressive Disorder, Major; Diffusion Tensor Imaging; Dipeptides; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nerve Degeneration; Rats; Stress, Psychological | 2011 |
Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dipeptides; Disease Models, Animal; Immunoenzyme Techniques; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Pelizaeus-Merzbacher Disease; Thalamus | 2012 |
Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Azo Compounds; Brain Chemistry; Canavan Disease; Creatine; Dipeptides; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Insect Proteins; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, Protein | 2003 |
Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.
Topics: Animals; Carrageenan; Dipeptides; Disease Models, Animal; Electric Stimulation; Glutamate Carboxypeptidase II; Ligation; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuralgia; Neuritis; Nociceptors; Organophosphorus Compounds; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2003 |
Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain.
Topics: Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Frontal Lobe; Hallucinogens; Hippocampus; Male; Phencyclidine; Psychotic Disorders; Rats; Rats, Long-Evans; Temporal Lobe | 2005 |
In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.
Topics: Amino Acids; Amygdala; Animals; Creatine; Dipeptides; Disease Models, Animal; Energy Metabolism; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glycine; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Magnetic Resonance Spectroscopy; Male; Neural Pathways; Rats; Rats, Wistar; Up-Regulation | 2005 |
Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain Ischemia; Dipeptides; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelin-1; Hypothermia; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Wistar; Time Factors; Xanthenes | 2005 |
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.
Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Up-Regulation | 2006 |
Selective vulnerability of hippocampal NAAGergic neurons in experimental temporal lobe epilepsy.
Topics: Animals; Cell Count; Cell Survival; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Glutamate Decarboxylase; Hippocampus; Isoenzymes; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Vesicular Glutamate Transport Protein 1 | 2007 |
Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.
Topics: Animals; Anti-Allergic Agents; Benzimidazoles; Coloring Agents; Conjunctivitis, Allergic; Dibenzoxepins; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Evans Blue; Guinea Pigs; Histamine H1 Antagonists; Ketotifen; Male; Olopatadine Hydrochloride; Ophthalmic Solutions; Phthalazines; Severity of Illness Index; Treatment Outcome | 2008 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuropeptides; Protons; Rats; Rats, Sprague-Dawley; Seizures; Temporal Lobe | 1997 |
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.
Topics: Animals; Brain Ischemia; Carboxypeptidases; Culture Techniques; Dipeptides; Disease Models, Animal; Drug Tolerance; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Ischemic Attack, Transient; Mice; Mice, Inbred ICR; Neuroprotective Agents; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Stroke | 1999 |
Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.
Topics: Animals; Carboxypeptidases; Carrageenan; Dipeptides; Disease Models, Animal; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Hindlimb; Hyperalgesia; Inflammation; Male; Neural Inhibition; Nociceptors; Organophosphorus Compounds; Pain; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 2001 |
Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Carboxypeptidases; Cyclic AMP; Cycloleucine; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Hippocampus; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Organophosphorus Compounds; Propionates; Rats; Rats, Sprague-Dawley; Xanthenes | 2002 |
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Brain Mapping; Dipeptidases; Dipeptides; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamates; Glutamic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Seizures | 1992 |