isosafrole and Body-Weight

isosafrole has been researched along with Body-Weight* in 2 studies

Other Studies

2 other study(ies) available for isosafrole and Body-Weight

Article	Year
Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats. Biochemistry international, 1990, Volume: 20, Issue:4 The influence of food restriction (FR) on the drug-inducible capacity of liver microsomal cytochrome P-450s IA1, IA2 and IIB1 and IIB2 was studied in 20-month-old male Fischer-344 rats. ELISA and Western Blotting revealed that the induction of the cytochrome P-450-IA1/IA2 and P-450-IIB1/IIB2 enzymes was considerably higher in the liver microsomes of FR rats than in their ad libitum (AL) fed counterparts. In order to determine whether the higher P-450 enzyme levels in FR rats were a reflection of an increased synthesis rate or a stabilization of these enzymes, hybridization studies were performed with a cDNA probe for P-450-IIB1/IIB2. These studies show markedly higher levels of P-450-IIB1/IIB2 mRNAs in the livers of FR rats as compared to AL animals. These results suggest that it is possible to prevent the age-dependent loss of drug-induced cytochrome P-450s by 40% dietary restriction which suggest FR may improve the drug-metabolizing capacity during aging. Topics: Aging; Animals; Blotting, Western; Body Weight; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Food Deprivation; Liver; Male; Microsomes, Liver; Organ Size; Rats; Rats, Inbred F344; RNA, Messenger; Safrole	1990
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone. Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:3 The characteristics of induction of rat-hepatic microsomal mono-oxygenase activity by promethazine and isosafrole have been investigated and compared with the classic inducers phenobarbitone and beta-naphthoflavone. Both promethazine and isosafrole pretreatments result in increased cytochromes P-450, and enhanced NADPH-cytochrome c reductase, aminopyrine N-demethylase, dichloronitroanisole O-demethylase, ethoxycoumarin O-deethylase and ethoxyresorufin O-deethylase activity. Isosafrole but not promethazine increased the liver to body weight ratio. It is concluded that promethazine and isosafrole pretreatment produces an induction of the rat-hepatic microsomal mono-oxygenase system which shows both phenobarbitone- and polycyclic aromatic hydrocarbon-type characteristics. Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole	1985

Article

Year

Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats.

Biochemistry international, 1990, Volume: 20, Issue:4

The influence of food restriction (FR) on the drug-inducible capacity of liver microsomal cytochrome P-450s IA1, IA2 and IIB1 and IIB2 was studied in 20-month-old male Fischer-344 rats. ELISA and Western Blotting revealed that the induction of the cytochrome P-450-IA1/IA2 and P-450-IIB1/IIB2 enzymes was considerably higher in the liver microsomes of FR rats than in their ad libitum (AL) fed counterparts. In order to determine whether the higher P-450 enzyme levels in FR rats were a reflection of an increased synthesis rate or a stabilization of these enzymes, hybridization studies were performed with a cDNA probe for P-450-IIB1/IIB2. These studies show markedly higher levels of P-450-IIB1/IIB2 mRNAs in the livers of FR rats as compared to AL animals. These results suggest that it is possible to prevent the age-dependent loss of drug-induced cytochrome P-450s by 40% dietary restriction which suggest FR may improve the drug-metabolizing capacity during aging.

Topics: Aging; Animals; Blotting, Western; Body Weight; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Food Deprivation; Liver; Male; Microsomes, Liver; Organ Size; Rats; Rats, Inbred F344; RNA, Messenger; Safrole

1990

Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.

Xenobiotica; the fate of foreign compounds in biological systems, 1985, Volume: 15, Issue:3

The characteristics of induction of rat-hepatic microsomal mono-oxygenase activity by promethazine and isosafrole have been investigated and compared with the classic inducers phenobarbitone and beta-naphthoflavone. Both promethazine and isosafrole pretreatments result in increased cytochromes P-450, and enhanced NADPH-cytochrome c reductase, aminopyrine N-demethylase, dichloronitroanisole O-demethylase, ethoxycoumarin O-deethylase and ethoxyresorufin O-deethylase activity. Isosafrole but not promethazine increased the liver to body weight ratio. It is concluded that promethazine and isosafrole pretreatment produces an induction of the rat-hepatic microsomal mono-oxygenase system which shows both phenobarbitone- and polycyclic aromatic hydrocarbon-type characteristics.

Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole

1985